The danger model: questioning an unconvincing theory

HMGB1 Binds to Lipoteichoic Acid and Enhances TNF-a and IL-6 Production through HMGB1-Mediated Transfer of Lipoteichoic Acid to CD14 and TLR2

(2015) Man Sup Kwak et al.   Journal of Innate Immunity

Oxidation by Neutrophils-Derived HOCl Increases Immunogenicity of Proteins by Converting Them into Ligands of Several Endocytic Receptors Involved in Antigen Uptake by Dendritic Cells and Macrophages

(2015) Rafał Biedroń et al.   PLoS One

Dectin-2 Is a Direct Receptor for Mannose-Capped Lipoarabinomannan of Mycobacteria

(2014) Akiko Yonekawa et al.   IMMUNITY

Toll-Like Receptor, Lipotoxicity and Chronic inflammation: The Pathological Link Between Obesity and Cardiometabolic Disease

(2014) Kosei Eguchi et al.   Journal of Atherosclerosis and Thrombosis

Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns

(2014) Liliana Schaefer   JOURNAL OF BIOLOGICAL CHEMISTRY

Selection of an Antibody Library Identifies a Pathway to Induce Immunity by Targeting CD36 on Steady-State CD8 + Dendritic Cells

(2014) E. Tagliani et al.   JOURNAL OF IMMUNOLOGY

Uncoupling of Induced Protein Processing from Maturation in Dendritic Cells Exposed to a Highly Antigenic Preparation from a Helminth Parasite

(2014) F. A. Marshall et al.   JOURNAL OF IMMUNOLOGY

High Mobility Group Box 1 Protein Binding to Lipopolysaccharide Facilitates Transfer of Lipopolysaccharide to CD14 and Enhances Lipopolysaccharide-Mediated TNF-  Production in Human Monocytes

(2014) J. H. Youn et al.   JOURNAL OF IMMUNOLOGY

NLRP3 Regulates Neutrophil Functions and Contributes to Hepatic Ischemia-Reperfusion Injury Independently of Inflammasomes

(2014) Y. Inoue et al.   JOURNAL OF IMMUNOLOGY

Inflammasomes and Metabolic Disorders: Old Genes in Modern Diseases

(2014) Gregory R. Robbins et al.   MOLECULAR CELL

Evaluation of the Contribution of Multiple DAMPs and DAMP Receptors in Cell Death-Induced Sterile Inflammatory Responses

(2014) Hiroshi Kataoka et al.   PLoS One

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

The class A scavenger receptor SR-A/CD204 and the class B scavenger receptor CD36 regulate immune functions of macrophages differently

(2013) Szczepan Józefowski et al.   Innate Immunity

Human Lipopolysaccharide-binding Protein (LBP) and CD14 Independently Deliver Triacylated Lipoproteins to Toll-like Receptor 1 (TLR1) and TLR2 and Enhance Formation of the Ternary Signaling Complex

(2013) Diana Rose E. Ranoa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Mechanisms Responsible for the Reduced Expression of Cholesterol Transporters From Macrophages by Low-Dose Endotoxin

(2012) Urmila Maitra et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mycobacterial and mouse HSP70 have immuno-modulatory effects on dendritic cells

(2012) R. Spiering et al.   CELL STRESS & CHAPERONES

Oxidatively Modified Low Density Lipoprotein (LDL) Inhibits TLR2 and TLR4 Cytokine Responses in Human Monocytes but Not in Macrophages

(2012) Yashaswini Kannan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HMGB1-RAGE regulates muscle satellite cell homeostasis through p38-MAPK- and myogenin-dependent repression of Pax7 transcription

(2012) F. Riuzzi et al.   JOURNAL OF CELL SCIENCE

The IL-1-Dependent Sterile Inflammatory Response Has a Substantial Caspase-1-Independent Component That Requires Cathepsin C

(2012) H. Kono et al.   JOURNAL OF IMMUNOLOGY

Plasmin as a proinflammatory cell activator

(2012) T. Syrovets et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Receptor for advanced glycation end products is protective during murine tuberculosis

(2012) Marieke A.D. van Zoelen et al.   MOLECULAR IMMUNOLOGY

The Role of Heat Shock Proteins in Antigen Cross Presentation

(2012) Ayesha Murshid et al.   Frontiers in Immunology

Activation of Th17/Th1 and Th1, but not Th17, is associated with the acute cardiac event in patients with acute coronary syndrome

(2011) Zhao Zhao et al.   ATHEROSCLEROSIS

Diet, commensals and the intestine as sources of pathogen-associated molecular patterns in atherosclerosis, type 2 diabetes and non-alcoholic fatty liver disease

(2011) Clett Erridge   ATHEROSCLEROSIS

Identification of lipopolysaccharide-binding peptide regions within HMGB1 and their effects on subclinical endotoxemia in a mouse model

(2011) Ju Ho Youn et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Danger Signal S100B Integrates Pathogen– and Danger–Sensing Pathways to Restrain Inflammation

(2011) Guglielmo Sorci et al.   PLoS Pathogens

An Inflammasome-Independent Role for Epithelial-Expressed Nlrp3 in Renal Ischemia-Reperfusion Injury

(2010) A. A. Shigeoka et al.   JOURNAL OF IMMUNOLOGY

Endogenous ligands of TLR2 and TLR4: agonists or assistants?

(2010) Clett Erridge   JOURNAL OF LEUKOCYTE BIOLOGY

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer

(2009) Jin Young Kang et al.   IMMUNITY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Receptor for Advanced Glycation End Products Facilitates Host Defense duringEscherichia coli–Induced Abdominal Sepsis in Mice

(2009) Marieke A. D. van Zoelen et al.   JOURNAL OF INFECTIOUS DISEASES

The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation

(2009) Hulda Sigridur Hreggvidsdottir et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

High-Mobility Group Box 1 Protein in Human and Murine Skin: Involvement in Wound Healing

(2008) Stefania Straino et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY