Genetics, genomics, and evolutionary biology of NKG2D ligands

A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection

(2015) W. Deng et al.   SCIENCE

Dynamic Co-evolution of Host and Pathogen: HCMV Downregulates the Prevalent Allele MICA∗008 to Escape Elimination by NK Cells

(2015) Einat Seidel et al.   Cell Reports

NKG2D Ligands in Tumor Immunity: Two Sides of a Coin

(2015) Jinyu Zhang et al.   Frontiers in Immunology

Effect of NKG2D ligand expression on host immune responses

(2015) Marine Champsaur et al.   IMMUNOLOGICAL REVIEWS

MIC gene polymorphism and haplotype diversity in Zhuang nationality of Southern China

(2014) E. Chen et al.   HUMAN IMMUNOLOGY

High diversity of MIC genes in non-human primates

(2014) Alice Meyer et al.   IMMUNOGENETICS

Human Tumor-Derived Exosomes Down-Modulate NKG2D Expression

(2014) A. Clayton et al.   JOURNAL OF IMMUNOLOGY

Two Novel NKG2D Ligands of the Mouse H60 Family with Differential Expression Patterns and Binding Affinities to NKG2D

(2014) A. Takada et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Down-Regulation of MHC Class I-Related Chain A on Tumor Cells by IFN- -Induced MicroRNA

(2014) D. Yadav et al.   JOURNAL OF IMMUNOLOGY

NKG2D-RAE-1 Receptor-Ligand Variation Does Not Account for the NK Cell Defect in Nonobese Diabetic Mice

(2014) L. M. Maier et al.   JOURNAL OF IMMUNOLOGY

Immunological Visibility: Posttranscriptional Regulation of Human NKG2D Ligands by the EGF Receptor Pathway

(2014) P. Vantourout et al.   Science Translational Medicine

MIC gene polymorphism and haplotype diversity in Li nationality of Southern China

(2014) L. Lin et al.   TISSUE ANTIGENS

Two Novel Human Cytomegalovirus NK Cell Evasion Functions Target MICA for Lysosomal Degradation

(2014) Ceri A. Fielding et al.   PLoS Pathogens

Identification of Multiple Genetic Susceptibility Loci in Takayasu Arteritis

(2013) Güher Saruhan-Direskeneli et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Regulation of Ligands for the NKG2D Activating Receptor

(2013) David H. Raulet et al.   Annual Review of Immunology

A GPI anchor explains the unique biological features of the common NKG2D-ligand allele MICA*008

(2013) Omodele Ashiru et al.   BIOCHEMICAL JOURNAL

Soluble ligands for the NKG2D receptor are released during HIV-1 infection and impair NKG2D expression and cytotoxicity of NK cells

(2013) Giulia Matusali et al.   FASEB JOURNAL

The distribution of MICA alleles in an Austrian population: Evidence for increasing polymorphism

(2013) Sabine Wenda et al.   HUMAN IMMUNOLOGY

RAET1/ULBP alleles and haplotypes among Kolla South American Indians

(2013) Steven T. Cox et al.   HUMAN IMMUNOLOGY

Distribution of MICB diversity in the Zhejiang Han population: PCR sequence-based typing for exons 2–6 and identification of five novel MICB alleles

(2013) Yanling Ying et al.   IMMUNOGENETICS

Shedding of endogenous MHC class I-related chain molecules A and B from different human tumor entities: Heterogeneous involvement of the “a disintegrin and metalloproteases” 10 and 17

(2013) Guranda Chitadze et al.   INTERNATIONAL JOURNAL OF CANCER

Allelic MHC class I chain related B (MICB) molecules affect the binding to the human cytomegalovirus (HCMV) unique long 16 (UL16) protein: Implications for immune surveillance

(2013) Kanya Klumkrathok et al.   JOURNAL OF MICROBIOLOGY

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

(2013) Christopher J Lessard et al.   NATURE GENETICS

Identification of multiple independent susceptibility loci in the HLA region in Behçet's disease

(2013) Travis Hughes et al.   NATURE GENETICS

Generation of Soluble NKG2D Ligands: Proteolytic Cleavage, Exosome Secretion and Functional Implications

(2013) G. Chitadze et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

The functional MICA-129 polymorphism is associated with skin but not joint manifestations of psoriatic disease independently of HLA-B and HLA-C

(2013) R. A. Pollock et al.   TISSUE ANTIGENS

Unraveling Multiple MHC Gene Associations with Systemic Lupus Erythematosus: Model Choice Indicates a Role for HLA Alleles and Non-HLA Genes in Europeans

(2012) David L. Morris et al.   AMERICAN JOURNAL OF HUMAN GENETICS

NKG2D ligand tumor expression and association with clinical outcome in early breast cancer patients: an observational study

(2012) Esther M de Kruijf et al.   BMC CANCER

MiR-10b Downregulates the Stress-Induced Cell Surface Molecule MICB, a Critical Ligand for Cancer Cell Recognition by Natural Killer Cells

(2012) P. Tsukerman et al.   CANCER RESEARCH

Diagnostic and prognostic impact of serum-soluble UL16-binding protein 2 in lung cancer patients

(2012) Kosuke Yamaguchi et al.   CANCER SCIENCE

Prevalence of the NKG2D Thr72Ala Polymorphism in Patients with Cervical Carcinoma

(2012) Andrzej Roszak et al.   Genetic Testing and Molecular Biomarkers

MICB polymorphism in a southern Chinese Han population: The identification of two new MICB alleles, MICB∗005:06 and MICB∗026

(2012) XueXiang Liu et al.   HUMAN IMMUNOLOGY

Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis

(2012) Jo Knight et al.   HUMAN MOLECULAR GENETICS

Immunogenetics of the NKG2D ligand gene family

(2012) Masanori Kasahara et al.   IMMUNOGENETICS

Follow-Up Study of the First Genome-Wide Association Scan in Alopecia Areata: IL13 and KIAA0350 as Susceptibility Loci Supported with Genome-Wide Significance

(2012) Dagny Jagielska et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Crystal Structure of the Cowpox Virus-Encoded NKG2D Ligand OMCP

(2012) E. Lazear et al.   JOURNAL OF VIROLOGY

Structural basis of mouse cytomegalovirus m152/gp40 interaction with RAE1  reveals a paradigm for MHC/MHC interaction in immune evasion

(2012) R. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel allele: MICA*064N with a stop codon in exon 4

(2012) S. Zhang et al.   TISSUE ANTIGENS

Prognostic value of soluble MICA levels in the serum of patients with advanced hepatocellular carcinoma

(2012) Jian-Jun Li et al.   Chinese Journal of Cancer

Characterization of MICA gene polymorphism of HLA complex in the Slovak population

(2011) V. Ďurmanová et al.   ANNALS OF HUMAN BIOLOGY

Cancer Immunotherapy Using a Bispecific NK Receptor Fusion Protein that Engages both T Cells and Tumor Cells

(2011) T. Zhang et al.   CANCER RESEARCH

Human NK Cells Are Alerted to Induction of p53 in Cancer Cells by Upregulation of the NKG2D Ligands ULBP1 and ULBP2

(2011) S. Textor et al.   CANCER RESEARCH

Tumor Suppressive MicroRNAs miR-34a/c Control Cancer Cell Expression of ULBP2, a Stress-Induced Ligand of the Natural Killer Cell Receptor NKG2D

(2011) A. Heinemann et al.   CANCER RESEARCH

MMP9 mediates MICA shedding in human osteosarcomas

(2011) Dahui Sun et al.   CELL BIOLOGY INTERNATIONAL

Exosomes and Cancer: A Newly Described Pathway of Immune Suppression

(2011) H.-G. Zhang et al.   CLINICAL CANCER RESEARCH

MICA genetic polymorphism and HLA-A,C,B,MICA and DRB1 haplotypic variation in a southern Chinese Han population: Identification of two new MICA alleles, MICA*060 and MICA*062

(2011) Wei Tian et al.   HUMAN IMMUNOLOGY

Characterization of the major histocompatibility complex class I chain-related gene B (MICB) polymorphism in a northern Chinese Han population: The identification of a new MICB allele, MICB*023

(2011) XueXiang Liu et al.   HUMAN IMMUNOLOGY

Major histocompatibility complex class I–related chain A allele mismatching, antibodies, and rejection in renal transplantation

(2011) Steven T. Cox et al.   HUMAN IMMUNOLOGY

ULBP4/RAET1E is highly polymorphic in the Old World monkey

(2011) Taeko K. Naruse et al.   IMMUNOGENETICS

Reduced NKG2D ligand expression in hepatocellular carcinoma correlates with early recurrence

(2011) Hiroteru Kamimura et al.   JOURNAL OF HEPATOLOGY

Prevalence of the NKG2D Thr72Ala polymorphism in patients with systemic lupus erythematosus

(2011) Piotr Piotrowski et al.   MOLECULAR BIOLOGY REPORTS

Thermal- and Oxidative Stress Causes Enhanced Release of NKG2D Ligand-Bearing Immunosuppressive Exosomes in Leukemia/Lymphoma T and B Cells

(2011) Malin Hedlund et al.   PLoS One

Innate or Adaptive Immunity? The Example of Natural Killer Cells

(2011) E. Vivier et al.   SCIENCE

An NKG2D-Mediated Human Lymphoid Stress Surveillance Response with High Interindividual Variation

