Self-tolerance in multiple sclerosis

Natural Naive CD4 + CD25 + CD127 low Regulatory T Cell (Treg) Development and Function Are Disturbed in Multiple Sclerosis Patients: Recovery of Memory Treg Homeostasis during Disease Progression

(2014) Koen Venken et al.   JOURNAL OF IMMUNOLOGY

Role of CD8 regulatory T Cells in multiple sclerosis

(2011) Jorge Correale et al.   ANNALS OF NEUROLOGY

Loss of Braking Signals During Inflammation

(2011) Francesca Gilli   ARCHIVES OF NEUROLOGY

Molecular and functional heterogeneity of T regulatory cells

(2011) Lequn Li et al.   CLINICAL IMMUNOLOGY

Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection

(2011) Yiyuan Yin et al.   EMBO JOURNAL

Characterization of the immunoregulatory function of human TCR-αβ+ CD4−CD8− double-negative T cells

(2011) Simon Voelkl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Control of central and peripheral tolerance by Aire

(2011) Todd C. Metzger et al.   IMMUNOLOGICAL REVIEWS

Neuroantigen-specific CD8+ regulatory T-cell function is deficient during acute exacerbation of multiple sclerosis

(2011) Ethan J. Baughman et al.   JOURNAL OF AUTOIMMUNITY

CD2 Costimulation Reveals Defective Activity by Human CD4+CD25hi Regulatory Cells in Patients with Multiple Sclerosis

(2011) C. M. Baecher-Allan et al.   JOURNAL OF IMMUNOLOGY

Reduced thymic output and peripheral naïve CD4 T-cell alterations in primary progressive multiple sclerosis (PPMS)

(2011) David G. Haegert et al.   JOURNAL OF NEUROIMMUNOLOGY

Evaluation of soluble HLA-G as a biomarker for multiple sclerosis

(2011) A. Waschbisch et al.   NEUROLOGY

Intracerebral Human Regulatory T Cells: Analysis of CD4+CD25+FOXP3+ T Cells in Brain Lesions and Cerebrospinal Fluid of Multiple Sclerosis Patients

(2011) Benedikt Fritzsching et al.   PLoS One

T Regulatory Cells Are Markers of Disease Activity in Multiple Sclerosis Patients

(2011) Dacia Dalla Libera et al.   PLoS One

To Be or Not to Be a Treg Cell: Lineage Decisions Controlled by Epigenetic Mechanisms

(2011) A. Toker et al.   Science Signaling

Recent insights into the role and molecular mechanisms of the autoimmune regulator (AIRE) gene in autoimmunity

(2010) Alessandra Fierabracci   AUTOIMMUNITY REVIEWS

Transplantation of autoimmune regulator-encoding bone marrow cells delays the onset of experimental autoimmune encephalomyelitis

(2010) Hyun-Ja Ko et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory T cells exhibit enhanced migratory characteristics, a feature impaired in patients with multiple sclerosis

(2010) Tilman Schneider-Hohendorf et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor–specified peripheral niche constraints

(2010) Junko Nishio et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

(2010) Yenkel Grinberg-Bleyer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Altered miRNA expression in T regulatory cells in course of multiple sclerosis

(2010) Giuseppe De Santis et al.   JOURNAL OF NEUROIMMUNOLOGY

Microarray analysis identifies altered regulation of nuclear receptor family members in the pre-disease state of multiple sclerosis

(2010) Anat Achiron et al.   NEUROBIOLOGY OF DISEASE

The autoimmune tautology

(2010) Juan-Manuel Anaya   ARTHRITIS RESEARCH & THERAPY

Structural alterations in peptide–MHC recognition by self-reactive T cell receptors

(2009) Kai W Wucherpfennig et al.   CURRENT OPINION IN IMMUNOLOGY

Thymocyte deletion can bias Treg formation toward low-abundance self-peptide

(2009) Cristina Cozzo Picca et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Potential role of soluble human leukocyte antigen-G molecules in multiple sclerosis

(2009) Enrico Fainardi et al.   HUMAN IMMUNOLOGY

TheCTLA-4gene polymorphisms are associated with CTLA-4 protein expression levels in multiple sclerosis patients and with susceptibility to disease

(2009) Lidia Karabon et al.   IMMUNOLOGY

CD39+Foxp3+ Regulatory T Cells Suppress Pathogenic Th17 Cells and Are Impaired in Multiple Sclerosis

(2009) J. M. Fletcher et al.   JOURNAL OF IMMUNOLOGY

Glatiramer acetate improves regulatory T-cell function by expansion of naive CD4+CD25+FOXP3+CD31+ T-cells in patients with multiple sclerosis

(2009) Juergen Haas et al.   JOURNAL OF NEUROIMMUNOLOGY

Effect of IFN-ß therapy on the frequency and function of CD4+CD25+ regulatory T cells and Foxp3 gene expression in relapsing–remitting multiple sclerosis (RRMS): A preliminary study

(2009) Afshin Namdar et al.   JOURNAL OF NEUROIMMUNOLOGY

Renewal of the T-cell compartment in multiple sclerosis patients treated with glatiramer acetate

(2009) M. Chiarini et al.   Multiple Sclerosis Journal

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

(2009) Arthur Liesz et al.   NATURE MEDICINE

The role of the CD58 locus in multiple sclerosis

(2009) P. L. De Jager et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterogeneity of natural Foxp3+T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity

(2009) Noriko Komatsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD40 and autoimmunity: The dark side of a great activator

(2009) Anna L. Peters et al.   SEMINARS IN IMMUNOLOGY

Interferon Beta–Induced Restoration of Regulatory T-Cell Function in Multiple Sclerosis Is Prompted by an Increase in Newly Generated Naive Regulatory T Cells

(2008) Mirjam Korporal et al.   ARCHIVES OF NEUROLOGY

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Decreased 4-1BB expression on CD4+CD25highregulatory T cells in peripheral blood of patients with multiple sclerosis

(2008) G.-Z. Liu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: Implications for the lesion pathogenesis of multiple sclerosis

(2008) Sonja Ortler et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

(2008) Xuexian O. Yang et al.   IMMUNITY

Are dendritic cells central to regulatory T cell function?

(2008) Caroline Coquerelle et al.   IMMUNOLOGY LETTERS

Thymic output and peripheral T lymphocyte subsets in relapsing–remitting multiple sclerosis patients treated or not by IFN-β

(2008) Bénédicte Puissant-Lubrano et al.   JOURNAL OF NEUROIMMUNOLOGY

Isolation and characterization of CD8+ regulatory T cells in multiple sclerosis

(2008) Jorge Correale et al.   JOURNAL OF NEUROIMMUNOLOGY

Expansion of CD4+CD28− T cells producing high levels of interferon-γ in peripheral blood of patients with multiple sclerosis

(2008) Y Miyazaki et al.   Multiple Sclerosis Journal

Study of Cbl-b dynamics in peripheral blood lymphocytes isolated from patients with multiple sclerosis

(2008) Wen-bin Zhou et al.   NEUROSCIENCE LETTERS

Revival of CD8+ Treg–mediated suppression

(2008) Trevor R.F. Smith et al.   TRENDS IN IMMUNOLOGY

Compromised CD4+ CD25highregulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level

(2007) Koen Venken et al.   IMMUNOLOGY