Structure and enzymatic mechanism of a moonlighting dUTPase

Phage dUTPases Control Transfer of Virulence Genes by a Proto-Oncogenic G Protein-like Mechanism

(2013) María Ángeles Tormo-Más et al.   MOLECULAR CELL

Increased uracil insertion in DNA is cytotoxic and increases the frequency of mutation, double strand break formation and VSG switching in Trypanosoma brucei

(2012) Víctor M. Castillo-Acosta et al.   DNA REPAIR

Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil

(2012) Berit Doseth et al.   DNA REPAIR

Discovery of a Novel Class of Potent Human Deoxyuridine Triphosphatase Inhibitors Remarkably Enhancing the Antitumor Activity of Thymidylate Synthase Inhibitors

(2012) Seiji Miyahara et al.   JOURNAL OF MEDICINAL CHEMISTRY

The dUTPase Enzyme Is Essential in Mycobacterium smegmatis

(2012) Ildiko Pecsi et al.   PLoS One

Investigation of stable and transient protein-protein interactions: Past, present, and future

(2012) Armand G. Ngounou Wetie et al.   PROTEOMICS

Uracil-Containing DNA in Drosophila: Stability, Stage-Specific Accumulation, and Developmental Involvement

(2012) Villő Muha et al.   PLoS Genetics

The structure ofBacillus subtilisSPβ prophage dUTPase and its complexes with two nucleotides

(2011) Javier García-Nafría et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystallization and preliminary crystallographic analysis of dUTPase from the ϕ11 helper phage ofStaphylococcus aureus

(2011) Ibolya Leveles et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

The CLN025 Decapeptide Retains a β-Hairpin Conformation in Urea and Guanidinium Chloride

(2011) Marcus P. D. Hatfield et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Delineation of Folding Pathways of a β-Sheet Miniprotein

(2011) Wenwei Zheng et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Inhibition of dUTPase Induces Synthetic Lethality with Thymidylate Synthase-Targeted Therapies in Non-Small Cell Lung Cancer

(2011) P. M. Wilson et al.   MOLECULAR CANCER THERAPEUTICS

Cellular Response to Efficient dUTPase RNAi Silencing in Stable HeLa Cell Lines Perturbs Expression Levels of Genes Involved in Thymidylate Metabolism

(2011) Gábor Merényi et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Regulatory networks integrating cell cycle control with DNA damage checkpoints and double-strand break repair

(2011) P. Langerak et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Nucleotide pyrophosphatase employs a P-loop-like motif to enhance catalytic power and NDP/NTP discrimination

(2011) I. Pecsi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of the genomicBacillus subtilisdUTPase: novel features in the Phe-lid

(2010) Javier García-Nafría et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Mechanisms of dNTP supply that play an essential role in maintaining genome integrity in eukaryotic cells

(2010) Hiroyuki Niida et al.   CANCER SCIENCE

Multilocus PCR typing strategy for differentiation of Staphylococcus aureus siphoviruses reflecting their modular genome structure

(2010) Jana Kahánková et al.   ENVIRONMENTAL MICROBIOLOGY

Direct contacts between conserved motifs of different subunits provide major contribution to active site organization in human and mycobacterial dUTPases

(2010) Enikő Takács et al.   FEBS LETTERS

Complete Genome Sequence of Staphylococcus aureus Strain JKD6159, a Unique Australian Clone of ST93-IV Community Methicillin-Resistant Staphylococcus aureus

(2010) K. Chua et al.   JOURNAL OF BACTERIOLOGY

Moonlighting bacteriophage proteins derepress staphylococcal pathogenicity islands

(2010) María Ángeles Tormo-Más et al.   NATURE

Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase

(2010) Ildiko Pecsi et al.   NUCLEIC ACIDS RESEARCH

Molecular replacement withMOLREP

(2009) Alexei Vagin et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystallization and crystal-packing studies ofChlorellavirus deoxyuridine triphosphatase

(2009) Kohei Homma et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Electrospray-ionization mass spectrometry as a tool for fast screening of protein structural properties

(2009) Rita Grandori et al.   Biotechnology Journal

Viral manipulation of DNA repair and cell cycle checkpoints

(2009) Mira S. Chaurushiya et al.   DNA REPAIR

Molecular shape and prominent role of β-strand swapping in organization of dUTPase oligomers

(2009) Enikő Takács et al.   FEBS LETTERS

Genome Sequence of a Recently Emerged, Highly Transmissible, Multi-Antibiotic- and Antiseptic-Resistant Variant of Methicillin-Resistant Staphylococcus aureus, Sequence Type 239 (TW)

(2009) M. T. G. Holden et al.   JOURNAL OF BACTERIOLOGY

The Flexible Motif V of Epstein-Barr Virus Deoxyuridine 5′-Triphosphate Pyrophosphatase Is Essential for Catalysis

(2009) Lucy Freeman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Keeping Uracil Out of DNA: Physiological Role, Structure and Catalytic Mechanism of dUTPases

(2008) Beáta G Vértessy et al.   ACCOUNTS OF CHEMICAL RESEARCH

Active site of mycobacterial dUTPase: Structural characteristics and a built-in sensor

(2008) Balázs Varga et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Staphylococcus aureus Pathogenicity Island DNA Is Packaged in Particles Composed of Phage Proteins

(2008) M. A. Tormo et al.   JOURNAL OF BACTERIOLOGY

Native mass spectrometry: a bridge between interactomics and structural biology

(2008) Albert J R Heck   NATURE METHODS

Uracil in DNA and its processing by different DNA glycosylases

(2008) T. Visnes et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Methylene substitution at the α–β bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site

(2007) Júlia Kovári et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS