Cytokine-induced killer cells as immunotherapy for solid tumors: current evidence and perspectives

Bone marrow mesenchymal stem cells suppressing activation of allogeneic cytokine-induced killer/natural killer cells either by direct or indirect interaction

(2015) Yang Li et al.   CELL BIOLOGY INTERNATIONAL

Cytokine-Induced Killer Cells Engineered with Exogenous T-Cell Receptors Directed Against Melanoma Antigens: Enhanced Efficacy of Effector Cells Endowed with a Double Mechanism of Tumor Recognition

(2015) Angela R. Elia et al.   HUMAN GENE THERAPY

MICA/B and ULBP1 NKG2D ligands are independent predictors of good prognosis in cervical cancer

(2015) Hanbyoul Cho et al.   BMC CANCER

Manipulating the expression of chemokine receptors enhances delivery and activity of cytokine-induced killer cells

(2014) Y Zou et al.   BRITISH JOURNAL OF CANCER

Clinical Activity of Adjuvant Cytokine-Induced Killer Cell Immunotherapy in Patients with Post-Mastectomy Triple-Negative Breast Cancer

(2014) K. Pan et al.   CLINICAL CANCER RESEARCH

Direct involvement of CD56 in cytokine-induced killer–mediated lysis of CD56+ hematopoietic target cells

(2014) Rut Valgardsdottir et al.   EXPERIMENTAL HEMATOLOGY

Analysis of adverse events following the treatment of autologous cytokine-induced killer cells for adoptive immunotherapy in malignant tumour sufferers

(2014) Yajing Zhang et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Cytokine-induced killer (CIK) cells in cancer immunotherapy: report of the international registry on CIK cells (IRCC)

(2014) Leonard Christopher Schmeel et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Chimeric antigen receptors against CD33/CD123 antigens efficiently target primary acute myeloid leukemia cells in vivo

(2014) I Pizzitola et al.   LEUKEMIA

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions

(2014) Christopher J Chan et al.   NATURE IMMUNOLOGY

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adoptive Immunotherapy of Cytokine-Induced Killer Cell Therapy in the Treatment of Non-Small Cell Lung Cancer

(2014) Min Wang et al.   PLoS One

A meta-analysis of cytokine-induced killer cells therapy in combination with minimally invasive treatment for hepatocellular carcinoma

(2014) Xiaofeng Li et al.   Clinics and Research in Hepatology and Gastroenterology

Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma

(2013) G. P. Linette et al.   BLOOD

Targeting of acute myeloid leukaemia by cytokine-induced killer cells redirected with a novel CD123-specific chimeric antigen receptor

(2013) Sarah Tettamanti et al.   BRITISH JOURNAL OF HAEMATOLOGY

Cytokine-Induced Killer Cells Eradicate Bone and Soft-Tissue Sarcomas

(2013) D. Sangiolo et al.   CANCER RESEARCH

Effective Activity of Cytokine-Induced Killer Cells against Autologous Metastatic Melanoma Including Cells with Stemness Features

(2013) L. Gammaitoni et al.   CLINICAL CANCER RESEARCH

Multivariate statistical data analysis as a tool to analyze ex vivo expansion dynamics of cytokine-induced killer cells

(2013) Cristina Zanon et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Potential for enhanced therapeutic activity of biological cancer therapies with doxycycline combination

(2013) H Tang et al.   GENE THERAPY

Combination of radiofrequency ablation and sequential cellular immunotherapy improves progression-free survival for patients with hepatocellular carcinoma

(2013) Jiuwei Cui et al.   INTERNATIONAL JOURNAL OF CANCER

A randomized phase II study of autologous cytokine-induced killer cells in treatment of hepatocelluar carcinoma

(2013) Xiaozhou Yu et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Upregulation of Adhesion Molecules on Leukemia Targets Improves the Efficacy of Cytotoxic T Cells Transduced With Chimeric Anti-CD19 Receptor

(2013) David Laurin et al.   JOURNAL OF IMMUNOTHERAPY

Arming Cytokine-induced Killer Cells With Chimeric Antigen Receptors: CD28 Outperforms Combined CD28–OX40 “Super-stimulation”

(2013) Andreas A Hombach et al.   MOLECULAR THERAPY

Effects of MICA Expression on the Prognosis of Advanced Non-Small Cell Lung Cancer and the Efficacy of CIK Therapy

(2013) Yu Chen et al.   PLoS One

Autologous cytokine-induced killer cell immunotherapy in lung cancer: a phase II clinical study

(2012) Runmei Li et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Cancer Stem Cells: Current Status and Evolving Complexities

(2012) Jane E. Visvader et al.   Cell Stem Cell

Randomized Study of Autologous Cytokine-Induced Killer Cell Immunotherapy in Metastatic Renal Carcinoma

(2012) L. Liu et al.   CLINICAL CANCER RESEARCH

Cytokine-induced killer (CIK) cells as feasible and effective adoptive immunotherapy for the treatment of solid tumors

(2012) Giulia Mesiano et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Molecular basis of lipid antigen presentation by CD1d and recognition by natural killer T cells

(2012) Enrico Girardi et al.   IMMUNOLOGICAL REVIEWS

Ex Vivo Allogeneic Stimulation Significantly Improves Expansion of Cytokine-Induced Killer Cells Without Increasing Their Alloreactivity Across HLA Barriers

(2012) Maja Todorovic et al.   JOURNAL OF IMMUNOTHERAPY

Cytokine Induced Killer Cells as Promising Immunotherapy for Solid Tumors

(2012) Dario Sangiolo   Journal of Cancer

Cytotoxic Capacity of IL-15-Stimulated Cytokine-Induced Killer Cells Against Human Acute Myeloid Leukemia and Rhabdomyosarcoma in Humanized Preclinical Mouse Models

(2012) Eva Rettinger et al.   Frontiers in Oncology

Adoptive Immunotherapy with Cytokine-Induced Killer Cells for Patients with Relapsed Hematologic Malignancies after Allogeneic Hematopoietic Cell Transplantation

(2011) Ginna G. Laport et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells

(2011) J. N. Kochenderfer et al.   BLOOD

Dual-functional capability of CD3+CD56+ CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity

(2011) A. Pievani et al.   BLOOD

Differentiation, phenotype, and function of interleukin-17-producing human V 9V 2 T cells

(2011) N. Caccamo et al.   BLOOD

Cytotoxic T-Lymphocyte-Associated Antigen-4

(2011) A. K. S. Salama et al.   CLINICAL CANCER RESEARCH

The cytotoxic potential of interleukin-15-stimulated cytokine-induced killer cells against leukemia cells

(2011) Eva Rettinger et al.   CYTOTHERAPY

Control of Immunity by the TNFR-Related Molecule OX40 (CD134)

(2010) Michael Croft   Annual Review of Immunology

Efficient lysis of rhabdomyosarcoma cells by cytokine-induced killer cells: implications for adoptive immunotherapy after allogeneic stem cell transplantation

(2010) S. Kuci et al.   HAEMATOLOGICA

Clinical trials on CIK cells: first report of the international registry on CIK cells (IRCC)

(2010) C. Hontscha et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Thymoglobulin, interferon-γ and interleukin-2 efficiently expand cytokine-induced killer (CIK) cells in clinical-grade cultures

(2010) Giuseppina Bonanno et al.   Journal of Translational Medicine

Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

(2010) Richard A Morgan et al.   MOLECULAR THERAPY

Increasing the frequency of CIK cells adoptive immunotherapy may decrease risk of death in gastric cancer patients

(2010) Jing-Ting Jiang   WORLD JOURNAL OF GASTROENTEROLOGY

Antitumor activity of cytokine-induced killer cells in nude mouse xenograft model

(2009) Hwan Mook Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Human Cytokine-Induced Killer Cells Specifically Infiltrated and Retarded the Growth of the Inoculated Human Cholangiocarcinoma Cells in SCID Mice

(2009) Adisak Wongkajornsilp et al.   CANCER INVESTIGATION

Cytokine-induced killer cells are terminallydifferentiated activated CD8 cytotoxic T-EMRA lymphocytes

(2009) Marta Franceschetti et al.   EXPERIMENTAL HEMATOLOGY

Immunotherapy with cytokine induced killer cells in solid and hematopoietic tumours: a pilot clinical trial

(2009) Paola Olioso et al.   HEMATOLOGICAL ONCOLOGY

T Cell Receptor (TCR) Gene Transfer with Lentiviral Vectors Allows Efficient Redirection of Tumor Specificity in Naive and Memory T Cells Without Prior Stimulation of Endogenous TCR

(2009) Paola Circosta et al.   HUMAN GENE THERAPY

Minimally Invasive Treatment Combined With Cytokine-induced Killer Cells Therapy Lower the Short-term Recurrence Rates of Hepatocellular Carcinomas

(2009) De-Sheng Weng et al.   JOURNAL OF IMMUNOTHERAPY

In vivo trafficking and survival of cytokine-induced killer cells resulting in minimal GVHD with retention of antitumor activity

(2008) R. Nishimura et al.   BLOOD

A randomized, controlled trial of postoperative adjuvant cytokine-induced killer cells immunotherapy after radical resection of hepatocellular carcinoma

(2008) Dong Hui et al.   DIGESTIVE AND LIVER DISEASE

Characterization of the recognition and functional heterogeneity exhibited by cytokine-induced killer cell subsets against acute myeloid leukaemia target cell

(2008) Yeh C. Linn et al.   IMMUNOLOGY

Alloreactivity and anti-tumor activity segregate within two distinct subsets of cytokine-induced killer (CIK) cells: implications for their infusion across major HLA barriers

(2008) Dario Sangiolo et al.   INTERNATIONAL IMMUNOLOGY

Inhibition of human cervical carcinoma growth by cytokine-induced killer cells in nude mouse xenograft model

(2008) Hwan Mook Kim et al.   INTERNATIONAL IMMUNOPHARMACOLOGY