Article
Immunology
Stina L. Wickstrom, Arnika K. Wagner, Sina Fuchs, Marjet Elemans, Joanna Kritikou, Ramit Mehr, Klas Karre, H. Johansson, Hanna Brauner
Summary: The expression of MHC class I in the host influences NK cells, resulting in education and a repertoire of inhibitory MHC I-specific receptors. This repertoire skewing can be observed in the bone marrow during the early developmental stages of NK cells, suggesting that it is established during development.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Marc Potempa, Oscar A. Aguilar, Maria D. R. Gonzalez-Hinojosa, Iliana Tenvooren, Diana M. Marquez, Matthew H. Spitzer, Lewis L. Lanier
Summary: The interaction between inhibitory Ly49 receptors and their self-MHC class I ligands have been found to limit NK cell proliferation during mouse CMV infection. Pre-existing NK cells with phenotypes indicative of Ag encounter or memory-like status were found in uninfected mice. The significant differences between licensed and unlicensed NK cells disappeared during CMV infection, and only a difference in CD16 expression was observed in memory NK cell populations.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Yanan Wu, Nianzhi Zhang, Keiichiro Hashimoto, Chun Xia, Johannes M. Dijkstra
Summary: The structures of peptide-loaded major histocompatibility complex class I (pMHC-I) and class II (pMHC-II) complexes are similar, but there are differences in the components. Comparative analysis of primitive vertebrate species' pMHC-I and pMHC-II structures sheds light on the evolution of MHC structures. The establishment of pMHC-I involved the development of important new functions that have been well conserved since their early inception.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Debopam Ghosh, Tho D. Pham, Padma P. Nanaware, Deepanwita Sengupta, Lital N. Adler, Caiyun G. Li, Xiao He, Mary E. O'Mara, Aaron B. Kantor, Khoa D. Nguyen, Yang Yang, Laurence C. Eisenlohr, Peter E. Jensen, Leonore A. Herzenberg, Lawrence J. Stern, Scott D. Boyd, Eliver E. B. Ghosn, Elizabeth D. Mellins
Summary: The absence of H2-M protein affects the survival and immunoglobulin selection of B-1 cells, and also alters the specificity of the B-1 cell clonal repertoire.
Article
Immunology
Qian-Nan Shang, Xing-Xing Yu, Zheng-Li Xu, Xun-Hong Cao, Xue-Fei Liu, Xiao-Su Zhao, Ying-Jun Chang, Yu Wang, Xiao-Hui Zhang, Lan-Ping Xu, Kai-Yan Liu, Xiao-Jun Huang, Xiang-Yu Zhao
Summary: This study finds that DNAM-1 expression correlates with the functional competence of human NK cells through the KIR/MHC-I interaction. NK cells with donor or recipient HLA molecules regulate DNAM-1 expression, thereby affecting NK cell education. The effects of recipient cells on NK cell education are greater, and activating receptors may collaborate with DNAM-1 to induce educated NK cell hyperresponsiveness.
JOURNAL OF IMMUNOLOGY
(2022)
Review
Immunology
Khadijeh Dizaji Asl, Kobra Velaei, Ali Rafat, Hamid Tayefi Nasrabadi, Ali Akbar Movassaghpour, Majid Mahdavi, Hojjatollah Nozad Charoudeh
Summary: NK cells play a crucial role in diseases through the interaction between KIR and MHC-I molecules. Researchers are focusing on understanding the molecular mechanisms of KIR-MHC-I interaction to enhance disease treatment strategies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Oncology
Lea Dubreuil, Patrice Chevallier, Christelle Retiere, Katia Gagne
Summary: Immunotherapies show promise in treating acute leukemias, with NK cells playing a crucial role in eliminating leukemic cells. Understanding the impact of genetic markers like KIR and HLA on NK cell subsets can improve patient outcomes. Investigating the immunogenetics of KIR/HLA and the immunobiology of NK cells may lead to improved treatments for leukemic patients undergoing HSCT.
Article
Virology
Alok K. Tembhurne, Amita Maheshwari, Himangi Warke, Hemangi Chaudhari, Shilpa C. Kerkar, Kedar Deodhar, Bharat Rekhi, Jayanti Mania-Pramanik
Summary: This study investigates the role of killer cell immunoglobulin-like receptors (KIRs) in cervical cancer among Indian women. The findings suggest that KIR2DS5, the C4T4 subset, and activating KIR genes are susceptible factors or positively associated with cervical cancer. Additionally, KIR2DL5B may have a protective association against cervical cancer, while KIR2DL1 and KIR2DL3 frequencies have important implications in healthy controls and HPV-infected women, respectively.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Biochemical Research Methods
Raphael Trevizani, Zhen Yan, Jason A. Greenbaum, Alessandro Sette, Morten Nielsen, Bjoern Peters
Summary: An approach to assess the reliability of different metrics for evaluating the performance of MHC class I binding predictors was developed. The study found that using percentile-ranked results improved the stability of the ranks and identified the top-performing tools in the benchmark.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Immunology
Tobias Held, Michael Basler, Klaus-Peter Knobeloch, Marcus Groettrup
Summary: ISG15, induced by type I IFNs, may enhance MHC-I restricted antigen presentation by promoting co-translational antigen processing, without directly inducing proteasomal degradation of ISG15 target proteins.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Review
Allergy
Nicholas R. Pollock, Genelle F. Harrison, Paul J. Norman
Summary: Interactions between killer cell immunoglobin-like receptors (KIR) and human leukocyte antigens (HLA) class I play crucial roles in regulating the effector functions of key cytotoxic cells in innate and adaptive immunity. The extreme diversity of this interaction is genetically determined and has evolved in response to the ever-changing environment of pathogen exposure. The independent segregation of KIR and HLA genes on separate chromosomes further contributes to the diversity. Specific combinations of inherited receptors and ligands may predispose individuals to certain immune-mediated diseases, including autoimmunity. The combinatorial diversity of KIR and HLA class I also affects the success rates of immunotherapy for these diseases. Detailed characterization of the extent and consequences of the combinatorial diversity is helping in understanding the etiopathology and predicting response to therapy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Nina Geng, Tuo Hu, Chunbo He
Summary: Immune checkpoint blockade therapies show durable responses in a subset of colorectal cancer patients, but the majority do not respond. Our study suggests that DDX60 may regulate MHC-I expression in colorectal cancer, and targeting DDX60 could potentially improve the efficacy of immunotherapy.
Review
Biochemistry & Molecular Biology
Akhil Shukla, Maryse Cloutier, Madanraj Appiya Santharam, Sheela Ramanathan, Subburaj Ilangumaran
Summary: The immune system constantly monitors and eliminates cancerous cells, with CD8(+) cytotoxic T lymphocytes playing a key role in tumor cell killing. Cancer cells evade immune surveillance by downregulating MHC-I and key proteins of the antigen processing and presentation machinery. NLRC5 has been identified as the key transcriptional activator of MHC-I and APM genes, and genetic lesions and epigenetic modifications of NLRC5 are common causes of MHC-I defects in cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jeff D. Colbert, Freidrich M. Cruz, Christina E. Baer, Kenneth L. Rock
Summary: This study reveals a molecular association between Tspan5 and MHC I molecules that is critical for the formation of MHC I nanoclusters and optimal T cell responses to antigens.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Florence Bettens, Zuleika Calderin Sollet, Stephane Buhler, Jean Villard
Summary: Direct allorecognition in transplantation involves a complex interplay between T-cell receptors and HLA molecules. The repertoire of alloreactive cytotoxic T-cells is influenced by HLA disparities and inflammatory status. Predicting alloreactive T-cell repertoires remains a major challenge in HLA mismatched HSCT.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pediatrics
Robin Kahn, Stefan Berg, Lillemor Berntson, Elisabet Berthold, Petter Brodin, Fredrik Backstrom, Michele Compagno, Anders Fasth, Jenny Lingman Framme, AnnaCarin Horne, Josefin Hattting, Petra Krol, Antti J. Kukka, Maria Mossberg, Bengt Mansson, Charlotta Nordenhall, Selma Idring Nordstrom, Fatine Khammari Nystrom, Karin Palmblad, Reza Rasti, Andre Rudolph, Karin Rydenman, Erik Sundberg, Eva Save-Soderbergh, Maria Altman
Summary: The aim of this study was to describe the outcomes of multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19. Findings showed that over a third of patients continued to experience symptoms 8 weeks after MIS-C diagnosis, with 5% having abnormal echocardiograms. Older age and higher levels of initial care were identified as potential risk factors for persistent symptoms and abnormal cardiac results. Structured follow-up visits were deemed important after MIS-C.
Review
Immunology
Petter Brodin
Summary: SARS-CoV-2 infections in children usually result in mild or asymptomatic infections, and the reasons behind this are not fully understood. Possible explanations include more efficient local tissue responses, better thymic function, and crossreactive immunity. Post-infectious hyperinflammatory syndromes are rare in children and young people, but very rarely seen in adults. This article offers an additional explanation to mild infections, viral dynamics, and the higher incidence of rare multisystem inflammatory syndromes in children and young people from a life history and energy allocation perspective.
Letter
Biochemistry & Molecular Biology
Petter Brodin, Giorgio Casari, Liam Townsend, Cliona O'Farrelly, Ivan Tancevski, Judith Loeffler-Ragg, Trine H. Mogensen, Jean Laurent Casanova
Review
Multidisciplinary Sciences
Petter Brodin
Summary: Research on newborn immunity has shown that cell ontogeny, feto-maternal tolerance, and maternal antibody transfer are important. The role of postnatal adaptation to environmental exposures is less understood. The mutualism between the immune system and gut microbes is likely a major factor in the increasing incidence of immune-mediated disorders.
Letter
Gastroenterology & Hepatology
Petter Brodin, Moshe Arditi
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Immunology
Tessa Mollie Campbell, Zhiyong Liu, Qian Zhang, Marcela Moncada-Velez, Laura E. Covill, Peng Zhang, Ilad Alavi Darazam, Paul Bastard, Lucy Bizien, Giorgia Bucciol, Sara Lind Enoksson, Emmanuelle Jouanguy, Semsi Nur Karabela, Taushif Khan, Yasemin Kendir-Demirkol, Andres Augusto Arias, Davood Mansouri, Per Marits, Nico Marr, Isabelle Migeotte, Leen Moens, Tayfun Ozcelik, Isabelle Pellier, Anton Sendel, Sevtap Senoglu, Mohammad Shahrooei, C. I. Edvard Smith, Isabelle Vandernoot, Karen Willekens, Kadriye Kart Yasar, Peter Bergman, Laurent Abel, Aurelie Cobat, Jean-Laurent Casanova, Isabelle Meyts, Yenan T. Bryceson
Summary: IRF7-deficient individuals are prone to viral infections of the respiratory tract but are otherwise healthy, potentially due to residual IFN-beta and compensatory adaptive immunity.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Qian Zhang, Daniela Matuozzo, Jeremie Le Pen, Danyel Lee, Leen Moens, Takaki Asano, Jonathan Bohlen, Zhiyong Liu, Marcela Moncada-Velez, Yasemin Kendir-Demirkol, Huie Jing, Lucy Bizien, Astrid Marchal, Hassan Abolhassani, Selket Delafontaine, Giorgia Bucciol, Gulsum Ical Bayhan, Sevgi Keles, Ayca Kiykim, Selda Hancerli, Filomeen Haerynck, Benoit Florkin, Nevin Hatipoglu, Tayfun Ozcelik, Guillaume Morelle, Mayana Zatz, Lisa F. P. Ng, David Chien Lye, Barnaby Edward Young, Yee-Sin Leo, Clifton L. Dalgard, Richard P. Lifton, Laurent Renia, Isabelle Meyts, Emmanuelle Jouanguy, Lennart Hammarstrom, Qiang Pan-Hammarstrom, Bertrand Boisson, Paul Bastard, Helen C. Su, Stephanie Boisson-Dupuis, Laurent Abel, Charles M. Rice, Shen-Ying Zhang, Aurelie Cobat, Jean-Laurent Casanova
Summary: In an international cohort of 112 hospitalized children with COVID-19 pneumonia, 12 children with recessive inborn errors of type I interferon immunity were identified. These deficiencies may contribute to the development of COVID-19 pneumonia in children. Additionally, these deficiencies were not found in individuals without pneumonia from SARS-CoV-2 infection.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Emilie W. Borgstrom, Marie Edvinsson, Lucia P. Perez, Anna C. Norlin, Sara L. Enoksson, Susanne Hansen, Anders Fasth, Vanda Friman, Olle Kampe, Robert Mansson, Hernando Y. Estupinan, Qing Wang, Tan Ziyang, Tadepally Lakshmikanth, Carl Inge E. Smith, Petter Brodin, Peter Bergman
Summary: This study investigated the clinical effects and biomarker alterations in three patients with chronic mucocutaneous candidiasis (CMC) caused by gain-of-function mutations in the STAT1 gene during treatment with Janus kinase (JAK) inhibitors. The results showed that JAK inhibitors improved clinical symptoms of CMC, but also caused side effects. The treatment had a sustained effect on the populations of neutrophils, T cells, B cells, and NK cells. Additionally, the treatment enhanced cellular reactivity against Candida albicans and altered plasma biomarkers.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Sepideh Dolatshahi, Audrey L. Butler, Christian Pou, Ewa Henckel, Anna Karin Bernhardsson, Anna Gustafsson, Kajsa Bohlin, Sally A. Shin, Douglas A. Lauffenburger, Petter Brodin, Galit Alter
Summary: Preterm newborns are more susceptible to infectious diseases at birth compared to full-term infants. The study found that the functional quality of antibodies in preterm and full-term infants is similar, despite quantitative differences. Placental transfer mechanisms are influenced by gestational age, ensuring that children receive robust humoral immunity even if born preterm.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Medicine, General & Internal
Danilo Buonsenso, Damian Roland, Adriana Yock-Corrales, Sebastian Gonzalez-Dambrauskas, Petter Brodin, Begona Santiago-Garcia, Antoni Soriano-Arandes, Marianne Koenraads, Daniele De Luca, Elizabeth Whittaker
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Editorial Material
Multidisciplinary Sciences
Petter Brodin
Article
Rheumatology
Samuel Channon-Wells, Ortensia Vito, Andrew J. McArdle, Eleanor G. Seaby, Harsita Patel, Priyen Shah, Ekaterina Pazukhina, Clare Wilson, Claire Broderick, Giselle D'Souza, Ilana Keren, Ruud G. Nijman, Adriana Tremoulet, Daniel Munblit, Rolando Ulloa-Gutierrez, Michael J. Carter, Padmanabhan Ramnarayan, Tisham De, Clive Hoggart, Elizabeth Whittaker, Jethro A. Herberg, Myrsini Kaforou, Aubrey J. Cunnington, Oleg Blyuss, Michael Levin
Summary: This study evaluated immunomodulatory treatments for multisystem inflammatory syndrome in children (MIS-C) and found that glucocorticoids or glucocorticoids plus intravenous immunoglobulin were not significantly different from intravenous immunoglobulin alone in terms of clinical efficacy. Initial treatment with glucocorticoids may be a safe alternative to immunoglobulin or combined therapy.
LANCET RHEUMATOLOGY
(2023)
Review
Immunology
Rikard Forlin, Anna James, Petter Brodin
Summary: The human immune system consists of specialized cell populations with unique functions that collectively respond to infections and immune-mediated diseases. However, there is variation in cell composition, plasma proteins, and functional responses among individuals. By using novel experimental and computational tools, it is possible to interpret the composition and function of the human immune system. Systems-level analyses offer an opportunity to improve diagnostic and curative precision for infectious and immune-associated diseases.
TRENDS IN IMMUNOLOGY
(2023)
Article
Hematology
Alvaro Haroun-Izquierdo, Pilar M. Lanuza, Aline Pfefferle, Herman Netskar, Eivind H. Ask, Johan Torlen, Andreas Bjorklund, Ebba Sohlberg, Karl -Johan Malmberg
Summary: Sirolimus, an inhibitor of mTOR, shows potential as a component of GVHD prophylaxis regimens in HSCT, but detailed immunologic studies are lacking. This study evaluated the effect of sirolimus on immune reconstitution using longitudinal patient samples. Sirolimus inhibited naive cell suppression and NK cell reconstitution, leading to impaired proliferation and functional responses.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Review
Gastroenterology & Hepatology
Omry Koren, Liza Konnikova, Petter Brodin, Indira U. Mysorekar, Maria Carmen Collado
Summary: The gut microbiome plays a crucial role in host metabolism and immunity, and its dysbiosis can have detrimental effects on human health. This review focuses on the interactions between the gut microbiome and the immune system during pregnancy and their impact on offspring development. Current knowledge is limited, highlighting the need for further research in this area.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
