Age-associated B cells: key mediators of both protective and autoreactive humoral responses

Reversing B cell aging

(2016) Ramit Mehr et al.   Aging-US

Long-Lived Plasma Cells Are Contained within the CD19−CD38hiCD138+ Subset in Human Bone Marrow

(2015) Jessica L. Halliley et al.   IMMUNITY

Salmonella Infection Drives Promiscuous B Cell Activation Followed by Extrafollicular Affinity Maturation

(2015) Roberto Di Niro et al.   IMMUNITY

Age-Associated B Cells: A T-bet–Dependent Effector with Roles in Protective and Pathogenic Immunity

(2015) Kira Rubtsova et al.   JOURNAL OF IMMUNOLOGY

CD11c-Expressing B Cells Are Located at the T Cell/B Cell Border in Spleen and Are Potent APCs

(2015) Anatoly V. Rubtsov et al.   JOURNAL OF IMMUNOLOGY

Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency

(2014) P. Stepensky et al.   BLOOD

Memory B cells form in aged mice despite impaired affinity maturation and germinal center kinetics

(2014) Radhika Goenka et al.   EXPERIMENTAL GERONTOLOGY

T-Cell-Receptor-Dependent Signal Intensity Dominantly Controls CD4+ T Cell Polarization In Vivo

(2014) Nicholas van Panhuys et al.   IMMUNITY

Cutting Edge: The Dependence of Plasma Cells and Independence of Memory B Cells on BAFF and APRIL

(2014) M. J. Benson et al.   JOURNAL OF IMMUNOLOGY

Functional Regulatory T Cells Accumulate in Aged Hosts and Promote Chronic Infectious Disease Reactivation

(2014) C. S. Lages et al.   JOURNAL OF IMMUNOLOGY

Aging Down-Regulates the Transcription Factor E2A, Activation-Induced Cytidine Deaminase, and Ig Class Switch in Human B Cells

(2014) D. Frasca et al.   JOURNAL OF IMMUNOLOGY

Clonal Expansions and Loss of Receptor Diversity in the Naive CD8 T Cell Repertoire of Aged Mice

(2014) M. Ahmed et al.   JOURNAL OF IMMUNOLOGY

Lasting Antibody Responses Are Mediated by a Combination of Newly Formed and Established Bone Marrow Plasma Cells Drawn from Clonally Distinct Precursors

(2014) Irene Chernova et al.   JOURNAL OF IMMUNOLOGY

CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype

(2014) Griselda V Zuccarino-Catania et al.   NATURE IMMUNOLOGY

In senescence, age-associated B cells secrete TNFα and inhibit survival of B-cell precursors*

(2013) Michelle Ratliff et al.   AGING CELL

Homeostatic Regulation of Aging and Rejuvenation in the B Lineage Cells

(2013) Doron Melamed   CRITICAL REVIEWS IN IMMUNOLOGY

Transcriptional Repression of Gata3 Is Essential for Early B Cell Commitment

(2013) Anupam Banerjee et al.   IMMUNITY

Exacerbated Autoimmunity in the Absence of TLR9 in MRL.Faslpr Mice Depends on Ifnar1

(2013) K. M. Nickerson et al.   JOURNAL OF IMMUNOLOGY

Mcl-1 is essential for the survival of plasma cells

(2013) Victor Peperzak et al.   NATURE IMMUNOLOGY

T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance

(2013) Kira Rubtsova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expansion of Autoreactive Unresponsive CD21−/lowB Cells in Sjögren's Syndrome-Associated Lymphoproliferation

(2012) D. Saadoun et al.   ARTHRITIS AND RHEUMATISM

Aging and neoteny in the B lineage

(2012) D. Melamed et al.   BLOOD

Long-Lived Bone Marrow Plasma Cells Are Induced Early in Response to T Cell-Independent or T Cell-Dependent Antigens

(2012) A. Bortnick et al.   JOURNAL OF IMMUNOLOGY

Divergent transcriptional programming of class-specific B cell memory by T-bet and RORα

(2012) Nathaniel S Wang et al.   NATURE IMMUNOLOGY

The development and fate of follicular helper T cells defined by an IL-21 reporter mouse

(2012) Katja Lüthje et al.   NATURE IMMUNOLOGY

B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging

(2011) Z. Keren et al.   BLOOD

A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice

(2011) Y. Hao et al.   BLOOD

Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity

(2011) A. V. Rubtsov et al.   BLOOD

ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6

(2011) Youn Soo Choi et al.   IMMUNITY

Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone

(2011) Steven M. Kerfoot et al.   IMMUNITY

Memory B cells, but not long-lived plasma cells, possess antigen specificities for viral escape mutants

(2011) Whitney E. Purtha et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alterations in Marginal Zone Macrophages and Marginal Zone B Cells in Old Mice

(2011) S. Z. Birjandi et al.   JOURNAL OF IMMUNOLOGY

Chronic B Cell Deficiency from Birth Prevents Age-Related Alterations in the B Lineage

(2011) Z. Keren et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Dendritic Cell-Restricted Antigen Presentation Initiates the Follicular Helper T Cell Program but Cannot Complete Ultimate Effector Differentiation

(2011) R. Goenka et al.   JOURNAL OF IMMUNOLOGY

Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut

(2011) Jörg H. Fritz et al.   NATURE

Different B Cell Populations Mediate Early and Late Memory During an Endogenous Immune Response

(2011) K. A. Pape et al.   SCIENCE

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

(2010) Michelle A. Linterman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism

(2010) Dimitra Zotos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR9 Regulates TLR7- and MyD88-Dependent Autoantibody Production and Disease in a Murine Model of Lupus

(2010) Kevin M. Nickerson et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Hierarchy of Maturity of Murine Memory B Cell Subsets

(2010) M. M. Tomayko et al.   JOURNAL OF IMMUNOLOGY

Immunosenescence and vaccination of the elderly I. Age-related immune impairment

(2009) J. Ongrádi et al.   ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

Effects of aging on hematopoietic stem and progenitor cells

(2009) Amanda Waterstrat et al.   CURRENT OPINION IN IMMUNOLOGY

Lunatic and Manic Fringe Cooperatively Enhance Marginal Zone B Cell Precursor Competition for Delta-like 1 in Splenic Endothelial Niches

(2009) Joanne B. Tan et al.   IMMUNITY

Mechanisms of costimulation

(2009) Arlene H. Sharpe   IMMUNOLOGICAL REVIEWS

IL-4–producing CD4+T cells in reactive lymph nodes during helminth infection are T follicular helper cells

(2009) Irah L. King et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Multiple layers of B cell memory with different effector functions

(2009) Ismail Dogan et al.   NATURE IMMUNOLOGY

Cytokine-secreting follicular T cells shape the antibody repertoire

(2009) R Lee Reinhardt et al.   NATURE IMMUNOLOGY

Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells

(2009) M. Rakhmanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects

(2009) H. Tsukamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional regulation of early B cell development

(2008) Daniel L. Northrup et al.   IMMUNOLOGIC RESEARCH

Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals

(2008) Susan Moir et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tonic B cell antigen receptor signals supply an NF-κB substrate for prosurvival BLyS signaling

(2008) Jason E Stadanlick et al.   NATURE IMMUNOLOGY

Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5

(2008) Jagan M R Pongubala et al.   NATURE IMMUNOLOGY

BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact

(2008) J. L. Scholz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA