Mechanisms involved in triggering rheumatoid arthritis

Cigarette Smoke–Induced Damage-Associated Molecular Pattern Release from Necrotic Neutrophils Triggers Proinflammatory Mediator Release

(2015) Irene H. Heijink et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss

(2015) Akilan Krishnamurthy et al.   ANNALS OF THE RHEUMATIC DISEASES

Stromal Cells in Chronic Inflammation and Tertiary Lymphoid Organ Formation

(2015) Christopher D. Buckley et al.   Annual Review of Immunology

Salmonella Infection Drives Promiscuous B Cell Activation Followed by Extrafollicular Affinity Maturation

(2015) Roberto Di Niro et al.   IMMUNITY

The B Cell–Stimulatory Cytokines BLyS and APRIL Are Elevated in Human Periodontitis and Are Required for B Cell–Dependent Bone Loss in Experimental Murine Periodontitis

(2015) Toshiharu Abe et al.   JOURNAL OF IMMUNOLOGY

Circulating Human CD27−IgA+Memory B Cells Recognize Bacteria with Polyreactive Igs

(2015) Magdalena A. Berkowska et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Redox Signaling Hypersensitivity Distinguishes Human Germinal Center B Cells

(2015) Hannah G. Polikowsky et al.   JOURNAL OF IMMUNOLOGY

Poncet's disease with high titers of rheumatoid factor and anti-citrullinated peptide antibodies mimicking rheumatoid arthritis

(2015) Hirokazu Sasaki et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

Anti-Citrullinated Peptide Antibodies in Sudanese Patients withLeishmania donovaniInfection Exhibit Reactivity not Dependent on Citrullination

(2015) E. Åhlin et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis

(2015) Yonghao Cao et al.   Science Translational Medicine

Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers: implications for autoimmunity in rheumatoid arthritis

(2015) Elena B Lugli et al.   ARTHRITIS RESEARCH & THERAPY

Rheumatoid arthritis–associated autoantibodies in non–rheumatoid arthritis patients with mucosal inflammation: a case–control study

(2015) Koen M J Janssen et al.   ARTHRITIS RESEARCH & THERAPY

Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss

(2015) Ulrike Harre et al.   Nature Communications

Interactions Between Amino Acid-Defined Major Histocompatibility Complex Class II Variants and Smoking in Seropositive Rheumatoid Arthritis

(2015) Kwangwoo Kim et al.   Arthritis & Rheumatology

Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid

(2015) Julia Spengler et al.   Arthritis & Rheumatology

Brief Report: Enrichment of Activated Group 3 Innate Lymphoid Cells in Psoriatic Arthritis Synovial Fluid

(2015) Emmerik F. A. Leijten et al.   Arthritis & Rheumatology

Expression of FcRL4 defines a pro-inflammatory, RANKL-producing B cell subset in rheumatoid arthritis

(2014) L Yeo et al.   ANNALS OF THE RHEUMATIC DISEASES

IgM rheumatoid factor amplifies the inflammatory response of macrophages induced by the rheumatoid arthritis-specific immune complexes containing anticitrullinated protein antibodies

(2014) Lætitia Laurent et al.   ANNALS OF THE RHEUMATIC DISEASES

Shared immunological targets in the lungs and joints of patients with rheumatoid arthritis: identification and validation

(2014) A Jimmy Ytterberg et al.   ANNALS OF THE RHEUMATIC DISEASES

A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides

(2014) L Bossini-Castillo et al.   ANNALS OF THE RHEUMATIC DISEASES

Effects of cigarette smoke on Toll-like receptor (TLR) activation of chronic obstructive pulmonary disease (COPD) macrophages

(2014) H. J. Metcalfe et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Cellular and humoral immunity in arthritis are profoundly influenced by the interaction between cigarette smoke effects and host HLA-DR and DQ genes

(2014) Robert Vassallo et al.   CLINICAL IMMUNOLOGY

Toll-like receptors and B cells: functions and mechanisms

(2014) Claire M. Buchta et al.   IMMUNOLOGIC RESEARCH

Lungs, joints and immunity against citrullinated proteins in rheumatoid arthritis

(2014) Anca I. Catrina et al.   Nature Reviews Rheumatology

Porphyromonas gingivalis Peptidylarginine Deiminase, a Key Contributor in the Pathogenesis of Experimental Periodontal Disease and Experimental Arthritis

(2014) Neville Gully et al.   PLoS One

Non-HLA genes PTPN22, CDK6 and PADI4 are associated with specific autoantibodies in HLA-defined subgroups of rheumatoid arthritis

(2014) Omri Snir et al.   ARTHRITIS RESEARCH & THERAPY

Identification of New Citrulline-Specific Autoantibodies, Which Bind to Human Arthritic Cartilage, by Mass Spectrometric Analysis of Citrullinated Type II Collagen

(2014) Sabrina Haag et al.   Arthritis & Rheumatology

Citrulline-Specific Th1 Cells Are Increased in Rheumatoid Arthritis and Their Frequency Is Influenced by Disease Duration and Therapy

(2014) Eddie A. James et al.   Arthritis & Rheumatology

Barcode-Enabled Sequencing of Plasmablast Antibody Repertoires in Rheumatoid Arthritis

(2014) Yann-Chong Tan et al.   Arthritis & Rheumatology

Comparison of the Respiratory Microbiome in Healthy Nonsmokers and Smokers

(2013) Alison Morris et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies

(2013) Arnd Kleyer et al.   ANNALS OF THE RHEUMATIC DISEASES

The cellular composition of lymph nodes in the earliest phase of inflammatory arthritis

(2013) L G M van Baarsen et al.   ANNALS OF THE RHEUMATIC DISEASES

Environmental and genetic factors in the development of anticitrullinated protein antibodies (ACPAs) and ACPA-positive rheumatoid arthritis: an epidemiological investigation in twins

(2013) Aase Haj Hensvold et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-carbamylated protein (anti-CarP) antibodies precede the onset of rheumatoid arthritis

(2013) Jing Shi et al.   ANNALS OF THE RHEUMATIC DISEASES

Multiplex Analyses of Antibodies Against Citrullinated Peptides in Individuals Prior to Development of Rheumatoid Arthritis

(2013) Mikael Brink et al.   ARTHRITIS AND RHEUMATISM

Association of Granulomatosis With Polyangiitis (Wegener's) WithHLA-DPB1*04andSEMA6AGene Variants: Evidence From Genome-Wide Analysis

(2013) Gang Xie et al.   ARTHRITIS AND RHEUMATISM

Adaptive immunity in rheumatoid arthritis

(2013) Lars Klareskog et al.   CURRENT OPINION IN RHEUMATOLOGY

Influence of periodontal disease, Porphyromonas gingivalisand cigarette smoking on systemic anti-citrullinated peptide antibody titres

(2013) David F. Lappin et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition

(2013) Khaled Amara et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

(2013) Stephen W. Scally et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Inflammatory monocytes and Fc  receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice

(2013) M. Seeling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

(2013) R. Khandpur et al.   Science Translational Medicine

Porphyromonas gingivalis Facilitates the Development and Progression of Destructive Arthritis through Its Unique Bacterial Peptidylarginine Deiminase (PAD)

(2013) Katarzyna J. Maresz et al.   PLoS Pathogens

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

(2013) Jose U Scher et al.   eLife

Structural Changes and Antibody Enrichment in the Lungs Are Early Features of Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis

(2013) Gudrun Reynisdottir et al.   Arthritis & Rheumatology

Features of the Synovium of Individuals at Risk of Developing Rheumatoid Arthritis: Implications for Understanding Preclinical Rheumatoid Arthritis

(2013) M. J. H. de Hair et al.   Arthritis & Rheumatology

Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile

(2012) Karin Lundberg et al.   ANNALS OF THE RHEUMATIC DISEASES

Porphyromonas gingivalisand disease-related autoantibodies in individuals at increased risk of rheumatoid arthritis

(2012) Ted R. Mikuls et al.   ARTHRITIS AND RHEUMATISM

Multifunctional T cell reactivity with native and glycosylated type II collagen in rheumatoid arthritis

(2012) Omri Snir et al.   ARTHRITIS AND RHEUMATISM

Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis

(2012) Jose U. Scher et al.   ARTHRITIS AND RHEUMATISM

Brief Report: Anti-Carbamylated Protein Antibodies Are Present in Arthralgia Patients and Predict the Development of Rheumatoid Arthritis

(2012) Jing Shi et al.   ARTHRITIS AND RHEUMATISM

Type II collagen-specific antibodies induce cartilage damage in mice independent of inflammation

(2012) Allyson M. Croxford et al.   ARTHRITIS AND RHEUMATISM

CD4+T cells recognize diverse epitopes within GAD65: implications for repertoire development and diabetes monitoring

(2012) Junbao Yang et al.   IMMUNOLOGY

Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin

(2012) Ulrike Harre et al.   JOURNAL OF CLINICAL INVESTIGATION

MHC Class II Tetramers

(2012) G. T. Nepom   JOURNAL OF IMMUNOLOGY

Expression of peptidylarginine deiminase-2 and -4, citrullinated proteins and anti-citrullinated protein antibodies in human gingiva

(2012) G. P. Harvey et al.   JOURNAL OF PERIODONTAL RESEARCH

Citrullination of proteins: a common post-translational modification pathway induced by different nanoparticlesin vitroandin vivo

(2012) Bashir M Mohamed et al.   Nanomedicine

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

(2012) Soumya Raychaudhuri et al.   NATURE GENETICS

Genetically Distinct Subsets within ANCA-Associated Vasculitis

(2012) Paul A. Lyons et al.   NEW ENGLAND JOURNAL OF MEDICINE

Loss of Sex and Age Driven Differences in the Gut Microbiome Characterize Arthritis-Susceptible *0401 Mice but Not Arthritis-Resistant *0402 Mice

(2012) Andres Gomez et al.   PLoS One

Whole Cigarette Smoke Increased the Expression of TLRs, HBDs, and Proinflammory Cytokines by Human Gingival Epithelial Cells through Different Signaling Pathways

(2012) Abdelhabib Semlali et al.   PLoS One

Lung disease with anti-CCP antibodies but not rheumatoid arthritis or connective tissue disease

(2012) Aryeh Fischer et al.   RESPIRATORY MEDICINE

Mapping pathogenesis of arthritis through small animal models

(2012) T. L. Vincent et al.   RHEUMATOLOGY

Cytokine mRNA profiling identifies B cells as a major source of RANKL in rheumatoid arthritis

(2011) L. Yeo et al.   ANNALS OF THE RHEUMATIC DISEASES

Development of the anti-citrullinated protein antibody repertoire prior to the onset of rheumatoid arthritis

(2011) Lotte A. van de Stadt et al.   ARTHRITIS AND RHEUMATISM

Brief Report: Airways abnormalities and rheumatoid arthritis-related autoantibodies in subjects without arthritis: Early injury or initiating site of autoimmunity?

(2011) M. Kristen Demoruelle et al.   ARTHRITIS AND RHEUMATISM

Cigarette smoke induces the release of CXCL-8 from human bronchial epithelial cells via TLRs and induction of the inflammasome

(2011) E. Mortaz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis

(2011) Lars Klareskog et al.   SEMINARS IN IMMUNOLOGY

Cigarette Smoke Inhibits Engulfment of Apoptotic Cells by Macrophages through Inhibition of Actin Rearrangement

(2010) Naoto Minematsu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Cigarette smoke extract enhances rhinovirus-induced toll-like receptor 3 expression and interleukin-8 secretion in A549 cells

(2010) Jong Hwan Wang et al.   American Journal of Rhinology & Allergy

A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis

(2010) L. Padyukov et al.   ANNALS OF THE RHEUMATIC DISEASES

Different stages of rheumatoid arthritis: features of the synovium in the preclinical phase

(2010) M. G. H. van de Sande et al.   ANNALS OF THE RHEUMATIC DISEASES

Immune complexes containing citrullinated fibrinogen costimulate macrophages via Toll-like receptor 4 and Fcγ receptor

(2010) Jeremy Sokolove et al.   ARTHRITIS AND RHEUMATISM

2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative

(2010) Daniel Aletaha et al.   ARTHRITIS AND RHEUMATISM

Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

(2010) Hsin-Jung Wu et al.   IMMUNITY

The anti-cyclic citrullinated peptide response in tuberculosis patients is not citrulline-dependent and sensitive to treatment

(2010) Ori Elkayam et al.   ARTHRITIS RESEARCH & THERAPY

The value of ultrasonography in predicting arthritis in auto-antibody positive arthralgia patients: a prospective cohort study

(2010) Lotte A van de Stadt et al.   ARTHRITIS RESEARCH & THERAPY

Gene-environment interaction between the DRB1 shared epitope and smoking in the risk of anti-citrullinated protein antibody-positive rheumatoid arthritis: All alleles are important

(2009) Emeli Lundström et al.   ARTHRITIS AND RHEUMATISM

Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways

(2009) L. A. Trouw et al.   ARTHRITIS AND RHEUMATISM

Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients

(2009) Omri Snir et al.   ARTHRITIS AND RHEUMATISM

Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis

(2009) Hüseyin Uysal et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Concomitant Inhalation of Cigarette Smoke and Aerosolized Protein Activates Airway Dendritic Cells and Induces Allergic Airway Inflammation in a TLR-Independent Way

(2009) L. J. Robays et al.   JOURNAL OF IMMUNOLOGY

Secondary Lymphoid Organs: Responding to Genetic and Environmental Cues in Ontogeny and the Immune Response

(2009) N. H. Ruddle et al.   JOURNAL OF IMMUNOLOGY

Comparison of Threshold Cutpoints and Continuous Measures of Anti-Cyclic Citrullinated Peptide Antibodies in Predicting Future Rheumatoid Arthritis

(2009) L. B. CHIBNIK et al.   JOURNAL OF RHEUMATOLOGY

Periodontitis in systemic rheumatic diseases

(2009) Paola de Pablo et al.   Nature Reviews Rheumatology

Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells

(2008) D Makrygiannakis et al.   ANNALS OF THE RHEUMATIC DISEASES

Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis

(2008) Shahla Abdollahi-Roodsaz et al.   JOURNAL OF CLINICAL INVESTIGATION

Discriminating gene expression profiles of memory B cell subpopulations

(2008) Götz R.A. Ehrhardt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CXCL13 expression and follicular dendritic cells in relation to B-cell infiltration in periodontal disease tissues

(2008) T. Nakajima et al.   JOURNAL OF PERIODONTAL RESEARCH

Duration of preclinical rheumatoid arthritis-related autoantibody positivity increases in subjects with older age at time of disease diagnosis

(2007) D S Majka et al.   ANNALS OF THE RHEUMATIC DISEASES