Selection, tuning, and adaptation in mouse NK cell education

Cytomegalovirus Infection Drives Adaptive Epigenetic Diversification of NK Cells with Altered Signaling and Effector Function

(2015) Heinrich Schlums et al.   IMMUNITY

The Distal Upstream Promoter in Ly49 Genes, Pro1, Is Active in Mature NK Cells and T Cells, Does Not Require TATA Boxes, and Displays Enhancer Activity

(2015) Frances Gays et al.   JOURNAL OF IMMUNOLOGY

Acquisition of Activation Receptor Ligand by Trogocytosis Renders NK Cells Hyporesponsive

(2015) Cathrine A. Miner et al.   JOURNAL OF IMMUNOLOGY

SHIP1 Intrinsically Regulates NK Cell Signaling and Education, Resulting in Tolerance of an MHC Class I–Mismatched Bone Marrow Graft in Mice

(2015) Matthew Gumbleton et al.   JOURNAL OF IMMUNOLOGY

Coordinated Expression of DNAM-1 and LFA-1 in Educated NK Cells

(2015) Monika Enqvist et al.   JOURNAL OF IMMUNOLOGY

Neutrophils Induced Licensing of Natural Killer Cells

(2015) Keishiro Amano et al.   MEDIATORS OF INFLAMMATION

DNAM-1 Expression Marks an Alternative Program of NK Cell Maturation

(2015) Ludovic Martinet et al.   Cell Reports

T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow

(2014) Cécile Daussy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Functional NK Cell Repertoires Are Maintained through IL-2R  and Fas Ligand

(2014) M. Felices et al.   JOURNAL OF IMMUNOLOGY

NK Cell Killer Ig-like Receptor Repertoire Acquisition and Maturation Are Strongly Modulated by HLA Class I Molecules

(2014) M. Sleiman et al.   JOURNAL OF IMMUNOLOGY

The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells

(2014) Antoine Marçais et al.   NATURE IMMUNOLOGY

NK cell self tolerance, responsiveness and missing self recognition

(2014) Nataliya Shifrin et al.   SEMINARS IN IMMUNOLOGY

SHP-1-mediated inhibitory signals promote responsiveness and anti-tumour functions of natural killer cells

(2014) Charlotte Viant et al.   Nature Communications

Ly49C-Dependent Control of MCMV Infection by NK Cells Is Cis-Regulated by MHC Class I Molecules

(2014) Catherine A. Forbes et al.   PLoS Pathogens

Ly49 Receptors: Innate and Adaptive Immune Paradigms

(2014) Mir Munir A. Rahim et al.   Frontiers in Immunology

Adaptations of Natural Killer Cells to Self-MHC Class I

(2014) Stéphanie Bessoles et al.   Frontiers in Immunology

The Critical Role of IL-15–PI3K–mTOR Pathway in Natural Killer Cell Effector Functions

(2014) Neethi Nandagopal et al.   Frontiers in Immunology

Controlling Natural Killer Cell Responses: Integration of Signals for Activation and Inhibition

(2013) Eric O. Long et al.   Annual Review of Immunology

Characterization of a novel NKG2D and NKp46 double-mutant mouse reveals subtle variations in the NK cell repertoire

(2013) S. Sheppard et al.   BLOOD

Influence of KIR gene copy number on natural killer cell education

(2013) V. Beziat et al.   BLOOD

Cisassociation of leukocyte Ig-like receptor 1 with MHC class I modulates accessibility to antibodies and HCMV UL18

(2013) Nicholas L. Li et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

HLA Reduces Killer Cell Ig-like Receptor Expression Level and Frequency in a Humanized Mouse Model

(2013) J. van Bergen et al.   JOURNAL OF IMMUNOLOGY

Education of Murine NK Cells Requires Both cis and trans Recognition of MHC Class I Molecules

(2013) S. Bessoles et al.   JOURNAL OF IMMUNOLOGY

NKG2D Triggers Cytotoxicity in Murine Epidermal γδ T Cells via PI3K-Dependent, Syk/ZAP70-Independent Signaling Pathway

(2013) Atsuko Ibusuki et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Natural killer cell licensing in mice with inducible expression of MHC class I

(2013) T. Ebihara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural Killer Cell Inhibitory Receptor Expression in Humans and Mice: A Closer Look

(2013) Michal Sternberg-Simon et al.   Frontiers in Immunology

Epigenetic regulation of NK cell differentiation and effector functions

(2013) Frank Cichocki et al.   Frontiers in Immunology

The Ly49 Gene Family. A Brief Guide to the Nomenclature, Genetics, and Role in Intracellular Infection

(2013) Alan Rowe Schenkel et al.   Frontiers in Immunology

The Transcription Factors T-bet and Eomes Control Key Checkpoints of Natural Killer Cell Maturation

(2012) Scott M. Gordon et al.   IMMUNITY

Models and methods for analysis of lymphocyte repertoire generation, development, selection and evolution

(2012) Ramit Mehr et al.   IMMUNOLOGY LETTERS

Neutrophil depletion impairs natural killer cell maturation, function, and homeostasis

(2012) Baptiste N. Jaeger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Skewing of the NK Cell Repertoire by MHC Class I via Quantitatively Controlled Enrichment and Contraction of Specific Ly49 Subsets

(2012) P. Brodin et al.   JOURNAL OF IMMUNOLOGY

A Modified FCCS Procedure Applied to Ly49A-MHC Class I cis-Interaction Studies in Cell Membranes

(2011) Johan Strömqvist et al.   BIOPHYSICAL JOURNAL

Identification of the earliest natural killer cell-committed progenitor in murine bone marrow

(2011) J. W. Fathman et al.   BLOOD

Different NK Cell Developmental Events Require Different Levels of IL-15 Trans-Presentation

(2011) G. A. Lee et al.   JOURNAL OF IMMUNOLOGY

Mature natural killer cells reset their responsiveness when exposed to an altered MHC environment

(2010) Nathalie T. Joncker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MHC class I–deficient natural killer cells acquire a licensed phenotype after transfer into an MHC class I–sufficient environment

(2010) Julie M. Elliott et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effect of Ly49 Haplotype Variance on NK Cell Function and Education

(2010) R. Patel et al.   JOURNAL OF IMMUNOLOGY

Effects of MHC Class I Alleles on Licensing of Ly49A+ NK Cells

(2010) A. H. Jonsson et al.   JOURNAL OF IMMUNOLOGY

Natural Killer Cell Tolerance Persists Despite Significant Reduction of Self MHC Class I on Normal Target Cells in Mice

(2010) Petter Brodin et al.   PLoS One

KIR acquisition probabilities are independent of self-HLA class I ligands and increase with cellular KIR expression

(2009) S. Andersson et al.   BLOOD

A Role for cis Interaction between the Inhibitory Ly49A Receptor and MHC Class I for Natural Killer Cell Education

(2009) Anick Chalifour et al.   IMMUNITY

PI3K Links NKG2D Signaling to a CrkL Pathway Involved in Natural Killer Cell Adhesion, Polarity, and Granule Secretion

(2009) C. M. Segovis et al.   JOURNAL OF IMMUNOLOGY

NK Cell Responsiveness Is Tuned Commensurate with the Number of Inhibitory Receptors for Self-MHC Class I: The Rheostat Model

(2009) N. T. Joncker et al.   JOURNAL OF IMMUNOLOGY

Dendritic Cells Support the In Vivo Development and Maintenance of NK Cells via IL-15 Trans-Presentation

(2009) E. F. Castillo et al.   JOURNAL OF IMMUNOLOGY

Evidence for high bi-allelic expression of activating Ly49 receptors

(2009) Arefeh Rouhi et al.   NUCLEIC ACIDS RESEARCH

NK cell education: not an on-off switch but a tunable rheostat

(2009) Petter Brodin et al.   TRENDS IN IMMUNOLOGY

The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells

(2008) P. Brodin et al.   BLOOD

MHC class I-specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response

(2008) M. Yawata et al.   BLOOD

Negative signaling by inhibitory receptors: the NK cell paradigm

(2008) Eric O. Long   IMMUNOLOGICAL REVIEWS

Tolerance of NK cells encountering their viral ligand during development

(2008) Joseph C. Sun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Continuous engagement of a self-specific activation receptor induces NK cell tolerance

(2008) Sandeep K. Tripathy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Natural killer cell recognition of missing self

(2008) Klas Kärre   NATURE IMMUNOLOGY

NK gene complex dynamics and selection for NK cell receptors

(2008) Michael G. Brown et al.   SEMINARS IN IMMUNOLOGY

The genetic and evolutionary balances in human NK cell receptor diversity

(2008) Peter Parham   SEMINARS IN IMMUNOLOGY