Structural analysis of Fc/FcγR complexes: a blueprint for antibody design

A Perspective on the Structure and Receptor Binding Properties of Immunoglobulin G Fc

(2015) Quinlin M. Hanson et al.   BIOCHEMISTRY

Differential Fc-Receptor Engagement Drives an Anti-tumor Vaccinal Effect

(2015) David J. DiLillo et al.   CELL

Suppression of Fcγ-Receptor-Mediated Antibody Effector Function during Persistent Viral Infection

(2015) Douglas H. Yamada et al.   IMMUNITY

Antibody Effector Functions Mediated by Fcγ-Receptors Are Compromised during Persistent Viral Infection

(2015) Andreas Wieland et al.   IMMUNITY

Of ITIMs, ITAMs, and ITAMis: revisiting immunoglobulin Fc receptor signaling

(2015) Andrew Getahun et al.   IMMUNOLOGICAL REVIEWS

Structural mechanism of high affinity FcγRI recognition of immunoglobulin G

(2015) Jinghua Lu et al.   IMMUNOLOGICAL REVIEWS

The Solution Structures of Two Human IgG1 Antibodies Show Conformational Stability and Accommodate Their C1q and FcγR Ligands

(2015) Lucy E. Rayner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protection in antibody- and T cell-mediated autoimmune diseases by antiinflammatory IgG Fcs requires type II FcRs

(2015) Benjamin M. Fiebiger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of FcγRI in complex with Fc reveals the importance of glycan recognition for high-affinity IgG binding

(2015) Jinghua Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FcγR dependent mechanisms of cytotoxic, agonistic, and neutralizing antibody activities

(2015) Falk Nimmerjahn et al.   TRENDS IN IMMUNOLOGY

Immune complexes regulate bone metabolism through FcRγ signalling

(2015) Takako Negishi-Koga et al.   Nature Communications

Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss

(2015) Ulrike Harre et al.   Nature Communications

Structural basis for binding of human IgG1 to its high-affinity human receptor FcγRI

(2015) Masato Kiyoshi et al.   Nature Communications

3D Structural Fluctuation of IgG1 Antibody Revealed by Individual Particle Electron Tomography

(2015) Xing Zhang et al.   Scientific Reports

Intramolecular N-Glycan/Polypeptide Interactions Observed at Multiple N-Glycan Remodeling Steps through [13C,15N]-N-Acetylglucosamine Labeling of Immunoglobulin G1

(2014) Adam W. Barb   BIOCHEMISTRY

Broadly Neutralizing Anti-HIV-1 Antibodies Require Fc Effector Functions for In Vivo Activity

(2014) Stylianos Bournazos et al.   CELL

Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice

(2014) Ariel Halper-Stromberg et al.   CELL

Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

(2014) Vaheh Oganesyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Experimental Antibody Therapy of Liver Metastases Reveals Functional Redundancy between Fc RI and Fc RIV

(2014) M. A. Otten et al.   JOURNAL OF IMMUNOLOGY

Structural Characterization of Anti-Inflammatory Immunoglobulin G Fc Proteins

(2014) Alysia A. Ahmed et al.   JOURNAL OF MOLECULAR BIOLOGY

Immunoglobulin G1 Fc Domain Motions: Implications for Fc Engineering

(2014) Martin Frank et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal structure of deglycosylated human IgG4-Fc

(2014) Anna M. Davies et al.   MOLECULAR IMMUNOLOGY

Type I and type II Fc receptors regulate innate and adaptive immunity

(2014) Andrew Pincetic et al.   NATURE IMMUNOLOGY

Broadly neutralizing hemagglutinin stalk–specific antibodies require FcγR interactions for protection against influenza virus in vivo

(2014) David J DiLillo et al.   NATURE MEDICINE

Obinutuzumab plus Chlorambucil in Patients with CLL and Coexisting Conditions

(2014) Valentin Goede et al.   NEW ENGLAND JOURNAL OF MEDICINE

UniProt: a hub for protein information

(2014)   NUCLEIC ACIDS RESEARCH

Emerging Principles for the Therapeutic Exploitation of Glycosylation

(2014) Martin Dalziel et al.   SCIENCE

Restricted Motion of the Conserved Immunoglobulin G1 N-Glycan Is Essential for Efficient FcγRIIIa Binding

(2014) Ganesh P. Subedi et al.   STRUCTURE

Cleavage of the interchain disulfide bonds in rituximab increases its affinity for FcγRIIIA

(2013) Mami Suzuki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The high-affinity human IgG receptor Fc RI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy

(2013) D. A. Mancardi et al.   BLOOD

Asymmetrical Fc Engineering Greatly Enhances Antibody-dependent Cellular Cytotoxicity (ADCC) Effector Function and Stability of the Modified Antibodies

(2013) Zhi Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Determinants of Unique Properties of Human IgG4-Fc

(2013) Anna M. Davies et al.   JOURNAL OF MOLECULAR BIOLOGY

Engineering Hydrophobic Protein–Carbohydrate Interactions to Fine-Tune Monoclonal Antibodies

(2013) Xiaojie Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel asymmetrically engineered antibody Fc variant with superior FcγR binding affinity and specificity compared with afucosylated Fc variant

(2013) Futa Mimoto et al.   mAbs

An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations

(2013) Omid Vafa et al.   METHODS

The binding of soluble recombinant human Fcγ receptor I for human immunoglobulin G is conferred by its first and second extracellular domains

(2013) Yoshiharu Asaoka et al.   MOLECULAR IMMUNOLOGY

IgG2 Fc structure and the dynamic features of the IgG CH2–CH3 interface

(2013) Alexey Teplyakov et al.   MOLECULAR IMMUNOLOGY

Crystal structure of a novel asymmetrically engineered Fc variant with improved affinity for FcγRs

(2013) F. Mimoto et al.   MOLECULAR IMMUNOLOGY

Crystal structure of sialylated IgG Fc: Implications for the mechanism of intravenous immunoglobulin therapy

(2013) M. Crispin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

General mechanism for modulating immunoglobulin effector function

(2013) P. Sondermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered antibody Fc variant with selectively enhanced Fc RIIb binding over both Fc RIIaR131 and Fc RIIaH131

(2013) F. Mimoto et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Revisiting the Role of Glycosylation in the Structure of Human IgG Fc

(2012) M. Jack Borrok et al.   ACS Chemical Biology

Effective expression of soluble aglycosylated recombinant human Fcγ receptor I by low translational efficiency in Escherichia coli

(2012) Kouta Hatayama et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The immunoglobulin, IgG Fc receptor and complement triangle in autoimmune diseases

(2012) Christian M. Karsten et al.   IMMUNOBIOLOGY

Pentraxins and Fc receptors

(2012) Jinghua Lu et al.   IMMUNOLOGICAL REVIEWS

The interactions of therapeutic antibodies with Fc receptors

(2012) Marcello Albanesi et al.   IMMUNOLOGY LETTERS

Selective Deactivation of Serum IgG: A General Strategy for the Enhancement of Monoclonal Antibody Receptor Interactions

(2012) Kavitha Baruah et al.   JOURNAL OF MOLECULAR BIOLOGY

Fc receptor-targeted therapies for the treatment of inflammation, cancer and beyond

(2012) P. Mark Hogarth et al.   NATURE REVIEWS DRUG DISCOVERY

Engineering of recombinant human Fc  receptor I by directed evolution

(2012) Y. Asaoka et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans

(2011) Tsunehiro Mizushima et al.   GENES TO CELLS

Crystal Structure of Fcγ Receptor I and Its Implication in High Affinity γ-Immunoglobulin Binding

(2011) Jinghua Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Fc RIIa Recognition of Human IgG and Formation of Inflammatory Signaling Complexes

(2011) P. A. Ramsland et al.   JOURNAL OF IMMUNOLOGY

Functional Characteristics of the High Affinity IgG Receptor, Fc RI

(2011) C. E. van der Poel et al.   JOURNAL OF IMMUNOLOGY

NMR analysis demonstrates immunoglobulin G N-glycans are accessible and dynamic

(2011) Adam W Barb et al.   Nature Chemical Biology

Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI

(2011) Mary D Holdom et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Unique carbohydrate-carbohydrate interactions are required for high affinity binding between Fc RIII and antibodies lacking core fucose

(2011) C. Ferrara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis

(2010) Altan Ercan et al.   ARTHRITIS AND RHEUMATISM

Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies

(2010) H. M. Horton et al.   BLOOD

Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity

(2010) E. Mossner et al.   BLOOD

Evolution of anti- CD20 monoclonal antibody therapeutics in oncology

(2010) Ezogelin Oflazoglu et al.   mAbs

Generation of a high-affinity Fc  receptor by Ig-domain swapping between human CD64A and CD16A

(2010) J. L. Ellsworth et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Engineered therapeutic antibodies with improved effector functions

(2009) Tsuguo Kubota et al.   CANCER SCIENCE

Fcγ receptors: structure, function and role as genetic risk factors in SLE

(2009) X Li et al.   GENES AND IMMUNITY

Anti-CD20 monoclonal antibodies: historical and future perspectives

(2009) S. H. Lim et al.   HAEMATOLOGICA

Fc receptors: Role in biology and antibody therapy

(2009) Jan G.J. van de Winkel   IMMUNOLOGY LETTERS

IgG antibodies produced during subcutaneous allergen immunotherapy mediate inhibition of basophil activation via a mechanism involving both FcγRIIA and FcγRIIB

(2009) Carol T. Cady et al.   IMMUNOLOGY LETTERS

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY

Recombinant antibody therapeutics: the impact of glycosylation on mechanisms of action

(2009) Royston Jefferis   TRENDS IN PHARMACOLOGICAL SCIENCES

Structural characterization of a human Fc fragment engineered for lack of effector functions

(2008) Vaheh Oganesyan et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage Fc RI, Fc RIII, and Fc RIV

(2008) V. Minard-Colin et al.   BLOOD

Specificity and affinity of human Fc  receptors and their polymorphic variants for human IgG subclasses

(2008) P. Bruhns et al.   BLOOD

Terminal sugars of Fc glycans influence antibody effector functions of IgGs

(2008) T Shantha Raju   CURRENT OPINION IN IMMUNOLOGY

Molecular engineering and design of therapeutic antibodies

(2008) Leonard G Presta   CURRENT OPINION IN IMMUNOLOGY

Identification of cyclic peptides able to mimic the functional epitope of IgG1-Fc for human FcγRI

(2008) Stephane Bonetto et al.   FASEB JOURNAL

Inhibition of destructive autoimmune arthritis in FcγRIIa transgenic mice by small chemical entities

(2008) Geoffrey A Pietersz et al.   IMMUNOLOGY AND CELL BIOLOGY

Structural characterization of a mutated, ADCC-enhanced human Fc fragment

(2008) Vaheh Oganesyan et al.   MOLECULAR IMMUNOLOGY

Structural recognition and functional activation of FcγR by innate pentraxins

(2008) Jinghua Lu et al.   NATURE

TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved

(2008) A. H. Keeble et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptors

(2008) S. L. Sazinsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc

(2008) R. M. Anthony et al.   SCIENCE