Clinical Trials in a Dish: A Perspective on the Coming Revolution in Drug Development
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Title
Clinical Trials in a Dish: A Perspective on the Coming Revolution in Drug Development
Authors
Keywords
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Journal
SLAS Discovery
Volume -, Issue -, Pages 247255521877502
Publisher
SAGE Publications
Online
2018-06-04
DOI
10.1177/2472555218775028
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Note: Only part of the references are listed.- Humanity in a Dish: Population Genetics with iPSCs
- (2018) Curtis R. Warren et al. TRENDS IN CELL BIOLOGY
- Structural Immaturity of Human iPSC-Derived Cardiomyocytes: In Silico Investigation of Effects on Function and Disease Modeling
- (2018) Jussi T. Koivumäki et al. Frontiers in Physiology
- Usefulness of cardiotoxicity assessment using calcium transient in human induced pluripotent stem cell-derived cardiomyocytes
- (2017) Hitoshi Watanabe et al. JOURNAL OF TOXICOLOGICAL SCIENCES
- Assessment of extracellular field potential and Ca2+ transient signals for early QT/pro-arrhythmia detection using human induced pluripotent stem cell-derived cardiomyocytes
- (2017) Najah Abi-Gerges et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells
- (2017) Francesca Stillitano et al. eLife
- Recapitulation of Clinical Individual Susceptibility to Drug-Induced QT Prolongation in Healthy Subjects Using iPSC-Derived Cardiomyocytes
- (2017) Tadahiro Shinozawa et al. Stem Cell Reports
- Human pluripotent stem cells: Prospects and challenges as a source of cardiomyocytes for in vitro modeling and cell-based cardiac repair
- (2016) Matthew E. Hartman et al. ADVANCED DRUG DELIVERY REVIEWS
- Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform
- (2016) Chris Denning et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro
- (2016) Elena Matsa et al. Cell Stem Cell
- Age-Related Accumulation of Somatic Mitochondrial DNA Mutations in Adult-Derived Human iPSCs
- (2016) Eunju Kang et al. Cell Stem Cell
- Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury
- (2016) Christopher Goldring et al. HEPATOLOGY
- Innovation in the pharmaceutical industry: New estimates of R&D costs
- (2016) Joseph A. DiMasi et al. JOURNAL OF HEALTH ECONOMICS
- The potential of induced pluripotent stem cell derived hepatocytes
- (2016) Zara Hannoun et al. JOURNAL OF HEPATOLOGY
- Influence of donor age on induced pluripotent stem cells
- (2016) Valentina Lo Sardo et al. NATURE BIOTECHNOLOGY
- Human induced pluripotent stem cell–derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity
- (2016) Paul W Burridge et al. NATURE MEDICINE
- iPSCs: On the Road to Reprogramming Aging
- (2016) Clara Soria-Valles et al. TRENDS IN MOLECULAR MEDICINE
- Physiological maturation and drug responses of human induced pluripotent stem cell-derived cortical neuronal networks in long-term culture
- (2016) A. Odawara et al. Scientific Reports
- Cardiotoxicity screening with simultaneous optogenetic pacing, voltage imaging and calcium imaging
- (2016) Graham T. Dempsey et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Pluripotent stem cell derived hepatocytes: using materials to define cellular differentiation and tissue engineering
- (2016) B. Lucendo-Villarin et al. Journal of Materials Chemistry B
- Changes in Prescription and Over-the-Counter Medication and Dietary Supplement Use Among Older Adults in the United States, 2005 vs 2011
- (2016) Dima M. Qato et al. JAMA Internal Medicine
- Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease
- (2016) Valentina Cappello et al. Scientific Reports
- Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency
- (2015) Lorenz Studer et al. Cell Stem Cell
- Joseph C. Wu:
- (2015) Susan Ince CIRCULATION RESEARCH
- Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Insights Into Molecular, Cellular, and Functional Phenotypes
- (2015) I. Karakikes et al. CIRCULATION RESEARCH
- Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes
- (2015) Melissa Baxter et al. JOURNAL OF HEPATOLOGY
- Induced pluripotent stem cell-derived cardiac myocytes to understand and test calcium handling: Pie in the sky?
- (2015) Christopher Kane et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Assessment of Interspecies Differences in Drug-Induced QTc Interval Prolongation in Cynomolgus Monkeys, Dogs and Humans
- (2015) V. F. S. Dubois et al. PHARMACEUTICAL RESEARCH
- Sensitivity to change and prediction of global change for the Alzheimer’s Questionnaire
- (2015) Michael Malek-Ahmadi et al. Alzheimers Research & Therapy
- Importance of being Nernst: Synaptic activity and functional relevance in stem cell-derived neurons
- (2015) Aaron B Bradford World Journal of Stem Cells
- Engineering Adolescence
- (2014) Xiulan Yang et al. CIRCULATION RESEARCH
- iPS cells: a game changer for future medicine
- (2014) H. Inoue et al. EMBO JOURNAL
- Tri-iodo-l-thyronine promotes the maturation of human cardiomyocytes-derived from induced pluripotent stem cells
- (2014) Xiulan Yang et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
- (2014) David Cook et al. NATURE REVIEWS DRUG DISCOVERY
- A Quantitative Framework to Evaluate Modeling of Cortical Development by Neural Stem Cells
- (2014) Jason L. Stein et al. NEURON
- Induced pluripotent stem cell-derived cardiomyocytes for drug development and toxicity testing
- (2014) Daniel Sinnecker et al. PHARMACOLOGY & THERAPEUTICS
- Assessment of Cardiomyocyte Contraction in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
- (2014) Amy Pointon et al. TOXICOLOGICAL SCIENCES
- An Impedance-Based Cellular Assay Using Human iPSC-Derived Cardiomyocytes to Quantify Modulators of Cardiac Contractility
- (2014) Clay W. Scott et al. TOXICOLOGICAL SCIENCES
- High-Throughput Multi-Parameter Profiling of Electrophysiological Drug Effects in Human Embryonic Stem Cell Derived Cardiomyocytes Using Multi-Electrode Arrays
- (2014) Mike Clements et al. TOXICOLOGICAL SCIENCES
- The aging signature: a hallmark of induced pluripotent stem cells?
- (2013) Leili Rohani et al. AGING CELL
- Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium
- (2013) Philip T. Sager et al. AMERICAN HEART JOURNAL
- High-Content Assays for Hepatotoxicity Using Induced Pluripotent Stem Cell–Derived Cells
- (2013) Oksana Sirenko et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- Patient-Specific Stem Cells and Cardiovascular Drug Discovery
- (2013) Nicholas M. Mordwinkin et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients
- (2013) Aleksandr Shcheglovitov et al. NATURE
- Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes
- (2013) Sara S Nunes et al. NATURE METHODS
- Cardiovascular Risks with Azithromycin and Other Antibacterial Drugs
- (2013) Andrew D. Mosholder et al. NEW ENGLAND JOURNAL OF MEDICINE
- Drug attrition during pre-clinical and clinical development: Understanding and managing drug-induced cardiotoxicity
- (2013) Nicola Ferri et al. PHARMACOLOGY & THERAPEUTICS
- Concise Review: Maturation Phases of Human Pluripotent Stem Cell-Derived Cardiomyocytes
- (2013) Claire Robertson et al. STEM CELLS
- Structural and Functional Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells
- (2013) Scott D. Lundy et al. STEM CELLS AND DEVELOPMENT
- Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity
- (2013) Oksana Sirenko et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Effect of Combined Fluoroquinolone and Azole Use on QT Prolongation in Hematology Patients
- (2012) John D. Zeuli et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Current status of drug screening and disease modelling in human pluripotent stem cells
- (2012) Divya Rajamohan et al. BIOESSAYS
- Aging and reprogramming: a two-way street
- (2012) Salah Mahmoudi et al. CURRENT OPINION IN CELL BIOLOGY
- Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells
- (2012) M. Kajiwara et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hepatocyte-like cells differentiated from human induced pluripotent stem cells: Relevance to cellular therapies
- (2012) Yue Yu et al. Stem Cell Research
- Pharmacokinetic interaction between domperidone and ketoconazole leads to QT prolongation in healthy volunteers: a randomized, placebo-controlled, double-blind, crossover study
- (2011) Malcolm J. Boyce et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?
- (2011) HG Laverty et al. BRITISH JOURNAL OF PHARMACOLOGY
- Growth of Engineered Human Myocardium With Mechanical Loading and Vascular Coculture
- (2011) Nathaniel L. Tulloch et al. CIRCULATION RESEARCH
- Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state
- (2011) L. Lapasset et al. GENES & DEVELOPMENT
- Electrophysiological Characterization of Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells
- (2011) Masaki Honda et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Energy Metabolism in Human Pluripotent Stem Cells and Their Differentiated Counterparts
- (2011) Sandra Varum et al. PLoS One
- Mitochondrial-Associated Cell Death Mechanisms Are Reset to an Embryonic-Like State in Aged Donor-Derived iPS Cells Harboring Chromosomal Aberrations
- (2011) Alessandro Prigione et al. PLoS One
- Estimating the Risk of Drug-Induced Proarrhythmia Using Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes
- (2011) Liang Guo et al. TOXICOLOGICAL SCIENCES
- Innovative clinical trial design for pediatric therapeutics
- (2011) Matthew M Laughon et al. Expert Review of Clinical Pharmacology
- Disparate Inclusion of Older Adults in Clinical Trials: Priorities and Opportunities for Policy and Practice Change
- (2010) Angelica P. Herrera et al. AMERICAN JOURNAL OF PUBLIC HEALTH
- Incidence and Contributors to Potential Drug-Drug Interactions in Hospitalized Patients
- (2010) Leanne Reimche et al. JOURNAL OF CLINICAL PHARMACOLOGY
- How to improve R&D productivity: the pharmaceutical industry's grand challenge
- (2010) Steven M. Paul et al. NATURE REVIEWS DRUG DISCOVERY
- An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation
- (2010) Gary Gintant PHARMACOLOGY & THERAPEUTICS
- Spontaneous reversal of the developmental aging of normal human cells following transcriptional reprogramming
- (2010) H Vaziri et al. Regenerative Medicine
- The Senescence-Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells
- (2010) Alessandro Prigione et al. STEM CELLS
- Participation and survival of geriatric patients in Phase I clinical trials: The Karmanos Cancer Institute (KCI) experience
- (2010) Syed F. Zafar et al. Journal of Geriatric Oncology
- Current challenges in the evaluation of cardiac safety during drug development: Translational medicine meets the Critical Path Initiative
- (2009) Jonathan P. Piccini et al. AMERICAN HEART JOURNAL
- The thorough QT/QTc study 4 years after the implementation of the ICH E14 guidance
- (2009) B Darpo BRITISH JOURNAL OF PHARMACOLOGY
- Betulin Is a Potent Anti-Tumor Agent that Is Enhanced by Cholesterol
- (2009) Franziska B. Mullauer et al. PLoS One
- Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes
- (2009) Stefan R. Braam et al. Stem Cell Research
- Clinically relevant QTc prolongation due to overridden drug-drug interaction alerts: a retrospective cohort study
- (2008) Heleen van der Sijs et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Principles of Safety Pharmacology
- (2008) M K Pugsley et al. BRITISH JOURNAL OF PHARMACOLOGY
- Ethnic Differences in Cardiovascular Drug Response
- (2008) Julie A. Johnson CIRCULATION
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