Journal
CHEMISTRYSELECT
Volume 3, Issue 6, Pages 1708-1712Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201702925
Keywords
[4+2] annulation; N-heterocyclic carbene; isochromanone; isoquinolinone; o-quinodimethane
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Funding
- National Natural Science Foundation of China [21242014, 21372101]
- PAPD
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An efficient insitu generation of ortho-quinodimethane (o-QDM) from 2-methyl-3,5-dinitrobenzoic acid through N-Heterocyclic Carbene (NHC) catalysis, which underwent a formal [4+2] annulation with activated C=O (or C=N) bonds for the assembly of isoquinolinone and isochromanone scaffolds, was disclosed. This method features challenging direct functionalizations of C(sp3)-H bond, readily available starting materials, mild reaction conditions and good yields.
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