New insights into cancer-related proteins provided by the yeast model

The Importance of Humanized Yeast to Better Understand the Role of Bcl-2 Family in Apoptosis: Finding of Novel Therapeutic Opportunities

(2011) Rui D. Silva et al.   CURRENT PHARMACEUTICAL DESIGN

A yeast BH3-only protein mediates the mitochondrial pathway of apoptosis

(2011) Sabrina Büttner et al.   EMBO JOURNAL

Aspartic vinyl sulfones: Inhibitors of a caspase-3-dependent pathway

(2011) Paulo M.C. Glória et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Distinct regulation of p53-mediated apoptosis by protein kinase Cα, δ, ε and ζ: Evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms

(2011) Isabel Coutinho et al.   EXPERIMENTAL CELL RESEARCH

p53 Transactivation and the Impact of Mutations, Cofactors and Small Molecules Using a Simplified Yeast-Based Screening System

(2011) Virginia Andreotti et al.   PLoS One

Cell death in yeast: growing applications of a dying buddy

(2010) D Carmona-Gutierrez et al.   CELL DEATH AND DIFFERENTIATION

Metacaspases are not caspases – always doubt

(2010) M Enoksson et al.   CELL DEATH AND DIFFERENTIATION

Modulation of Bax mitochondrial insertion and induced cell death in yeast by mammalian protein kinase Cα

(2010) Rui D. Silva et al.   EXPERIMENTAL CELL RESEARCH

The tumor-associated EpCAM regulates morphogenetic movements through intracellular signaling

(2010) Nadim Maghzal et al.   JOURNAL OF CELL BIOLOGY

Determinants of BH3 Binding Specificity for Mcl-1 versus Bcl-xL

(2010) Sanjib Dutta et al.   JOURNAL OF MOLECULAR BIOLOGY

The BCL-2 Family Reunion

(2010) Jerry E. Chipuk et al.   MOLECULAR CELL

Translating p53 into the clinic

(2010) Chit Fang Cheok et al.   Nature Reviews Clinical Oncology

Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast?

(2010) Vikram Khurana et al.   NATURE REVIEWS NEUROSCIENCE

Selective activation of protein kinase C-δ and -ɛ by 6,11,12,14-tetrahydroxy-abieta-5,8,11,13-tetraene-7-one (coleon U)

(2009) I. Coutinho et al.   BIOCHEMICAL PHARMACOLOGY

Human initiator caspases trigger apoptotic and autophagic phenotypes in Saccharomyces cerevisiae

(2009) Patricia Lisa-Santamaría et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Caspase substrates and neurodegenerative diseases

(2009) Natasa Bulat et al.   BRAIN RESEARCH BULLETIN

PUMA- and Bax-induced autophagy contributes to apoptosis

(2009) K S Yee et al.   CELL DEATH AND DIFFERENTIATION

Differential regulation of p53 function by protein kinase C isoforms revealed by a yeast cell system

(2009) Isabel Coutinho et al.   FEBS LETTERS

Protein kinase C isoforms: Multi-functional regulators of cell life and death

(2009) Mary et al.   Frontiers in Bioscience-Landmark

Apoptosis and cancer: mutations within caspase genes

(2009) S Ghavami et al.   JOURNAL OF MEDICAL GENETICS

Versatile Assays for High Throughput Screening for Activators or Inhibitors of Intracellular Proteases and Their Cellular Regulators

(2009) Hideki Hayashi et al.   PLoS One

Transcription-independent p53 apoptosis: an alternative route to death

(2009) Daniel Speidel   TRENDS IN CELL BIOLOGY

Human p53 induces cell death and downregulates thioredoxin expression inSaccharomyces cerevisiae

(2008) Ines Yacoubi Hadj Amor et al.   FEMS YEAST RESEARCH

A systematic library for comprehensive overexpression screens in Saccharomyces cerevisiae

(2008) Grace Marie Jones et al.   NATURE METHODS

Reconstitution of Mdm2-Dependent Post-Translational Modifications of p53 in Yeast

(2008) Barbara Di Ventura et al.   PLoS One

Nuclear trafficking of pro-apoptotic kinases in response to DNA damage

(2008) Kiyotsugu Yoshida   TRENDS IN MOLECULAR MEDICINE

Coactivator requirements for p53-dependent transcription in the yeastSaccharomyces cerevisiae

(2007) Ahmed F. Yousef et al.   INTERNATIONAL JOURNAL OF CANCER