Review
Biotechnology & Applied Microbiology
Guihua Chen, Jun Shen
Summary: Inflammatory bowel disease (IBD) is a global disease with high morbidity and medical costs. Early diagnosis and intervention are crucial for controlling its progression.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Zhujiang Dai, Weimin Xu, Rui Ding, Xiang Peng, Xia Shen, Jinglue Song, Peng Du, Zhongchuan Wang, Yun Liu
Summary: This study validated the association between inflammatory bowel disease (IBD) and osteoporosis using genome-wide association studies (GWAS) data. It was found that there is a significant causal relationship between Crohn's disease (CD) and osteoporosis, while the causal relationship between ulcerative colitis (UC) and osteoporosis was not significant. Overall, there is an association between IBD and osteoporosis prediction.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Multidisciplinary Sciences
Yuanhao Yang, Hannah Musco, Steve Simpson-Yap, Zhihong Zhu, Ying Wang, Xin Lin, Jiawei Zhang, Bruce Taylor, Jacob Gratten, Yuan Zhou
Summary: The study found a strong genetic correlation between MS and UC, while the genetic relationship between MS and CD was weaker. Using Mendelian randomization, there was suggestive evidence for a causal effect of MS on UC and IBD, but not a clear causal effect of IBD or UC on MS. The study also observed consistent patterns of tissue-specific heritability enrichment for MS and IBDs, as well as cell-type-specific enrichment in specific cell types.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Guojiu Fang, Fanzhi Kong, Haiqing Zhang, Bin Huang, Jifa Zhang, Xueli Zhang
Summary: Mendelian randomization (MR) analysis revealed that IL-16, IL-18, and CXCL10 are positively associated with inflammatory bowel disease (IBD), while IL-12p70 and CCL23 are negatively associated with IBD. IL-16 and IL-18 may increase the risk of ulcerative colitis (UC), and CXCL10 may increase the risk of Crohn's disease (CD). However, there is no evidence to support a causal relationship between IBD and its main subtypes (UC and CD) with the levels of ILs and chemokines. Sensitivity analyses showed robust results without heterogeneity and pleiotropy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Florian Uellendahl-Werth, Carlo Maj, Oleg Borisov, Simonas Juzenas, Eike Matthias Wacker, Isabella Friis Jorgensen, Tim Alexander Steiert, Saptarshi Bej, Peter Krawitz, Per Hoffmann, Christoph Schramm, Olaf Wolkenhauer, Karina Banasik, Soren Brunak, Stefan Schreiber, Tom Hemming Karlsen, Franziska Degenhardt, Markus Noethen, Andre Franke, Trine Folseraas, David Ellinghaus
Summary: This study aims to explore shared genetic mechanisms between immune-related and psychiatric traits using transcriptome-wide association studies and identifies several genes, including PPP3CA, that may mediate the interplay between psychiatric and inflammatory diseases.
COMMUNICATIONS BIOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Kathryn M. McRae, Sue M. Cooper, John C. McEwan, Rayna Anderson, Wendy E. Bain, Hayley J. Baird, Ken G. Dodds, Shannon M. Clarke, Natalie K. Pickering, Geoff Holmes
Summary: This study investigates the genetic variability in the New Zealand sheep population for economically important skin traits. The research confirms that suitable lamb skins for high-value shoe leather can be bred, although these traits are polygenic and moderately to highly heritable.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Oncology
Yu Min, Zheran Liu, Ruidan Li, Jing Jin, Zhigong Wei, Yiyan Pei, Xiaolin Hu, Xingchen Peng
Summary: This study used two-sample Mendelian randomization to explore the causal effect of inflammatory bowel disease (IBD) on pancreatic cancer. The results showed that Crohn's disease has a significant causal effect on pancreatic cancer, while ulcerative colitis does not. These findings are of great importance for the follow-up surveillance of IBD patients.
FRONTIERS IN ONCOLOGY
(2023)
Review
Neurosciences
Mary K. Herrick, Malu G. Tansey
Summary: Links between gastrointestinal system and Parkinson's disease have become more common, with similarities to Crohn's disease. Mutations in LRRK2 are strongly associated with PD and CD, suggesting a potential therapeutic target in inflammatory diseases that increase PD risk.
NPJ PARKINSONS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Michael Wainberg, Daniele Merico, Matthew C. Keller, Eric B. Fauman, Shreejoy J. Tripathy
Summary: This study introduces a causal gene prioritization method, PsyOPS, specifically designed for psychiatric GWAS loci. Despite its simple form, PsyOPS achieves state-of-the-art performance compared to prior methods. Genes prioritized by PsyOPS have a higher likelihood of direct regulation by GWAS variants, supported by experimental evidence.
MOLECULAR PSYCHIATRY
(2022)
Article
Genetics & Heredity
Kai Xia, Andrey A. Shabalin, Zhaoyu Yin, Wonil Chung, Patrick F. Sullivan, Fred A. Wright, Martin Styner, John H. Gilmore, Rebecca C. Santelli, Fei Zou
Summary: We developed an efficient alternative called TwinEQTL to the linear mixed-effects model for twin genome-wide association study data. TwinEQTL splits twin samples into two independent groups and combines the test results using a meta-analysis-like approach. Mathematical derivations and simulations show that TwinEQTL is valid and has comparable power to the gold-standard linear mixed-effects models.
Review
Clinical Neurology
Juan J. Madrid-Valero, Maria Rubio-Aparicio, Alice M. Gregory, Julio Sanchez-Meca, Juan R. Ordonana
Summary: Twin studies consistently show that genetic factors play a significant role in explaining variance for insomnia, with a mean heritability estimate of 0.39. However, there is considerable heterogeneity among studies, highlighting the need for further research to identify variables that may explain this variation.
SLEEP MEDICINE REVIEWS
(2021)
Review
Pharmacology & Pharmacy
Rocio Rivera Rodriguez, Jeremy James Johnson
Summary: Inflammatory Bowel Disease (IBD) is a chronic autoimmune disease characterized by intestinal inflammation. The incidence of IBD is rapidly increasing in newly developed countries, making it a global concern. Two major types of IBD, ulcerative colitis (UC) and Crohn's disease (CD), have different manifestations and locations of inflammation in the digestive tract. Current FDA-approved treatments for IBD are only effective for 50% of patients and come with serious side effects, highlighting the need for safer and more effective therapies. Plant-based diets, such as the Mediterranean diet rich in anti-inflammatory phytochemicals, have shown benefits in preventing and improving symptoms of IBD. Terpenes, a class of phytochemicals abundant in Mediterranean herbs and citrus fruits, have been studied for their potential to modulate inflammatory signaling in IBD. However, there is still conflicting and inconclusive evidence regarding their effectiveness. This review evaluates preclinical studies on terpenes and their impact on basic inflammatory signaling in IBD.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Genetics & Heredity
Emil M. Pedersen, Esben Agerbo, Oleguer Plana-Ripoll, Jakob Grove, Julie W. Dreier, Katherine L. Musliner, Marie Baekvad-Hansen, Georgios Athanasiadis, Andrew Schork, Jonas Bybjerg-Grauholm, David M. Hougaard, Thomas Werge, Merete Nordentoft, Ole Mors, Soren Dalsgaard, Jakob Christensen, Anders D. Borglum, Preben B. Mortensen, John J. McGrath, Florian Prive, Bjarni J. Vilhjalmsson
Summary: Genome-wide association studies (GWASs) have greatly advanced human genetics research by identifying disease-related genes and drug targets. However, the current methods used in GWASs do not take into account factors such as age of onset, sex, and family history. The proposed LT-FH++ method, which considers these factors, shows significant power gains over existing methods and has identified numerous significant genetic associations.
AMERICAN JOURNAL OF HUMAN GENETICS
(2022)
Review
Chemistry, Medicinal
Dandan Liu, Varma Saikam, Katie A. Skrada, Didier Merlin, Suri S. Iyer
Summary: Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract, which can be diagnosed through endoscopy and biopsy. However, these methods are expensive and invasive, so alternative noninvasive biomarkers are being explored for disease management and prognosis.
MEDICINAL RESEARCH REVIEWS
(2022)
Review
Gastroenterology & Hepatology
Anna M. Buchner, Yecheskel Schneider, Gary R. Lichtenstein
Summary: Biological therapy targeting tumor necrosis factor-alpha has become crucial in treating patients with inflammatory bowel disease, but high costs limit accessibility. Biosimilars offer the potential to reduce expenditures and increase availability, providing more options for patients.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Hannah Gordon, William Blad, Frederik Trier Moller, Timothy Orchard, Alan Steel, Gareth Trevelyan, Siew Ng, Marcus Harbord
Summary: The study explores the heritability of IBD using twin pairs and identifies associations with environmental factors such as smoking, breastfeeding, and occurrence of gastroenteritis. While smoking is predictive of CD, breastfeeding is protective against UC, and less occurrences of gastroenteritis are protective against future UC onset. Delivery method, parental hygiene attitudes, and diet recall do not impact future IBD concordance.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Federico Canzian, Chiara Piredda, Angelica Macauda, Daria Zawirska, Niels Frost Andersen, Arnon Nagler, Jan Maciej Zaucha, Grzegorz Mazur, Charles Dumontet, Marzena Watek, Krzysztof Jamroziak, Juan Sainz, Judit Varkonyi, Aleksandra Butrym, Katia Beider, Niels Abildgaard, Fabienne Lesueur, Marek Dudzinski, Annette Juul Vangsted, Matteo Pelosini, Edyta Subocz, Mario Petrini, Gabriele Buda, Malgorzata Razny, Federica Gemignani, Herlander Marques, Enrico Orciuolo, Katalin Kadar, Artur Jurczyszyn, Agnieszka Druzd-Sitek, Ulla Vogel, Vibeke Andersen, Rui Manuel Reis, Anna Suska, Herve Avet-Loiseau, Marcin Kruszewski, Waldemar Tomczak, Marcin Rymko, Stephane Minvielle, Daniele Campa
Summary: Multiple myeloma (MM) risk has a strong genetic background, with 23 risk loci identified through genome-wide association studies (GWAS). Combining SNPs into a polygenic risk score (PRS) showed significant associations with MM risk, providing a first step towards using genetics for risk stratification in the general population.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Infectious Diseases
Frederik Plesner Lyngse, Carsten Kirkeby, Tariq Halasa, Viggo Andreasen, Robert Leo Skov, Frederik Trier Moller, Tyra Grove Krause, Kare Molbak
Summary: This observational study in Denmark investigated the transmission of SARS-CoV-2 within households during the early stages of the COVID-19 pandemic. The study found a high transmission risk and attack rate within households, with an increasing risk with age and the ability of children to transmit the virus.
Article
Nutrition & Dietetics
Line E. Landgrebe, Vibeke Andersen, Corinna Bang, Lucas Moitinho-Silva, Herbert Schwarz, Claus B. Juhl, Else-Marie Bladbjerg
Summary: Repeated weight loss cycles may lead to increased cardiovascular morbidity. Meal-induced thrombin formation, observed in individuals with overweight after weight loss, may be one of the mechanisms underlying harm during intentional weight loss. Consumption of high-fat meals during intentional weight loss may trigger a prothrombotic state by increasing postprandial F1 + 2 or decreasing fibrin clot lysis, and this response may be associated with gut bacteria composition.
NUTRITION RESEARCH
(2022)
Article
Rheumatology
Saedis Saevarsdottir, Lilja Stefansdottir, Patrick Sulem, Gudmar Thorleifsson, Egil Ferkingstad, Gudrun Rutsdottir, Bente Glintborg, Helga Westerlind, Gerdur Grondal, Isabella C. Loft, Signe Bek Sorensen, Benedicte A. Lie, Mikael Brink, Lisbeth Arlestig, Asgeir Orn Arnthorsson, Eva Baecklund, Karina Banasik, Steffen Bank, Lena Bjorkman, Torkell Ellingsen, Christian Erikstrup, Oleksandr Frei, Inger Gjertsson, Daniel F. Gudbjartsson, Sigurjon A. Gudjonsson, Gisli H. Halldorsson, Oliver Hendricks, Jan Hillert, Estrid Hogdall, Soren Jacobsen, Dorte Vendelbo Jensen, Helgi Jonsson, Alf Kastbom, Ingrid Kockum, Salome Kristensen, Helga Kristjansdottir, Margit H. Larsen, Asta Linauskas, Ellen-Margrethe Hauge, Anne G. Loft, Bjorn R. Ludviksson, Sigrun H. Lund, Thorsteinn Markusson, Gisli Masson, Pall Melsted, Kristjan H. S. Moore, Heidi Munk, Kaspar R. Nielsen, Gudmundur L. Norddahl, Asmundur Oddsson, Thorunn A. Olafsdottir, Pall Olason, Tomas Olsson, Sisse Rye Ostrowski, Kim Horslev-Petersen, Solvi Rognvaldsson, Helga Sanner, Gilad N. Silberberg, Hreinn Stefansson, Erik Sorensen, Inge J. Sorensen, Carl Turesson, Thomas Bergman, Lars Alfredsson, Tore K. Kvien, Soren Brunak, Kristjan Steinsson, Vibeke Andersen, Ole A. Andreassen, Solbritt Rantapaa-Dahlqvist, Merete Lund Hetland, Lars Klareskog, Johan Askling, Leonid Padyukov, Ole Bv Pedersen, Unnur Thorsteinsdottir, Ingileif Jonsdottir, Kari Stefansson
Summary: This study identified causal genes for rheumatoid arthritis (RA) and its subsets through a genome-wide association study. Most of these genes encode proteins related to interferon and IL-12/23 signaling, particularly in the JAK/STAT pathway. Variants in some of these genes were found to increase or decrease the risk of seropositive RA.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Marc Bennedbaek, Mia Sarah Fischer Button, Lise Birk Nielsen, Jonas Bybjerg-Grauholm, Christina Wiid Svarrer, Karina Lauenborg Moller, Brian Kristensen, Rebecca Legarth, Vithiagaran Gunalan, Ditte Rechter Zenas, Irfatha Irshad, Sophie Gubbels, Raphael N. Sieber, Marc Stegger, Palle Valentiner-Branth, Morten Rasmussen, Camilla Holten Moller, Jannik Fonager, Frederik Trier Moller
Summary: During and after the 2020 UEFA European championships in Denmark, the rise of COVID-19 cases was correlated with the replacement of the Alpha lineage by the Delta lineage, as well as increasing vaccination rates and the easing of restrictions. A cohort study revealed that the celebrations during the tournament contributed to the increase in cases in Denmark in the early summer of 2021.
EPIDEMIOLOGY AND INFECTION
(2022)
Article
Education & Educational Research
Kala M. Mehta, Karin Lottrup Petersen, Steve Goodman, Henrik Toft Sorensen, Martin Bogsted, Jeppe Dorup Olesen, Sylvia Burks, Richard E. Shaw, Jens Dahlgaard Hove, Jakob Ousager, Carlos Milla, Vibeke Andersen, Niels Ejskjaer, Vibeke Brix-Christensen, Shomit Ghose, Andreas Kjaer, Peter V. Chin-Hong
Summary: The Danish-American Research Exchange (DARE) program provides Danish medical students with the opportunity to collaborate and conduct biomedical research with US medical institutions. This program enhances students' research skills and interdisciplinary thinking, and encourages exploration of low-cost healthcare interventions. Analysis of the research outcomes and intentions of DARE alumni suggests that this medical student-initiated research model has positive effects on promoting binational collaboration in medicine.
BMC MEDICAL EDUCATION
(2023)
Article
Infectious Diseases
Lene Wulff Krogsgaard, Laura Espenhain, Siri Tribler, Charlotte Svaerke Jorgensen, Christian Holm Hansen, Frederik Trier Moller, Ida Glode Helmuth, Ute Wolff Sonksen, Anne-Marie Vangsted, Henrik Ullum, Steen Ethelberg
Summary: The Danish National Seroprevalence Survey of SARS-CoV-2 infections (DSS) conducted five separate surveys between May 2020 and May 2021. The results from the February and May 2021 surveys showed a seroprevalence rate of 7.2% and 8.6% respectively. The study also found variations in seroprevalence by age group and geography, and compared the results to vaccination uptake and RT-PCR test results. The findings suggest that Denmark had comparatively low infection rates but high test coverage.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Microbiology
Emma Olivia Schultz Harringer, Juliana Durack, Yvette Piceno, Vibeke Andersen, Susan V. V. Lynch
Summary: Several studies have shown that a gluten-free diet can improve disease symptoms in ulcerative colitis (UC) patients. This study hypothesized that UC-associated enteric microbes metabolize dietary gluten differently, producing immunogenic products that promote inflammation. The study found that UC patients did not consume gluten differently from healthy controls, but the profile of gluten-degrading bacteria in their stool was distinct. The products of gluten degradation by certain bacteria induced inflammation and affected barrier function in colonocyte cultures. These preliminary findings suggest a need for further investigation into the mechanisms by which gut microbiota contribute to UC pathogenesis through gluten degradation.
Article
Biochemistry & Molecular Biology
Esther Clavero, Jose Manuel Sanchez-Maldonado, Angelica Macauda, Rob Ter Horst, Belem Sampaio-Marques, Artur Jurczyszyn, Alyssa Clay-Gilmour, Angelika Stein, Michelle A. T. Hildebrandt, Niels Weinhold, Gabriele Buda, Ramon Garcia-Sanz, Waldemar Tomczak, Ulla Vogel, Andres Jerez, Daria Zawirska, Marzena Watek, Jonathan N. Hofmann, Stefano Landi, John J. Spinelli, Aleksandra Butrym, Abhishek Kumar, Joaquin Martinez-Lopez, Sara Galimberti, Maria Eugenia Sarasquete, Edyta Subocz, Elzbieta Iskierka-Jazdzewska, Graham G. Giles, Malwina Rybicka-Ramos, Marcin Kruszewski, Niels Abildgaard, Francisco Garcia Verdejo, Pedro Sanchez Rovira, Miguel Inacio da Silva Filho, Katalin Kadar, Malgorzata Razny, Wendy Cozen, Matteo Pelosini, Manuel Jurado, Parveen Bhatti, Marek Dudzinski, Agnieszka Druzd-Sitek, Enrico Orciuolo, Yang Li, Aaron D. Norman, Jan Maciej Zaucha, Rui Manuel Reis, Miroslaw Markiewicz, Juan Jose Rodriguez Sevilla, Vibeke Andersen, Krzysztof Jamroziak, Kari Hemminki, Sonja I. Berndt, Vicent Rajkumar, Grzegorz Mazur, Shaji K. Kumar, Paula Ludovico, Arnon Nagler, Stephen J. Chanock, Charles Dumontet, Mitchell J. Machiela, Judit Varkonyi, Nicola J. Camp, Elad Ziv, Annette Juul Vangsted, Elizabeth E. Brown, Daniele Campa, Celine M. Vachon, Mihai G. Netea, Federico Canzian, Asta Foersti, Juan Sainz
Summary: By conducting a meta-analysis on the germline genetic data of 234 autophagy-related genes from three independent study populations, we investigated the influence of autophagy-related variants on the risk of Multiple Myeloma (MM) and examined the functional mechanisms behind the observed associations. We identified SNPs within the six CD46, IKBKE, PARK2, ULK4, ATG5, and CDKN2A loci associated with MM risk and found that their effect on disease risk was mediated by specific subsets of immune cells, as well as vitamin D3-, MCP-2-, and IL20-dependent mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Zhanju Liu, Ruize Liu, Han Gao, Seulgi Jung, Xiang Gao, Ruicong Sun, Xiaoming Liu, Yongjae Kim, Ho-Su Lee, Yosuke Kawai, Masao Nagasaki, Junji Umeno, Katsushi Tokunaga, Yoshitaka Kinouchi, Atsushi Masamune, Wenzhao Shi, Chengguo Shen, Zhenglin Guo, Kai Yuan, Shu Zhu, Dalin Li, Jianjun Liu, Tian Ge, Judy Cho, Mark J. Daly, Dermot P. B. McGovern, Byong Duk Ye, Kyuyoung Song, Yoichi Kakuta, Mingsong Li, Hailiang Huang, Maria Abreu, Jean-Paul Achkar, Vibeke Andersen, Charles Bernstein, Steven R. Brant, Luis Bujanda, Siew Chien Ng, Judy Cho, Mark J. Daly, Lee A. Denson, Richard H. Duerr, Lynnette R. Ferguson, Denis Franchimont, Andre Franke, Richard Gearry, Hakon Hakonarson, Jonas Halfvarson, Caren Heller, Hailiang Huang, Antonio Julia, Judith Kelsen, Hamed Khalili, Subramaniam Kugathasan, Juozas Kupcinskas, Anna Latiano, Edouard Louis, Reza Malekzadeh, Jacob L. McCauley, Dermot P. B. McGovern, Christopher Moran, David Okou, Tim Orchard, Aarno Palotie, Miles Parkes, Joel Pekow, Uros Potocnik, Graham Radford-Smith, John D. Rioux, Gerhard Rogler, Bruce Sands, Mark Silverberg, Harry Sokol, Severine Vermeire, Rinse K. Weersma, Ramnik J. Xavier, Naizhong Hu, Qian Cao, Yufang Wang, Yinglei Miao, Hongjie Zhang, Xiaoping Lv, Xiang Gao, Hu Zhang, Jingling Su, Baisui Feng, Ye Zhao, Liangru Zhu, Yan Chen, Lanxiang Zhu, Chunxiao Chen, Yali Wang, Yingde Wang, Zhi Pang, Yingxuan Chen, Xiaolan Zhang, Hui Li, Qin Yu, Mei Ye, Sumin Zhang, Wen Tang, Mei Wang, Xiaocang Cao, Ruixin Zhu, Guangxi Zhou, Zhaolian Bian, Xiaofeng Guo, Xiaoli Wu, Jinchun Liu, Wei Xu, Yuqin Li, Qin Guo, Zhiguo Guo, Mingsong Li, Zhanju Liu
Summary: This study provides the largest investigation of inflammatory bowel diseases (IBDs) in individuals of East Asian ancestries, identifying 80 IBD loci, including 81 new loci. The study also discovers new IBD genes, such as ADAP1 and GIT2, and improves the accuracy of predicting IBD risk by incorporating data from both East Asian and European ancestries.
Review
Biochemistry & Molecular Biology
Vibeke Andersen, Tue B. Bennike, Corinna Bang, John D. Rioux, Isabelle Hebert-Milette, Toshiro Sato, Axel K. Hansen, Ole H. Nielsen
Summary: Inflammatory bowel diseases (IBD) are challenging to manage due to the diversity between patients and the lack of reliable biomarkers. Diet, gut microbiota, genetics, and patient factors are all crucial for disease occurrence and progression. Recent research has identified potential biomarkers for IBD management, but further evaluation is needed. This review provides an update on cutting-edge research in IBD to improve disease management and patient quality of life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Oncology
Angelica Macauda, Klara Briem, Alyssa Clay-Gilmour, Wendy Cozen, Asta Foersti, Matteo Giaccherini, Chiara Corradi, Juan Sainz, Yasmeen Niazi, Rob ter Horst, Yang Li, Mihai G. Netea, Ulla Vogel, Kari Hemminki, Susan L. Slager, Judit Varkonyi, Vibeke Andersen, Elzbieta Iskierka-Jazdzewska, Joaquin Martinez-Lopez, Jan Zaucha, Nicola J. Camp, S. Vincent Rajkumar, Agnieszka Druzd-Sitek, Parveen Bhatti, Stephen J. Chanock, Shaji K. Kumar, Edyta Subocz, Grzegorz Mazur, Stefano Landi, Mitchell J. Machiela, Andres Jerez, Aaron D. Norman, Michelle A. T. Hildebrandt, Katalin Kadar, Sonja I. Berndt, Elad Ziv, Gabriele Buda, Arnon Nagler, Charles Dumontet, Malgorzata Razny, Marzena Watek, Aleksandra Butrym, Norbert Grzasko, Marek Dudzinski, Malwina Rybicka-Ramos, Eva-Laure Matera, Ramon Garcia-Sanz, Hartmut Goldschmidt, Krzysztof Jamroziak, Artur Jurczyszyn, Esther Clavero, Graham G. Giles, Matteo Pelosini, Daria Zawirska, Marcin Kruszewski, Herlander Marques, Eva Haastrup, Jose Manuel Sanchez-Maldonado, Uta Bertsch, Marcin Rymko, Marc-Steffen Raab, Elizabeth E. Brown, Jonathan N. Hofmann, Celine Vachon, Daniele Campa, Federico Canzian
Article
Immunology
Marcio Luis Acencio, Marek Ostaszewski, Alexander Mazein, Philip Rosenstiel, Konrad Aden, Neha Mishra, Vibeke Andersen, Prodromos Sidiropoulos, Aggelos Banos, Anastasia Filia, Souad Rahmouni, Axel Finckh, Wei Gu, Reinhard Schneider, Venkata Satagopam
Summary: Chronic inflammatory diseases involve complex molecular mechanisms and pose challenges for effective treatments. Using a systemic network model can help understand the interaction of key pathways. The SYSCID map is an interactive causal interaction network that aids in understanding the molecular mechanisms of inflammatory bowel disease, rheumatoid arthritis, and systemic lupus erythematosus, as well as the complexity of omics data.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Allan Stensballe, Tue Bjerg Bennike, Gitte Ravn-Haren, Alicja Mortensen, Christopher Aboo, Lina Almind Knudsen, Malte C. C. Ruehlemann, Svend Birkelund, Corinne Bang, Andre Franke, Ulla Vogel, Axel Kornerup Hansen, Vibeke Andersen
Summary: Inflammatory Bowel Disease (IBD) affects a small portion of the world's population and its incidence rates are increasing globally. The interplay between factors such as diet, gut microbiota, genetics, and the immune system plays a crucial role in the development of IBD. This study examined the impact of protein sources on a genetic colitis mouse model and found that protein transporter deficiency and diet-induced intestinal inflammation significantly influenced the microbiota. Proteomic and microbiota analysis of the mouse model provided insights into gastrointestinal interactions and potential biomarkers for IBD in human patients.
FRONTIERS IN MEDICINE
(2023)