Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 15, Pages -Publisher
MDPI
DOI: 10.3390/ijms22158110
Keywords
programmed cell death; autophagy; apoptosis; pyroptosis; silicosis
Funding
- National Natural Science Foundation of China [81703199]
- Natural Science Foundation of Hunan Province [2019JJ50398]
- Key Project of Hunan provincial science and technology innovation [2020SK1015-3]
- Hunan Normal University [2019116]
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Silicosis, caused by chronic exposure to silica dust, is closely associated with programmed cell death, including autophagy, apoptosis, and pyroptosis, with the potential for becoming important targets for intervention or therapeutic methods in the future.
Silicosis remains one of the most severe pulmonary fibrotic diseases worldwide, caused by chronic exposure to silica dust. In this review, we have proposed that programmed cell death (PCD), including autophagy, apoptosis, and pyroptosis, is closely associated with silicosis progression. Furthermore, some autophagy, apoptosis, or pyroptosis-related signaling pathways or regulatory proteins have also been summarized to contribute greatly to the formation and development of silicosis. In addition, silicosis pathogenesis depends on the crosstalk among these three ways of PCD to a certain extent. In summary, more profound research on these mechanisms and effects may be expected to become promising targets for intervention or therapeutic methods of silicosis in the future.
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