Review
Pharmacology & Pharmacy
Gerallt Williams, Julie D. Suman
Summary: Nasal drug delivery has been used for locally acting diseases for decades. It is also a gateway to the systemic circulation and central nervous system. With the increase in nasal sprays for vaccination and respiratory disease prevention, targeted regional deposition in the nose has become important in nasal drug development. In vitro tools such as nasal casts have been used to facilitate formulation and product development, and to study nasal deposition and its impact on pharmacokinetics.
Review
Chemistry, Physical
Aleksandr Kakinen, Ibrahim Javed, Thomas P. Davis, Pu Chun Ke
Summary: Amyloid diseases are global epidemics with limited solutions for diagnosis, treatment, and prevention;
The research on amyloidosis inhibition has evolved into a new frontier in nanomedicine, offering interdisciplinary research opportunities in materials, chemistry, and biophysics;
Due to the complex and overlapping physiopathologies of amyloid diseases, there is a crucial need for appropriate in vitro and in vivo models to validate novel anti-amyloidosis nanomedicines, and the development of new animal models reflecting the behavioral, symptomatic, and cross-talk hallmarks of amyloid diseases such as Alzheimer's, Parkinson's, and type 2 diabetes.
NANOSCALE HORIZONS
(2021)
Article
Thermodynamics
Barbara Cristina Campos Ribeiro, Emilio Ramos Cintra, Eliana Martins Lima, Luis Antonio Dantas Silva, Danielle Guimaraes Almeida Diniz
Summary: Testosterone, a poorly water-soluble cholesterol-derived hormone, was formulated into a liquid self-emulsifying drug delivery system (L-SEDDS) to improve its bioavailability. Pre-formulation studies were conducted to investigate the compatibility of testosterone with oils and surfactants, and the selection of excipients for the development of L-SEDDS.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Review
Chemistry, Multidisciplinary
Wenlu Yan, Tianqun Lang, Runqi Zhu, Xiao Zhu, Yu Li, Ting Wu, Qi Yin, Yaping Li
Summary: This review summarizes the latest research progress on improving cancer therapy using anti-hypoxia nanosized drug delivery systems (NDDSs), including mechanisms such as increasing oxygen supply, reducing oxygen consumption, and inhibiting hypoxia-related signaling pathways.
Article
Polymer Science
Da Huang, Qiang Tang, Minglang Zou, Yongming Wang, Fang Luo, Jinyi Mu, Yuanzi Wu, Zuquan Weng, Zhenyu Lin
Summary: Inflammation is an immune response that can lead to diseases when uncontrolled. Natural products like curcumin have potential as alternative anti-inflammatory drugs, but their bioavailability is low. This study introduces PACE micelles as a promising platform for targeted and responsive anti-inflammatory therapy, demonstrating remarkable stability and significant anti-inflammatory activity.
Article
Chemistry, Physical
Daorun Hu, Congkai Zhang, Chao Sun, Haijing Bai, Jialiang Xie, Yawen Gu, Mengyuan Li, Junkai Jiang, Aiping Le, Jiaxuan Qiu, Xiaolei Wang
Summary: This study developed a near-infrared light-responsive nano-drug delivery system based on carvacrol, which has antibacterial, anti-inflammatory, and immunoregulatory capacities, showing great promise in the clinical practice of periodontitis.
Review
Pharmacology & Pharmacy
Carlota Salgado, Olivier Jordan, Eric Allemann
Summary: OA in vitro models play a crucial role in the development of IA formulation, offering insights into molecular pathways, drug interactions, cytotoxicity assessments, and in vivo predictions. However, improvements are needed in understanding the intricacies of cellular models for a more accurate representation of in vivo conditions in 2D and 3D contexts.
Article
Biochemistry & Molecular Biology
Marcin Holota, Sylwia Michlewska, Sandra Garcia-Gallego, Natalia Sanz del Olmo, Paula Ortega, Maria Bryszewska, Francisco Javier de la Mata, Maksim Ionov
Summary: Copper carbosilane metallodendrimers were conjugated with conventional anticancer drugs and showed enhanced effectiveness against cancer cells. The combination therapy significantly decreased cancer cell viability and induced apoptosis and necrosis. The presence of copper ions in the dendrimer structures enhanced the anticancer properties of the whole nanosystem.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Yonglong He, Wanting Zhang, Qingqing Xiao, Lifang Fan, Dechun Huang, Wei Chen, Wei He
Summary: Liposomes, as the first nanomedicine successfully marketed and used in human patients, have advanced in delivering small molecular-weight compounds and biological drugs. They have been extensively investigated for various treatments such as anti-tumor, anti-fungal, anti-bacterial, and clinical analgesia, showing improved therapeutic efficacy and combinatorial delivery by reducing drug cytotoxicity. The approval of liposomal vaccines for COVID-19 in 2021 highlights the significance of liposomes in combating infectious diseases.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Instruments & Instrumentation
Nathan Woodhouse, Jan Majer, Peter Marshall, Steve Hood, Ioan Notingher
Summary: Quantitative analysis of drug delivery in biological systems using Raman spectroscopy has been studied in rat brain and liver tissue models, showing promising results for assessing drug delivery in tissue applications.
APPLIED SPECTROSCOPY
(2023)
Review
Chemistry, Applied
Masoud Hamidi, Oseweuba Valentine Okoro, Peiman Brouki Milan, Mohammad Reza Khalili, Hadi Samadian, Lei Nie, Amin Shavandi
Summary: Fungal exopolysaccharides have diverse potential applications in various industries. However, there are only a few commercialized products based on fungal EPSs in the biomedical field. This review critically discusses the potential biomedical applications of fungal EPSs in tissue engineering, drug and gene delivery.
CARBOHYDRATE POLYMERS
(2022)
Review
Biochemistry & Molecular Biology
Marcin Sobczak, Karolina Kedra
Summary: With the development of polymeric biomaterials, drug delivery systems (DDSs) have become crucial in cancer therapy. Polyurethanes (PUs) are widely used in medicine and biomaterial engineering, and can be synthesized for anti-cancer DDSs by selecting suitable building blocks.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Salah M. Tawfik, Shavkatjon Azizov, Mohamed R. Elmasry, Mirkomil Sharipov, Yong-Ill Lee
Summary: Nanomicelles as drug carriers show potential in selective and efficient drug delivery, forming organized structures through self-assembly and releasing drugs in response to various stimuli. The properties of core and corona forming blocks determine the size and shape of nanomicelles.
Article
Chemistry, Multidisciplinary
Mudassar Shahid, Afzal Hussain, Azmat Ali Khan, Mohhammad Ramzan, Ahmed L. Alaofi, Amer M. Alanazi, Mohammad M. Alanazi, Mohd Ahmar Rauf
Summary: The study successfully optimized a cationic nanoemulsion loaded with KTZ for improved topical delivery, showing enhanced drug entrapment efficiency, better drug release behavior, and stronger antifungal activity.
Review
Chemistry, Multidisciplinary
Sandy Elmehrath, Ha L. Nguyen, Sherif M. Karam, Amr Amin, Yaser E. Greish
Summary: A variety of nanomaterials, including both synthetic and natural nanoparticles and nanofibers, have been developed for drug delivery in cancer treatment. Metal-organic framework (MOF) nanostructures have emerged as highly successful drug delivery systems (DDSs) due to their high surface area, interconnected porosity, and variable chemical functionality. This review provides an overview of the development and applications of chemically-functionalized MOF nanostructures in DDSs for cancer treatment.
Article
Chemistry, Physical
Daniel A. Real, Stefan Hoffmann, Dario Leonardi, Francisco M. Goycoolea, Claudio J. Salomon
Summary: The study focuses on developing nanoemulsions loaded with hydrophobic drugs and investigating the roles of excipients and experimental conditions. By conducting experiments and analyzing parameters, the study identifies key factors influencing the characteristics of the formulations and optimal conditions for stable nanoemulsions. The results suggest that concentration of excipients and log P values of drugs have a significant impact on the stability of nanosystems.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Multidisciplinary
Eva C. Arrua, Olga Hartwig, Duy-Khiet Ho, Brigitta Loretz, Xabier Murgia, Claudio J. Salomon, Claus-Michael Lehr
Summary: This study formulated and characterized surfactant-free glibenclamide nanoparticles using Eudragit RLPO and polyethylene glycol as stabilizers. The nanoparticles had a particle size range of 140-460 nm and exhibited stability in terms of size after 120 days of storage at 4 degrees C. In vitro studies showed minimal interactions with mucin glycoproteins and increased permeation through epithelial cells, indicating potential for improved treatment of non-insulin dependent diabetes.
PHARMACEUTICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Daniel Andres Real, Ailen Gagliano, Nahuel Sonsini, Gaspar Wicky, Lucas Orzan, Dario Leonardi, Claudio Salomon
Summary: The Design of Experiments (DoE) techniques were used to optimize the formulation of triclabendazole nanoparticles, resulting in a pH-sensitive Eudragit (R) nanosystem with improved drug solubility and dissolution rate.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Lucia Lopez-Vidal, Juan Pablo Real, Daniel Andres Real, Nahuel Camacho, Marcelo J. Kogan, Alejandro J. Paredes, Santiago Daniel Palma
Summary: This study is the first to report the inclusion of nanocrystals in 3D-printed tablets using the MESO-PP printing technique, which successfully incorporated ABZ nanocrystals in high concentrations. Physicochemical analyses showed no impact of the NCs on the ink's crystallinity and chemical properties, while also demonstrating improved drug dissolution rates in the printlets.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Analytical
Natalia L. Calvo, Guillermo Tejada, Laura A. Svetaz, Ariel D. Quiroga, Vera A. Alvarez, Maria C. Lamas, Dario Leonardi
Summary: A new mucoadhesive film based on a biodegradable blend was developed for treatment of vaginal candidiasis, showing excellent drug release properties. Extensive characterization studies confirmed the efficacy and safety of the formulation through in vitro tests.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Review
Pharmacology & Pharmacy
Daniel Andres Real, Karen Bolanos, Josefina Priotti, Nicolas Yutronic, Marcelo J. Kogan, Rodrigo Sierpe, Orlando Donoso-Gonzalez
Summary: This review focuses on the application of CD-modified or CD-based nanomaterials in drug delivery, highlighting their potential in formulating new systems and achieving controlled drug release and increased bioavailability in in vivo studies.
Article
Public, Environmental & Occupational Health
Erica Tex Paulino, Monique Ribeiro de Lima, Alessandra Lifsitch Vicosa, Cleber Hooper da Silva, Claudio Javier Salomon, Daniel Andres Real, Dario Leonardi, Clelia Christina Mello Silva, Antonio Henrique Almeida de Moraes Neto
Summary: This study evaluated the effects of two formulations of Praziquantel (PZQ) - PZQ-NANO and PZQ-API - on the prepatent phase of schistosomiasis. The results showed that PZQ-API could reduce the parasite load of infected animals and treatment at 15 days post-infection prevented increased serum levels of ALT, AST, and TP.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Materials Science, Multidisciplinary
Maria L. Formica, Daniel A. Real, Matias L. Picchio, Elise Catlin, Ryan F. Donnelly, Alejandro J. Paredes
Summary: Intranasal administration provides a promising route for delivering drugs to the brain due to its unique anatomical features. Nanoparticle-based systems have demonstrated outstanding ability to overcome the challenges of this route and achieve drug accumulation in the brain while avoiding systemic distribution.
APPLIED MATERIALS TODAY
(2022)
Article
Food Science & Technology
Diego Dusso, Claudio J. J. Salomon
Summary: Probiotics are beneficial live microorganisms that are usually taken orally. However, their survival through the gastrointestinal tract is often compromised. This research developed alginate-based microparticles with various adjuvants as carriers to improve the survival of Lactococcus lactis. The microparticles demonstrated high drug encapsulation efficiency and provided protection for the bacteria against gastric and intestinal fluids, maintaining their viability for at least 24 weeks.
JOURNAL OF FOOD SCIENCE
(2023)
Article
Chemistry, Physical
Guillermo Tejada, Natalia L. Calvo, Mauro Morri, Maximiliano Sortino, Celina Lamas, Vera A. Alvarez, Dario Leonardi
Summary: Oral candidiasis is an opportunistic infection mainly affecting individuals with weakened immune systems. This study aimed to develop buccal films loaded with lidocaine and miconazole nitrate to topically treat this pathology. The films showed adequate adhesiveness and thickness and provided a fast release of lidocaine and a controlled release of miconazole nitrate with antifungal activity for 24 hours, reducing the need for daily applications compared to conventional treatments.
Article
Pharmacology & Pharmacy
Juan Pablo Real, Daniel Andres Real, Lucia Lopez-Vidal, Bruno Andres Barrientos, Karen Bolanos, Mariano Guillermo Tinti, Nicolas Javier Litterio, Marcelo Javier Kogan, Santiago Daniel Palma
Summary: This study aimed to formulate NICLO nanocrystals (NICLO-NCRs) to improve the dissolution rate of the drug and incorporate them into a floating dosage form for slow release in the stomach. The results showed the potential of the technique in obtaining slow-release gastro-retentive oral solid dosage forms for treating gastric pathologies like H. pylori.
Article
Pharmacology & Pharmacy
Maria Alejandra Operto, Ruben Maggio, Dario Leonardi, Silvana Vignaduzzo
Summary: The development of age-appropriate formulations in the pharmaceutical industry is challenging, especially for pediatric and geriatric patients who may have difficulty swallowing oral medications. This study aimed to obtain a new dosage form of Carvedilol suitable for pediatric and geriatric patients. The solubility of Carvedilol was improved by analyzing and optimizing various factors, and the physical stability of the formulations was enhanced by adding HPMC. Microbiological tests were conducted to assess the stability of the formulations.
Article
Pharmacology & Pharmacy
Marina Claire Vinaud, Daniel Real, Carolina Miguel Fraga, Nayana F. Lima, Ruy De Souza Lino Junior, Dario Leonardi, Claudio J. Salomon
THERAPEUTIC DELIVERY
(2020)
