Targeting Nrf2 for the treatment of Duchenne Muscular Dystrophy

NRF2 Activates Growth Factor Genes and Downstream AKT Signaling to Induce Mouse and Human Hepatomegaly

(2020) Feng He et al.   JOURNAL OF HEPATOLOGY

Adenylosuccinic acid therapy ameliorates murine Duchenne Muscular Dystrophy

(2020) Cara A. Timpani et al.   Scientific Reports

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Dysfunction Is an Early Consequence of Partial or Complete Dystrophin Loss in mdx Mice

(2020) Timothy M. Moore et al.   Frontiers in Physiology

The Dark Side of Nrf2 in the Heart

(2020) Huimei Zang et al.   Frontiers in Physiology

Dimethyl Fumarate and Its Esters: A Drug with Broad Clinical Utility?

(2020) Stephanie Kourakis et al.   Pharmaceuticals

Reduced mitochondrial respiration and increased calcium deposits in the EDL muscle, but not in soleus, from 12-week-old dystrophic mdx mice

(2019) Rhayanna B. Gaglianone et al.   Scientific Reports

The intracellular Ca2+ concentration is elevated in cardiomyocytes differentiated from hiPSCs derived from a Duchenne muscular dystrophy patient

(2019) Fumitoshi Tsurumi et al.   PLoS One

Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H 2 O 2 emission during impaired oxidative phosphorylation

(2019) Meghan C. Hughes et al.   Journal of Cachexia Sarcopenia and Muscle

The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration

(2019) David Sala et al.   Nature Communications

Dimethyl fumarate alters intracellular Ca2+ handling in immune cells by redox-mediated pleiotropic effects

(2019) Ann-Kathrin Herrmann et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2: Redox and Metabolic Regulator of Stem Cell State and Function

(2019) Xiaozhen Dai et al.   TRENDS IN MOLECULAR MEDICINE

The Role of Nrf2 Activity in Cancer Development and Progression

(2019) Alina-Andreea Zimta et al.   Cancers

Heme Oxygenase-1 Influences Satellite Cells and Progression of Duchenne Muscular Dystrophy in Mice

(2018) Katarzyna Pietraszek-Gremplewicz et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2-Keap1 signaling in oxidative and reductive stress

(2018) Ilaria Bellezza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nrf2 Pathway in Age-Related Neurological Disorders: Insights into MicroRNAs

(2018) Simona Paladino et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Polyphenols and Bioavailability: an update

(2018) Hui Teng et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Modulation of Protein Quality Control and Proteasome to Autophagy Switch in Immortalized Myoblasts from Duchenne Muscular Dystrophy Patients

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings

(2018) Giampaolo Morciano et al.   NEOPLASIA

Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass

(2018) Bumsoo Ahn et al.   Redox Biology

Nrf2 sequesters Keap1 preventing podosome disassembly: a quintessential duet moonlights in endothelium

(2018) Damian Klóska et al.   ANTIOXIDANTS & REDOX SIGNALING

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

(2018) Claudio Soto et al.   NATURE NEUROSCIENCE

Resveratrol Ameliorates Mitophagy Disturbance and Improves Cardiac Pathophysiology of Dystrophin-deficient mdx Mice

(2018) Atsushi Kuno et al.   Scientific Reports

NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells

(2018) Soumyadip Paul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Duchenne muscular dystrophy: Focus on arachidonic acid metabolites

(2018) Malvina Hoxha   BIOMEDICINE & PHARMACOTHERAPY

Responses to reductive stress in the cardiovascular system

(2017) Diane E. Handy et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dimethyl fumarate mediates Nrf2-dependent mitochondrial biogenesis in mice and humans

(2017) Genki Hayashi et al.   HUMAN MOLECULAR GENETICS

Oxidative stress in Duchenne muscular dystrophy: focus on the NRF2 redox pathway

(2017) Sara Petrillo et al.   HUMAN MOLECULAR GENETICS

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

(2017) Charbel Moussa et al.   Journal of Neuroinflammation

Pre-clinical evaluation of N -acetylcysteine reveals side effects in the mdx mouse model of Duchenne muscular dystrophy

(2017) Gavin J. Pinniger et al.   JOURNAL OF PHYSIOLOGY-LONDON

NRF2 Activation Impairs Quiescence and Bone Marrow Reconstitution Capacity of Hematopoietic Stem Cells

(2017) Shohei Murakami et al.   MOLECULAR AND CELLULAR BIOLOGY

ABCF2 , an Nrf2 target gene, contributes to cisplatin resistance in ovarian cancer cells

(2017) Lingjie Bao et al.   MOLECULAR CARCINOGENESIS

Deceptive curcumin offers cautionary tale for chemists

(2017) Monya Baker   NATURE

Daily versus weekend steroid use in DMD: age at loss of ambulation is equivalent in a retrospective patient cohort

(2017) M. Waldrop et al.   NEUROMUSCULAR DISORDERS

Vitamin E treatment decreases muscle injury in mdx mice

(2017) Rafael Dias Mâncio et al.   NUTRITION

The burden, epidemiology, costs and treatment for Duchenne muscular dystrophy: an evidence review

(2017) S. Ryder et al.   Orphanet Journal of Rare Diseases

Therapeutic potential of heat shock protein induction for muscular dystrophy and other muscle wasting conditions

(2017) Savant S. Thakur et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Muscle redox disturbances and oxidative stress as pathomechanisms and therapeutic targets in early-onset myopathies

(2017) Maryline Moulin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Heat shock protein70 is implicated in modulating NF-κB activation in alveolar macrophages of patients with active pulmonary tuberculosis

(2017) Chun-Hua Wang et al.   Scientific Reports

Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination

(2017) YouJin Lee et al.   Cell Reports

Recent developments in Duchenne muscular dystrophy: facts and numbers

(2017) Maggie C. Walter et al.   Journal of Cachexia Sarcopenia and Muscle

Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence

(2017) Annika Höhn et al.   Redox Biology

Utrophin influences mitochondrial pathology and oxidative stress in dystrophic muscle

(2017) Tahnee L. Kennedy et al.   Skeletal Muscle

Beneficial effects of high dose taurine treatment in juvenile dystrophic mdx mice are offset by growth restriction

(2017) Jessica R. Terrill et al.   PLoS One

Resveratrol protects against lipopolysaccharide-induced cardiac dysfunction by enhancing SERCA2a activity through promoting the phospholamban oligomerization

(2016) Tao Bai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Oral Monomethyl Fumarate Therapy Ameliorates Retinopathy in a Humanized Mouse Model of Sickle Cell Disease

(2016) Wanwisa Promsote et al.   ANTIOXIDANTS & REDOX SIGNALING

Enhanced autophagy as a potential mechanism for the improved physiological function by simvastatin in muscular dystrophy

(2016) Nicholas P. Whitehead   Autophagy

NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth

(2016) H. Satoh et al.   CANCER RESEARCH

Oxidative stress in multiple sclerosis: Central and peripheral mode of action

(2016) Kim Ohl et al.   EXPERIMENTAL NEUROLOGY

Exercise-induced Nrf2-signaling is impaired in aging

(2016) Aaron J. Done et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sulforaphane mitigates muscle fibrosis in mdx mice via Nrf2-mediated inhibition of TGF-β/Smad signaling

(2016) Chengcao Sun et al.   JOURNAL OF APPLIED PHYSIOLOGY

Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide

(2016) Chenran Wang et al.   JOURNAL OF CELL BIOLOGY

The importance of genetic diagnosis for Duchenne muscular dystrophy

(2016) Annemieke Aartsma-Rus et al.   JOURNAL OF MEDICAL GENETICS

Eliminating Nox2 reactive oxygen species production protects dystrophic skeletal muscle from pathological calcium influx assessedin vivoby manganese-enhanced magnetic resonance imaging

(2016) James A. Loehr et al.   JOURNAL OF PHYSIOLOGY-LONDON

The ubiquitin ligase tripartite-motif-protein 32 is induced in Duchenne muscular dystrophy

(2016) Stefania Assereto et al.   LABORATORY INVESTIGATION

Lycopene inhibits ICAM-1 expression and NF-κB activation by Nrf2-regulated cell redox state in human retinal pigment epithelial cells

(2016) Po-Min Yang et al.   LIFE SCIENCES

Muscle damage, metabolism, and oxidative stress inmdxmice: Impact of aerobic running

(2016) Kevin E. Schill et al.   MUSCLE & NERVE

Attempting to Compensate for Reduced Neuronal Nitric Oxide Synthase Protein with Nitrate Supplementation Cannot Overcome Metabolic Dysfunction but Rather Has Detrimental Effects in Dystrophin-Deficient mdx Muscle

(2016) Cara A. Timpani et al.   Neurotherapeutics

Oxidative Stress-Mediated Skeletal Muscle Degeneration: Molecules, Mechanisms, and Therapies

(2016) Min Hee Choi et al.   Oxidative Medicine and Cellular Longevity

Role of ROS and RNS Sources in Physiological and Pathological Conditions

(2016) Sergio Di Meo et al.   Oxidative Medicine and Cellular Longevity

Absence of Dystrophin Disrupts Skeletal Muscle Signaling: Roles of Ca2+, Reactive Oxygen Species, and Nitric Oxide in the Development of Muscular Dystrophy

(2016) David G. Allen et al.   PHYSIOLOGICAL REVIEWS

Elevated expression of Nrf2 mediates multidrug resistance in CD133+ head and neck squamous cell carcinoma stem cells

(2016) Bao-Cai Lu et al.   Oncology Letters

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

Nutraceuticals and Their Potential to Treat Duchenne Muscular Dystrophy: Separating the Credible from the Conjecture

(2016) Keryn Woodman et al.   Nutrients

STAT3 Regulates Self-Renewal of Adult Muscle Satellite Cells during Injury-Induced Muscle Regeneration

(2016) Han Zhu et al.   Cell Reports

Redox homeostasis: The Golden Mean of healthy living

(2016) Fulvio Ursini et al.   Redox Biology

Heme oxygenase and carbon monoxide protect from muscle dystrophy

(2016) Mun Chun Chan et al.   Skeletal Muscle

Can't live with or without it: calcium and its role in Duchenne muscular dystrophy-induced muscle weakness. Focus on “SERCA1 overexpression minimizes skeletal muscle damage in dystrophic mouse models”

(2015) Arthur J. Cheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition

(2015) Stephanie M. Tortorella et al.   ANTIOXIDANTS & REDOX SIGNALING

KEAP1–NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity

(2015) Matthew Dodson et al.   BIOCHEMICAL JOURNAL

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

(2015) Stjepana Kovac et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The emerging role of Nrf2 in mitochondrial function

(2015) Albena T. Dinkova-Kostova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2-Mediated Cardiac Maladaptive Remodeling and Dysfunction in a Setting of Autophagy InsufficiencyNovelty and Significance

(2015) Qingyun Qin et al.   HYPERTENSION

Sulforaphane alleviates muscular dystrophy in mdx mice by activation of Nrf2

(2015) Chengcao Sun et al.   JOURNAL OF APPLIED PHYSIOLOGY

Sulforaphane Attenuates Muscle Inflammation in Dystrophin-deficientmdxMice via NF-E2-related Factor 2 (Nrf2)-mediated Inhibition of NF-κB Signaling Pathway

(2015) Cheng-Cao Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DMF, but not other fumarates, inhibits NF-κB activity in vitro in an Nrf2-independent manner

(2015) Geoffrey O. Gillard et al.   JOURNAL OF NEUROIMMUNOLOGY

Revisiting the dystrophin-ATP connection: How half a century of research still implicates mitochondrial dysfunction in Duchenne Muscular Dystrophy aetiology

(2015) Cara A. Timpani et al.   MEDICAL HYPOTHESES

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Aberrantly elevated redox sensing factor Nrf2 promotes cancer stem cell survival via enhanced transcriptional regulation of ABCG2 and Bcl-2/Bmi-1 genes

(2015) YAN JIA et al.   ONCOLOGY REPORTS

Identification and functional characterization of TRPA1 in human myoblasts

(2015) Markus Osterloh et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Immune-mediated pathology in Duchenne muscular dystrophy

(2015) Amy S. Rosenberg et al.   Science Translational Medicine

Systemic Inflammation in Duchenne Muscular Dystrophy: Association with Muscle Function and Nutritional Status

(2015) Oriana del Rocío Cruz-Guzmán et al.   Biomed Research International

Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training

(2015) T. Scott Bowen et al.   Journal of Cachexia Sarcopenia and Muscle

Therapeutic potential of orphan drugs for the rare skeletal muscle diseases

(2015) Kristy Swiderski et al.   Expert Opinion on Orphan Drugs

Dimethyl fumarate in the treatment of relapsing–remitting multiple sclerosis: an overview

(2015) Roberto Bomprezzi   Therapeutic Advances in Neurological Disorders

Dimethyl Fumarate and Monoethyl Fumarate Exhibit Differential Effects on KEAP1, NRF2 Activation, and Glutathione Depletion In Vitro

(2015) Melanie S. Brennan et al.   PLoS One

Evidence of Notch-Hesr-Nrf2 Axis in Muscle Stem Cells, but Absence of Nrf2 Has No Effect on Their Quiescent and Undifferentiated State

(2015) Masahiko Yamaguchi et al.   PLoS One

NRF2 Regulates PINK1 Expression under Oxidative Stress Conditions

(2015) Hitoshi Murata et al.   PLoS One

The PTEN/NRF2 Axis Promotes Human Carcinogenesis

(2014) Ana I. Rojo et al.   ANTIOXIDANTS & REDOX SIGNALING

Resveratrol improves muscle function but not oxidative capacity in young mdx mice

(2014) Bradley S. Gordon et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Nrf2 augments skeletal muscle regeneration after ischaemia-reperfusion injury

(2014) Othman Al-Sawaf et al.   JOURNAL OF PATHOLOGY

Age-Dependent Effect of Every-Other-Day Feeding and Aerobic Exercise in Ubiquinone Levels and Related Antioxidant Activities in Mice Muscle

(2014) Elizabeth Rodríguez-Bies et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

STAT3 signaling controls satellite cell expansion and skeletal muscle repair

(2014) Matthew Timothy Tierney et al.   NATURE MEDICINE

Unraveling the Truth About Antioxidants: Mitohormesis explains ROS-induced health benefits

(2014) Michael Ristow   NATURE MEDICINE

Defects in Mitochondrial ATP Synthesis in Dystrophin-Deficient Mdx Skeletal Muscles May Be Caused by Complex I Insufficiency

(2014) Emma Rybalka et al.   PLoS One

Combating oxidative stress in diabetic complications with Nrf2 activators: How much is too much?

(2014) Sih Min Tan et al.   REDOX REPORT

Resveratrol and Endometrium

(2014) S. C. Amaya et al.   Reproductive Sciences

The Nrf2 transcription factor contributes to resistance to cisplatin in bladder cancer

(2014) Annette Hayden et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Src-dependent impairment of autophagy by oxidative stress in a mouse model of Duchenne muscular dystrophy

(2014) Rituraj Pal et al.   Nature Communications

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation

(2013) Marthe H. R. Ludtmann et al.   BIOCHEMICAL JOURNAL

Genetic and clinical specificity of 26 symptomatic carriers for dystrophinopathies at pediatric age

(2013) Sandra Mercier et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Oxidative stress and pathology in muscular dystrophies: focus on protein thiol oxidation and dysferlinopathies

(2013) Jessica R. Terrill et al.   FEBS Journal

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

Misregulation of autophagy and protein degradation systems in myopathies and muscular dystrophies

(2013) M. Sandri et al.   JOURNAL OF CELL SCIENCE

Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

(2013) Dick de Zeeuw et al.   NEW ENGLAND JOURNAL OF MEDICINE

Roles Nrf2 Plays in Myeloid Cells and Related Disorders

(2013) Eri Kobayashi et al.   Oxidative Medicine and Cellular Longevity

Bortezomib (PS-341) Treatment Decreases Inflammation and Partially Rescues the Expression of the Dystrophin-Glycoprotein Complex in GRMD Dogs

(2013) Karla P. C. Araujo et al.   PLoS One

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

(2013) K. M. Holmstrom et al.   Biology Open

Skeletal muscle heat shock protein 70: diverse functions and therapeutic potential for wasting disorders

(2013) Sarah M. Senf   Frontiers in Physiology

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

(2013) Emilia Kansanen et al.   Redox Biology

Role of Oxidative Stress in Parkinson's Disease

(2013) Onyou Hwang   Experimental Neurobiology

Disruption of Nrf2/ARE signaling impairs antioxidant mechanisms and promotes cell degradation pathways in aged skeletal muscle

(2012) Corey J. Miller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A role for sequestosome 1/p62 in mitochondrial dynamics, import and genome integrity

(2012) M. Lamar Seibenhener et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Methylation of the KEAP1 gene promoter region in human colorectal cancer

(2012) Naoyuki Hanada et al.   BMC CANCER

Cellular and molecular mechanisms of muscle atrophy

(2012) P. Bonaldo et al.   Disease Models & Mechanisms

Assurance of mitochondrial integrity and mammalian longevity by the p62–Keap1–Nrf2–Nqo1 cascade

(2012) Jeongho Kwon et al.   EMBO REPORTS

Nrf2-dependent Induction of Proteasome and Pa28αβ Regulator Are Required for Adaptation to Oxidative Stress

(2012) Andrew M. Pickering et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp72 preserves muscle function and slows progression of severe muscular dystrophy

(2012) Stefan M. Gehrig et al.   NATURE

Placebo-Controlled Phase 3 Study of Oral BG-12 or Glatiramer in Multiple Sclerosis

(2012) Robert J. Fox et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autophagy as a new therapeutic target in Duchenne muscular dystrophy

