Article
Biochemistry & Molecular Biology
Malgorzata Grzesiak, Kinga Kaminska, Aleksandra Bodzioch, Ewa M. Drzewiecka, Anita Franczak, Katarzyna Knapczyk-Stwora
Summary: This study reveals the presence of vitamin D-3 metabolism in the uterus of pigs, with both endometrium and myometrium capable of synthesizing vitamin D-3, while only the endometrium is involved in its metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Karim Mrouj, Nuria Andres-Sanchez, Geronimo Dubra, Priyanka Singh, Michal Sobecki, Dhanvantri Chahar, Emile Al Ghoul, Ana Bella Aznar, Susana Prieto, Nelly Pirot, Florence Bernex, Benoit Bordignon, Cedric Hassen-Khodja, Martin Villalba, Liliana Krasinska, Daniel Fisher
Summary: Ki-67, while not necessary for cell proliferation, plays a crucial role in tumor initiation, growth, and metastasis. Its absence leads to changes in the transcriptome and immune response, making cancer cells more susceptible to drugs and immune attacks.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Oncology
Qixin Liu, Ziheng Peng, Liangfang Shen, Lin Shen
Summary: Ki-67 overexpression is associated with poor overall survival rates in melanoma patients, but not correlated with PFS and RFS rates. Ki-67 expression levels are associated with tumor thickness.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Li Zhang, Mengyi Shen, Dingyi Zhang, Xin He, Qinglin Du, Nian Liu, Xiaohua Huang
Summary: A nomogram based on dual-sequence MRI radiomic features and clinical characteristics was developed to assess Ki-67 expression in breast cancer. It showed improved prediction efficiency compared to single-sequence models and clinical models.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Biochemistry & Molecular Biology
Lucy Remnant, Natalia Y. Kochanova, Caitlin Reid, Fernanda Cisneros-Soberanis, William C. Earnshaw
Summary: Ki-67 is a well-known marker protein used to identify proliferating cells, but our understanding of its molecular biology and biochemistry is incomplete, and its exact molecular function remains mysterious. Recent studies have revealed that Ki-67 is dispensable for cell proliferation, contrary to previous understanding. Its intrinsically disordered structure may play a role in controlling liquid-liquid phase separation of nucleolar proteins and RNAs, aiding in the assembly of the enigmatic mitotic chromosome periphery compartment.
Review
Oncology
Matthew G. Davey, Sean O. Hynes, Michael J. Kerin, Nicola Miller, Aoife J. Lowery
Summary: In breast cancer development, the expression of Ki-67 is a valuable indicator for prognosis and treatment decision making. The advent of molecular medicine has transformed breast cancer management by recognizing the heterogeneity of the disease and using a combination of factors for substratification and personalization of treatment modalities. Routine evaluation of Ki-67 as a proliferation marker in breast cancer patients has limitations, but promising strategies are being explored to enhance its utility in future oncology.
Article
Developmental Biology
Haiming Yu, Xiaoqing Zhou, Yujing Zhang, Kexin Wen, Zhengli Yan, Hu Fu, Yongfei Zhu
Summary: Exposure to flutamide during pregnancy resulted in lower bodyweight, ovarian and uterine weights in female offspring, along with histopathological changes such as fewer developed follicles. Flutamide increased the expression of UPR members and autophagy- and apoptosis-related genes, suggesting a potential mechanism of endoplasmic reticulum stress-induced damage in the uterus and ovaries of offspring.
REPRODUCTION FERTILITY AND DEVELOPMENT
(2021)
Article
Genetics & Heredity
Yuehui Zhang, Min Hu, Fan Yang, Yizhuo Zhang, Shuting Ma, Dongqi Zhang, Xu Wang, Amanda Nancy Sferruzzi-Perri, Xiaoke Wu, Mats Brannstrom, Linus R. Shao, Hakan Billig
Summary: This study reveals that the regulation of uterine androgen receptor (AR) levels is crucial for normal pregnancy, with abnormal AR regulation potentially contributing to pregnancy-related complications in women with polycystic ovary syndrome (PCOS). Exposure to DHT and INS during pregnancy leads to elevated uterine AR levels, impacting endometrial receptivity and decidualization gene expression. Treatment with the anti-androgen flutamide can prevent these defects, improve mitochondrial homeostasis, and enhance pregnancy outcomes.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Cell Biology
Koji Okudela, Tetsukan Woo, Yusuke Saigusa, Hiromasa Arai, Mai Matsumura, Hideaki Mitsui, Misaki Sugiyama, Motoki Sekiya, Yoshihiro Ishikawa, Hisashi Oshiro, Yoichi Kameda, Kenichi Ohashi
Summary: This study optimized a procedure for measuring the Ki-67 index in lung adenocarcinoma and established the best cut-off value. Using the SP6 antibody for immunohistochemical staining, they successfully developed an optimal procedure for determining the Ki-67 labeling index. They identified an optimal cut-off value of 0.12 and achieved a coverage probability >70% and a confidence interval of <0.05 in over 90% of cases.
Article
Biochemistry & Molecular Biology
Barbara Jana, Jaroslaw Calka, Bartosz Micinski
Summary: Inflammation reduces GALR1 protein expression in pig myometrium, while GALR1 and GALR2 participate in the contractile regulation of an inflamed uterus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Soon Bo Choi, Jung Min Park, Jee Hyun Ahn, Jieon Go, Jeeye Kim, Hyung Seok Park, Seung Il Kim, Byeong-Woo Park, Seho Park
Summary: This study aimed to explore the relationship between Ki-67 level and the prognosis of breast cancer patients, regardless of the timing of Ki-67 testing. The results showed that patients with higher Ki-67 levels had poorer survival, larger tumors, higher grade, and more aggressive treatment, regardless of when the testing was conducted.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Biology
Vita Konopecka, Mara Pilmane, Dins Sumerags, Gunta Sumeraga
Summary: This study investigated the appearance and distribution of several markers in laryngeal tissue affected by Reinke's oedema. Results showed a higher number of immunoreactive structures, a notable increase in IL-10 positive structures, and an increased number of IL-1 alpha structures in the patient group. The expression increase of PGP 9.5 is involved in the morphopathogenesis of Reinke's oedema.
Article
Cell Biology
Wen-Jie Jiang, Song-Hee Lee, Geun Heo, Hak Jae Chung, Eun Seok Cho, Soo Jin Sa, Shinichi Hochi, Xiang-Shun Cui
Summary: YBX1 plays important roles in the development of porcine preimplantation embryos, and its knockdown leads to decreased mitochondrial function, increased ER stress, and enhanced autophagy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Medicine, General & Internal
Tingting Liu, Mengjie Chen, Xueqin Li, He Wang
Summary: This study aimed to investigate the expression of serum folate and red blood cell (RBC) folate, folate receptor alpha (FR alpha), p(16INK4a) (p16), and Ki-67 in different levels of cervical intraepithelial neoplasia (CIN), and analyze their role in the progression of CIN and their value as an early warning indicator. The results showed that RBC folate, FR alpha, p16, and Ki-67 can be used as valuable clinical test indicators for predicting the progression of CIN, and the combined detection model of Ki-67+FR alpha can be used as an early warning model for predicting the progression of CIN.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Oncology
Pingping Wang, Hai Li, Yu Hu, Xiaojing Peng, Xinhua Ye, Di Xu, Ao Li
Summary: This study found a moderate correlation between vascular density grade and Ki-67 LI in soft tissue sarcoma, with other ultrasound features showing no correlation. The optimal cut-off point for distinguishing low and high proliferation groups was determined to be grade II. The area under the ROC curve was 0.74, with a sensitivity of 60.6% and specificity of 78.6%.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Abril Alondra Barrientos-Bonilla, Paola Belem Pensado-Guevara, Abraham Puga-Olguin, Rasajna Nadella, Aurora del Carmen Sanchez-Garcia, Laura Mireya Zavala-Flores, Arnulfo Villanueva-Olivo, Iliana Tamara Cibrian-Llanderal, Maria de Jesus Rovirosa-Hernandez, Daniel Hernandez-Baltazar
Summary: This study evaluated the impact of BrdU on liver function and found that multiple injections of BrdU did not induce hepatocellular damage.
Article
Cell Biology
Pan Zhang, Qun Feng, Wenxiao Chen, Xizhuang Bai
Summary: It was found that catalpol antagonizes LPS-mediated inflammation and suppressive osteoblast differentiation by inhibiting inflammation and promoting osteoblast differentiation. This finding contributes to a better understanding of the pathogenesis of osteoporosis.