RHOBTB3 promotes proteasomal degradation of HIFα through facilitating hydroxylation and suppresses the Warburg effect

STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy

(2013) João Vasco Ferreira et al.   Autophagy

Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation

(2013) Maimon E. Hubbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prolyl Hydroxylase Domain Protein 2 (PHD2) Binds a Pro-Xaa-Leu-Glu Motif, Linking It to the Heat Shock Protein 90 Pathway

(2013) Daisheng Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Golgi-associated RhoBTB3 targets Cyclin E for ubiquitylation and promotes cell cycle progression

(2013) Albert Lu et al.   JOURNAL OF CELL BIOLOGY

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

MUF1/Leucine-Rich Repeat Containing 41 (LRRC41), a Substrate of RhoBTB-Dependent Cullin 3 Ubiquitin Ligase Complexes, Is a Predominantly Nuclear Dimeric Protein

(2012) Kristína Schenková et al.   JOURNAL OF MOLECULAR BIOLOGY

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

(2012) Peppi Koivunen et al.   NATURE

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity

(2012) Daniel E. Foxler et al.   NATURE CELL BIOLOGY

Oxygen Sensing, Homeostasis, and Disease

(2011) Gregg L. Semenza   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia-inducible Factor-1 Activation in Nonhypoxic Conditions: The Essential Role of Mitochondrial-derived Reactive Oxygen Species

(2010) David A. Patten et al.   MOLECULAR BIOLOGY OF THE CELL

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Hypoxia and cell cycle regulation of the von Hippel–Lindau tumor suppressor

(2010) W Liu et al.   ONCOGENE

Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1α-induced metabolic reprograming

(2010) F Zhao et al.   ONCOGENE

High-resolution DNA copy number and gene expression analyses distinguish chromophobe renal cell carcinomas and renal oncocytomas

(2009) Maria V Yusenko et al.   BMC CANCER

Patterns of Gene Expression and Copy-Number Alterations in von-Hippel Lindau Disease-Associated and Sporadic Clear Cell Carcinoma of the Kidney

(2009) R. Beroukhim et al.   CANCER RESEARCH

RhoBTB3: A Rho GTPase-Family ATPase Required for Endosome to Golgi Transport

(2009) Eric J. Espinosa et al.   CELL

15-Deoxy-Δ12,14-prostaglandin-J2 reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1α degradation

(2009) Gemma Olmos et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1  Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species

(2009) S. Sudarshan et al.   MOLECULAR AND CELLULAR BIOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Rho GTPases of the RhoBTB subfamily and tumorigenesis

(2008) Jessica BERTHOLD et al.   ACTA PHARMACOLOGICA SINICA

Epidermal Sensing of Oxygen Is Essential for Systemic Hypoxic Response

(2008) Adam T. Boutin et al.   CELL

The role of hypoxia-inducible factors in tumorigenesis

(2008) E B Rankin et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial complex III regulates hypoxic activation of HIF

(2008) T Klimova et al.   CELL DEATH AND DIFFERENTIATION

Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes — Evidence for an autoregulatory mechanism

(2008) Jessica Berthold et al.   EXPERIMENTAL CELL RESEARCH

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development

(2008) T. V. Sharp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA