Plant Adaptogens: Natural Medicaments for 21st Century?

Hypericum perforatum (St John's wort) beyond depression: A therapeutic perspective for pain conditions

(2017) Nicoletta Galeotti   JOURNAL OF ETHNOPHARMACOLOGY

A current update on phytochemistry, pharmacology and herb–drug interactions of Hypericum perforatum

(2017) Vinay S. Velingkar et al.   PHYTOCHEMISTRY REVIEWS

Improved enzyme-mediated synthesis and supramolecular self-assembly of naturally occurring conjugates of β-sitosterol

(2017) Martina Wimmerová et al.   STEROIDS

Stimulation of Neurogenesis and Synaptogenesis by Bilobalide and Quercetin via Common Final Pathway in Hippocampal Neurons

(2017) Flaubert Tchantchou et al.   JOURNAL OF ALZHEIMERS DISEASE

Design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterase 2

(2016) Li-Wei Zou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Rhodiola rosea L. as a putative botanical antidepressant

(2016) Jay D. Amsterdam et al.   PHYTOMEDICINE

A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies

(2016) Angelo A. Izzo et al.   PHYTOTHERAPY RESEARCH

Plant ecdysteroids: plant sterols with intriguing distributions, biological effects and relations to plant hormones

(2016) Danuše Tarkowská et al.   PLANTA

Bivalent ligands incorporating curcumin and diosgenin as multifunctional compounds against Alzheimer’s disease

(2015) Jeremy E. Chojnacki et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Biosynthesis and biotechnological production of ginsenosides

(2015) Yu-Jin Kim et al.   BIOTECHNOLOGY ADVANCES

Rhodiola plants: Chemistry and biological activity

(2015) Hsiu-Mei Chiang et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Biotechnological production of eleutherosides: current state and perspectives

(2014) Hosakatte Niranjana Murthy et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Abrupt Discontinuation Compared With a 1-Week Taper Regimen in Depressed Outpatients Treated for 24 Weeks With Desvenlafaxine 50 mg/d

(2014) Arif Khan et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Saponins: the phytochemical with an emerging potential for curing clinical depression

(2014) Ghulam Abbas et al.   NATURAL PRODUCT RESEARCH

Bergenia crassifolia (L.) Fritsch – Pharmacology and phytochemistry

(2014) Alexander N. Shikov et al.   PHYTOMEDICINE

The discovery of Yuanzhi-1, a triterpenoid saponin derived from the traditional Chinese medicine, has antidepressant-like activity

(2014) Zeng-liang Jin et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Do Other Hypericum Species Have Medical Potential As St. John’s Wort (Hypericum perforatum)?

(2013) G. Stojanovic et al.   CURRENT MEDICINAL CHEMISTRY

Influence of Gastrointestinal Digestion and Edible Plant Combination on Oral Bioavailability of Triterpene Saponins, Using a Biomimetic Digestion and Absorption System and Determination by HPLC

(2013) Shun-Xing Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Hepatoprotective Effects of Ixora parviflora Extract against Exhaustive Exercise-Induced Oxidative Stress in Mice

(2013) Nai-Wen Kan et al.   MOLECULES

The antidepressant-like effect of bacopaside I: Possible involvement of the oxidative stress system and the noradrenergic system

(2013) Xiaojun Liu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The world ginseng market and the ginseng (Korea)

(2013) In-Ho Baeg et al.   Journal of Ginseng Research

Antidepressant-like effects of ginsenoside Rg1 are due to activation of the BDNF signalling pathway and neurogenesis in the hippocampus

(2012) Bo Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Absorption, Disposition, and Pharmacokinetics of Saponins from Chinese Medicinal Herbs: What Do We Know and What Do We Need to Know More?

(2012) Ke Yu et al.   CURRENT DRUG METABOLISM

Effects of salidroside on exhaustive exercise-induced oxidative stress in rats

(2012) JIANSHENG XU et al.   Molecular Medicine Reports

Terpenoids as Potential Anti-Alzheimer’s Disease Therapeutics

(2012) Ki-Yeol Yoo et al.   MOLECULES

Potential Antidepressant Activity ofAreca catechuNut via Elevation of Serotonin and Noradrenaline in the Hippocampus of Rats

(2012) Ghulam Abbas et al.   PHYTOTHERAPY RESEARCH

Effects ofHypericum montbrettiExtract on the Central Nervous System and Involvement of GABA (A)/Benzodiazepine Receptors in its Pharmacological Activity

(2012) Özgür Devrim Can et al.   PHYTOTHERAPY RESEARCH

Ginsenosides as anticancer agents: In vitro and in vivo activities, structure–activity relationships, and molecular mechanisms of action

(2012) Subhasree Ashok Nag   Frontiers in Pharmacology

Ketamine plus imipramine treatment induces antidepressant-like behavior and increases CREB and BDNF protein levels and PKA and PKC phosphorylation in rat brain

(2011) Gislaine Z. Réus et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of treatment with St. John's Wort on blood glucose levels and pain perceptions of streptozotocin-diabetic rats

(2011) Özgür Devrim Can et al.   FITOTERAPIA

Panax ginsengRhodiola rosea and Schisandra chinensis

(2011) Shun-Wan Chan   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

A High Content Drug Screen Identifies Ursolic Acid as an Inhibitor of Amyloid β Protein Interactions with Its Receptor CD36

(2011) Kim Wilkinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HPTLC-Densitometric Method for Determination of Eleutherosides B, E, and E1 in Different Eleutherococcus Species

(2011) L. Ciesla et al.   JOURNAL OF CHROMATOGRAPHIC SCIENCE

Ginkgolide B reduces neuronal cell apoptosis in the hemorrhagic rat brain: Possible involvement of Toll-like receptor 4/nuclear factor-kappa B pathway

(2011) Yue-Yu Hu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Ginsenoside Rb3 exerts antidepressant-like effects in several animal models

(2011) Jihong Cui et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Cryptotanshinione Inhibits β-Amyloid Aggregation and Protects Damage from β-Amyloid in SH-SY5Y Cells

(2011) Zhengrong Mei et al.   NEUROCHEMICAL RESEARCH

Molecular activities, biosynthesis and evolution of triterpenoid saponins

(2011) Jörg M. Augustin et al.   PHYTOCHEMISTRY

The antidepressant effects and mechanism of action of total saponins from the caudexes and leaves of Panax notoginseng in animal models of depression

(2011) Hui Xiang et al.   PHYTOMEDICINE

Effects of long-term antidepressant treatment on oxidative status in major depressive disorder: A 24-week follow-up study

(2011) Vahap Ozan Kotan et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Cryptotanshinione upregulates α-secretase by activation PI3K pathway in cortical neurons

(2010) Zhengrong Mei et al.   BRAIN RESEARCH

Ginkgolide B protects hippocampal neurons from apoptosis induced by beta-amyloid 25–35 partly via up-regulation of brain-derived neurotrophic factor

(2010) Qian Xiao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Anti-oxidative effect of Rhodiola imbricata root extract in rats during cold, hypoxia and restraint (C–H–R) exposure and post-stress recovery

(2010) Vanita Gupta et al.   FOOD AND CHEMICAL TOXICOLOGY

Panax ginseng (G115) improves aspects of working memory performance and subjective ratings of calmness in healthy young adults

(2010) Jonathon L. Reay et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

SCLM, total saponins extracted fromChaihu-jia-longgu-muli-tang, reduces chronic mild stress-induced apoptosis in the hippocampus in mice

(2010) Yadong Liu et al.   PHARMACEUTICAL BIOLOGY

Chemical composition of the essential oils of Rhodiola rosea L. of three different origins

(2010) Milka Todorova et al.   Pharmacognosy Magazine

Rosenroot (Rhodiola rosea): Traditional use, chemical composition, pharmacology and clinical efficacy

(2010) A. Panossian et al.   PHYTOMEDICINE

20(S)-protopanaxadiol, an active ginseng metabolite, exhibits strong antidepressant-like effects in animal tests

(2010) Changjiang Xu et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Tenuifolin, an extract derived fromtenuigenin, inhibits amyloid-β secretionin vitro

(2009) J. Lv et al.   Acta Physiologica

Anti-ischemic activities of Aralia cordata and its active component, oleanolic acid

(2009) Soon Ock Cho et al.   ARCHIVES OF PHARMACAL RESEARCH

Evaluation of hydrogen bonds of ecdysteroids in the ligand–receptor interactions using a protein modeling system

(2009) Toshiyuki Harada et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Neurobiological mechanisms in major depressive disorder

(2009) M. aan het Rot et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Protective effects of Ginkgo biloba extract (EGb761) and its constituents quercetin and ginkgolide B against β-amyloid peptide-induced toxicity in SH-SY5Y cells

(2009) Chun Shi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Aralia cordata Protects Against Amyloid β Protein (25–35)–Induced Neurotoxicity in Cultured Neurons and Has Antidementia Activities in Mice

(2009) Soon Ock Cho et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Neurogenesis-Dependent and -Independent Effects of Fluoxetine in an Animal Model of Anxiety/Depression

(2009) Denis J. David et al.   NEURON

Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates β-amyloid deposition through upregulating α-secretase in vivo and in vitro

(2009) Zhengrong Mei et al.   NEUROSCIENCE LETTERS

Chemistry and pharmacology of Rhaponticum carthamoides: A review

(2009) Ladislav Kokoska et al.   PHYTOCHEMISTRY

Anti-inflammatory activity ofRhodiola rosea- “a second-generation adaptogen”

(2009) Pooja et al.   PHYTOTHERAPY RESEARCH

Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression

(2009) Haixia Dang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Adaptogenic effect of black and fermented leaves of Bergenia crassifolia L. in mice

(2009) Alexander N. Shikov et al.   Journal of Functional Foods

Panax Ginseng Enhances Cognitive Performance in Alzheimer Disease

(2008) Soon-Tae Lee et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Antioxidant Evaluation of Three Adaptogen Extracts

(2008) Tung-Sheng Chen et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Effect of several flavonoid-containing plant preparations on activity of mitochondrial ATP-dependent potassium channel

(2008) G. D. Mironova et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

The Use of Lipid-Based Formulations to Increase the Oral Bioavailability of Panax Notoginseng Saponins Following a Single Oral Gavage to Rats

(2008) Jing Xiong et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

A dose dependent adaptogenic and safety evaluation of Rhodiola imbricata Edgew, a high altitude rhizome

(2008) V. Gupta et al.   FOOD AND CHEMICAL TOXICOLOGY

Ginkgolides protect against amyloid-β1–42-mediated synapse damage in vitro

(2008) Clive Bate et al.   Molecular Neurodegeneration

Effects of tenuifolin extracted from radix polygalae on learning and memory: A behavioral and biochemical study on aged and amnesic mice

(2008) Hong Zhang et al.   PHYTOMEDICINE

A Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study of the Standardised Extract SHR-5 of the Roots ofRhodiola roseain the Treatment of Subjects with Stress-Related Fatigue

(2008) Erik Olsson et al.   PLANTA MEDICA

Protection against β-amyloid induced abnormal synaptic function and cell death by Ginkgolide J

(2007) Ottavio Vitolo et al.   NEUROBIOLOGY OF AGING

Withania somnifera: An Indian ginseng

(2007) S.K. Kulkarni et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY