Article
Cell Biology
Ekaterini Tiligada, Bernhard F. Gibbs, Satoshi Tanaka
Summary: This joint webinar focused on the roles of mast cells and basophils, highlighting their contributions to inflammatory and immune-related diseases and introducing potential targets for novel treatments.
INFLAMMATION RESEARCH
(2022)
Review
Food Science & Technology
Witchaya Srisuwatchari, Kantima Kanchanaphoomi, Jutamard Nawiboonwong, Torpong Thongngarm, Mongkhon Sompornrattanaphan
Summary: Food-dependent exercise-induced allergic reactions (FDEIA) is a distinct clinical phenomenon where symptoms arise during exercise following the consumption of specific trigger foods. Diagnosis requires rigorous testing, and exercise is the primary trigger.
Article
Allergy
Pierre Bruhns, Sylvie Chollet-Martin
Summary: Drug-induced anaphylaxis is a hyperacute reaction affecting multiple organs that can be fatal, with increasing incidence possibly due to global sensitization to various allergens and drugs. Mechanisms involve rapid release of diverse mediators and drug-specific antibodies, leading to activation of various cell types and severity of the reaction.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Allergy
Hans C. Oettgen
Summary: Mast cells throughout the gastrointestinal tract play a crucial role in IgE-mediated allergic reactions to foods. Aside from immediate reactions, recent evidence suggests that mast cells are also important regulators of adaptive immunity to foods. They provide cytokines that initiate and consolidate immune responses to allergens in the gastrointestinal mucosa, as well as molecules that recruit leukocytes causing tissue inflammation. By counteracting the activating effects of IgE antibodies, food-specific IgG antibodies suppress both immediate allergic reactions and mast cell-mediated immune responses.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Didier G. Ebo, Michiel Beyens, Kevin Heremans, Marie-Line M. van der Poorten, Athina L. Van Gasse, Christel Mertens, Michel Van Houdt, Vito Sabato, Jessy Elst
Summary: Immediate hypersensitivity reactions are challenging to diagnose due to their wide range of clinical presentations and uncertain mechanisms. These reactions can be caused by activation and degranulation of specific and nonspecific mast cells and basophils. Degranulation of these cells leads to the release of inflammatory mediators, which can vary depending on the trigger.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Allergy
Maria Anna Bruusgaard-Mouritsen, Bettina Margrethe Jensen, Lars K. Poulsen, Jeanne Duus Johansen, Lene Heise Garvey
Summary: This study evaluated the reactivity of different molecular weight PEGs in skin prick tests and investigated cross-sensitization patterns in PEG allergy. The results showed that skin test reactivity to PEG can decrease over time, but titrated SPT with increasing concentrations of PEG 20,000 can be diagnostic.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Allergy
Antonella Cianferoni
Summary: Anaphylaxis is not only IgE-mediated, but also involves non-IgE pathways; mast cells and basophils can be activated by various substances, leading to reactions similar to anaphylaxis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Anesthesiology
Tomonori Takazawa, Tatsuo Horiuchi, Kazuhiro Nagumo, Yuki Sugiyama, Tsubasa Akune, Yasuhiro Amano, Masataka Fukuda, Takashi Haraguchi, Chika Ishibashi, Eiki Kanemaru, Takao Kato, Keiichi Katoh, Takashi Kawano, Tsukasa Kochiyama, Michioki Kuri, Akihide Kurita, Yoshikazu Matsuoka, Takahiro Muramatsu, Masaki Orihara, Yutaka Saito, Nobukazu Sato, Toshie Shiraishi, Kaoru Suzuki, Miyuki Takahashi, Toshifumi Takahashi, Kumiko Tanabe, Akihiro Tomioka, Yukinari Tomita, Tatsuya Tsuji, Iwao Watanabe, Takashige Yamada, Nagahide Yoshida, Masao Yamaguchi, Shigeru Saito
Summary: This study describes the utility of a newly developed tool for identifying patients with a high possibility of anaphylaxis and investigates the frequency of anaphylaxis with each drug during the perioperative period in Japan. The developed composite score, which includes skin tests and basophil activation tests, improved the certainty of anaphylaxis diagnosis. The top causative agents were rocuronium, sugammadex, and cefazolin.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Allergy
Yi-Kui Xiang, Pavel Kolkhir, Jorg Scheffel, Merle Sauer, Carolina Vera, Stefan Frischbutter, Karoline Krause, Frank Siebenhaar, Martin Metz, Marcus Maurer, Sabine Altrichter
Summary: This study investigated the rates of two subtypes of chronic spontaneous urticaria (CSU), autoallergic chronic spontaneous urticaria (aaCSU) and autoimmune chronic spontaneous urticaria (aiCSU), in CSU patients. Among 111 CSU patients, 58% had aaCSU and 8% had aiCSU. Furthermore, the coexistence of aiCSU and aaCSU needs further research.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Immunology
Masato Terashi, Kouya Yamaki, Yutaka Koyama
Summary: This study established a novel model for IgG(1) anaphylaxis and identified a new mechanism, the Fc gamma RIII-basophils and/or mast cell-histamine pathway, that plays a crucial role in this model.
IMMUNOLOGICAL INVESTIGATIONS
(2023)
Review
Allergy
Joan Bartra, Paul J. Turner, Rosa M. Munoz-Cano
Summary: Around 25% to 50% of food-induced allergic reactions in adults cause anaphylaxis, and cofactors can influence the severity of the reactions. Cofactors can either reduce the reaction threshold or increase reaction severity. Exercise, nonsteroidal anti-inflammatory drugs, alcohol, and sleep deprivation are common reported cofactors. Routine evaluation of cofactors is essential in managing patients with food anaphylaxis. ©2023 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Article
Cell Biology
Nada S. Alakhras, Jaeho Shin, Scott A. Smith, Anthony L. Sinn, Wenwu Zhang, Gyoyeon Hwang, Jenna Sjoerdsma, Emily K. Bromley, Karen E. Pollok, Basar Bilgicer, Mark H. Kaplan
Summary: Peanut-induced allergy is a type I hypersensitivity reaction mediated by IgE, which can range from local edema to life-threatening anaphylaxis. There are currently few preventive therapies for this type of allergy, but a covalent heterobivalent inhibitor (cHBI) has shown promise in both in vitro and in vivo models. In this study, a humanized mouse model expressing human mast cells was developed and used to demonstrate that cHBI can prevent allergic reactions, including fatal anaphylaxis, when administered before or shortly after allergen exposure.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Ge Liu, Mizuki Kaneko, Kento Yoshioka, Keisuke Obara, Yoshio Tanaka
Summary: In this study, the effects of platelet-activating factor (PAF) on the contractile activities of guinea pig and mouse urinary bladder smooth muscle tissues were investigated. The results showed that PAF can enhance the basal tone and spontaneous contractile activities of the smooth muscle tissues through its receptor. The mRNA expression of PAF-synthesizing and -degrading enzymes was also detected in the urinary bladder tissues. These findings suggest that PAF plays a role in regulating the contractility of the urinary bladder smooth muscle and may contribute to detrusor overactivity.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Tomoaki Ando, Jiro Kitaura
Summary: The emergence of anti-IgE drugs highlights the importance of IgE-dependent pathways in allergic disorders. IgE enables fast memory responses against threats like venoms and bacteria, but dysregulation can lead to life-threatening allergic diseases. Various IgE-associating molecules fine-tune the reactivity of the IgE sensor, impacting mast cell activation.
Article
Physiology
I. T. Parsons, M. J. Stacey, L. Faconti, N. Hill, J. O'Hara, E. Walter, B. Farukh, R. McNally, H. Sharp, A. Patten, R. Grimaldi, N. Gall, P. Chowienczyk, D. R. Woods
Summary: Heat stress exacerbates post-exercise hypotension (PEH) and cardiovascular disturbances from elevated body temperature may contribute to exertion-related incapacity. This study found that mast cell degranulation may be a vasodilatory mechanism underlying PEH and exercise associated collapse.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
