☆ 4.8 Article

Near-Surface Oxidized Sulfur Modifications and Self-Assembly of Thiol-Modified Aptamer on Au Thin Film Substrates Influenced by Piranha Treatment

ACS APPLIED MATERIALS & INTERFACES (2012)

Journal

ACS APPLIED MATERIALS & INTERFACES

Volume 4, Issue 11, Pages 5945-5948

Publisher

AMER CHEMICAL SOC

DOI: 10.1021/am301589k

Keywords

Au thin films; piranha treatment; thrombin binding aptamer; self-assembly; oxidized sulfur modifications

Categories

Nanoscience & Nanotechnology Materials Science, Multidisciplinary

Funding

Natural Sciences and Engineering Research Council of Canada

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Abstract

Self-assembly of thiol-modified oligonucleotides on Au films has great importance for biosensor applications. Prior to the self-assembly, a piranha treatment (PT) is commonly used to clean the Au surface. Here we report that near-surface oxidized sulfur modifications on Au thin films by PT for longer than 60 s have serious effects on the self-assembled monolayer (SAM) formation of thiol-modified single-stranded thrombin binding aptamer (s-TBA), and a PT time of 10-30 s is optimal for s-TBA SAM formation. These results have important implication to SAM formation of biomolecules, especially for the thiol-modified ones where a careful consideration of this key step could significantly enhance the SAM formation and biosensor performance.

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Materials Science, Multidisciplinary

Solid-state dewetting of thin Au films on oxidized surface of biomedical TiAlV alloy

Aliya Sharipova, Leonid Klinger, Anuj Bisht, Boris B. Straumal, Eugen Rabkin

Summary: Recent research investigates the initial stages of solid-state dewetting of thin nanocrystalline gold (Au) films on surfaces with natural roughness. The study finds that while a high number of dewetting holes are formed in the film at the early stages of dewetting at 300 degrees C, the nanoporous but continuous film morphology remains stable even after prolonged anneals at a higher temperature of 500 degrees C. Models considering Au diffusion along grain boundaries are developed to explain the film flattening. This work demonstrates the potential of solid-state dewetting for producing continuous nanoporous metal coatings on rough surfaces.

ACTA MATERIALIA (2022)

Add to Collection

Review Pharmacology & Pharmacy

G-quadruplex-based aptamers targeting human thrombin: Discovery, chemical modifications and antithrombotic effects

Claudia Riccardi, Ettore Napolitano, Chiara Platella, Domenica Musumeci, Daniela Montesarchio

Summary: Research on DNA aptamers targeting thrombin began in 1992, with TBA being the most well-characterized aptamer. However, unmodified aptamers exhibit limited pharmacokinetic properties, leading to the exploration of chemical modifications to improve their biological performance.

PHARMACOLOGY & THERAPEUTICS (2021)

Add to Collection

Article Materials Science, Multidisciplinary

Structural and optical modifications of CdS properties in CdS-Au thin films prepared by CBD

J. I. Contreras-Rascon, J. Diaz-Reyes, A. Flores-Pacheco, R. Lozada Morales, M. E. Alvarez-Ramos, J. A. Balderas-Lopez

Summary: This work investigates the modifications of the crystalline structure and properties of nanostructured cadmium sulphide (CdS) thin films by introducing gold quantum dots to form a hybrid metal-semiconductor system. Various characterization techniques such as XPS, XRD, and TEM were used to study the structural changes, showing a significant impact on properties in the CdS-Au samples, indicating a strong quantum confinement effect.

RESULTS IN PHYSICS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Structural and Binding Effects of Chemical Modifications on Thrombin Binding Aptamer (TBA)

Vibhav Valsangkar, Sweta Vangaveti, Goh Woon Lee, Walid M. Fahssi, Waqas S. Awan, Yicheng Huang, Alan A. Chen, Jia Sheng

Summary: Chemical modifications of the thrombin binding aptamer were studied for their effects on structure and thrombin binding affinity, with modifications found to maintain stability and binding patterns similar to the native form. Potential positions for modifications were identified without adverse effects, providing insights for the design and development of more functional TBA analogues.

MOLECULES (2021)

Add to Collection

Article Chemistry, Physical

Optical properties of Au-Hf thin films

Hugh Littlehailes, William R. Hendren, Robert M. Bowman, Fumin Huang

Summary: The optical properties of intermetallic Au3Hf thin films were experimentally investigated and found to exhibit significant plasmonic characteristics. Compared to similar alloys, Au3Hf films demonstrated more negative epsilon' values and lower epsilon'' values across most of the tested wavelengths. The study also identified key conditions for isolating the pure Au3Hf phase.

JOURNAL OF ALLOYS AND COMPOUNDS (2022)

Add to Collection

Article Polymer Science

Relaxation Phenomena in Chitosan-Au Nanoparticle Thin Films

Elodie Strupiechonski, Marisa Moreno-Rios, Erika O. Avila-Davila, Ramon Roman-Doval, Evgeny Prokhorov, Yuriy Kovalenko, Diana G. Zarate-Trivino, Dora Medina, Gabriel Luna-Barcenas

Summary: Chitosan-gold nanoparticle thin films were synthesized through chemical reduction of HAuCl4. The behavior of these films was investigated in relation to moisture and HAuCl4 content, revealing two relaxation processes related to glass transition and local diffusion of ions. The HAuCl4 content affected the conductivity of the films, demonstrating a percolation effect.

POLYMERS (2021)

Add to Collection

Article Engineering, Electrical & Electronic

Electron irradiation effects in Au thin films

Franciele S. M. de Oliveira, Mauricio J. Nogueira, Zacarias E. Fabrim, Paulo F. P. Fichtner

Summary: This study investigates the effects of 200 keV electron irradiation on the area retraction behavior of Au thin films at room temperature, revealing a strong dependence on the thermal diffusivity values. Results suggest that irradiation-induced atomic displacements follow the same thermodynamic driving forces as thermal processes. The work also introduces a new method to study surface atoms' behavior and promote microstructural modifications at low temperatures.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS (2021)

Add to Collection

Article Nanoscience & Nanotechnology

Nanoscratch-Directed Self-Assembly of Block Copolymer Thin Films

Dong Hyup Kim, Ahram Suh, Geonhyeong Park, Dong Ki Yoon, So Youn Kim

Summary: Nanoscratch-directed self-assembly (DSA) is introduced as a simple and scalable strategy to achieve highly aligned block copolymer (BCP) nanopatterns over a large area, allowing versatile nanofabrication for various functional nanomaterials.

ACS APPLIED MATERIALS & INTERFACES (2021)

Add to Collection

Article Chemistry, Analytical

Enzyme-free signal amplified Au nanoparticle fluorescence detection of thrombin via target-triggered catalytic hairpin assembly

Terefe Tafese Bezuneh, Tadesse Haile Fereja, Shimeles Addisu Kitte, Haijuan Li, Yongdong Jin

Summary: An enzyme-free target-triggered catalytic hairpin assembly (CHA) was proposed for signal amplified fluorescence thrombin detection, demonstrating a limit of detection (LOD) of 165 pM and linear range from 0.2 to 100 nM. The method could be potentially applied in complex biological matrices for sensitive detection of thrombin.

MICROCHEMICAL JOURNAL (2021)

Add to Collection

Article Materials Science, Multidisciplinary

Thermal stability of thin Au films deposited on salt whiskers

Ehud Almog, Vadim Derkach, Amit Sharma, Amy Novick-Cohen, Julia R. Greer, Eugen Rabkin

Summary: The solid state dewetting of nanocrystalline Au thin films deposited on prismatic single crystalline KCl whiskers in a three-dimensional setting was studied, revealing faster dewetting along the whisker edges than on the side facets. A numerical model was developed to describe the growth of anisotropic elliptical holes in the thin film, elongated along the whisker axis. The change in orientation relationship between Au grains and KCl whisker along the whisker edges was identified as an important factor in the experimental results.

ACTA MATERIALIA (2021)

Add to Collection

Article Materials Science, Multidisciplinary

Texture evolution of obliquely deposited Au thin films

Mengsheng Yang, Kewei Gao

Summary: Understanding the formation and evolution of the texture of obliquely deposited films is essential for improving their performance. In this study, Au films were prepared by magnetron sputtering oblique deposition and their texture and morphology were analyzed using X-ray diffraction, scanning electron microscopy, and atomic force microscopy. The results showed that the films deposited at different oblique angles exhibited different structures, with densely arranged grains in films deposited at angles less than 60 degrees and highly porous nanorods in films deposited at angles greater than or equal to 70 degrees.

VACUUM (2023)

Add to Collection

Article Materials Science, Multidisciplinary

Ho and Nd ion beam modifications of ZnO thin films

O. Oberemok, V. Kladko, V. Melnik, O. Dubikovskyi, O. Kosulya, O. Gudymenko, B. Romanyuk, Z. Maksimenko, T. Sabov, O. Kolomys

Summary: This work investigates the impact of annealing temperature on the structural and optical properties of ZnO films implanted with Ho+ and Nd+ ions. Highly oriented nanorods arrays of ZnO films were synthesized on silicon substrates using RF magnetron sputtering. Ion implantation enhanced the crystallinity of the films. The temperature-induced changes in lattice parameters and sizes of ZnO nanocrystals in nanorods were observed. Threshold temperatures for bulk crystallization and the photoluminescent properties of nanorods were identified. The study reveals that the implanted elements are distributed uniformly throughout the film thickness and accumulate at the SiOx/Si interface during high-temperature annealing.

MATERIALS CHEMISTRY AND PHYSICS (2023)

Add to Collection

Article Materials Science, Multidisciplinary

Plasmon thermal conductivity of thin Au and Ag films

Dong-min Kim, Jeongmin Nam, Bong Jae Lee

Summary: In this study, we investigated the in-plane thermal conductivity of surface plasmon polaritons (SPPs) propagating along thin metal films. Numerical simulations and experiments showed that considering the size effect of the permittivity of thin metal films reduces the plasmon thermal conductivity by approximately 30% and increases the film thickness at which maximum thermal conductivity occurs.

PHYSICAL REVIEW B (2023)

Add to Collection

Article Chemistry, Multidisciplinary

Self-Assembly-Driven Nanomechanics in Porous Covalent Organic Framework Thin Films

Kaushik Dey, Surojit Bhunia, Himadri Sekhar Sasmal, C. Malla Reddy, Rahul Banerjee

Summary: This study investigates the mechanical behavior of different types of COF thin films by controlling the internal order and self-assembly of building blocks, revealing that defect density and the nature of supramolecular interactions play a significant role in determining the stress-strain behavior of the films.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Add to Collection

Article Materials Science, Multidisciplinary

Optical properties of annealed nearly percolated Au thin films

Elizabeth Hedl, Vesna Blazek Bregovic, Iva Srut Rakic, Simun Mandic, Zeljko Samec, Alexander Bergmann, Jordi Sancho-Parramon

Summary: The evolution of optical properties of thermally annealed gold films is studied and correlated with changes in morphology. Nearly percolated gold films of different mass thicknesses are deposited and annealed at temperatures ranging from 200°C to 525°C. Optical characterization is done using transmittance and spectroscopic ellipsometry, while film morphology is analyzed with SEM and AFM. The optical properties reflect the morphological modifications caused by annealing, resulting in a large variation in films annealed around the temperature where depercolation occurs.

OPTICAL MATERIALS (2023)

Add to Collection

Article Nanoscience & Nanotechnology

Performance Enhancement by Secondary Doping in PEDOT:PSS/Planar-Si Hybrid Solar Cells

Donald McGillivray, Joseph P. Thomas, Marwa Abd-Ellah, Nina F. Heinig, K. T. Leung

ACS APPLIED MATERIALS & INTERFACES (2016)

Add to Collection

Article Chemistry, Multidisciplinary

Defect-Rich Dopant-Free ZrO2 Nanostructures with Superior Dilute Ferromagnetic Semiconductor Properties

Md Anisur Rahman, S. Rout, Joseph P. Thomas, Donald McGillivray, Kam Tong Leung

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

Add to Collection

Article Chemistry, Multidisciplinary

Plasmonic gold nanoparticles for ZnO-nanotube photoanodes in dye-sensitized solar cell application

Marwa Abd-Ellah, Nafiseh Moghimi, Lei Zhang, Joseph. P. Thomas, Donald McGillivray, Saurabh Srivastava, Kam Tong Leung

NANOSCALE (2016)

Add to Collection

Article Energy & Fuels

Enhancement of solar cell performance of p-Cu2O/n-ZnO-nanotube and nanorod heterojunction devices

Marwa Abd-Ellah, Joseph P. Thomas, Lei Zhang, Kam Tong Leung

SOLAR ENERGY MATERIALS AND SOLAR CELLS (2016)

Add to Collection

Article Chemistry, Multidisciplinary

Hierarchical hexagonal boron nitride nanowall-diamond nanorod heterostructures with enhanced optoelectronic performance

Kamatchi Jothiramalingam Sankaran, Duc Quang Hoang, Svetlana Korneychuk, Srinivasu Kunuku, Joseph Palathinkal Thomas, Paulius Pobedinskas, Sien Drijkoningen, Marlies K. Van Bael, Jan D'Haen, Johan Verbeeck, Keh-Chyang Leou, Kam Tong Leung, I. -Nan Lin, Ken Haenen

RSC ADVANCES (2016)

Add to Collection

Article Chemistry, Multidisciplinary

Efficient photoelectrochemical water splitting on ultrasmall defect-rich TaOx nanoclusters enhanced by size-selected Pt nanocluster promoters

Saurabh Srivastava, Joseph Palathinkal Thomas, Nina Heinig, Marwa Abd-Ellah, Md Anisur Rahman, Kam Tong Leung

NANOSCALE (2017)

Add to Collection

Article Chemistry, Physical

A Delaminated Defect-Rich ZrO2 Hierarchical Nanowire Photocathode for Efficient Photoelectrochemical Hydrogen Evolution

Md Anisur Rahman, Joseph P. Thomas, Kam Tong Leung

ADVANCED ENERGY MATERIALS (2018)

Add to Collection

Article Physics, Applied

Thin film metrology and microwave loss characterization of indium and aluminum/indium superconducting planar resonators

C. R. H. McRae, J. H. Bejanin, C. T. Earnest, T. G. McConkey, J. R. Rinehart, C. Deimert, J. P. Thomas, Z. R. Wasilewski, M. Mariantoni

JOURNAL OF APPLIED PHYSICS (2018)

Add to Collection

Article Chemistry, Multidisciplinary

Highly Conducting Hybrid Silver-Nanowire-Embedded Poly(3,4-ethylenedioxythiophene):Poly(styrenesulfo nate) for High-Efficiency Planar Silicon/Organic Heterojunction Solar Cells

Joseph P. Thomas, Md Anisur Rahman, Saurabh Srivastava, Jung-Soo Kang, Donald McGillivray, Marwa Abd-Ellah, Nina F. Heinig, Kam Tong Leung

ACS NANO (2018)

Add to Collection

Article Nanoscience & Nanotechnology

Charge Transfer in Nanowire-Embedded PEDOT:PSS and Planar Heterojunction Solar Cells

Joseph P. Thomas, Quyu Shi, Marwa Abd-Ellah, Lei Zhang, Nina F. Heinig, Kam Tong Leung

ACS APPLIED MATERIALS & INTERFACES (2020)

Add to Collection

Article Nanoscience & Nanotechnology

Defect-Rich Dopant-Free ZrO2 Nanoclusters and Their Size-Dependent Ferromagnetism

Xiaoyi Guan, Saurabh Srivastava, Joseph Palathinkal Thomas, Nina F. Heinig, Jung-Soo Kang, Md Anisur Rahman, Kam Tong Leung

ACS APPLIED MATERIALS & INTERFACES (2020)

Add to Collection

Article Nanoscience & Nanotechnology

Induced Complementary Resistive Switching in Forming-Free TiOx/TiO2/TiOx Memristors

Saurabh Srivastava, Joseph Palathinkal Thomas, Xiaoyi Guan, Kam Tong Leung

Summary: This study introduces a new heterojunction design of oxide multilayer stacking to manipulate the oxidation state, successfully changing the BRS behavior to CRS and constructing a device architecture with a double-junction active matrix to overcome the undesirable sneak current path.

ACS APPLIED MATERIALS & INTERFACES (2021)

Add to Collection

Article Nanoscience & Nanotechnology

High-Performance Single-Active-Layer Memristor Based on an Ultrananocrystalline Oxygen-Deficient TiOx Film

Saurabh Srivastava, Joseph P. Thomas, Nina F. Heinig, K. T. Leung

ACS APPLIED MATERIALS & INTERFACES (2017)

Add to Collection

Article Electrochemistry

Probing the flat band potential and effective electronic carrier density in vertically aligned nitrogen doped diamond nanorods via electrochemical method

Gourav Bhattacharya, Kamatchi Jothiramalingam Sankaran, Shashi B. Srivastava, Joseph Palathinkal Thomas, Sujit Deshmukh, Paulius Pobedinskas, Samarendra P. Singh, Kam Tong Leung, Marlies K. Van Bael, Ken Haenen, Susanta Sinha Roy

ELECTROCHIMICA ACTA (2017)

Add to Collection

Article Physics, Applied

Field electron emission enhancement in lithium implanted and annealed nitrogen-incorporated nanocrystalline diamond films

K. J. Sankaran, K. Srinivasu, C. J. Yeh, J. P. Thomas, S. Drijkoningen, P. Pobedinskas, B. Sundaravel, K. C. Leou, K. T. Leung, M. K. Van Bael, M. Schreck, I. N. Lin, K. Haenen

APPLIED PHYSICS LETTERS (2017)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.