Fungal G-protein-coupled receptors: mediators of pathogenesis and targets for disease control

The global problem of antifungal resistance: prevalence, mechanisms, and management

(2017) David S Perlin et al.   LANCET INFECTIOUS DISEASES

Discovery of new GPCR ligands to illuminate new biology

(2017) Bryan L Roth et al.   Nature Chemical Biology

New approaches towards the understanding of integral membrane proteins: A structural perspective on G protein-coupled receptors

(2017) Reinhard Grisshammer   PROTEIN SCIENCE

Stop neglecting fungi

(2017)   Nature Microbiology

Analysis of Light- and Carbon-Specific Transcriptomes Implicates a Class of G-Protein-Coupled Receptors in Cellulose Sensing

(2017) Eva Stappler et al.   mSphere

GPCR–styrene maleic acid lipid particles (GPCR–SMALPs): their nature and potential

(2016) Mark Wheatley et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The contribution of Aspergillus fumigatus stress responses to virulence and antifungal resistance

(2016) Neil A. Brown et al.   JOURNAL OF MICROBIOLOGY

Structure-based discovery of opioid analgesics with reduced side effects

(2016) Aashish Manglik et al.   NATURE

Structure-function analyses of the Pth11 receptor reveal an important role for CFEM motif and redox regulation in rice blast

(2016) Yanjun Kou et al.   NEW PHYTOLOGIST

Characterization of gprK Encoding a Putative Hybrid G-Protein-Coupled Receptor in Aspergillus fumigatus

(2016) Mun-Gu Jung et al.   PLoS One

Evolution of a G protein-coupled receptor response by mutations in regulatory network interactions

(2016) Raphaël B. Di Roberto et al.   Nature Communications

Modular Integrated Secretory System Engineering in Pichia pastoris To Enhance G-Protein Coupled Receptor Expression

(2016) Katrien Claes et al.   ACS Synthetic Biology

Lactate signalling regulates fungal β-glucan masking and immune evasion

(2016) Elizabeth R. Ballou et al.   Nature Microbiology

Genetic control of morphogenesis in Dictyostelium

(2015) William F. Loomis   DEVELOPMENTAL BIOLOGY

Unisexual versus bisexual mating in Cryptococcus neoformans: Consequences and biological impacts

(2015) Ci Fu et al.   FUNGAL GENETICS AND BIOLOGY

The impact of Septoria tritici Blotch disease on wheat: An EU perspective

(2015) Helen Fones et al.   FUNGAL GENETICS AND BIOLOGY

G-protein coupled receptor-mediated nutrient sensing and developmental control inAspergillus nidulans

(2015) Neil Andrew Brown et al.   MOLECULAR MICROBIOLOGY

Fungal pathogen uses sex pheromone receptor for chemotropic sensing of host plant signals

(2015) David Turrà et al.   NATURE

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

The CarO rhodopsin of the fungus Fusarium fujikuroi is a light-driven proton pump that retards spore germination

(2015) Jorge García-Martínez et al.   Scientific Reports

Hunting for the function of orphan GPCRs - beyond the search for the endogenous ligand

(2014) Raise Ahmad et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ste18p Is a Positive Control Element in the Mating Process of Candida albicans

(2014) Hui Lu et al.   EUKARYOTIC CELL

How nutritional status signalling coordinates metabolism and lignocellulolytic enzyme secretion

(2014) Neil Andrew Brown et al.   FUNGAL GENETICS AND BIOLOGY

The cryptic sexual strategies of human fungal pathogens

(2014) Iuliana V. Ene et al.   NATURE REVIEWS MICROBIOLOGY

Quorum Sensing-Mediated, Cell Density-Dependent Regulation of Growth and Virulence in Cryptococcus neoformans

(2014) P. Albuquerque et al.   mBio

Global Survey of Canonical Aspergillus flavus G Protein-Coupled Receptors

(2014) K. J. Affeldt et al.   mBio

Structural and biophysical characterisation of G protein-coupled receptor ligand binding using resonance energy transfer and fluorescent labelling techniques

(2013) Richard J. Ward et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Unisexual Reproduction Enhances Fungal Competitiveness by Promoting Habitat Exploration via Hyphal Growth and Sporulation

(2013) Sujal S. Phadke et al.   EUKARYOTIC CELL

Evolution of fungal sexual reproduction

(2013) Joseph Heitman et al.   MYCOLOGIA

Crop pests and pathogens move polewards in a warming world

(2013) Daniel P. Bebber et al.   Nature Climate Change

The Late Endosomal HOPS Complex Anchors Active G-Protein Signaling Essential for Pathogenesis in Magnaporthe oryzae

(2013) Ravikrishna Ramanujam et al.   PLoS Pathogens

Receptor-mediated signaling in Aspergillus fumigatus

(2013) C. M. Grice et al.   Frontiers in Microbiology

Mycotoxin contamination of the feed supply chain: Implications for animal productivity and feed security

(2012) Wayne L. Bryden   ANIMAL FEED SCIENCE AND TECHNOLOGY

Non-genomic progesterone signalling and its non-canonical receptor

(2012) Patricia Moussatche et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Regulation of Filamentous Growth in Yeast

(2012) Paul J. Cullen et al.   GENETICS

Tight Control of Trehalose Content Is Required for Efficient Heat-induced Cell Elongation inCandida albicans

(2012) Joke Serneels et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quorum sensing in fungi – a review

(2012) Patrícia Albuquerque et al.   MEDICAL MYCOLOGY

Emerging fungal threats to animal, plant and ecosystem health

(2012) Matthew C. Fisher et al.   NATURE

Update on mechanisms of azole resistance inMycosphaerella graminicolaand implications for future control

(2012) Hans J Cools et al.   PEST MANAGEMENT SCIENCE

LAAT-1 Is the Lysosomal Lysine/Arginine Transporter That Maintains Amino Acid Homeostasis

(2012) B. Liu et al.   SCIENCE

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

Regulation of phenotypic transitions in the fungal pathogenCandida albicans

(2012) Guanghua Huang   Virulence

Nanobody stabilization of G protein-coupled receptor conformational states

(2011) Jan Steyaert et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Cryptococcal Titan Cell Formation Is Regulated by G-Protein Signaling in Response to Multiple Stimuli

(2011) Laura H. Okagaki et al.   EUKARYOTIC CELL

Causes and Consequences of Variability in Peptide Mating Pheromones of Ascomycete Fungi

(2011) S. H. Martin et al.   MOLECULAR BIOLOGY AND EVOLUTION

Ligand discovery from a dopamine D3 receptor homology model and crystal structure

(2011) Jens Carlsson et al.   Nature Chemical Biology

Heptahelical Receptors GprC and GprD of Aspergillus fumigatus Are Essential Regulators of Colony Growth, Hyphal Morphogenesis, and Virulence

(2010) A. Gehrke et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Evolution of Eukaryotic Microbial Pathogens via Covert Sexual Reproduction

(2010) Joseph Heitman   Cell Host & Microbe

Conserved Regulators of Mating Are Essential for Aspergillus fumigatus Cleistothecium Formation

(2010) Edyta Szewczyk et al.   EUKARYOTIC CELL

Regulation of white-opaque switching in Candida albicans

(2010) Joachim Morschhäuser   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

A constitutively active GPCR governs morphogenic transitions in Cryptococcus neoformans

(2009) Yen-Ping Hsueh et al.   EMBO JOURNAL

Spores as Infectious Propagules of Cryptococcus neoformans

(2009) R. Velagapudi et al.   INFECTION AND IMMUNITY

Azole resistance in Aspergillus fumigatus: a side-effect of environmental fungicide use?

(2009) Paul E Verweij et al.   LANCET INFECTIOUS DISEASES

Nutrient sensing G protein-coupled receptors: interesting targets for antifungals?

(2009) Patrick Van Dijck   MEDICAL MYCOLOGY

Suppression of anti-Candidaactivity of macrophages by a quorum-sensing molecule, farnesol, through induction of oxidative stress

(2009) Shigeru Abe et al.   MICROBIOLOGY AND IMMUNOLOGY

Fluorescent and Bioluminescent Protein-Fragment Complementation Assays in the Study of G Protein-Coupled Receptor Oligomerization and Signaling

(2009) P.-A. Vidi et al.   MOLECULAR PHARMACOLOGY

Oxygenase Coordination Is Required for Morphological Transition and the Host–Fungus Interaction ofAspergillus flavus

(2009) Sigal Horowitz Brown et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Fusarium oxysporumhijacks COI1-mediated jasmonate signaling to promote disease development in Arabidopsis

(2009) Louise F. Thatcher et al.   PLANT JOURNAL

The fatal fungal outbreak on Vancouver Island is characterized by enhanced intracellular parasitism driven by mitochondrial regulation

(2009) H. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-based discovery of  2-adrenergic receptor ligands

(2009) P. Kolb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Aromatic Alcohol Production in Candida albicans

(2008) S. Ghosh et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Heterotrimeric G-Protein Subunit Function inCandida albicans: both the α and β Subunits of the Pheromone Response G Protein Are Required for Mating

(2008) Daniel Dignard et al.   EUKARYOTIC CELL

Combined Inactivation of the Candida albicans GPR1 and TPS2 Genes Results in Avirulence in a Mouse Model for Systemic Infection

(2008) M. M. Maidan et al.   INFECTION AND IMMUNITY

Gliotoxin Production inAspergillus fumigatusContributes to Host‐Specific Differences in Virulence

(2008) Sara Spikes et al.   JOURNAL OF INFECTIOUS DISEASES

Farnesol induces the transcriptional accumulation of the Aspergillus nidulans Apoptosis-Inducing Factor (AIF)-like mitochondrial oxidoreductase

(2008) Marcela Savoldi et al.   MOLECULAR MICROBIOLOGY

The Parasexual Cycle in Candida albicans Provides an Alternative Pathway to Meiosis for the Formation of Recombinant Strains

(2008) Anja Forche et al.   PLOS BIOLOGY