Article
Engineering, Biomedical
Sergio Alexandre Gehrke, Jaime Aramburu Junior, Tiago Luis Eirles Treichel, Berenice Anina Dedavid
Summary: In the early osseointegration period, tapered implant groups exhibited superior results in all parameters compared to cylindrical implants in rabbit tibiae.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Engineering, Biomedical
Dimitrios Karazisis, Lars Rasmusson, Sarunas Petronis, Anders Palmquist, Furqan A. Shah, Hossein Agheli, Lena Emanuelsson, Anna Johansson, Omar Omar, Peter Thomsen
Summary: This study investigated the effects of controlled nanoscale topography and microscale roughness on the development of osseointegration in implants. The results showed that nanotopography promoted implant stability and downregulated the expression of the proinflammatory cytokine TNF-alpha. Nanoscale-driven mechanisms may involve attenuation of the inflammatory response at the titanium implant site.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Nikhil Anand, Neha Mehrotra, Kaushik Pal
Summary: In this study, a biodegradable Zn-1Mg-1Cu-1HA (ZHA) and Zn-1Mg-1Cu-1ZrO2 (ZZR) composite was created using the stir-casting process and enhanced with a ceramic composite coating by electrodeposition technique. Microstructural analysis revealed uniform distribution of fine MgZn2 and CuZn2 phases in an α-Zn matrix. The mechanical test confirmed high tensile and compressive properties of the ZZR composite, along with low corrosion rate and degradation rate, and good cell viability. Overall, the coated ZZR composite shows promise as a material for implant applications.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Metallurgy & Metallurgical Engineering
Xiang-yu Zhang, Shu-xin Lu, Dong-mei He, Mao-zhou Chai, Zhuang-zhuang Wu, Xiao-hong Yao, Yong-qiang Yang
Summary: In this study, graphene quantum dots (GQDs) were incorporated into TiO2 nanorods (TiO2 NR) by hydrothermal treatment, leading to the successful preparation of GQDs-modified TiO2 NR with excellent antimicrobial effect and good biocompatibility. The GQDs-modified TiO2 NR showed a high efficiency of 97.8% against Streptococcus mutans and contributed to new bone formation under bacteria-induced implant infection.
TRANSACTIONS OF NONFERROUS METALS SOCIETY OF CHINA
(2023)
Article
Chemistry, Multidisciplinary
Henrique Ferreira, Carlos Fernando Mourao, Rafael Coutinho Mello-Machado, Kayvon Javid, Rodrigo dos Santos Pereira, Plinio Mendes Senna
Summary: This study investigated the impact of a xenograft bone wall on the initial stability of dental implants. The results showed that the use of a xenograft bone wall increased bone volume and trabecular thickness, while decreasing trabecular separation, resulting in improved stability of the implants.
APPLIED SCIENCES-BASEL
(2023)
Article
Engineering, Biomedical
Ranyue Ren, Jiachao Guo, Hao Song, Yong Wei, Chao Luo, Yayun Zhang, Liangxi Chen, Biao Gao, Jijiang Fu, Wei Xiong
Summary: Implants made of Ti and its alloys are commonly used in orthopaedic surgeries. However, poor integration with bone often leads to complications. This study aimed to investigate the effects of magnetized titanium dioxide nanorods (TNrs) combined with a sinusoidal electromagnetic field (SEMF) on osteoblastogenesis, osseointegration, and angiogenesis. The addition of SEMF to VR-EPCs cultured on Fe3O4-TNrs activated the calcineurin/NFAT signaling pathway, reversing the inhibitory effect on angiogenesis. Furthermore, SEMF enhanced osteogenic differentiation and osseointegration. These findings suggest that the modification of implants with Fe3O4-TNrs and SEMF could promote osseointegration and provide a new avenue for implant modification.
MATERIALS TODAY BIO
(2023)
Review
Nanoscience & Nanotechnology
Bingfeng Wu, Yufei Tang, Kai Wang, Xuemei Zhou, Lin Xiang
Summary: TiO2 nanotube arrays (TiO2 NTAs) on titanium implant surfaces play an important role in osseointegration by manipulating protein adsorption, inflammatory cell adhesion and response, additional relevant cell adhesion, as well as angiogenesis and osteogenesis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sabine Stoetzel, Deeksha Malhan, Ute Wild, Christian Helbing, Fathi Hassan, Sameh Attia, Klaus D. Jandt, Christian Heiss, Thaqif El Khassawna
Summary: In this preclinical study, the effects of different bioactive coatings on titanium implants were evaluated using histological analysis and cellular balance assessment. The results showed that the chitosan/gelatin-coated titanium implants exhibited improved bone matrix quality and cellular balance compared to the chitosan/hyaluronic acid-coated and native implants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Sukanya Mishra, Manoj Kumar, Lora Mishra, Rinkee Mohanty, Rashmita Nayak, Abhaya Chandra Das, Sambhab Mishra, Saurav Panda, Barbara Lapinska
Summary: This systematic review analyzed the use of Fractal Dimension (FD) as a tool to measure implant stability based on trabecular changes. The results showed that FD can serve as a measure of implant stability, but it should be used in conjunction with other methods and factors, as it may not be a sole indicator.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Engineering, Biomedical
Per Kjellin, Karin Danielsson, Joakim Hakansson, Karin Agrenius, Therese Andersson, Patrik Stenlund
Summary: A biomechanical method was developed and evaluated to study the integration of implants into porcine skin in an ex vivo model. Results showed that using nanosized hydroxyapatite (HA) on titanium and PEEK could increase pullout force, while using nanosized zirconium phosphate (ZrP) did not have the same effect. Pullout force was inversely proportional to epidermal downgrowth (ED) and tissue to implant contact (TIC) was significantly higher for PEEK compared to titanium.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2022)
Article
Surgery
Jun Shi, Yuxin Sun, Yan Han, Mi Chai, Huxian Liu, Juan Wang
Summary: This study investigated the biomechanical performance of implant-retained finger prostheses designed for Asians under external loads using the finite element method. It found that as the load increased, cancellous bone yielded first, while dense bone and implants could withstand higher loads. Increasing implant depth significantly increased the maximum strain of cancellous bone.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Review
Medicine, General & Internal
Xinrui Lang, Bo Qiao, Ziyu Ge, Jiahui Yan, Yanzhen Zhang
Summary: Photofunctionalization has a positive effect on implant stability and osseointegration speed, leading to improved stability and faster healing time. However, its effect on marginal bone loss remains unclear.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Engineering, Biomedical
Jorge Felipe Lima Teixeira, Joao Antonio Chaves de Souza, Fernando Augusto Cintra Magalhaes, Guilherme Jose Pimentel Lopes de Oliveira, Jose Bernardo de Santis, Carlos Alberto de Souza Costa, Pedro Paulo Chaves de Souza
Summary: This study aimed to evaluate the effects of conditioned media from osteoblasts cultured on laser-modified titanium surfaces on the differentiation of bone marrow cells in a paracrine manner and to analyze the expression of Wnt pathway inhibitors. The study found that the conditioned media from osteoblasts cultured on laser-modified titanium surfaces can promote mineralized nodule formation and alkaline phosphatase activity in bone marrow cells, influencing the osteoblastic differentiation of neighboring cells. Among the regulated mediators, Dickkopf-1 (DKK1) is one of them.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Yao Ding, Zhang Yuan, Jin-Wei Hu, Kun Xu, Hong Wang, Peng Liu, Kai-Yong Cai
Summary: The fabrication of micro-nano-structured Ti substrates using double acid corrosion and hydrothermal treatment, followed by immobilization of mesoporous polydopamine nanoparticles as photothermal agent, resulted in physical stress on bacteria and enhanced mesenchymal stem cell osteogenic differentiation. In vivo animal experiments confirmed that the modified Ti implants could improve osseointegration.
Article
Engineering, Biomedical
K. Harawaza, B. Cousins, P. Roach, A. Fernandez
Summary: As society ages, there is a growing demand for advanced, safe, and sophisticated implants. Current research is mainly focused on developing modified-surface medical implants that can direct specific immunomodulation at a cellular level. Despite abundant research information, there are challenges in translating academic knowledge into clinical trials and commercial technologies.
