Review
Cell Biology
Lawrence M. Schwartz
Summary: Cell death is a normal and essential component of development and homeostasis, but dysregulation of this process underlies most human diseases. Autophagy is a process mediated by the formation of double membrane vesicles, which allows cells to survive stresses and may also mediate cell death during development and pathogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Liuhua Zhou, Jiateng Sun, Lingfeng Gu, Sibo Wang, Tongtong Yang, Tianwen Wei, Tiankai Shan, Hao Wang, Liansheng Wang
Summary: Abnormalities in programmed cell death signaling cascades play a crucial role in the development and progression of cardiovascular diseases, leading to excessive cardiac remodeling and heart failure. Timely activation of cell death pathways post-injury can help in repairing cardiac structure and function. Drugs targeting key players in cell death signaling pathways may hold potential for future therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Yifan Cheng, Misha Mao, Yong Lu
Summary: YAP plays a critical role in regulating tumor progression and is closely related to programmed cell death (PCD). YAP activity can be regulated by kinase cascade pathways and other proteins. It has been found that YAP can affect multiple forms of PCD and act as a bridge between different forms of PCD in tumor development.
BIOMARKER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Juan A. Montero, Carlos Ignacio Lorda-Diez, Juan M. Hurle
Summary: This paper proposes a new perspective on the regulation of programmed cell death (PCD) in developing systems based on epigenetics. It challenges the traditional view that PCD is solely controlled by specific gene-encoded signals, arguing that the signals and local tissue interactions responsible for embryonic tissue growth and differentiation play a significant role in PCD. The study suggests that cells retain an epigenetic profile sensitive to DNA damage, resulting in their subsequent elimination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Subashani Maniam, Sandra Maniam
Summary: Targeted chemotherapy has become the forefront of cancer treatment, offering more effective treatment with reduced side effects through selective and specific features; Research targeting the compensatory mechanisms in tumor cells is progressing in order to overcome drug resistance; Promising small molecules that target autophagy and apoptosis are being developed for the difficult-to-treat TNBC, showing potential in preclinical data.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Chang Liu, Zecheng Jiang, Zhongjie Pan, Liang Yang
Summary: Atherosclerosis is a chronic inflammatory vascular disease, and macrophages play a significant role in its progression. Recent studies have highlighted the critical role of programmed cell death in macrophages in the development of vulnerable plaques in atherosclerosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Jianan Zhao, Ping Jiang, Shicheng Guo, Steven J. Schrodi, Dongyi He
Summary: Rheumatoid arthritis is a chronic inflammatory joint disease characterized by chronic synovial inflammation and degeneration of bones and joints. Despite the variety of treatment options available, some patients still have a poor prognosis due to the complex mechanism of the disease. Programmed cell death has been identified as one of the essential pathological mechanisms of RA, contributing to its development through dysregulation in various cell types.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Shiyi Tan, Shi Chen
Summary: Silicosis, caused by chronic exposure to silica dust, is closely associated with programmed cell death, including autophagy, apoptosis, and pyroptosis, with the potential for becoming important targets for intervention or therapeutic methods in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Yan Zhang, Xinghua Lv, Feng Chen, Qian Fan, Yongqiang Liu, Zhanhai Wan, Janvier Nibaruta, Jipeng Lv, Xuena Han, Lin Wu, Hao Wang, Yufang Leng
Summary: MicroRNAs play a crucial role in regulating gene expression in kidney development and disease. Dysregulation of miRNAs can lead to various renal diseases. Understanding the mechanisms by which miRNAs regulate renal development and diseases is important for developing new diagnostic and therapeutic approaches, but more research is needed to fully understand these mechanisms.
Article
Cell Biology
Ying-chen Xia, Jian-hua Zha, Yong-Hua Sang, Hui Yin, Guo-qiu Xu, Jie Zhen, Yan Zhang, Ben-tong Yu
Summary: Activation of AMPK by ASP4132 effectively inhibits NSCLC cell growth in vitro and in vivo, inducing apoptosis, causing mitochondrial dysfunction and autophagy. AMPK activation also leads to downstream events including mTORC1 inhibition, receptor tyrosine kinase degradation, Akt inhibition, and programmed necrosis.
CELL DEATH & DISEASE
(2021)
Review
Chemistry, Multidisciplinary
Lu Wang, Yiqi Wu, Renqi Yao, Yun Li, Yurou Wei, Yuan Cao, Zicheng Zhang, Mengyao Wu, Hanyu Zhu, Yongming Yao, Hongjun Kang
Summary: Mesenchymal stem cells (MSCs) have been extensively studied for their immunomodulatory properties in inflammatory diseases. Recently, MSC-derived extracellular vesicles (MSC-EVs) have gained attention as a major pathway for intercellular communication. This review summarizes the potential influences of MSC-EVs on different types of programmed cell death and diseases, and discusses the therapeutic effects, current research progress, and challenges of clinical applications of MSC-EVs. Understanding the regulation of inflammation-associated programmed cell death by MSC-EVs is important for identifying molecular mechanisms and modulatory targets.
Article
Cell Biology
Jia-Heng Zhang, Shi-Yu Ni, Ya-Ting Tan, Jia Luo, Shu-Chao Wang
Summary: By conducting bibliometric analyses, this study explores the research trends and hotspots of Pin1 and cell death. The results indicate that the research on Pin1 and cell death has been increasing annually since 2001, but growth after 2014 appears to be stagnant. The cooperation between core institutions needs to be strengthened, and recently, Fujian Medical University in China has emerged as the institution with the highest citation count. Further research is required to understand the role of Pin1 in cell death and to identify new research hotspots. Future studies are likely to focus on disease treatment using Pin1 inhibitors, before breakthroughs are made in understanding the molecular mechanisms or signaling pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Neurosciences
Yan Zhang, Suliman Khan, Yang Liu, Ruiyi Zhang, Hongmin Li, Guofeng Wu, Zhouping Tang, Mengzhou Xue, V. Wee Yong
Summary: This review summarizes the knowledge of cell death induced by intracerebral hemorrhage (ICH), with a focus on apoptosis and necrosis. It also discusses the involvement of recently described modes of cell death including necroptosis, pyroptosis, ferroptosis, autophagy, and parthanatos in ICH. Treatment strategies to mitigate brain injury based on specific cell death pathways after ICH are also summarized.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Jinhao Chen, Mujie Ye, Jianan Bai, Chunhua Hu, Feiyu Lu, Danyang Gu, Ping Yu, Qiyun Tang
Summary: N6-methyladenosine (m6A) methylation is the most prevalent and abundant RNA modification in eukaryotes and has recently gained attention in research. Studies have shown that dysregulation of m6A modification is associated with the progression of various diseases, particularly cancer. Programmed cell death (PCD) is an active and orderly form of cell death, and there is growing evidence of the mutual regulation between m6A modification and PCD, which can affect cancer treatment sensitivity. This review summarizes recent advances in the interplay and potential mechanisms of m6A modification and PCD, as well as their relevance to cancer therapeutic resistance.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Virology
Shannic-Le Kerr, Cynthia Mathew, Reena Ghildyal
Summary: Rhinoviruses are common causes of the common cold and can lead to more severe diseases in lower respiratory tract infections. These viruses hijack host cell pathways to suppress antiviral responses, and the mechanism of how they exit infected cells remains unclear.
Article
Critical Care Medicine
Kun Wang, Xin Zhang, Jiaxing Sun, Jia Ye, Feilong Wang, Jing Hua, Huayu Zhang, Ting Shi, Qiang Li, Xiaodong Wu
Article
Cardiac & Cardiovascular Systems
Zhibing Luo, Na Wang, Ping Liu, Qian Guo, Linyu Ran, Feilong Wang, Yuling Tang, Qiang Li
RESPIRATORY MEDICINE
(2020)
Article
Oncology
Han Lei, Kun Wang, Tongying Jiang, Jingjing Lu, Xue Dong, Feilong Wang, Qiang Li, Liming Zhao
Article
Hematology
Feilong Wang, Linyu Ran, Chenchen Qian, Jing Hua, Zhibing Luo, Min Ding, Xing Zhang, Wei Guo, Shaoyong Gao, Weibo Gao, Chaoping Li, Zhongmin Liu, Qiang Li, Claudio Ronco
Summary: This multicenter retrospective study found that nearly half of COVID-19 patients with ARDS experienced AKI during their hospital stay, and the coexistence of AKI significantly increased the mortality of these patients.
BLOOD PURIFICATION
(2021)
Article
Cell Biology
Xiaodong Wu, Chenghong Li, Shi Chen, Xin Zhang, Feilong Wang, Ting Shi, Qiang Li, Lin Lin
Summary: This study found that obesity is associated with an increased risk of IMV therapy, ICU admission, and ARDS in COVID-19 pneumonia, while underweight is linked to higher mortality. Additionally, BMI has a U-shaped association with ICU admission and death, and a linear relationship with IMV therapy and ARDS. These findings suggest that caution should be taken in treating COVID-19 patients with underweight and obesity.
Article
Oncology
Jiaxing Sun, Jing Zhang, Haiyan Hu, Huan Qin, Ximing Liao, Feilong Wang, Wei Zhang, Qi Yin, Xiaoping Su, Yanan He, Wenfeng Li, Kun Wang, Qiang Li
Summary: NRT cells induced by RNA mutanome vaccine exhibit significant anti-tumour effect in mouse lung cancer by promoting active T-cell infiltration into the tumor tissue and delaying tumor progression.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Jing Hua, Xin Zhang, Na Wang, Linyu Ran, Shengyun Wang, Chiungwei Huang, Wei Gao, Chenchen Qian, Wei Guo, Zhongmin Liu, Qiang Li, Feilong Wang
Summary: ECMO may be an effective treatment for critically ill patients with COVID-19, but careful patient selection and management by a trained team are crucial. More randomized controlled trials with larger sample sizes are needed to evaluate the actual effectiveness of ECMO in patients with COVID-19.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
He Sun, Feilong Wang, Ming Zhang, Xiaoyong Xu, Miaomiao Li, Wei Gao, Xiaodong Wu, Huize Han, Qin Wang, Gehong Yao, Zheng Lou, Han Xia, Yi Shi, Qiang Li
Summary: This study evaluates the value of metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid (BALF) in the diagnosis of Pneumocystis jirovecii pneumonia (PJP) and its mixed infection in non-human immunodeficiency virus (HIV) immunosuppressed patients. The study found that BALF-mNGS had a higher positive detection rate for various pathogens, especially mixed infections, compared to conventional methods. BALF-mNGS had higher sensitivity and specificity for the diagnosis of PJP compared to traditional methods, and its detection time was significantly shorter.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Guosheng Wang, Jiaxing Sun, Jing Zhang, Qiping Zhu, Jingjing Lu, Shaoyong Gao, Feilong Wang, Qi Yin, Yuan Wan, Qiang Li
Summary: This study found a significant increase in EOMES+CD8+ T cells in TKI-resistant lung cancer patients, which was correlated with poor survival. The increase in EOMES+CD8+ T cells was confirmed in both tissue samples and peripheral blood of TKI-resistant patients. The integrated analysis suggested that the increase in EOMES+CD8+ T cells may be related to TRM T cell conversion and metabolic reprogramming.
DRUG RESISTANCE UPDATES
(2023)
Article
Engineering, Biomedical
Ru Zhang, Jing Zhang, Fei Tan, Deqi Yang, Bingfang Wang, Jing Dai, Yin Qi, Linyu Ran, Wenjuan He, Yingying Lv, Feilong Wang, Yin Fang
Summary: Researchers developed a portable multi-channel sputum-based device for noninvasive diagnosis of lung cancer. The device utilizes signal amplification and simultaneous detection of biomarkers in sputum to distinguish lung cancer patients from healthy individuals. The device can also track biomarker changes in lung cancer patients after radiotherapy/chemotherapy.
MATERIALS TODAY BIO
(2022)
Article
Biochemistry & Molecular Biology
Xia Fang, Pei Zhao, Shaoyong Gao, Dongmei Liu, Song Zhang, Mengtian Shan, Yuanyuan Wang, Joerg Herrmann, Qiang Li, Feilong Wang
Summary: Tumor cell-derived lactate has been identified as the main factor in the polarization of tumor-associated macrophages (TAMs). Previous studies have highlighted the importance of mitochondrial pyruvate carrier (MPC)-mediated transport in TAMs polarization. However, our genetic depletion study demonstrated that MPC is not necessary for lactate-induced macrophages polarization or tumor growth.It also had no impact on the stabilization of hypoxia-inducible factor 1 alpha (HIF-1 alpha) and histone lactylation, which are both crucial for TAMs polarization. This suggests that lactate itself, rather than its downstream metabolites, is responsible for TAMs polarization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Cell Biology
Na Wang, Jing Hua, Yuhua Fu, Jun An, Xiangyu Chen, Chuancui Wang, Yanghong Zheng, Feilong Wang, Yingqun Ji, Qiang Li
Summary: Pulmonary hypertension (PH) is characterized by irreversible vascular remodeling and elevated pulmonary vascular resistance and pressure, leading to right heart failure and death. Current strategies focus on symptom alleviation through pulmonary vessel dilation. The relationship between PH and hypoxia-inducible factors family, particularly EPAS1, has been studied, but the detailed mechanism is not fully understood. This article provides a comprehensive summary of EPAS1, including its structure, function, and regulatory network in PH and related cardiovascular diseases, and offers theoretical reference for potential novel targets for PH intervention.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Linyu Ran, Song Zhang, Guosheng Wang, Pei Zhao, Jiaxing Sun, Jiaqi Zhou, Haiyun Gan, Ryounghoon Jeon, Qiang Li, Joerg Herrmann, Feilong Wang
Summary: Glycolysis is essential for macrophage activation, but the involvement of glycolytic pathway metabolites in this process is not fully understood. Previous studies suggested the importance of the mitochondrial pyruvate carrier (MPC) in M1 activation, but using genetic approaches, this study shows that MPC is dispensable for M1 macrophage activation. The MPC inhibitor UK5099 inhibits inflammatory responses in M1 macrophages independent of MPC expression.
Letter
Respiratory System
Feilong Wang, Kun Wang, Cole Bowerman, Hogne Ulla, Jiaxing Sun, Marko Topalovic, Sanja Stanojevic, Qiang Li
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Emergency Medicine
Wei Guo, Lin-yu Ran, Ji-hong Zhu, Qing-gang Ge, Zhe Du, Fei-long Wang, Wei-bo Gao, Tian-bing Wang
Summary: This study included 121 critically ill patients, with 28.9% (35/121) of them dying in the hospital. Non-survivors were older and more likely to develop acute organ dysfunction, with higher SOFA and qSOFA scores. Twelve useful biomarkers for predicting in-hospital mortality were identified, such as NLR, FT3, and ferritin, suggesting their potential as powerful predictors for fatal outcomes in COVID-19 patients.
WORLD JOURNAL OF EMERGENCY MEDICINE
(2021)
