Article
Clinical Neurology
Melis Orhan, Sigfried Schouws, Patricia van Oppen, Max Stek, Paul Naarding, Didi Rhebergen, Annemieke Dols, Nicole Korten
Summary: This study found that both older age bipolar disorder (OABD) and late life depression (LLD) are associated with cognitive dysfunction. OABD patients showed more severe cognitive dysfunction compared to LLD patients, regardless of the severity of depressive symptoms. These findings suggest that other disease characteristics may contribute to the differences in cognitive functioning between OABD and LLD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Irene Hana Flones, Harald Nyland, Dagny-Ann Sandnes, Guido Werner Alves, Ole-Bjorn Tysnes, Charalampos Tzoulis
Summary: Early alpha-synuclein aggregation is associated with mitochondrial respiratory complex I (CI) deficiency in neurons of idiopathic Parkinson's disease (iPD), and there is selective loss of neurons affected by both pathologies.
Article
Biochemistry & Molecular Biology
Yun Fan, Yunpeng Sun, Wenbo Yu, Youqi Tao, Wencheng Xia, Yiqi Liu, Qinyue Zhao, Yilin Tang, Yimin Sun, Fengtao Liu, Qin Cao, Jianjun Wu, Cong Liu, Jian Wang, Dan Li
Summary: We amplified α-syn aggregates from PD patients and found that fibrils derived from late-stage PD patients are most potent in inducing endogenous a-syn aggregation, followed by mid-stage and pre-stage PD fibrils. Cryo-electron microscopy revealed significant differences in conformational species among samples from different clinical stages. Our study suggests potential conformational transitions of a-syn fibrils during the progression of PD.
Article
Clinical Neurology
Shahram Bahrami, Guy Hindley, Bendik Slagsvold Winsvold, Kevin S. O'Connell, Oleksandr Frei, Alexey Shadrin, Weiqiu Cheng, Francesco Bettella, Linn Rodevand, Ketil J. Odegaard, Chun C. Fan, Matti J. Pirinen, Heidi M. Hautakangas, Anders M. Dale, Srdjan Djurovic, Olav B. Smeland, Ole A. Andreassen
Summary: Migraine shows a certain level of shared genetic basis with bipolar disorder, depression, and schizophrenia, with some shared genetic loci. It is less polygenic compared to mental disorders and shares variants with intelligence and educational attainment. Specific loci were identified that are jointly associated with migraine and depression, as well as with migraine and schizophrenia, implicating shared molecular mechanisms and highlighting candidate migraine genes for further research.
Article
Neurosciences
Xi Chen, Elpida Tsika, Nathan Levine, Darren J. Moore
Summary: The VPS35 gene mutation is associated with Parkinson's disease, but it is not related to α-synuclein. Overexpression of VPS35 does not protect against α-synuclein-induced neurodegeneration in mice models. The study suggests a limited interaction between VPS35 and α-synuclein in the pathogenesis of Parkinson's disease.
MOLECULAR NEURODEGENERATION
(2023)
Article
Neurosciences
David J. Koss, Daniel Erskine, Andrew Porter, Pawel Palmoski, Hariharan Menon, Olivia G. J. Todd, Marta Leite, Johannes Attems, Tiago F. Outeiro
Summary: Through a multidisciplinary approach, this study confirms the presence of nuclear alpha-synuclein in the brains of patients with dementia with Lewy bodies, which may undergo pathogenic modifications and contribute to the disease phenotype.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Clinical Neurology
Raphael O. Cerqueira, Carolina Ziebold, Daniel Cavalcante, Giovany Oliveira, Javiera Vasquez, Juan Undurraga, Alfonso Gonzalez-Valderrama, Ruben Nachar, Carlos Lopez-Jaramillo, Cristiano Noto, Nicolas Crossley, Ary Gadelha
Summary: This study compares patients with affective and non-affective psychosis (A-FEP and NA-FEP) in a Latin American sample. The findings suggest that characteristics of FEP patients could be utilized to enhance diagnosis and inform treatment decisions.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Nutrition & Dietetics
Ting Liu, Kunhong Deng, Ying Xue, Rui Yang, Rong Yang, Zhicheng Gong, Mimi Tang
Summary: Depression is one of the most common mental diseases, but its understanding is insufficient. The relationship between carnitine and depression has been confirmed in multiple studies, and the level of acylcarnitines can serve as biomarkers for depression, while supplementing acetyl-L-carnitine is beneficial for the treatment of depression.
FRONTIERS IN NUTRITION
(2022)
Article
Psychiatry
Aidin Abbaspour, Masoud Bahreini, Sherafat Akaberian, Kamran Mirzaei
Summary: The study found that most patients with psychiatric disorders were affected by ineffective parenting styles. Despite the involvement of several bio-psycho-social factors in the development of psychiatric disorders, the crucial roles of parents, especially mothers, should not be ignored. It was suggested that parents and parental bonding were important and fundamental factors for mental health promotion.
Article
Psychiatry
Tuyen T. Le, Joshua D. Di Vincenzo, Kayla M. Teopiz, Yena Lee, Danielle S. Cha, Leanna M. W. Lui, Nelson B. Rodrigues, Roger C. Ho, Bing Cao, Kangguang Lin, Flora Nasri, Hartej Gill, Orly Lipsitz, Mehala Subramaniapillai, Rodrigo B. Mansur, Joshua D. Rosenblat, Roger S. McIntyre
Summary: Psychotic depression is a severe subtype of major depressive disorder with high relapse and mortality rates. Ketamine may be an alternative pharmacotherapy, but its efficacy and safety in patients with psychotic depression have not been established.
PSYCHIATRY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Manuel Moreno-Valladares, Veronica Moncho-Amor, Iraide Bernal-Simon, Enaut Agirre-Iturrioz, Maria Alvarez-Satta, Ander Matheu
Summary: This case report highlights a complex interplay between norovirus infection, alpha-synuclein synthesis in the gastrointestinal mucosa, and Lewy pathology in the central nervous system in an older woman with unspecific symptoms. The presence of alpha-synuclein deposits and Lewy pathology support Braak's hypothesis about the pathogenic mechanisms underlying synucleinopathies, providing valuable insights into the understanding of these disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Dror Ben-Zeev, Ayesha Chander, Justin Tauscher, Benjamin Buck, Subigya Nepal, Andrew Campbell, Guy Doron
Summary: This study conducted a fully remote randomized waitlist-controlled trial of CORE, a smartphone intervention for people with serious mental illness (SMI). Results showed that CORE was highly usable and acceptable, with significant reductions in psychiatric symptoms and disability levels, as well as improvements in recovery and self-esteem.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Psychiatry
Sophie-Kathrin Kirchner, Michael Lauseker, Kristina Adorjan, Heike Anderson-Schmidt, Ion-George Anghelescu, Bernhardt T. Baune, Monika Budde, Udo Dannlowski, Detlef E. Dietrich, Andreas J. Fallgatter, Peter Falkai, Christian Figge, Katrin Gade, Urs Heilbronner, Lena Hiendl, Georg Juckel, Janos L. Kalman, Farahnaz Kloehn-Saghatolislam, Carsten Konrad, Fabian U. Lang, Mojtaba Oraki Kohshour, Sergi Papiol, Daniela Reich-Erkelenz, Jens Reimer, Eva Z. Reininghaus, Sabrina K. Schaupp, Max Schmauss, Andrea Schmitt, Eva Christina Schulte, Simon Senner, Carsten Spitzer, Thomas Vogl, Joerg Zimmermann, Alkomiet Hasan, Thomas G. Schulze, Fanny Senner
Summary: This study comprehensively evaluates the association of sociodemographic, clinical, personality, and quality of life related factors with medication adherence by analyzing data from the PsyCourse study. The results show that never having used illicit drugs, the number of prescribed antipsychotics, the personality trait conscientiousness, and the environmental domain of quality of life have the strongest association with medication adherence.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Bhupendra Khobragade, Vikas Sharma, Smita N. Deshpande
Summary: The cognitive effects of tobacco use among women with schizophrenia, bipolar disorder, or depression have not been extensively studied. However, a study found that female tobacco users in these groups demonstrated poorer cognitive functioning and smoking may exacerbate cognitive dysfunction associated with major mental illnesses among women.
PSYCHIATRY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Nina Vindegaard Sorensen, Beate Holmelund Frandsen, Sonja Orlovska-Waast, Terkild Brink Buus, Niels Odum, Rune Haubo Christensen, Michael Eriksen Benros
Summary: This study systematically evaluated the circulating immune cells in blood and cerebrospinal fluid (CSF) from patients with unipolar depression compared to healthy controls. The findings suggest that patients with depression have higher overall leukocyte count, higher neutrophil count, higher monocyte count, and significant alterations in lymphocyte subsets. These immune cell alterations may be related to depression severity.
MOLECULAR PSYCHIATRY
(2023)