MATERIALS TODAY BIO
(2021)
Article
Cell Biology
Jaime S. Marques Filho, Jorge Gobara Jr, Gustavo Vargas da Silva Salomao, Laura M. Sumita, Jamil A. Shibli, Renato G. Viana, Humberto O. Schwartz Filho, Claudio Sergio Pannuti, Paulo Henrique Braz-Silva, Debora Pallos
MEDIATORS OF INFLAMMATION
(2018)
Article
Multidisciplinary Sciences
Antiope Lotsari, Anand K. Rajasekharan, Mats Halvarsson, Martin Andersson
NATURE COMMUNICATIONS
(2018)
Article
Materials Science, Biomaterials
Mats Hulander, Hakon Valen-Rukke, Gustav Sundell, Martin Andersson
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2019)
Article
Biochemistry & Molecular Biology
Anna Peterson, Ida Ostergren, Antiope Lotsari, Abhijit Venkatesh, Johannes Thunberg, Anna Strom, Ramiro Rojas, Martin Andersson, Lars A. Berglund, Antal Boldizar, Christian Mueller
Article
Chemistry, Multidisciplinary
Anand K. Rajasekharan, Christoffer Gyllensten, Edvin Blomstrand, Marianne Liebi, Martin Andersson
Article
Multidisciplinary Sciences
Yuan Rui, David R. Wilson, John Choi, Mahita Varanasi, Katie Sanders, Johan Karlsson, Michael Lim, Jordan J. Green
Article
Biochemistry & Molecular Biology
Kristin Hyltegren, Mats Hulander, Martin Andersson, Marie Skepoe
Review
Pharmacology & Pharmacy
Johan Karlsson, Kelly R. Rhodes, Jordan J. Green, Stephany Y. Tzeng
EXPERT OPINION ON DRUG DELIVERY
(2020)
Article
Chemistry, Multidisciplinary
Johan Karlsson, Stephany Y. Tzeng, Shayan Hemmati, Kathryn M. Luly, Olivia Choi, Yuan Rui, David R. Wilson, Kristen L. Kozielski, Alfredo Quinones-Hinojosa, Jordan J. Green
Summary: This study introduces a novel strategy involving photocrosslinking of bioreducible nanoparticles to enhance the systemic delivery of RNA. The photocrosslinked bioreducible nanoparticles exhibit improved stability and efficient siRNA-mediated gene silencing effects in melanoma tumors, providing potential for advancing nucleic acid-based therapeutics delivery technologies.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Adrian Rodriguez-Palomo, Viviane Lutz-Bueno, Xiaobao Cao, Roland Kadar, Martin Andersson, Marianne Liebi
Summary: The study shows that in regions with high extensional flow, the material is oriented perpendicular to the flow, while in regions with high enough shear rate, the material is oriented in the flow direction. A flow-induced morphological transition from aligned lamellae toward multilamellar vesicles is observed in the lamellar phase with different shear rates.
Article
Materials Science, Biomaterials
Saba Atefyekta, Edvin Blomstrand, Anand K. Rajasekharan, Sara Svensson, Margarita Trobos, Jaan Hong, Thomas J. Webster, Peter Thomsen, Martin Andersson
Summary: The covalent immobilization of antimicrobial peptides (AMPs) in amphiphilic hydrogels increases long-term stability and shows high antibacterial activity. The AMP-hydrogels are non-toxic to human fibroblasts and retain their antimicrobial activity up to 48 hours in human blood serum.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Review
Pharmacology & Pharmacy
Johan Karlsson, Kathryn M. Luly, Stephany Y. Tzeng, Jordan J. Green
Summary: Glioblastoma is an aggressive brain cancer with poor prognosis, and current standard treatments have limited effectiveness. New approaches like immunotherapies, targeted therapies, and gene therapies show promise in extending patient survival. Nanoparticles as carriers for nucleic acid delivery have potential, but face challenges such as low blood-brain barrier permeability and limited targeting ability.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Nanoscience & Nanotechnology
Annija Stepulane, Anand Kumar Rajasekharan, Martin Andersson
Summary: This study presents a coating technique that improves the antibacterial properties of polydimethylsiloxane (PDMS), a commonly used biomaterial in medical devices, and also provides drug delivery capabilities. The coating, composed of cross-linked triblock copolymers and an antimicrobial peptide, effectively kills Staphylococcus aureus and Staphylococcus epidermidis and shows sustained drug release profiles.
ACS APPLIED BIO MATERIALS
(2022)
Article
Engineering, Biomedical
Sarah Y. Neshat, Chun Hei Ryan Chan, Jawaun Harris, Osamah M. Zmily, Savannah Est-Witte, Johan Karlsson, Sydney R. Shannon, Manav Jain, Joshua C. Doloff, Jordan J. Green, Stephany Y. Tzeng
Summary: Immuno-oncology therapies aim to induce sustained tumor regression, but current methods are in need of improvement. An antigen-free method of cancer immunotherapy that stimulates the immune system without knowledge of neoantigens has been developed, along with a local delivery system to minimize systemic toxicity. A gene delivery nanoparticle platform has been engineered to reprogram the tumor microenvironment and activate cytotoxic lymphocytes, resulting in tumor regression and clearance.
Article
Chemistry, Multidisciplinary
Johan Karlsson, Yuan Rui, Kristen L. Kozielski, Amanda L. Placone, Olivia Choi, Stephany Y. Tzeng, Jayoung Kim, Jamal J. Keyes, Max Bogorad, Kathleen Gabrielson, Hugo Guerrero-Cazares, Alfredo Quifiones-Hinojosa, Peter C. Searson, Jordan J. Green
