Bladder Cancer: New Insights into Its Molecular Pathology

Re: Comprehensive Molecular Characterization of Muscle Invasive Bladder Cancer

(2018) Marcus G. Cumberbatch et al.   EUROPEAN UROLOGY

Biological significance of TERT promoter mutation in papillary urothelial neoplasm of low malignant potential

(2018) Chung-Chieh Wang et al.   HISTOPATHOLOGY

Bladder Cancer Incidence and Mortality: A Global Overview and Recent Trends

(2017) Sebastien Antoni et al.   EUROPEAN UROLOGY

Understanding the Role of Non-Coding RNAs in Bladder Cancer: From Dark Matter to Valuable Therapeutic Targets

(2017) Cecilia Pop-Bica et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular classification of urothelial carcinoma: global mRNA classification versus tumour-cell phenotype classification

(2017) Gottfrid Sjödahl et al.   JOURNAL OF PATHOLOGY

Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial

(2017) Arjun V Balar et al.   LANCET

First-line pembrolizumab in cisplatin-ineligible patients with locally advanced and unresectable or metastatic urothelial cancer (KEYNOTE-052): a multicentre, single-arm, phase 2 study

(2017) Arjun V Balar et al.   LANCET ONCOLOGY

Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): a multicentre, single-arm, phase 2 trial

(2017) Padmanee Sharma et al.   LANCET ONCOLOGY

Bladder cancer: Multi-omic profiling refines the molecular view

(2017) Carolyn D. Hurst et al.   Nature Reviews Clinical Oncology

The evolving genomic landscape of urothelial carcinoma

(2017) Alexander P. Glaser et al.   Nature Reviews Urology

Bladder cancer in 2017: Advancing care through genomics and immune checkpoint blockade

(2017) Matthew D. Galsky   Nature Reviews Urology

Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma

(2017) Joaquim Bellmunt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Toward personalized management in bladder cancer: the promise of novel molecular taxonomy

(2017) Marie-Lisa Eich et al.   VIRCHOWS ARCHIV

miR-199a-3p and miR-214-3p improve the overall survival prediction of muscle-invasive bladder cancer patients after radical cystectomy

(2017) Thorsten H. Ecke et al.   Cancer Medicine

Bladder cancer

(2017) Oner Sanli et al.   Nature Reviews Disease Primers

Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma

(2016) Jakob Hedegaard et al.   CANCER CELL

Analysis of papillary urothelial carcinomas of the bladder with grade heterogeneity: supportive evidence for an early role ofCDKN2Adeletions in theFGFR3pathway

(2016) Michelle R Downes et al.   HISTOPATHOLOGY

Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial

(2016) Jonathan E Rosenberg et al.   LANCET

Invasive Bladder Cancer: Genomic Insights and Therapeutic Promise

(2015) J. Kim et al.   CLINICAL CANCER RESEARCH

Genomic Predictors of Survival in Patients with High-grade Urothelial Carcinoma of the Bladder

(2015) Philip H. Kim et al.   EUROPEAN UROLOGY

Identification of Distinct Basal and Luminal Subtypes of Muscle-Invasive Bladder Cancer with Different Sensitivities to Frontline Chemotherapy

(2014) Woonyoung Choi et al.   CANCER CELL

New Insights into Subtypes of Invasive Bladder Cancer: Considerations of the Clinician

(2014) David J. McConkey et al.   EUROPEAN UROLOGY

Comprehensive molecular characterization of urothelial bladder carcinoma

(2014)   NATURE

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

Bladder cancers arise from distinct urothelial sub-populations

(2014) Jason Van Batavia et al.   NATURE CELL BIOLOGY

Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology

(2014) J. S. Damrauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutational Context and Diverse Clonal Development in Early and Late Bladder Cancer

(2014) Iver Nordentoft et al.   Cell Reports

The role of immunohistochemistry in the diagnosis of flat urothelial lesions: a study using CK20, CK5/6, P53, Cd138, and Her2/Neu

(2013) Sungmi Jung et al.   Annals of Diagnostic Pathology

The Role of Telomeres in Stem Cells and Cancer

(2013) Cagatay Günes et al.   CELL

EAU Guidelines on Non–Muscle-invasive Urothelial Carcinoma of the Bladder: Update 2013

(2013) Marko Babjuk et al.   EUROPEAN UROLOGY

Telomerase Reverse Transcriptase Promoter Mutations in Bladder Cancer: High Frequency Across Stages, Detection in Urine, and Lack of Association with Outcome

(2013) Yves Allory et al.   EUROPEAN UROLOGY

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation

(2013) Guangwu Guo et al.   NATURE GENETICS

Frequent truncating mutations of STAG2 in bladder cancer

(2013) David A Solomon et al.   NATURE GENETICS

Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy

(2013) Cristina Balbás-Martínez et al.   NATURE GENETICS

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

(2013) Steven A Roberts et al.   NATURE GENETICS

Targeted agents in second-line bladder cancer therapy

(2012) Holger Gerullis et al.   ANTI-CANCER DRUGS

Oncogenic FGFR3 gene fusions in bladder cancer

(2012) Sarah V. Williams et al.   HUMAN MOLECULAR GENETICS

Integrated Genomic and Gene Expression Profiling Identifies Two Major Genomic Circuits in Urothelial Carcinoma

(2012) David Lindgren et al.   PLoS One

New Strategies in Muscle-Invasive Bladder Cancer: On the Road to Personalized Medicine

(2011) J. B. Shah et al.   CLINICAL CANCER RESEARCH

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

(2011) Yaoting Gui et al.   NATURE GENETICS

Combined Gene Expression and Genomic Profiling Define Two Intrinsic Molecular Subtypes of Urothelial Carcinoma and Gene Signatures for Molecular Grading and Outcome

(2010) David Lindgren et al.   CANCER RESEARCH

FGFR3, HRAS, KRAS, NRAS and PIK3CA Mutations in Bladder Cancer and Their Potential as Biomarkers for Surveillance and Therapy

(2010) Lucie C. Kompier et al.   PLoS One

The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional RepressorsZEB1andZEB2

(2008) Manav Korpal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY