Article
Cardiac & Cardiovascular Systems
Are Annesonn Kalstad, Peder Langeland Myhre, Kristian Laake, Sjur Hansen Tveit, Erik Berg Schmidt, Paal Smith, Dennis Winston Trygve Nilsen, Arnljot Tveit, Morten Wang Fagerland, Svein Solheim, Ingebjorg Seljeflot, Harald Arnesen
Summary: The addition of 1.8g n-3 PUFA to standard care did not result in a significant reduction in cardiovascular events during a 2-year follow-up in elderly patients with recent AMI.
Article
Endocrinology & Metabolism
Alexis Ceecee Britten-Jones, Jordan T. Kamel, Leslie J. Roberts, Sabine Braat, Jennifer P. Craig, Richard J. MacIsaac, Laura E. Downie
Summary: In this study, it was found that long-chain omega-3 fatty acid supplements have neuroregenerative effects on peripheral nerves in type 1 diabetes patients, indicating a potential role in modulating nerve health.
Review
Nutrition & Dietetics
Linlin Huang, Fanjie Zhang, Ping Xu, Yijie Zhou, Yijun Liu, Hongdie Zhang, Xiaozhen Tan, Xinxu Ge, Yong Xu, Man Guo, Yang Long
Summary: Current guidelines recommend regular consumption of fat-rich fish to obtain sufficient omega-3 polyunsaturated fatty acids for preventing cardiovascular events. However, the cardiovascular benefits of omega-3 polyunsaturated fatty acids in patients with diabetes are uncertain. This meta-analysis of randomized controlled trials found that omega-3 fatty acid supplementation reduces cardiovascular disease risk in patients with diabetes, with eicosapentaenoic acid showing a significant effect. Further well-designed trials are needed to evaluate safety and effects on atrial fibrillation.
ADVANCES IN NUTRITION
(2023)
Article
Multidisciplinary Sciences
Aleksandra Arsic, Predrag Krstic, Marija Paunovic, Jasmina Nedovic, Vladimir Jakovljevic, Vesna Vucic
Summary: This study investigates the anti-inflammatory effects of fish oil and evening primrose oil supplementation in breast cancer patients undergoing chemotherapy. The results show improvements in PUFA status and a decrease in IL-6 levels, suggesting the potential benefits of this treatment in reducing cancer complications.
SCIENTIFIC REPORTS
(2023)
Article
Nutrition & Dietetics
Jae-Woo Lee, Yonghwan Kim, Taisun Hyun, Seunghye Song, Woojung Yang, Ye-Seul Kim, Hyo-Sun You, Young-Chang Chang, Seung-Ho Shin, Hee-Taik Kang
Summary: The study found that incorporating a low omega-6/omega-3 fatty acid ratio home meal replacement (HMR) can improve cardiometabolic parameters and reduce the prevalence of metabolic syndrome in obese individuals. This randomized crossover trial demonstrated significant reductions in BMI, weight, and MetS prevalence after a 4-week intervention with the HMR.
Article
Psychiatry
Renata Pauluci, Ana Regina Noto, Daniela Fernandez Curado, Miguel Siqueira-Campos Jr, Andreia Gomes Bezerra, Jose Carlos Fernandes Galduroz
Summary: This study aimed to evaluate if omega-3 supplementation can prevent relapse of alcohol use disorder after hospital discharge. The results showed that the group receiving omega-3 had fewer days of alcohol consumption at 2 and 3 months after discharge. Further research is needed to confirm these findings.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Erika F. H. Saunders, Dahlia Mukherjee, Tiffany Myers, Emily Wasserman, Ahmad Hameed, Venkatesh Bassappa Krishnamurthy, Beth Maclntosh, Anthony Domenichiello, Christopher E. Ramsden, Ming Wang
Summary: The study investigated the preliminary efficacy of a high n-3 plus low n-6 (H3-L6) dietary intervention in improving mood stability in Bipolar Disorder (BD) patients. Results showed that the H3-L6 group had reduced variability in mood, energy, irritability, and pain compared to the control group, but no significant differences were found in mean ratings of mood symptoms between the two groups. The dietary intervention showed potential in improving mood symptom variability in BD participants.
Article
Behavioral Sciences
Masoumeh Rajabi-Naeeni, Mahrokh Dolatian, Mostafa Qorbani, Amir Abbas Vaezi
Summary: This study aimed to evaluate the effectiveness of omega-3 and vitamin D co-supplementation on psychological distress in women of reproductive age with pre-diabetes and hypovitaminosis D. The results demonstrated a significant reduction in anxiety and improvement in sleep quality in the co-supplementation group compared with the other groups, as well as a significant decrease in depression and stress in the group receiving both supplements versus the placebo group.
BRAIN AND BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Maria Notarnicola, Valentina De Nunzio, Tamara Lippolis, Valeria Tutino, Anna Maria Cisternino, Palma Aurelia Iacovazzi, Rosa Anna Milella, Marica Gasparro, Roberto Negro, Maurizio Polignano, Maria Gabriella Caruso
Summary: This clinical trial investigated the effects of fresh table grape intake on the serum Omega-3 index. The results showed that grape intake increased oleic acid content, improved the Omega-3 index, increased adiponectin levels, and reduced FGF21 levels, leading to beneficial effects on liver function.
Review
Medicine, General & Internal
Fubin Xiao, Wei Han, Qing Yue, Jianji Ke, Baoxing Jia, Xiaojuan Fu
Summary: The meta-analysis showed that perioperative omega-3 fatty acids may be beneficial in reducing the incidence of infection after liver surgery, but did not have a significant impact on complications, mortality, liver failure, biliary leakage, bleeding, or ileus.
Article
Psychology, Developmental
Sarah A. Keim, Abigail Jude, Katie Smith, Aiman Q. Khan, Daniel L. Coury, Joseph Rausch, Shivika Udaipuria, Megan Norris, Lindsay R. Bartram, Anita R. Narayanan, Lynette K. Rogers
Summary: This study is a double-blind, randomized controlled trial that tested the effect of fatty acid supplementation in children aged 2-6 years with recently diagnosed Autism Spectrum Disorder (ASD). The results showed that the FA supplement increased levels of omega-3 and omega-6 fatty acids and reduced IL-2 levels. The treatment was well tolerated and had a high adherence rate.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2022)
Article
Nutrition & Dietetics
Nancy Samir Elbarbary, Eman Abdel Rahman Ismail, Sarah Abdelaal Mohamed
Summary: This study aimed to evaluate the effects of oral omega-3 supplementation on pediatric patients with type 1 diabetes mellitus (T1DM) and diabetic nephropathy. The results demonstrated that omega-3 fatty acids significantly improved glycemic control, dyslipidemia, delayed disease progression, and subclinical atherosclerosis in these patients.
CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Beate S. Solvik, Jannike Oyen, Ingrid Kvestad, Maria W. Markhus, Per M. Ueland, Adrian McCann, Tor A. Strand
Summary: An intervention of fatty fish intake in preschool children resulted in significant effects on biomarkers such as n-3 PUFAs, UIC, hair mercury, and plasma 1-MH. No or limited effects were observed on biomarkers related to micronutrient status, inflammation, or essential amino acid, choline oxidation, and tryptophan pathways.
JOURNAL OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Elena Garcia-Maldonado, Alexandra Alcorta, Belen Zapatera, M. Pilar Vaquero
Summary: This study investigated the serum fatty acid profile of lacto-ovo vegetarian, vegan, and omnivorous adults, and analyzed the effects of consuming a vegetable origin DHA supplement on the fatty acid profile. The results showed that the supplement effectively increased serum DHA levels and improved the n-6/n-3 ratio.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Jacqueline F. Gould, Peter J. Anderson, Lisa N. Yelland, Robert A. Gibson, Maria Makrides
Summary: This study found that prenatal DHA supplementation did not provide benefits to childhood behavior and may instead have a negative impact on behavioral functioning.
Article
Nutrition & Dietetics
Jun Tang, Wanglong Gou, Yuanqing Fu, Kelei Li, Xiaofei Guo, Tao Huang, Huijuan Liu, Duo Li, Ju-Sheng Zheng
Summary: The study suggests that postterm pregnancy may result in lower growth parameters and increased risk of thinness in preschool-age children, highlighting potential long-term impacts on offspring growth.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Medicine, General & Internal
Kui Deng, Menglei Shuai, Zheqing Zhang, Zengliang Jiang, Yuanqing Fu, Luqi Shen, Ju-Sheng Zheng, Yu-ming Chen
Summary: This study revealed the temporal relationship between adiposity and gut microbiota and identified Lachnospiraceae bacterium 3 1 57FAA CT1 as a potential mediator of the effect of adiposity on insulin resistance. The findings are helpful for the discovery of novel therapeutic targets.
Article
Agriculture, Multidisciplinary
Kelei Li, Xianfeng Shao, Huiying Li, Xiaotong Kuang, Xiaolei Song, Yan Wang, Suqin Zhu, Duo Li
Summary: This study found that a combination of folic acid and n-3 polyunsaturated fatty acids has a better preventive effect on neural tube defects induced by maternal diabetes compared to folic acid alone. The combination treatment reduced neuroepithelial cell apoptosis and regulated the expression of key genes involved in diabetes-induced defects. The combination therapy also attenuated diabetes-induced hypermethylation and overexpression of genes related to one-carbon metabolism and lowered levels of homocysteine.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Xiaotong Kuang, Kelei Li, Yan Shi, Xianfeng Shao, Huiying Li, Duo Li
Summary: The effects of dietary fiber on obesity-related traits have shown inconsistent results in previous studies. This study aimed to investigate whether genetic variants related to satiety and appetite can modify the impact of dietary fiber on obesity-related traits. The findings revealed that defatted flaxseed flour biscuits significantly reduced body weight and BMI in A-allele carriers of the FTO gene, but not in non-carriers. The biscuits also had a greater impact on fasting serum glucose reduction in participants with the CC genotype of the NPY gene compared to those with the TC and TT genotypes. Additionally, the presence of the T allele of the PCSK1 gene and the A allele of the BDNF gene increased the effectiveness of defatted flaxseed flour in reducing body weight and BMI. These results suggest that genetic variants related to satiety and appetite can modulate the effects of dietary fiber on obesity-related traits.
Article
Biochemistry & Molecular Biology
Kelei Li, Huiying Li, Xiaolei Song, Xiaotong Kuang, Shiyi Liu, Suqing Zhu, Duo Li
Summary: The present study investigated the preventive effect of mussel oil (MO) on gestational diabetes mellitus (GDM) in mice fed a high-fat and high-sucrose (HFHS) diet. Results showed that the MO group had lower AUC for OGTT and ITT compared with the control group. In addition, the MO group exhibited lower insulin resistance and fasting serum insulin levels, as well as higher levels of SphK2, Akt, and P-Akt in the liver. Overall, mussel oil showed better effects in improving glucose intolerance and insulin resistance during pregnancy compared to fish oil.
Review
Nutrition & Dietetics
Andrew J. Sinclair, Yonghua Wang, Duo Li
Summary: DHA is crucial for neural and visual function, but there is limited evidence to support the claim that low DHA levels are associated with child development disorders and neurological conditions.
Article
Food Science & Technology
Zhiyuan Liu, Jihong Yuan, Ping Wen, Xiaofei Guo, Kelei Li, Yinpeng Wang, Ruirui Liu, Yanjun Guo, Duo Li
Summary: This study aimed to assess the effects of blend oil on liver function markers in healthy subjects. The results showed that blend oil was more effective in reducing liver function markers such as aspartate aminotransferase (AST) and alanine aminotransferase (ALT) compared with soybean oil or lard alone. This suggests that blend oil may be beneficial for preventing non-alcoholic fatty liver disease in the healthy population.
Article
Biochemistry & Molecular Biology
Zhiyuan Liu, Jihong Yuan, Ping Wen, Xiaofei Guo, Haichao Wen, Yanjun Guo, Duo Li
Summary: The study found that blend oil (lard plus soybean oil) is more beneficial for body weight and liver function compared to the individual use of lard and soybean oil. It also reduces cardiometabolic risk factors in healthy subjects.
Article
Biochemistry & Molecular Biology
Andong Ji, Wei Chen, Chang Liu, Tianyu Zhang, Runjia Shi, Xinqi Wang, Huina Xu, Duo Li
Summary: The aim of this study was to investigate the preventive effect of soy protein and whey protein on high-fat diet-induced insulin resistance and its potential molecular mechanisms. The results showed that compared with the whey protein group, the soy protein group had significantly lower insulin concentration, insulin resistance, and liver weight. Furthermore, the expression levels of lipid metabolism-related genes in the liver, as well as the expression levels of glucose transport proteins and insulin receptor signaling pathway proteins in the liver and muscle, were significantly altered in the soy protein group. Additionally, the composition of gut microbiota was also changed in the soy protein group.
Article
Biochemistry & Molecular Biology
Xiangyuan Meng, Chunyan Tian, Chenqi Xie, Hao Zhang, Haoyu Wang, Mai Zhang, Zhenquan Lu, Duo Li, Lei Chen, Tianlin Gao
Summary: Obesity can greatly impair skeletal muscle function, but punicalagin (PUN) can prevent obesity-induced skeletal muscle dysfunction by regulating TET2. PUN supplementation increases muscle weight, grip strength, and muscle fiber count in obese mice. Additionally, PUN enhances the stability of TET2 protein and increases its demethylation activity.
Review
Biochemistry & Molecular Biology
Yi Ren, Fuhuai Jia, Duo Li
Summary: Instant powder foods are widely used in various food sectors and have the potential to provide health benefits with functional or beneficial compounds. The design of instant powder foods can be challenging due to their complex structures and flexible formulations. This review proposes a new classification method based on ingredient solubility and reconstituted product structure. The structure of instant powder foods is significantly influenced by their ingredients.
Article
Biochemistry & Molecular Biology
Andong Ji, Wei Chen, Tianyu Zhang, Runjia Shi, Xinqi Wang, Yan Wang, Huina Xu, Duo Li
Summary: The study found that whey protein was more effective than soy protein in preventing obesity, possibly by suppressing lipogenesis, activating brown adipose tissue, and promoting browning of inguinal white adipose tissue. In addition, lowering the protein-to-carbohydrate ratio was beneficial for combating obesity.
Article
Biochemistry & Molecular Biology
Shan Li, Mengli Li, Ronghua Guo, Ting Zhao, Xiang Gao, Kelei Li, Xiaofei Guo, Junhui Li, Duo Li
Summary: The study found that fucoidans extracted from sea cucumber Pearsonothuria graeffei (fuc-Pg) can prevent obesity and systemic inflammation through multiple mechanisms. Adding fuc-Pg significantly reduces weight gain and fat accumulation caused by a high-fat diet, improves serum lipid profile, reverses intestinal and white adipose tissue abnormalities induced by a high-fat diet, and reduces systemic inflammation.
Article
Biochemistry & Molecular Biology
Ze-Kai Fan, Wen-Jun Ma, Wei Zhang, Hui Li, Jie Zhai, Ting Zhao, Xiao-Fei Guo, Andrew J. Sinclair, Duo Li
Summary: This study investigated the relationship between changes in serum lipid metabolites and risk factors of NAFLD after fish oil or fish oil plus vitamin D intervention. The results showed that serum levels of phosphatidylcholine (PC) (16:1/22:6) were increased after interventions. These levels were correlated with liver function, lipid metabolism, and inflammation markers in NAFLD subjects.
Article
Biochemistry & Molecular Biology
Zekai Fan, Chong Wang, Ting Yang, Tianlin Gao, Dan Wang, Xiaoyan Zhao, Xiaofei Guo, Duo Li
Summary: Coffee peel extracts containing caffeine and seven monomers of flavonoids can protect against NAFLD by regulating the FGF21-adiponectin signaling pathway.
