Toward personalized management in bladder cancer: the promise of novel molecular taxonomy

Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma

(2017) Joaquim Bellmunt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma

(2016) Jakob Hedegaard et al.   CANCER CELL

Paired Exome Analysis Reveals Clonal Evolution and Potential Therapeutic Targets in Urothelial Carcinoma

(2016) Philippe Lamy et al.   CANCER RESEARCH

Role for anti-PD-L1 immune checkpoint inhibitor in advanced urothelial carcinoma

(2016) George J Netto   LANCET

Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial

(2016) Jonathan E Rosenberg et al.   LANCET

Spatial and temporal clonal evolution during development of metastatic urothelial carcinoma

(2016) Mathilde B.H. Thomsen et al.   Molecular Oncology

Emerging Bladder Cancer Biomarkers and Targets of Therapy

(2016) George J. Netto et al.   UROLOGIC CLINICS OF NORTH AMERICA

Meta-Analysis of the Luminal and Basal Subtypes of Bladder Cancer and the Identification of Signature Immunohistochemical Markers for Clinical Use

(2016) Vipulkumar Dadhania et al.   EBioMedicine

Emerging therapeutic targets in bladder cancer

(2015) Benedito A. Carneiro et al.   CANCER TREATMENT REVIEWS

Invasive Bladder Cancer: Genomic Insights and Therapeutic Promise

(2015) J. Kim et al.   CLINICAL CANCER RESEARCH

Morphologic and Molecular Backgrounds for Personalized Management of Genito-Urinary Cancers: An Overview

(2015) Rodolfo Montironi et al.   CURRENT DRUG TARGETS

Genetic subtypes of invasive bladder cancer

(2015) David J. McConkey et al.   CURRENT OPINION IN UROLOGY

Multicenter Assessment of Neoadjuvant Chemotherapy for Muscle-invasive Bladder Cancer

(2015) Homayoun Zargar et al.   EUROPEAN UROLOGY

Genomic Predictors of Survival in Patients with High-grade Urothelial Carcinoma of the Bladder

(2015) Philip H. Kim et al.   EUROPEAN UROLOGY

Defects in DNA Repair Genes Predict Response to Neoadjuvant Cisplatin-based Chemotherapy in Muscle-invasive Bladder Cancer

(2015) Elizabeth R. Plimack et al.   EUROPEAN UROLOGY

Therapeutic Opportunities in the Intrinsic Subtypes of Muscle-Invasive Bladder Cancer

(2015) David J. McConkey et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Targeting HER2 with T-DM1, an Antibody Cytotoxic Drug Conjugate, is Effective in HER2 Over Expressing Bladder Cancer

(2015) Tetsutaro Hayashi et al.   JOURNAL OF UROLOGY

The Role of EGFR Family Inhibitors in Muscle Invasive Bladder Cancer: A Review of Clinical Data and Molecular Evidence

(2015) Benjamin A. Mooso et al.   JOURNAL OF UROLOGY

A phase I study of two dosing schedules of volasertib (BI 6727), an intravenous polo-like kinase inhibitor, in patients with advanced solid malignancies

(2014) C-C Lin et al.   BRITISH JOURNAL OF CANCER

Identification of Distinct Basal and Luminal Subtypes of Muscle-Invasive Bladder Cancer with Different Sensitivities to Frontline Chemotherapy

(2014) Woonyoung Choi et al.   CANCER CELL

Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains

(2014) Duncan A. Hay et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Comprehensive molecular characterization of urothelial bladder carcinoma

(2014)   NATURE

MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer

(2014) Thomas Powles et al.   NATURE

Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology

(2014) J. S. Damrauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel neoadjuvant therapy paradigms for bladder cancer: Results from the National Cancer Center Institute Forum

(2014) Colin P.N. Dinney et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Mutational Context and Diverse Clonal Development in Early and Late Bladder Cancer

(2014) Iver Nordentoft et al.   Cell Reports

Independent Component Analysis Uncovers the Landscape of the Bladder Tumor Transcriptome and Reveals Insights into Luminal and Basal Subtypes

(2014) Anne Biton et al.   Cell Reports

TERT Promoter Mutations Occur Early in Urothelial Neoplasia and Are Biomarkers of Early Disease and Disease Recurrence in Urine

(2013) I. Kinde et al.   CANCER RESEARCH

Emerging drugs for urothelial carcinoma

(2013) Benjamin A Gartrell et al.   EXPERT OPINION ON EMERGING DRUGS

Relevance of the mammalian target of rapamycin pathway in the prognosis of patients with high-risk non–muscle invasive bladder cancer

(2013) Mona Fahmy et al.   HUMAN PATHOLOGY

[1,2,4]Triazolo[4,3-a]phthalazines: Inhibitors of Diverse Bromodomains

(2013) Oleg Fedorov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Frequent truncating mutations of STAG2 in bladder cancer

(2013) David A Solomon et al.   NATURE GENETICS

Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy

(2013) Cristina Balbás-Martínez et al.   NATURE GENETICS

Molecular targets on the horizon for kidney and urothelial cancer

(2013) Joaquim Bellmunt et al.   Nature Reviews Clinical Oncology

Phase I Study of Aurora A Kinase Inhibitor MLN8237 in Advanced Solid Tumors: Safety, Pharmacokinetics, Pharmacodynamics, and Bioavailability of Two Oral Formulations

(2012) E. C. Dees et al.   CLINICAL CANCER RESEARCH

Dysregulation of mammalian target of rapamycin pathway in plasmacytoid variant of urothelial carcinoma of the urinary bladder

(2012) Nilda D. Gonzalez-Roibon et al.   HUMAN PATHOLOGY

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Comprehensive genomic characterization of squamous cell lung cancers

(2012)   NATURE

Normal and neoplastic urothelial stem cells: getting to the root of the problem

(2012) Philip Levy Ho et al.   Nature Reviews Urology

Integrated Genomic and Gene Expression Profiling Identifies Two Major Genomic Circuits in Urothelial Carcinoma

(2012) David Lindgren et al.   PLoS One

High Levels of Phosphatase and Tensin Homolog Expression Are Associated With Tumor Progression, Tumor Recurrence, and Systemic Metastases in pT1 Urothelial Carcinoma of the Bladder: A Tissue Microarray Study of 156 Patients Treated by Transurethral Resection

(2012) Alcides Chaux et al.   UROLOGY

Immunoexpression Status and Prognostic Value of mTOR and Hypoxia-Induced Pathway Members in Primary and Metastatic Clear Cell Renal Cell Carcinomas

(2011) Luciana Schultz et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

International Phase III Trial Assessing Neoadjuvant Cisplatin, Methotrexate, and Vinblastine Chemotherapy for Muscle-Invasive Bladder Cancer: Long-Term Results of the BA06 30894 Trial

(2011)   JOURNAL OF CLINICAL ONCOLOGY

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

(2011) Yaoting Gui et al.   NATURE GENETICS

Phase 1 study of MLN8054, a selective inhibitor of Aurora A kinase in patients with advanced solid tumors

(2010) E. Claire Dees et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Combined Gene Expression and Genomic Profiling Define Two Intrinsic Molecular Subtypes of Urothelial Carcinoma and Gene Signatures for Molecular Grading and Outcome

(2010) David Lindgren et al.   CANCER RESEARCH

Molecular Grade (FGFR3/MIB-1) and EORTC Risk Scores Are Predictive in Primary Non–Muscle-Invasive Bladder Cancer

(2010) Bas W.G. van Rhijn et al.   EUROPEAN UROLOGY

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Multi-Institutional Validation of the Predictive Value of Ki-67 Labeling Index in Patients With Urinary Bladder Cancer

(2009) V. Margulis et al.   JNCI-Journal of the National Cancer Institute

HER2Overexpression and Amplification in Urothelial Carcinoma of the Bladder Is Associated WithMYCCoamplification in a Subset of Cases

(2008) Donna E. Hansel et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Molecular Pathogenesis and Diagnostics of Bladder Cancer

(2008) Anirban P. Mitra et al.   Annual Review of Pathology-Mechanisms of Disease