Cancer cell specific inhibition of Wnt/β-catenin signaling by forced intracellular acidification

The therapeutic potential of targeting ABC transporters to combat multi-drug resistance

(2017) Piyush Bugde et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Metformin use and survival of lung cancer patients: Meta-analysis findings

(2017) J Zhao et al.   INDIAN JOURNAL OF CANCER

Roles of Wnt Target Genes in the Journey of Cancer Stem Cells

(2017) Jee-Heun Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metformin as a repurposed therapy in advanced non-small cell lung cancer (NSCLC): results of a phase II trial

(2017) Anish B. Parikh et al.   INVESTIGATIONAL NEW DRUGS

Cancer cell behaviors mediated by dysregulated pH dynamics at a glance

(2017) Katharine A. White et al.   JOURNAL OF CELL SCIENCE

Metformin use and the risk of colorectal adenoma: A systematic review and meta-analysis

(2017) Yoon Suk Jung et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

TTK Inhibitors as a Targeted Therapy for CTNNB1 ( β -catenin) Mutant Cancers

(2017) Guido J.R. Zaman et al.   MOLECULAR CANCER THERAPEUTICS

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

(2017) Felipe de Sousa e Melo et al.   NATURE

Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling

(2017) Claudia Y. Janda et al.   NATURE

A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma

(2017) Tuomas Tammela et al.   NATURE

Metformin use and survival of lung cancer patients: Meta-analysis findings

(2017) J Zhao et al.   INDIAN JOURNAL OF CANCER

Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation

(2017) Peiguo Shi et al.   Cell Discovery

A combined approach against tumorigenesis using glucose deprivation and mitochondrial complex 1 inhibition by rotenone

(2016) Nupur Rani Agarwal et al.   CELL BIOLOGY INTERNATIONAL

Strategies for encapsulation of small hydrophilic and amphiphilic drugs in PLGA microspheres: State-of-the-art and challenges

(2016) Farshad Ramazani et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Wnt signaling in cancer

(2016) T Zhan et al.   ONCOGENE

Cancer: fundamentals behind pH targeting and the double-edged approach

(2016) Tomas Koltai   OncoTargets and Therapy

Syrosingopine sensitizes cancer cells to killing by metformin

(2016) Don Benjamin et al.   Science Advances

Extracellular pH Modulates Neuroendocrine Prostate Cancer Cell Metabolism and Susceptibility to the Mitochondrial Inhibitor Niclosamide

(2016) Joseph E. Ippolito et al.   PLoS One

Targeting Wnt signaling in colorectal cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanisms

(2015) Laura Novellasdemunt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Selective Inhibition of Deactivated Mitochondrial Complex I by Biguanides

(2015) Satoshi Matsuzaki et al.   BIOCHEMISTRY

Glucose-deprivation increases thyroid cancer cells sensitivity to metformin

(2015) Athanasios Bikas et al.   ENDOCRINE-RELATED CANCER

Down-regulated SOX4 Expression Suppresses Cell Proliferation, Metastasis and Induces Apoptosis in Xuanwei Female Lung Cancer Patients

(2015) Yongchun Zhou et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Targeting mitochondria metabolism for cancer therapy

(2015) Samuel E Weinberg et al.   Nature Chemical Biology

Metformin Use Is Associated With Better Survival of Breast Cancer Patients With Diabetes: A Meta-Analysis

(2015) H. Xu et al.   ONCOLOGIST

Epithelial–mesenchymal transition in human cancer: Comprehensive reprogramming of metabolism, epigenetics, and differentiation

(2015) Linna Li et al.   PHARMACOLOGY & THERAPEUTICS

SOX4 overexpression is a novel biomarker of malignant status and poor prognosis in breast cancer patients

(2015) Guo-Dong Song et al.   TUMOR BIOLOGY

Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation

(2015) Derek James Hanson et al.   Oncotarget

New insights into the roles of CHOP-induced apoptosis in ER stress

(2014) Yiming Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

Bortezomib-Induced Unfolded Protein Response Increases Oncolytic HSV-1 Replication Resulting in Synergistic Antitumor Effects

(2014) J. Y. Yoo et al.   CLINICAL CANCER RESEARCH

Mitotic Wnt Signaling Promotes Protein Stabilization and Regulates Cell Size

(2014) Sergio P. Acebron et al.   MOLECULAR CELL

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

Differential effects of AMPK agonists on cell growth and metabolism

(2014) E E Vincent et al.   ONCOGENE

Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells

(2014) A. Janzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sox4 Links Tumor Suppression to Accelerated Aging in Mice by Modulating Stem Cell Activation

(2014) Miguel Foronda et al.   Cell Reports

Sox4 Is a Master Regulator of Epithelial-Mesenchymal Transition by Controlling Ezh2 Expression and Epigenetic Reprogramming

(2013) Neha Tiwari et al.   CANCER CELL

Regulation of APC and AXIN2 expression by intestinal tumor suppressor CDX2 in colon cancer cells

(2013) Anders Krüger Olsen et al.   CARCINOGENESIS

Synergistic Effects of Metformin Treatment in Combination with Gefitinib, a Selective EGFR Tyrosine Kinase Inhibitor, in LKB1 Wild-type NSCLC Cell Lines

(2013) F. Morgillo et al.   CLINICAL CANCER RESEARCH

SOX4 Mediates TGF-β-Induced Expression of Mesenchymal Markers during Mammary Cell Epithelial to Mesenchymal Transition

(2013) Stephin J. Vervoort et al.   PLoS One

Clinical and Prognostic Implications of Transcription Factor SOX4 in Patients with Colon Cancer

(2013) Chun-Mao Lin et al.   PLoS One

Multiplex Profiling of Cellular Invasion in 3D Cell Culture Models

(2013) Gerald Burgstaller et al.   PLoS One

Acidic tumor microenvironment and pH-sensing G protein-coupled receptors

(2013) Calvin R. Justus et al.   Frontiers in Physiology

Salinomycin as a Drug for Targeting Human Cancer Stem Cells

(2012) Cord Naujokat et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation

(2012) Makoto Kuwahara et al.   NATURE IMMUNOLOGY

Enhanced cytotoxic effect of low doses of metformin combined with ionizing radiation on hepatoma cells via ATP deprivation and inhibition of DNA repair

(2012) JIFANG LIU et al.   ONCOLOGY REPORTS

C/EBP Homologous Protein (CHOP) Deficiency Aggravates Hippocampal Cell Apoptosis and Impairs Memory Performance

(2012) Chang-Mu Chen et al.   PLoS One

Mitochondrial inhibitor as a new class of insulin sensitizer

(2012) Yong Zhang et al.   Acta Pharmaceutica Sinica B

Encapsulation of Exenatide in Poly-(d,l-Lactide-Co-Glycolide) Microspheres Produced an Investigational Long-Acting Once-Weekly Formulation for Type 2 Diabetes

(2011) Mary Beth DeYoung et al.   Diabetes Technology & Therapeutics

Metformin differentially activates ER stress signaling pathways without inducing apoptosis

(2011) T. Quentin et al.   Disease Models & Mechanisms

Model-based extension of high-throughput to high-content data

(2010) Andrea C Pfeifer et al.   BMC Systems Biology

Identification of β-catenin binding regions in colon cancer cells using ChIP-Seq

(2010) Daniel Bottomly et al.   NUCLEIC ACIDS RESEARCH

Requirement of Prorenin Receptor and Vacuolar H+-ATPase-Mediated Acidification for Wnt Signaling

(2010) C.-M. Cruciat et al.   SCIENCE

Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein

(2009) Ling He et al.   CELL

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL

Bioavailability, distribution and depletion of monensin in chickens

(2009) J. HENRI et al.   JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

In vivo measurement of cytosolic and mitochondrial pH using a pH-sensitive GFP derivative in Saccharomyces cerevisiae reveals a relation between intracellular pH and growth

(2009) R. Orij et al.   MICROBIOLOGY-SGM

Targeting PKC: a novel role for beta-catenin in ER stress and apoptotic signaling

(2008) M. S. Raab et al.   BLOOD