Intratumoral BO-112 in combination with radiotherapy synergizes to achieve CD8 T-cell-mediated local tumor control

(Oligo)metastasis as a spectrum of disease

(2021) Stanley I. Gutiontov et al.   CANCER RESEARCH

Beyond immune checkpoint blockade: emerging immunological strategies

(2021) Shawn P. Kubli et al.   NATURE REVIEWS DRUG DISCOVERY

Real-life use of talimogene laherparepvec (T-VEC) in melanoma patients in centers in Austria, Switzerland and Germany

(2021) Julia Maria Ressler et al.   Journal for ImmunoTherapy of Cancer

Intratumoural administration and tumour tissue targeting of cancer immunotherapies

(2021) Ignacio Melero et al.   Nature Reviews Clinical Oncology

Low Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy

(2021) Fernanda G Herrera et al.   Cancer Discovery

961 Preliminary results of a phase 2 study of intratumoral administration of BO-112 with pembrolizumab in patients with advanced melanoma that have progressive disease on anti-PD-1-based therapy

(2021) Iván Márquez Rodas et al.   Journal for ImmunoTherapy of Cancer

Intratumoral co-injection of the poly I:C-derivative BO-112 and a STING agonist synergize to achieve local and distant anti-tumor efficacy

(2021) Maite Alvarez et al.   Journal for ImmunoTherapy of Cancer

Radiotherapy‐immunotherapy combinations: perspectives and challenges

(2020) Michele Mondini et al.   Molecular Oncology

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Intratumoral nanoplexed poly I:C BO-112 in combination with systemic anti–PD-1 for patients with anti–PD-1–refractory tumors

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Uncoupling interferon signaling and antigen presentation to overcome immunotherapy resistance due to JAK1 loss in melanoma

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Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination

(2019) Linda Hammerich et al.   NATURE MEDICINE

Immunotherapeutic effects of intratumoral nanoplexed poly I:C

(2019) M. Angela Aznar et al.   Journal for ImmunoTherapy of Cancer

Apoptotic caspases inhibit abscopal responses to radiation and identify a new prognostic biomarker for breast cancer patients

(2019) Maria Esperanza Rodriguez-Ruiz et al.   OncoImmunology

Immunological impact of cell death signaling driven by radiation on the tumor microenvironment

(2019) Maria Esperanza Rodriguez-Ruiz et al.   NATURE IMMUNOLOGY

Combined immunotherapy encompassing intratumoral poly-ICLC, dendritic-cell vaccination and radiotherapy in advanced cancer patients

(2018) M E Rodríguez-Ruiz et al.   ANNALS OF ONCOLOGY

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(2018) Chrisann Kyi et al.   CLINICAL CANCER RESEARCH

Safety and Clinical Activity of Pembrolizumab and Multisite Stereotactic Body Radiotherapy in Patients With Advanced Solid Tumors

(2018) Jason J. Luke et al.   JOURNAL OF CLINICAL ONCOLOGY

Incorporating Radiation Oncology into Immunotherapy: proceedings from the ASTRO-SITC-NCI immunotherapy workshop

(2018) Ariel E. Marciscano et al.   Journal for ImmunoTherapy of Cancer

In Situ Vaccination with a TLR9 Agonist and Local Low-Dose Radiation Induces Systemic Responses in Untreated Indolent Lymphoma

(2018) Matthew J. Frank et al.   Cancer Discovery

Radiotherapy induces responses of lung cancer to CTLA-4 blockade

(2018) Silvia C. Formenti et al.   NATURE MEDICINE

Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming

(2016) M. E. Rodriguez-Ruiz et al.   CANCER RESEARCH

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

(2015) Christina Twyman-Saint Victor et al.   NATURE

Radiotherapy and Immunogenic Cell Death

(2015) Encouse B. Golden et al.   SEMINARS IN RADIATION ONCOLOGY

Cancer Immunotherapy with Immunomodulatory Anti-CD137 and Anti-PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells

(2015) A. R. Sanchez-Paulete et al.   Cancer Discovery

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

(2015) Abhishek D. Garg et al.   Frontiers in Immunology

Role of Local Radiation Therapy in Cancer Immunotherapy

(2015) Sandra Demaria et al.   JAMA Oncology

Irradiation and anti–PD-L1 treatment synergistically promote antitumor immunity in mice

(2014) Liufu Deng et al.   JOURNAL OF CLINICAL INVESTIGATION

Trial Watch: Radioimmunotherapy for oncological indications

(2014) Norma Bloy et al.   OncoImmunology

The TLR7 agonist imiquimod as an adjuvant for radiotherapy-elicited in situ vaccination against breast cancer

(2013) Sandra Demaria et al.   OncoImmunology

Synergy of Topical Toll-like Receptor 7 Agonist with Radiation and Low-Dose Cyclophosphamide in a Mouse Model of Cutaneous Breast Cancer

(2012) M. Z. Dewan et al.   CLINICAL CANCER RESEARCH

In situ vaccination against mycosis fungoides by intratumoral injection of a TLR9 agonist combined with radiation: a phase 1/2 study

(2011) Y. H. Kim et al.   BLOOD

In Situ Vaccination With a TLR9 Agonist Induces Systemic Lymphoma Regression: A Phase I/II Study

(2010) Joshua D. Brody et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeted Activation of Innate Immunity for Therapeutic Induction of Autophagy and Apoptosis in Melanoma Cells

(2009) Damià Tormo et al.   CANCER CELL

Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti-CTLA-4 Antibody

(2009) M. Z. Dewan et al.   CLINICAL CANCER RESEARCH

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

(2009) Theocharis Panaretakis et al.   EMBO JOURNAL

Immunotransplantation preferentially expands T-effector cells over T-regulatory cells and cures large lymphoma tumors

(2008) J. D. Brody et al.   BLOOD