(2012) C De Palma et al.   Cell Death & Disease

Oxidative Stress and Antioxidant Defense

(2012) Esra Birben et al.   World Allergy Organization Journal

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

(2011) Julie Adam et al.   CANCER CELL

Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids

(2011) Emilia Kansanen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle

(2011) Sanjeewa A. Goonasekera et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural basis of fumarate hydratase deficiency

(2011) Sarah Picaud et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Resveratrol Ameliorates Muscular Pathology in the Dystrophic mdx Mouse, a Model for Duchenne Muscular Dystrophy

(2011) Y. S. Hori et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Melatonin improves muscle function of the dystrophic mdx5Cv mouse, a model for Duchenne muscular dystrophy

(2011) Youssef Hibaoui et al.   JOURNAL OF PINEAL RESEARCH

Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study

(2011) Sebahattin Cirak et al.   LANCET

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

N-Acetylcysteine treatment of dystrophic mdx mice results in protein thiol modifications and inhibition of exercise induced myofibre necrosis

(2011) Jessica R. Terrill et al.   NEUROMUSCULAR DISORDERS

Ascorbic acid protects the diaphragm muscle against myonecrosis in mdx mice

(2011) Erika Tonon et al.   NUTRITION

Therapeutic Potential of Proteasome Inhibition in Duchenne and Becker Muscular Dystrophies

(2010) Elisabetta Gazzerro et al.   AMERICAN JOURNAL OF PATHOLOGY

When NRF2 Talks, Who's Listening?

(2010) Nobunao Wakabayashi et al.   ANTIOXIDANTS & REDOX SIGNALING

The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes

(2010) Andrew M. Pickering et al.   BIOCHEMICAL JOURNAL

Nrf2 and Keap1 Abnormalities in Non-Small Cell Lung Carcinoma and Association with Clinicopathologic Features

(2010) L. M. Solis et al.   CLINICAL CANCER RESEARCH

Role of autophagy in suppression of inflammation and cancer

(2010) Eileen White et al.   CURRENT OPINION IN CELL BIOLOGY

Increased oxidative stress in dystrophin deficient (mdx) mice masticatory muscles

(2010) Alexander Spassov et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

(2010) Michael Ristow et al.   EXPERIMENTAL GERONTOLOGY

Increased catalase expression improves muscle function inmdxmice

(2010) Joshua T. Selsby   EXPERIMENTAL PHYSIOLOGY

Dysfunctional Nrf2–Keap1 redox signaling in skeletal muscle of the sedentary old

(2010) Adeel Safdar et al.   FREE RADICAL BIOLOGY AND MEDICINE

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Fibrosis in Duchenne Muscular Dystrophy

(2010) Lan Zhou et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Increased fatigue resistance linked to Ca2+-stimulated mitochondrial biogenesis in muscle fibres of cold-acclimated mice

(2010) Joseph D. Bruton et al.   JOURNAL OF PHYSIOLOGY-LONDON

Loss of Kelch-Like ECH-Associated Protein 1 Function in Prostate Cancer Cells Causes Chemoresistance and Radioresistance and Promotes Tumor Growth

(2010) P. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

(2010) Deepti Malhotra et al.   NUCLEIC ACIDS RESEARCH

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

(2010) M. McMahon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sulforaphane Inhibits Prostate Carcinogenesis and Pulmonary Metastasis in TRAMP Mice in Association with Increased Cytotoxicity of Natural Killer Cells

(2009) S. V. Singh et al.   CANCER RESEARCH

Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin

(2009) Yoo Ri Kim et al.   JOURNAL OF PATHOLOGY

Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study

(2009) Maria Kinali et al.   LANCET NEUROLOGY

Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway

(2008) Wen Lin et al.   BIOCHEMICAL PHARMACOLOGY

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

(2008) X.-J. Wang et al.   CARCINOGENESIS

Highly Efficient, Functional Engraftment of Skeletal Muscle Stem Cells in Dystrophic Muscles

(2008) Massimiliano Cerletti et al.   CELL

Long-term blinded placebo-controlled study of SNT-MC17/idebenone in the dystrophin deficient mdx mouse: cardiac protection and improved exercise performance

(2008) G. M. Buyse et al.   EUROPEAN HEART JOURNAL

N-Acetylcysteine ameliorates skeletal muscle pathophysiology inmdxmice

(2008) Nicholas P. Whitehead et al.   JOURNAL OF PHYSIOLOGY-LONDON

Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study

(2008) Ludwig Kappos et al.   LANCET

The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds

(2008) M. Kobayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy

(2008) Douglas P Millay et al.   NATURE MEDICINE

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

(2008) T. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA