Discrete roles and bifurcation of PTEN signaling and mTORC1-mediated anabolic metabolism underlie IL-7–driven B lymphopoiesis

Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation

(2017) Haiyan Tan et al.   IMMUNITY

Signal transducer and activator of transcription STAT5 is recruited to c-Myc super-enhancer

(2016) Sophia Pinz et al.   BMC MOLECULAR BIOLOGY

TSLP or IL-7 provide an IL-7Rα signal that is critical for human B lymphopoiesis

(2016) Terry-Ann M. Milford et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Conditional Disruption of Raptor Reveals an Essential Role for mTORC1 in B Cell Development, Survival, and Metabolism

(2016) Terri N. Iwata et al.   JOURNAL OF IMMUNOLOGY

Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination

(2016) Wendy K. Pierce et al.   JOURNAL OF MOLECULAR BIOLOGY

JUMPg: An Integrative Proteogenomics Pipeline Identifying Unannotated Proteins in Human Brain and Cancer Cells

(2016) Yuxin Li et al.   JOURNAL OF PROTEOME RESEARCH

PTEN opposes negative selection and enables oncogenic transformation of pre-B cells

(2016) Seyedmehdi Shojaee et al.   NATURE MEDICINE

The 4E-BP–eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes

(2016) Lomon So et al.   Science Signaling

PAX7 is a required target for microRNA-206-induced differentiation of fusion-negative rhabdomyosarcoma

(2016) J A Hanna et al.   Cell Death & Disease

The 4E-BP–eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes

(2016) Lomon So et al.   Science Signaling

The BioPlex Network: A Systematic Exploration of the Human Interactome

(2015) Edward L. Huttlin et al.   CELL

Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth

(2015) Joseph Mertz et al.   MOLECULAR & CELLULAR PROTEOMICS

Targeting the translation machinery in cancer

(2015) Mamatha Bhat et al.   NATURE REVIEWS DRUG DISCOVERY

hCD2-iCre and Vav-iCre Mediated Gene Recombination Patterns in Murine Hematopoietic Cells

(2015) Sabine Siegemund et al.   PLoS One

Transcriptional Control of Early T and B Cell Developmental Choices

(2014) Ellen V. Rothenberg   Annual Review of Immunology

Single-Cell Trajectory Detection Uncovers Progression and Regulatory Coordination in Human B Cell Development

(2014) Sean C. Bendall et al.   CELL

Rational combination therapies targeting survival signaling in aggressive B-cell leukemia/lymphoma

(2014) Michaela Waibel et al.   CURRENT OPINION IN HEMATOLOGY

Systematic Optimization of Long Gradient Chromatography Mass Spectrometry for Deep Analysis of Brain Proteome

(2014) Hong Wang et al.   JOURNAL OF PROTEOME RESEARCH

JUMP: A Tag-based Database Search Tool for Peptide Identification with High Sensitivity and Accuracy

(2014) Xusheng Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Rictor Is Required for Early B Cell Development in Bone Marrow

(2014) Yingchi Zhang et al.   PLoS One

Viral suppressors of the RIG-I-mediated interferon response are pre-packaged in influenza virions

(2014) Swantje Liedmann et al.   Nature Communications

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Requirement for Rictor in homeostasis and function of mature B lymphoid cells

(2013) K. Lee et al.   BLOOD

PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development

(2013) Ram K C Venigalla et al.   EMBO JOURNAL

T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming

(2013) Kai Yang et al.   IMMUNITY

Cutting Edge: Cell-Autonomous Control of IL-7 Response Revealed in a Novel Stage of Precursor B Cells

(2013) G. J. Sandoval et al.   JOURNAL OF IMMUNOLOGY

B Cell-Specific Deficiencies in mTOR Limit Humoral Immune Responses

(2013) S. Zhang et al.   JOURNAL OF IMMUNOLOGY

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers

(2013) M. Pourdehnad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR Complex 1 Plays Critical Roles in Hematopoiesis and Pten-Loss-Evoked Leukemogenesis

(2012) Demetrios Kalaitzidis et al.   Cell Stem Cell

Disruption of Fnip1 Reveals a Metabolic Checkpoint Controlling B Lymphocyte Development

(2012) Heon Park et al.   IMMUNITY

Subnuclear cyclin D3 compartments and the coordinated regulation of proliferation and immunoglobulin variable gene repression

(2012) Sarah E. Powers et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination

(2012) Alabbas Alkhatib et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+T cells

(2012) David K. Finlay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Novel Foxo1-dependent transcriptional programs control Treg cell function

(2012) Weiming Ouyang et al.   NATURE

A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation

(2012) Kyoko Ochiai et al.   NATURE IMMUNOLOGY

Molecular signatures database (MSigDB) 3.0

(2011) A. Liberzon et al.   BIOINFORMATICS

Nuclear PTEN Regulates the APC-CDH1 Tumor-Suppressive Complex in a Phosphatase-Independent Manner

(2011) Min Sup Song et al.   CELL

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

B Lymphocyte Commitment Program Is Driven by the Proto-Oncogene c-myc

(2011) M. Vallespinos et al.   JOURNAL OF IMMUNOLOGY

Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production

(2010) S. Zhang et al.   BLOOD

Phase I Study of Recombinant Human Interleukin-7 Administration in Subjects with Refractory Malignancy

(2010) C. Sportes et al.   CLINICAL CANCER RESEARCH

Transcription control of early B cell differentiation

(2010) Elizabeth M Mandel et al.   CURRENT OPINION IN IMMUNOLOGY

BCL6 is critical for the development of a diverse primary B cell repertoire

(2010) Cihangir Duy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-7 Is Essential for Homeostatic Control of T Cell Metabolism In Vivo

(2010) S. R. Jacobs et al.   JOURNAL OF IMMUNOLOGY

The PI3K Isoforms p110  and p110  Are Essential for Pre-B Cell Receptor Signaling and B Cell Development

(2010) F. Ramadani et al.   Science Signaling

IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection

(2009) I. Sereti et al.   BLOOD

PI3 Kinase Signals BCR-Dependent Mature B Cell Survival

(2009) Lakshmi Srinivasan et al.   CELL

IL-7 Dependence in Human B Lymphopoiesis Increases during Progression of Ontogeny from Cord Blood to Bone Marrow

(2009) Y. K. Parrish et al.   JOURNAL OF IMMUNOLOGY

c-Myb Is Required for Pro-B Cell Differentiation

(2009) S. P. Fahl et al.   JOURNAL OF IMMUNOLOGY

Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development

(2009) Stephen Malin et al.   NATURE IMMUNOLOGY

Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation

(2008) M. Wall et al.   BLOOD

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

Dynamic regulation ofc-Myc proto-oncogene expression during lymphocyte development revealed by aGFP-c-Myc knock-in mouse

(2008) Ching-Yu Huang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY

Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation

(2008) Hart S Dengler et al.   NATURE IMMUNOLOGY

Three-Dimensional Super-Resolution Imaging by Stochastic Optical Reconstruction Microscopy

(2008) B. Huang et al.   SCIENCE