A multi-step continuous flow synthesis of the cystic fibrosis medicine ivacaftor

Flow-Assisted Synthesis: A Key Fragment of SR 142948A

(2017) Matthew O. Kitching et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Fused Pyrimidinone and Quinolone Derivatives in an Automated High-Temperature and High-Pressure Flow Reactor

(2017) Jennifer Tsoung et al.   JOURNAL OF ORGANIC CHEMISTRY

Development and Scale-up of a Flow Chemistry Lithiation–Borylation Route to a Key Boronic Acid Starting Material

(2017) Hirotsugu Usutani et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Simple and Versatile Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times

(2017) Michael R. Chapman et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Novel Organic Synthesis through Ultrafast Chemistry

(2016) Thomas Wirth   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system

(2016) A. Adamo et al.   SCIENCE

A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds

(2015) Jian-Siang Poh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Continuous-Flow Technology-A Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients

(2015) Bernhard Gutmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Continuous-Flow Multistep Synthesis of Cinnarizine, Cyclizine, and a Buclizine Derivative from Bulk Alcohols

(2015) Svetlana Borukhova et al.   ChemSusChem

Breaking and Making of Rings: A Method for the Preparation of 4-Quinolone-3-carb­oxylic Acid Amides and the Expensive Drug Ivacaftor

(2015) N. Vasudevan et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Origins of the Quinolone Class of Antibacterials: An Expanded “Discovery Story”

(2015) Gregory S. Bisacchi   JOURNAL OF MEDICINAL CHEMISTRY

Achieving Continuous Manufacturing for Final Dosage Formation: Challenges and How to Meet Them May 20–21 2014 Continuous Manufacturing Symposium

(2015) Stephen Byrn et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Achieving Continuous Manufacturing May 20–21 2014 Continuous Manufacturing Symposium

(2015) Clive Badman et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Multistep continuous-flow synthesis of (R)- and (S)-rolipram using heterogeneous catalysts

(2015) Tetsu Tsubogo et al.   NATURE

One-pot quadruple/triple reaction sequence: a useful tool for the synthesis of natural products

(2015) K. Kashinath et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Machines vs Malaria: A Flow-Based Preparation of the Drug Candidate OZ439

(2015) Shing-Hing Lau et al.   ORGANIC LETTERS

Synthesis of Condensed Heterocycles by the Gould–Jacobs Reaction in a Novel Three-Mode Pyrolysis Reactor

(2015) László Csaba Lengyel et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Flow Chemistry: Recent Developments in the Synthesis of Pharmaceutical Products

(2015) Riccardo Porta et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

One-Pot Oxidative Cleavage of Olefins to Synthesize Carboxylic Acids by a Telescoped Ozonolysis–Oxidation Process

(2015) Brian Cochran   SYNLETT

Accelerating Spirocyclic Polyketide Synthesis using Flow Chemistry

(2014) Sean Newton et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expeditious Synthesis of Ivacaftor

(2014) Jingshan Shen et al.   HETEROCYCLES

Synthesis and Pharmacological Evaluation of Analogues of Benzyl Quinolone Carboxylic Acid (BQCA) Designed to Bind Irreversibly to an Allosteric Site of the M1 Muscarinic Acetylcholine Receptor

(2014) Briana J. Davie et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drug Shortages: A Complex Health Care Crisis

(2014) Erin R. Fox et al.   MAYO CLINIC PROCEEDINGS

Chemotherapy Drug Shortages in Pediatric Oncology: A Consensus Statement

(2014) M. DeCamp et al.   PEDIATRICS

End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation

(2013) Salvatore Mascia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Flow chemistry syntheses of natural products

(2013) Julio C. Pastre et al.   CHEMICAL SOCIETY REVIEWS

Ozonolysis of some complex organic substrates in flow

(2013) M. D. Roydhouse et al.   RSC Advances

Establishing a Flow Process to Coumarin-8-Carbaldehydes as Important Synthetic Scaffolds

(2012) Jaroslav Zak et al.   CHEMISTRY-A EUROPEAN JOURNAL

Tandem Application of C–C Bond-Forming Reactions with Reductive Ozonolysis

(2012) Rachel Willand-Charnley et al.   JOURNAL OF ORGANIC CHEMISTRY

Ivacaftor

(2012) Pamela B. Davis et al.   NATURE REVIEWS DRUG DISCOVERY

Pyridine Is an Organocatalyst for the Reductive Ozonolysis of Alkenes

(2012) Rachel Willand-Charnley et al.   ORGANIC LETTERS

A Flow-Based Synthesis of 2-Aminoadamantane-2-carboxylic Acid

(2012) Claudio Battilocchio et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Continuous Flow Ozonolysis in a Laboratory Scale Reactor

(2011) Muhammad Irfan et al.   ORGANIC LETTERS

A flow-based synthesis of Imatinib: the API of Gleevec

(2010) Mark D. Hopkin et al.   CHEMICAL COMMUNICATIONS

Flow Ozonolysis Using a Semipermeable Teflon AF-2400 Membrane To Effect Gas−Liquid Contact

(2010) Matthew O’Brien et al.   ORGANIC LETTERS

The Development of Continuous Process for Alkene Ozonolysis Based on Combined in Situ FTIR, Calorimetry, and Computational Chemistry

(2010) Ayman D. Allian et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

The Continuous-Flow Synthesis of Ibuprofen

(2009) Andrew R. Bogdan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The 4-Quinolone-3-Carboxylic Acid Motif as a Multivalent Scaffold in Medicinal Chemistry

(2009) Claudia Mugnaini et al.   CURRENT MEDICINAL CHEMISTRY

Production of (S)-1-Benzyl-3-diazo-2-oxopropylcarbamic Acidtert-Butyl Ester, a Diazoketone Pharmaceutical Intermediate, Employing a Small Scale Continuous Reactor

(2009) Pamela Pollet et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

An Ozonolysis−Reduction Sequence for the Synthesis of Pharmaceutical Intermediates in Microstructured Devices

(2009) Sandra Hübner et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT