Multi-target drugs to address multiple checkpoints in complex inflammatory pathologies: evolutionary cues for novel “first-in-class” anti-inflammatory drug candidates: a reviewer’s perspective

AMPK promotes macrophage fatty acid oxidative metabolism to mitigate inflammation: implications for diabetes and cardiovascular disease

(2014) Gregory R Steinberg et al.   IMMUNOLOGY AND CELL BIOLOGY

Disruption of the Transcription Factor Nrf2 Promotes Pro-Oxidative Dendritic Cells That Stimulate Th2-Like Immunoresponsiveness upon Activation by Ambient Particulate Matter

(2014) M. A. Williams et al.   JOURNAL OF IMMUNOLOGY

The discovery of first-in-class drugs: origins and evolution

(2014) Jörg Eder et al.   NATURE REVIEWS DRUG DISCOVERY

Tissue-specific tumor suppression by BRCA1

(2014) E. Y.- H. P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin as adjunct antituberculosis therapy

(2014) A. Singhal et al.   Science Translational Medicine

Recommendations for the management of cardiovascular risk in patients with rheumatoid arthritis: Scientific evidence and expert opinion

(2014) María A. Martín-Martínez et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

The value of translational biomarkers to phenotypic assays

(2014) David C. Swinney   Frontiers in Pharmacology

The Crosstalk Between Nrf2 and AMPK Signal Pathways Is Important for the Anti-Inflammatory Effect of Berberine in LPS-Stimulated Macrophages and Endotoxin-Shocked Mice

(2013) Chunfen Mo et al.   ANTIOXIDANTS & REDOX SIGNALING

Phenotypic vs. Target-Based Drug Discovery for First-in-Class Medicines

(2013) D C Swinney   CLINICAL PHARMACOLOGY & THERAPEUTICS

Polypharmacology in a Single Drug: Multitarget Drugs

(2013) M. L. Bolognesi   CURRENT MEDICINAL CHEMISTRY

AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer

(2013) D. G. Hardie   DIABETES

Shifting from the single to the multitarget paradigm in drug discovery

(2013) José L. Medina-Franco et al.   DRUG DISCOVERY TODAY

Phenotypic screens as a renewed approach for drug discovery

(2013) Wei Zheng et al.   DRUG DISCOVERY TODAY

A multimodal Darwinian strategy for alleviating the atherosclerosis pandemic

(2013) Geetha Mathew et al.   MEDICAL HYPOTHESES

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

Chemotography for multi-target SAR analysis in the context of biological pathways

(2012) Eugen Lounkine et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A possible involvement of Nrf2-mediated heme oxygenase-1 up-regulation in protective effect of the proton pump inhibitor pantoprazole against indomethacin-induced gastric damage in rats

(2012) Ho-Jae Lee et al.   BMC GASTROENTEROLOGY

TheHelicobacter PyloriProtein HspB Interferes With Nrf2/Keap1 Pathway Altering The Antioxidant Response of Ags Cells

(2012) Elisabetta Buommino et al.   HELICOBACTER

Th2 Skewing by Activation of Nrf2 in CD4+ T Cells

(2012) C. E. Rockwell et al.   JOURNAL OF IMMUNOLOGY

Abbott boosts investment in NRF2 activators for reducing oxidative stress

(2012) Sarah Crunkhorn   NATURE REVIEWS DRUG DISCOVERY

Placebo-Controlled Phase 3 Study of Oral BG-12 for Relapsing Multiple Sclerosis

(2012) Ralf Gold et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multi-Target Drugs: The Trend of Drug Research and Development

(2012) Jin-Jian Lu et al.   PLoS One

The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

(2012) S. A. Hawley et al.   SCIENCE

Metabolic pathways in T cell fate and function

(2012) Valerie A. Gerriets et al.   TRENDS IN IMMUNOLOGY

5-Adenosine Monophosphate-Activated Protein Kinase and the Metabolic Syndrome

(2012) Vijay Mor et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

(2011) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Role of dendritic cells: a step forward for the hygiene hypothesis

(2011) Xi Yang et al.   Cellular & Molecular Immunology

Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway

(2011) Miao Yu et al.   CELLULAR SIGNALLING

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Estrogen-related receptor-  is a metabolic regulator of effector T-cell activation and differentiation

(2011) R. D. Michalek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis

(2010) Aiping Bai et al.   BIOCHEMICAL PHARMACOLOGY

The complicated role of NF-κB in T-cell selection

(2010) Mingzhao Zhu et al.   Cellular & Molecular Immunology

Reduction of AMP-Activated Protein Kinase α2 Increases Endoplasmic Reticulum Stress and Atherosclerosis In Vivo

(2010) Yunzhou Dong et al.   CIRCULATION

The ‘hygiene hypothesis’ for autoimmune and allergic diseases: an update

(2010) H. Okada et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

IL-6: Regulator of Treg/Th17 balance

(2010) Akihiro Kimura et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox Regulation of Lipopolysaccharide-mediated Sulfiredoxin Induction, Which Depends on Both AP-1 and Nrf2

(2010) Hojin Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Anti-Inflammatory Action of 5-Aminoimidazole-4-carboxamide Ribonucleoside with Protective Effect in Dextran Sulfate Sodium-Induced Acute and Chronic Colitis

(2010) A. Bai et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Grand Challenge Commentary: Synthetic immunology to engineer human immunity

(2010) David A Spiegel   Nature Chemical Biology

Cardiovascular Complications of Rheumatoid Arthritis: Assessment, Prevention, and Treatment

(2010) Mariana J. Kaplan   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Evolutionary inspirations for drug discovery

(2010) Hong-Yu Zhang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

AMPK and the biochemistry of exercise: implications for human health and disease

(2009) Erik A. Richter et al.   BIOCHEMICAL JOURNAL

Activation of AMPK inhibits inflammation in MRL/lpr mouse mesangial cells

(2009) A. Peairs et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin-induced gastric ulcers in Type 2 diabetic rats

(2009) Mohamed A Morsy et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

The Yin and Yang of CD4+ Regulatory T Cells in Autoimmunity and Cancer

(2009) M. Galgani et al.   CURRENT MEDICINAL CHEMISTRY

Activation of the AMPK-FOXO3 Pathway Reduces Fatty Acid-Induced Increase in Intracellular Reactive Oxygen Species by Upregulating Thioredoxin

(2009) X.-N. Li et al.   DIABETES

Precarious Balance: Th17 Cells in Host Defense

(2009) A. Peck et al.   INFECTION AND IMMUNITY

Materials engineering for immunomodulation

(2009) Jeffrey A. Hubbell et al.   NATURE

AMPK in Health and Disease

(2009) Gregory R. Steinberg et al.   PHYSIOLOGICAL REVIEWS

Adaptive HNE-Nrf2-HO-1 pathway against oxidative stress is associated with acute gastric mucosal lesions

(2008) Kazuki Ueda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

CD4 T cells: fates, functions, and faults

(2008) J. Zhu et al.   BLOOD

Inflammation

(2008) Ursula Weiss   NATURE

Nrf2 as a Master Redox Switch in Turning on the Cellular Signaling Involved in the Induction of Cytoprotective Genes by Some Chemopreventive Phytochemicals

(2008) Young-Joon Surh et al.   PLANTA MEDICA