Article
Plant Sciences
Ah-Won Kwak, Jin Woo Park, Seung-On Lee, Jin-Young Lee, Ji-hye Seo, Goo Yoon, Mee-Hyun Lee, Joon-Seok Choi, Jung-Hyun Shim
Summary: This study found that Isolinderalactone (ILL) can exert its anticancer effect in colorectal cancer (CRC) cells sensitive and resistant to oxaliplatin (Ox) by inducing ROS-mediated apoptosis through JNK/p38 MAPK signaling pathways. This provides a new insight into therapeutic strategies targeting drug-resistant CRC.
Article
Agriculture, Dairy & Animal Science
Haorong He, Huadong Yin, Xueke Yu, Yao Zhang, Menggen Ma, Diyan Li, Qing Zhu
Summary: This study demonstrated that PDLIM5 can promote proliferation and differentiation of chicken skeletal muscle satellite cells through the p38-MAPK pathway. These findings suggest that PDLIM5 may play a role in the growth and development of chicken skeletal muscle.
Article
Chemistry, Medicinal
Gui-zhou Zheng, Qi-hao Zhang, Bo Chang, Peng Xie, Hang Liao, Shi-xin Du, Xue-dong Li
Summary: Dioscin exhibits antitumor activities against osteosarcoma cells by inhibiting cell proliferation, migration, and invasion, and inducing apoptosis through upregulation of ROS-mediated p38 MAPK signaling.
DRUG DEVELOPMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ah-Won Kwak, Woo-Keun Kim, Seung-On Lee, Goo Yoon, Seung-Sik Cho, Ki-Taek Kim, Mee-Hyun Lee, Yung Hyun Choi, Jin-Young Lee, Jin Woo Park, Jung-Hyun Shim
Summary: This study aims to investigate the antitumor potential and molecular mechanism of Licochalcone B (LCB) in human colorectal cancer cells. The results demonstrate that LCB has a potential therapeutic effect against colorectal cancer cells through the ROS-mediated JNK/p38 MAPK signaling pathway, making it a promising anticancer therapeutic and prophylactic agent.
Article
Cell Biology
Caili Bi, Xue Zhang, Yueyue Chen, Yushuo Dong, Yixin Shi, Yunshen Lei, Dan Lv, Xiaowei Cao, Wei Li, Hongcan Shi
Summary: MAGT1 plays a crucial role in cell proliferation and cell cycle regulation, impacting the expression of multiple key genes and being associated with the MAPK signaling pathway. Down-regulation of MAGT1 results in restricted cell proliferation, indicating its potential as a novel target for anticancer research.
Article
Biochemistry & Molecular Biology
Michael A. Fawzy, Sherif A. Maher, Sally M. Bakkar, Mahmoud A. El-Rehany, Moustafa Fathy
Summary: This study demonstrated the protective effect of pantoprazole on renal ischemia/reperfusion injury in rats for the first time, by suppressing apoptosis, reducing pro-inflammatory cytokines levels, and impacting intracellular signaling pathways. Moreover, multiple doses of pantoprazole showed a greater therapeutic effect than a single dose.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Li Zhang, Mengwen Feng, Xuejun Wang, Hao Zhang, Jingjing Ding, Zijie Cheng, Lingmei Qian
Summary: This study demonstrated the cardioprotective effects of SS31 in ameliorating DOX-induced cardiotoxicity by reducing ROS levels, stabilizing mitochondrial membrane potential, and attenuating myocardial apoptosis and fibrosis. The inhibition of the p38 MAPK signaling pathway by SS31 was found to be associated with its cardioprotective function, highlighting the potential of SS31 as a drug for the treatment of DOX-induced cardiotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Shima Taherkhani, Kosar Valaei, Hamid Arazi, Katsuhiko Suzuki
Summary: Moderate to high-intensity and short-duration physical activities can lead to overproduction of reactive oxygen species (ROS), causing damage to body tissues, while antioxidant defense systems can control ROS effectively during low to moderate intensity and long-term exercises. In stressful situations, antioxidant supplements can be considered to prevent ROS damage. Further research needs to take into account factors such as dosage and duration of antioxidant supplements, exercise intensity, duration, frequency, among others.
Article
Cell Biology
Giulia Pozzi, Valentina Presta, Elena Masselli, Giancarlo Condello, Samuele Cortellazzi, Maria Luisa Arcari, Cristina Micheloni, Marco Vitale, Giuliana Gobbi, Prisco Mirandola, Cecilia Carubbi
Summary: Reactive oxygen species (ROS) are key players in physiological processes and can affect myogenic differentiation. Protein kinase C epsilon (PKCe) is involved in muscle stem cell differentiation and skeletal muscle regeneration. PKCs have a role in redox biology and may regulate ROS production. Our study suggests that PKCe is a molecular link between redox homeostasis and myogenic differentiation. We found that PKCe interacts with Nrf2 to activate antioxidant signaling, preventing ROS accumulation and promoting myogenic differentiation.
Article
Cardiac & Cardiovascular Systems
Hideo Nambu, Shingo Takada, Satoshi Maekawa, Junichi Matsumoto, Naoya Kakutani, Takaaki Furihata, Ryosuke Shirakawa, Takashi Katayama, Takayuki Nakajima, Katsuma Yamanashi, Yoshikuni Obata, Ippei Nakano, Masaya Tsuda, Akimichi Saito, Arata Fukushima, Takashi Yokota, Junko Nio-Kobayashi, Hironobu Yasui, Kei Higashikawa, Yuji Kuge, Toshihisa Anzai, Hisataka Sabe, Shintaro Kinugawa
Summary: Exercise intolerance in patients with heart failure is partly attributed to skeletal muscle abnormalities caused by XO-derived ROS, which can be prevented by inhibition of their production.
CARDIOVASCULAR RESEARCH
(2021)
Article
Critical Care Medicine
Juan Chen, Xin Yi Chen, Xiao Xia Cong, Shen Wang, Shui Bo Xu, Yu Ting Sun, Yi Ting Zhou, Li Ling Zheng, Man Huang
Summary: This study found that both weight and strength of muscles were significantly decreased in septic mice induced by cecum ligation and puncture or LPS. Inhibition of p53 expression reduced the number of senescent myoblasts, indicating that sepsis-induced cellular senescence is dependent on p53. Additionally, metformin attenuated muscle senescence and improved muscle strength in septic mice, suggesting it as a potential therapeutic drug for ICU-AW.
Review
Biochemistry & Molecular Biology
Stephanie Kourakis, Cara A. Timpani, Judy B. de Haan, Nuri Gueven, Dirk Fischer, Emma Rybalka
Summary: This article discusses the theoretical background of targeting Nrf2 as a disease-modifying treatment for Duchenne Muscular Dystrophy, highlighting the potential of targeted Nrf2 activation to simultaneously modulate different pathological features of the disease to enhance therapeutic effectiveness.
Article
Sport Sciences
Malcolm Brown, Amelie Rebillard, Nicolas H. Hart, Dominic O'Connor, Gillian Prue, Joe M. O'Sullivan, Suneil Jain
Summary: Prostate cancer is a complex disease that can be treated with radiotherapy. However, the efficacy of this treatment is influenced by factors within the tumor microenvironment, particularly hypoxia. Exercise may have the potential to sensitize tumors to treatment and improve outcomes by activating redox-sensitive factors within the tumor microenvironment.
SPORTS MEDICINE-OPEN
(2022)
Article
Environmental Sciences
Azubuike Victor Chukwuka, Fisayo C. Jerome, Adesola Hassan, Benjamin Ebonwu, Aina O. Adeogun
Summary: This study investigates the association between muscle pathologies and oxidative stress in blue crabs. The findings show that the uptake of redox-active metals in muscle tissue is related to lipid peroxidation and the prevalence of myopathies. The study also identifies severe skeletal muscle deterioration associated with parasite cysts.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Medicine, Research & Experimental
Lili Guo, Ming Liu, Tao Duan
Summary: The study found that hydrogen can decrease reactive oxygen species (ROS) content and inhibit the MAPK pathway, therefore providing protection against preeclampsia.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Cell Biology
Nino Muradashvili, Syed Jalal Khundmiri, Reeta Tyagi, Allison Gartung, William L. Dean, Menq-Jer Lee, David Lominadze
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2014)
Review
Neurosciences
Nino Muradashvili, David Lominadze
Article
Biochemistry & Molecular Biology
Nino Muradashvili, Richard L. Benton, Reeta Tyagi, Suresh C. Tyagi, David Lominadze
CELL BIOCHEMISTRY AND BIOPHYSICS
(2014)
Article
Biochemistry & Molecular Biology
Natia Qipshidze, Naira Metreveli, Paras K. Mishra, David Lominadze, Suresh C. Tyagi
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2012)
Article
Biochemistry & Molecular Biology
Charu Munjal, Neetu Tyagi, David Lominadze, Suresh C. Tyagi
JOURNAL OF CELLULAR BIOCHEMISTRY
(2012)
Article
Endocrinology & Metabolism
Nino Muradashvili, Natia Qipshidze, Charu Munjal, Srikanth Givvimani, Richard L. Benton, Andrew M. Roberts, Suresh C. Tyagi, David Lominadze
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2012)
Article
Endocrinology & Metabolism
Nino Muradashvili, Reeta Tyagi, Naira Metreveli, Suresh C. Tyagi, David Lominadze
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2014)
Article
Endocrinology & Metabolism
Nino Muradashvili, Richard L. Benton, Kathryn E. Saatman, Suresh C. Tyagi, David Lominadze
METABOLIC BRAIN DISEASE
(2015)
Review
Neurosciences
Mariam Charkviani, Nino Muradashvili, David Lominadze
EUROPEAN JOURNAL OF NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Nurul Sulimai, Jason Brown, David Lominadze
Summary: The extravasation of fibrinogen during neuroinflammatory diseases like AD and TBI can lead to interactions with neuronal receptors, ultimately causing neuronal death and memory impairment.
Review
Biochemistry & Molecular Biology
Nurul H. Sulimai, Jason Brown, David Lominadze
Summary: This review discusses the role of fibrinogen and its derivatives in inflammatory diseases and their effects on immunomodulation.
Article
Biochemistry & Molecular Biology
Nurul Sulimai, Jason Brown, David Lominadze
Summary: Traumatic brain injury (TBI) is linked to inflammation and compromised blood-brain barrier, which can lead to neurodegeneration. Inflammation causes an increase in fibrinogen (Fg) levels in the blood, and this protein can extravasate into the brain parenchyma and interact with neurons. This interaction results in the upregulation of pro-inflammatory cytokines, oxidative damage, and cell death. The transcription factor NF-kappa B is involved in this process. This mechanism may play a role in vascular cognitive impairment during neuroinflammatory diseases.
Review
Biochemistry & Molecular Biology
Nurul Sulimai, Jason Brown, David Lominadze
Summary: Neurons and glial cells in the brain are protected by the blood brain barrier (BBB). Local regulation of blood flow in the brain is determined by neurons and astrocytes. Changes in cerebral vessels, particularly in cerebrovascular permeability, play a crucial role in the development and progression of neuroinflammatory and neurodegenerative diseases, resulting in memory decline.
Article
Neurosciences
Nino Muradashvili, Suresh C. Tyagi, David Lominadze