Artesunate Protects Against Sepsis-Induced Lung Injury Via Heme Oxygenase-1 Modulation

Epidemiology of severe sepsis in the intensive care unit

(2014) Jean-Louis Vincent et al.   BRITISH JOURNAL OF HOSPITAL MEDICINE

Hemin inhibits NLRP3 inflammasome activation in sepsis-induced acute lung injury, involving heme oxygenase-1

(2014) Yun-peng Luo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Artesunate Reduces Serum Lipopolysaccharide in Cecal Ligation/Puncture Mice via Enhanced LPS Internalization by Macrophages through Increased mRNA Expression of Scavenger Receptors

(2014) Bin Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Heme Oxygenase-1 As a Target for Drug Discovery

(2013) Roberto Motterlini et al.   ANTIOXIDANTS & REDOX SIGNALING

Heme Oxygenase-1/Carbon Monoxide: Novel Therapeutic Strategies in Critical Care Medicine

(2012) Stefan W. Ryter et al.   CURRENT DRUG TARGETS

Heme oxygenase-1 modulates thrombomodulin and activated protein c levels to attenuate lung injury in cecal ligation and puncture–induced acute lung injury mice

(2012) Dongsheng Fei et al.   EXPERIMENTAL LUNG RESEARCH

Melatonin inhibits type 1 interferon signaling of toll-like receptor 4 via heme oxygenase-1 induction in hepatic ischemia/reperfusion

(2012) Jung-Woo Kang et al.   JOURNAL OF PINEAL RESEARCH

Rho-Kinase Signaling Regulates Pulmonary Infiltration of Neutrophils in Abdominal Sepsis Via Attenuation of CXC Chemokine Formation and Mac-1 Expression on Neutrophils

(2012) Zirak Hasan et al.   SHOCK

The Anti-inflammatory Mechanism of Heme Oxygenase-1 Induced by Hemin in Primary Rat Alveolar Macrophages

(2011) Chen Hualin et al.   INFLAMMATION

Artesunate in combination with oxacillin protect sepsis model mice challenged with lethal live methicillin-resistant Staphylococcus aureus (MRSA) via its inhibition on proinflammatory cytokines release and enhancement on antibacterial activity of oxacillin

(2011) Weiwei Jiang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Enhanced induction of heme oxygenase-1 suppresses thrombus formation and affects the protein C system in sepsis

(2011) Dongsheng Fei et al.   Translational Research

Mechanisms of Cell Protection by Heme Oxygenase-1

(2010) Raffaella Gozzelino et al.   Annual Review of Pharmacology and Toxicology

Artesunate protects sepsis model mice challenged with Staphylococcus aureus by decreasing TNF-α release via inhibition TLR2 and Nod2 mRNA expressions and transcription factor NF-κB activation

(2009) Bin Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

COX-2 Inhibition Improves Immune System Homeostasis and Decreases Liver Damage in Septic Rats

(2009) Bin Li et al.   JOURNAL OF SURGICAL RESEARCH

Dipyrithione inhibits lipopolysaccharide-induced iNOS and COX-2 up-regulation in macrophages and protects against endotoxic shock in mice

(2008) Ziwen Liu et al.   FEBS LETTERS

Antimalarial artesunate protects sepsis model mice against heat-killed Escherichia coli challenge by decreasing TLR4, TLR9 mRNA expressions and transcription factor NF-κB activation

(2008) Bin Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY