The dUTPase Enzyme Is Essential in Mycobacterium smegmatis

Antifolate Inhibitors of Thymidylate Synthase as Anticancer Drugs

(2012) A. Jarmula   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Mycobacterium tuberculosis thymidylate synthase gene thyX is essential and potentially bifunctional, while thyA deletion confers resistance to p-aminosalicylic acid

(2011) A. S. Fivian-Hughes et al.   MICROBIOLOGY-SGM

The challenge of new drug discovery for tuberculosis

(2011) Anil Koul et al.   NATURE

Cellular Response to Efficient dUTPase RNAi Silencing in Stable HeLa Cell Lines Perturbs Expression Levels of Genes Involved in Thymidylate Metabolism

(2011) Gábor Merényi et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Nucleotide pyrophosphatase employs a P-loop-like motif to enhance catalytic power and NDP/NTP discrimination

(2011) I. Pecsi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism

(2011) Jennifer E. Griffin et al.   PLoS Pathogens

Toward the estimation of the absolute quality of individual protein structure models

(2010) Pascal Benkert et al.   BIOINFORMATICS

Direct contacts between conserved motifs of different subunits provide major contribution to active site organization in human and mycobacterial dUTPases

(2010) Enikő Takács et al.   FEBS LETTERS

Moonlighting bacteriophage proteins derepress staphylococcal pathogenicity islands

(2010) María Ángeles Tormo-Más et al.   NATURE

A one-step method for quantitative determination of uracil in DNA by real-time PCR

(2010) András Horváth et al.   NUCLEIC ACIDS RESEARCH

Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase

(2010) Ildiko Pecsi et al.   NUCLEIC ACIDS RESEARCH

Mutational Analysis of Mycobacterium UvrD1 Identifies Functional Groups Required for ATP Hydrolysis, DNA Unwinding, and Chemomechanical Coupling

(2009) Krishna Murari Sinha et al.   BIOCHEMISTRY

Keeping Uracil Out of DNA: Physiological Role, Structure and Catalytic Mechanism of dUTPases

(2008) Beáta G Vértessy et al.   ACCOUNTS OF CHEMICAL RESEARCH

Active site of mycobacterial dUTPase: Structural characteristics and a built-in sensor

(2008) Balázs Varga et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Extensively drug-resistant tuberculosis

(2008) Mandeep Jassal et al.   LANCET INFECTIOUS DISEASES

Novel opportunities for thymidylate metabolism as a therapeutic target

(2008) P. M. Wilson et al.   MOLECULAR CANCER THERAPEUTICS

Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage

(2008) Peter M. Wilson et al.   NUCLEIC ACIDS RESEARCH

Electroporation of Mycobacteria

(2008) Renan Goude et al.   Jove-Journal of Visualized Experiments

Mechanism of dTTP Inhibition of the Bifunctional dCTP Deaminase:dUTPase Encoded by Mycobacterium tuberculosis

(2007) Signe Smedegaard Helt et al.   JOURNAL OF MOLECULAR BIOLOGY