(2011) S. Shafi et al.   Science Translational Medicine

Identification of a novel allele, MICA*063N, in a Chinese lung cancer patient

(2011) Y. Huang et al.   TISSUE ANTIGENS

MICB polymorphisms and haplotypes with MICA and HLA alleles in Koreans

(2011) C.-H. Cha et al.   TISSUE ANTIGENS

Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus

(2010) Robert M. Clancy et al.   ARTHRITIS AND RHEUMATISM

Natural Killer Cell Cytotoxicity Is Suppressed by Exposure to the Human NKG2D Ligand MICA*008 That Is Shed by Tumor Cells in Exosomes

(2010) O. Ashiru et al.   CANCER RESEARCH

Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations

(2010) Ayman Antoun et al.   HUMAN IMMUNOLOGY

Development of antibodies to human leukocyte antigen precedes development of antibodies to major histocompatibility class I–related chain A and are significantly associated with development of chronic rejection after human lung transplantation

(2010) Nataraju Angaswamy et al.   HUMAN IMMUNOLOGY

MICA polymorphism in a northern Chinese Han population: The identification of a new MICA allele, MICA*059

(2010) Wei Tian et al.   HUMAN IMMUNOLOGY

Comparative genomic analysis of mammalian NKG2D ligand family genes provides insights into their origin and evolution

(2010) Mizuho Kondo et al.   IMMUNOGENETICS

ULBP2 and RAET1E NKG2D ligands are independent predictors of poor prognosis in ovarian cancer patients

(2010) Roger W. McGilvray et al.   INTERNATIONAL JOURNAL OF CANCER

Cutting Edge: The Membrane Type Matrix Metalloproteinase MMP14 Mediates Constitutive Shedding of MHC Class I Chain-Related Molecule A Independent of A Disintegrin and Metalloproteinases

(2010) G. Liu et al.   JOURNAL OF IMMUNOLOGY

The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia

(2010) H Nückel et al.   LEUKEMIA

Clinical significance of the immunostimulatory MHC class I chain-related molecule A and NKG2D receptor on NK cells in pancreatic cancer

(2010) Xiaohui Duan et al.   MEDICAL ONCOLOGY

Studies of the H60a locus in C57BL/6 and 129/Sv mouse strains identify the H60a 3′UTR as a regulator of H60a expression

(2010) Hui Zhang et al.   MOLECULAR IMMUNOLOGY

Systematic mutation and thermodynamic analysis of central tyrosine pairs in polyspecific NKG2D receptor interactions

(2010) David J. Culpepper et al.   MOLECULAR IMMUNOLOGY

Genome-wide association study in alopecia areata implicates both innate and adaptive immunity

(2010) Lynn Petukhova et al.   NATURE

An influence of HLA-A, B, DR, DQ, and MICA on the occurrence of Celiac disease in patients with type 1 diabetes

(2010) N. Bratanic et al.   TISSUE ANTIGENS

MICA Gene Polymorphism in Kidney Allografts and Possible Impact of Functionally Relevant Variants

(2010) P. Tonnerre et al.   TRANSPLANTATION PROCEEDINGS

MHC class I chain-related protein A shedding in chronic HIV-1 infection is associated with profound NK cell dysfunction

(2010) Anne Nolting et al.   VIROLOGY

Structure of the HCMV UL16-MICB Complex Elucidates Select Binding of a Viral Immunoevasin to Diverse NKG2D Ligands

(2010) Steffen Müller et al.   PLoS Pathogens

Donor-recipient mismatches in MHC class I chain-related gene A in unrelated donor transplantation lead to increased incidence of acute graft-versus-host disease

(2009) S. Parmar et al.   BLOOD

Diverse Herpesvirus MicroRNAs Target the Stress-Induced Immune Ligand MICB to Escape Recognition by Natural Killer Cells

(2009) Daphna Nachmani et al.   Cell Host & Microbe

Differential Clinical Significance of Individual NKG2D Ligands in Melanoma: Soluble ULBP2 as an Indicator of Poor Prognosis Superior to S100B

(2009) A. Paschen et al.   CLINICAL CANCER RESEARCH

NKG2D Ligand Expression in Human Colorectal Cancer Reveals Associations with Prognosis and Evidence for Immunoediting

(2009) R. W. McGilvray et al.   CLINICAL CANCER RESEARCH

ULBP6/RAET1L is an additional human NKG2D ligand

(2009) Robert A. Eagle et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NKG2D gene polymorphism has a significant impact on transplant outcomes after HLA-fully-matched unrelated bone marrow transplantation for standard risk hematologic malignancies

(2009) J. L. Espinoza et al.   HAEMATOLOGICA

Sorafenib inhibits the shedding of major histocompatibility complex class I-related chain A on hepatocellular carcinoma cells by down-regulating a disintegrin and metalloproteinase 9

(2009) Keisuke Kohga et al.   HEPATOLOGY

Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in Northeastern Thais

(2009) Amornrat V. Romphruk et al.   IMMUNOGENETICS

Normally occurring NKG2D+CD4+T cells are immunosuppressive and inversely correlated with disease activity in juvenile-onset lupus

(2009) Zhenpeng Dai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anti-MICA Antibodies Are Related to Adverse Outcome in Heart Transplant Recipients

(2009) Teresa Kauke et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Costimulation of Dendritic Epidermal    T Cells by a New NKG2D Ligand Expressed Specifically in the Skin

(2009) M. I. Whang et al.   JOURNAL OF IMMUNOLOGY

NKG2D Ligand MICA Is Retained in the cis-Golgi Apparatus by Human Cytomegalovirus Protein UL142

(2009) O. Ashiru et al.   JOURNAL OF VIROLOGY

Differential Susceptibility of RAE-1 Isoforms to Mouse Cytomegalovirus

(2009) J. Arapovic et al.   JOURNAL OF VIROLOGY

HDAC3 represses the expression of NKG2D ligands ULBPs in epithelial tumour cells: potential implications for the immunosurveillance of cancer

(2009) A López-Soto et al.   ONCOGENE

Cellular Expression, Trafficking, and Function of Two Isoforms of Human ULBP5/RAET1G

(2009) Robert A. Eagle et al.   PLoS One

Distribution ofMICAdiversity in the Chinese Han population by polymerase chain reaction sequence-based typing for exons 2-6

(2009) F. Zhu et al.   TISSUE ANTIGENS

Induction of NKG2D Ligands by Gamma Radiation and Tumor Necrosis Factor-α May Participate in the Tissue Damage During Acute Graft-Versus-Host Disease

(2009) Monique Gannagé et al.   TRANSPLANTATION

Association of MICA with rheumatoid arthritis independent of known HLA-DRB1 risk alleles in a family-based and a case control study

(2009) Holger Kirsten et al.   ARTHRITIS RESEARCH & THERAPY

Multiple Loci within the Major Histocompatibility Complex Confer Risk of Psoriasis

(2009) Bing-Jian Feng et al.   PLoS Genetics

High-Density SNP Screening of the Major Histocompatibility Complex in Systemic Lupus Erythematosus Demonstrates Strong Evidence for Independent Susceptibility Regions

(2009) Lisa F. Barcellos et al.   PLoS Genetics

Clinical significance of the NKG2D ligands, MICA/B and ULBP2 in ovarian cancer: high expression of ULBP2 is an indicator of poor prognosis

(2008) Kui Li et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Tumor-Associated MICA Is Shed by ADAM Proteases

(2008) I. Waldhauer et al.   CANCER RESEARCH

High frequencies of alleles MICA*020 and MICA*027 in Amerindians and evidence of positive selection on exon 3

(2008) L A Oliveira et al.   GENES AND IMMUNITY

Allelic diversity of MICA gene and MICA/HLA-B haplotypic variation in a population of the Murcia region in southeastern Spain

(2008) Daniel Lucas et al.   HUMAN IMMUNOLOGY

NKG2D-Deficient Mice Are Defective in Tumor Surveillance in Models of Spontaneous Malignancy

(2008) Nadia Guerra et al.   IMMUNITY

Murine NKG2D ligands: “Double, double toil and trouble”

(2008) Asanga Samarakoon et al.   MOLECULAR IMMUNOLOGY

Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D

(2008) Noam Stern-Ginossar et al.   NATURE IMMUNOLOGY

Up on the tightrope: natural killer cell activation and inhibition

(2008) Lewis L Lanier   NATURE IMMUNOLOGY

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY

NKG2D ligands in tumor immunity

(2008) N Nausch et al.   ONCOGENE

Genetic influence of the nonclassical major histocompatibility complex class I molecule MICB in multiple sclerosis susceptibility

(2008) J. L. Fernandez-Morera et al.   TISSUE ANTIGENS

Major histocompatibility complex class I chain-related gene A polymorphism and linkage disequilibrium with HLA-B alleles in Euro-Brazilians

(2008) F. Ribas et al.   TISSUE ANTIGENS

NKG2D ligands: key targets of the immune response

(2008) Segundo González et al.   TRENDS IN IMMUNOLOGY

On the utility of screening for anti-MICA antibodies before kidney transplantation

(2008) Jean-Paul Soulillou   Nature clinical practice. Nephrology