Journal
CHEMISTRYSELECT
Volume 3, Issue 12, Pages 3511-3515Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201800177
Keywords
Alkyne; Copper; Pyrazole; Regioselective reaction; Alkynylation
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Funding
- Department of Science & Technology, Government of India, New Delhi [SR/FST/CSII-026/2013]
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A copper-catalyzed regioselective N-alkynylation of unsymmetrically substituted pyrazoles from the reactions of pyrazoles with aromatic and aliphatic terminal alkynes under aerobic condition is reported here. The single crystal XRD structures of the N-substituted pyrazoles confirm the regioselectivity. The cytotoxicity towards MDA-MB 231 breast cancer cells of three of the alkynyl pyrazoles has been investigated.
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