Article
Food Science & Technology
Deniz Gunal-Koroglu, Hilal Yilmaz, Semra Turan, Esra Capanoglu
Summary: This paper investigated the fluorescence quenching effect of two phenolic extracts (red and yellow onion skin) on lentil protein isolate (LPI), and analyzed their thermodynamic parameters. The study found that the red onion skin extract had a more effective quenching effect at lower concentrations, while the yellow onion skin extract caused a blue shift at higher concentrations.
Article
Environmental Sciences
Mysoon M. Al-Ansari, Latifah Al-Humaid, Majdoleen Aldawsari, Islem Faraj Abid, G. K. Jhanani, Rajasree Shanmuganathan
Summary: In this study, ethanol extraction was used to optimize the maximum yield of quercetin from small onions, and its antioxidant activity was investigated. The highest quercetin yield was obtained with an ethanol: water ratio. RP-HPLC analysis revealed the presence of 2,122 mg/g of quercetin and 0.34 mg/g of isorhamnetin in the extracted material. The onion skin extract had a total phenolic content of 301.03 mg GAE/g dry weight and 156 mg/g of quercetin equivalents. DPPH and ABTS free radical scavenging potentials of the extract were dose-dependent, with IC50 values of 62.27 mu g/mL and 53.65 mu g/mL, respectively. Therefore, the study suggests that small onion skin extract rich in quercetin may have potential as an antioxidant and anticancer agent.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Malgorzata Olszowy-Tomczyk, Sylwia Garbaczewska, Dorota Wianowska
Summary: This study showed that the fungistatic and antioxidant activities of onion extracts depend on the type of liquid used for extraction and the extraction technique. The antioxidant properties of white and red onion extracts were found to change with the temperature of the pressurized hot water extraction process, which is similar to the changes that occur during cooking. The research demonstrated the significant contribution of quercetin and phenols, the main components of onions, to the antifungal and antioxidant properties of the extracts. The study's findings suggest that onion waste materials, such as onion husks, have high potential for producing functional materials and should be popularized.
Article
Chemistry, Applied
Arti Nile, Enkhtaivan Gansukh, Gyun-Seok Park, Doo-Hwan Kim, Shivraj Hariram Nile
Summary: The study demonstrated that flavonol glucosides extracted from red onion solid waste showed significant antioxidant, enzyme inhibitory, and anticancer effects, suggesting their potential utility in therapeutic and functional food development.
Article
Biochemistry & Molecular Biology
Natalia Rosiak, Judyta Cielecka-Piontek, Robert Skibinski, Kornelia Lewandowska, Waldemar Bednarski, Przemyslaw Zalewski
Summary: The influence of ionizing radiation on the physicochemical properties of quercetin and rutin in the solid state was investigated. The results showed that irradiation caused the formation of a small number of free radicals, but did not change the chemical structure or antioxidant properties of the tested flavonoids. Spectroscopic and chromatographic analyses confirmed the radiostability of quercetin and rutin.
Article
Electrochemistry
Gabriella Magarelli, Juliana K. S. Dutra, Rafaela G. da Silva, Bruna M. D. Tripode, Lucia Hoffmann, Clarissa S. P. de Castro
Summary: A voltammetric method was used to detect differences in phenolic compounds between Gossypium hirsutum and Gossypium barbadense, and to determine the impact of caterpillar infestation. The results showed that older leaves of G. hirsutum had higher levels of phenolic compounds when infested.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Food Science & Technology
S. Savitha, Nikita Bhatkar, Snehasis Chakraborty, Bhaskar N. Thorat
Summary: This review emphasizes the role of quercetin in onions, the effects of onion dehydration, and the importance of improving immunity. Dehydrated onions can be a convenient and economical source of phytochemicals, essential for enhancing immunity and fighting viral infections.
Article
Biochemistry & Molecular Biology
Alice Cattivelli, Lorenzo Nissen, Flavia Casciano, Davide Tagliazucchi, Andrea Gianotti
Summary: In this study, the stability and bioaccessibility of phenolics in differently cooked red-skinned onion were investigated. The results showed that raw onions had a significant increase in beneficial taxa and higher inhibition of opportunistic bacteria compared to heat-treated onions. This study is one of the first to explore the impact of different cooking methods on phenolic metabolism and microbiota composition in the large intestine of humans, providing important insights for fine-tuning the antioxidant nature of foods.
Article
Chemistry, Analytical
Abdullah, Esra Alveroglu, Aamna Balouch, Sabir Khan, Ali Muhammad Mahar, Muhammad Saqaf Jagirani, Abdul Hameed Pato
Summary: In this study, a selective magnetite molecular imprinted polymer was synthesized for the first time using a simple ultrasonic mediated co-precipitation polymerization route, and applied for the selective extraction of quercetin from onion samples. The results showed that the polymeric sorbent had a good extraction performance and exhibited promising potential for regeneration.
MICROCHEMICAL JOURNAL
(2021)
Article
Plant Sciences
Ivana Buljeta, Ina Corkovic, Anita Pichler, Josip Simunovic, Mirela Kopjar
Summary: This study investigates the use of apple and citrus fibers as carriers of quercetin, aiming to improve its solubility and permeability. The results show that apple fibers exhibit higher affinity towards quercetin and have greater antioxidant potential compared to citrus fibers. The adsorption of quercetin also affects the thermal stability of the fiber aggregates, with negative impact on apple fiber and positive impact on citrus fiber.
Article
Food Science & Technology
Lan Gao, Christine Schafer, Katja O'Reardon, Eva Gorgus, Ruth Schulte-Hubbert, Dieter Schrenk
Summary: Onion juice showed mild mutagenicity and toxicity in the Ames test, with the major flavonoid glycosides quercetin and rutin not being the main contributors to these effects.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Deniz Gunal-Koroglu, Semra Turan, Esra Capanoglu
Summary: This study aimed to evaluate the protein-phenolic interaction in functional crackers made with wheat/lentil flour and onion skin phenolics. The recovery of phenolics and antioxidants in the crackers decreased with a higher addition of phenolics. The nutritional attributes of the functional crackers were similar, but they had lower L* values and higher a* values. The phenolic/antioxidant recovery in the functional crackers decreased with an increased ratio of phenolic supplements. The bioavailability index of phenolics was higher in co-digested crackers compared to functional crackers, while the bioavailability index of antioxidants was mostly similar. Quercetin was only identified in functional wheat/lentil crackers with onion skin phenolic extract. After digestion, the peptides of wheat crackers could not be identified, while the level of free amino groups in co-digested/functional crackers was lower than the control group.
Review
Biochemistry & Molecular Biology
Weidong Qi, Wanxiang Qi, Dongwei Xiong, Miao Long
Summary: This review explores the biological activities of quercetin, including its antioxidant and antibacterial properties, intervention effects on pesticide poisoning, detoxification process, and its potential in reducing mycotoxin toxicity. The harmful effects of heavy metal poisoning on quercetin application are also evaluated. This review provides valuable insights for the clinical application of quercetin.
Article
Biochemistry & Molecular Biology
Alicia Moreno-Ortega, Iziar A. Ludwig, Maria-Jose Motilva, Jose Manuel Moreno-Rojas, Gema Pereira-Caro
Summary: This study monitored the excretion of organosulfur compounds (OSCs) in urine after acute ingestion of black onion. A total of 31 OSCs were detected, with the main components being methiin, isoalliin, and deoxypropiin. N-acetylated metabolites of the major OSCs were also found in urine. This study provides the basis for further research on the metabolism of OSCs after black onion consumption.
Review
Chemistry, Applied
Sara Chadorshabi, Somayeh Hallaj-Nezhadi, Zahra Ghasempour
Summary: Onion waste is a major environmental concern, but red onion skin contains bioactive compounds that can be extracted and used to produce value-added products. This study summarizes various methods for extracting compounds from red onion waste and investigates the potential industrial applications of natural bioactives derived from red onion skin in food systems.
Review
Biotechnology & Applied Microbiology
Min Shi, Pan Liao, Shivraj Hariram Nile, Milen Georgiev, Guoyin Kai
Summary: Hairy roots, or transformed root cultures, provide a feasible approach for producing valuable secondary metabolites from medicinal plants. Various strategies have been used to enhance secondary metabolite production in hairy roots, including increasing substrate availability, regulating key biosynthetic genes, multigene engineering, and introducing new genes. Recent research focuses on techniques to boost production of desired secondary metabolites and the development of new technologies to study these metabolites.
TRENDS IN BIOTECHNOLOGY
(2021)
Article
Chemistry, Applied
Arti Nile, Enkhtaivan Gansukh, Gyun-Seok Park, Doo-Hwan Kim, Shivraj Hariram Nile
Summary: The study demonstrated that flavonol glucosides extracted from red onion solid waste showed significant antioxidant, enzyme inhibitory, and anticancer effects, suggesting their potential utility in therapeutic and functional food development.
Article
Chemistry, Applied
Enkhtaivan Gansukh, Arti Nile, Doo Hwan Kim, Jae Wook Oh, Shivraj Hariram Nile
Summary: Quercetin and its derivatives were screened for their potential antiviral properties targeting the cap-binding site of the influenza viral RNA polymerase PB2 subunit. Among them, quercetin 3'-glucuronide (Q3G) showed the strongest binding affinity, while quercetin 3'-glucuronide (Q7G) exhibited the highest anti-influenza activity with low cytotoxic effects.
Article
Biochemistry & Molecular Biology
Rohini Pungle, Shivraj Hariram Nile, Arun S. Kharat
Summary: Plant extracts were used to synthesize silver nanoparticles, which showed promising antimicrobial activity against multidrug-resistant Gram-negative clinical isolates.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Review
Food Science & Technology
Ramkumar Samynathan, Muthu Thiruvengadam, Shivraj Hariram Nile, Mohammad Ali Shariati, Maksim Rebezov, Raghvendra Kumar Mishra, Baskar Venkidasamy, Sureshkumar Periyasamy, Ill-Min Chung, Mirian Pateiro, Jose M. Lorenzo
Summary: Tea, made from the shoots of Camellia sinensis (L.) O. Kuntze, is the most commonly consumed nonalcoholic drink worldwide. The metabolites in tea have a wide range of therapeutic applications, particularly their antioxidant and disease-fighting properties in synergy with synthetic drugs. The bioactive flavonoids in tea also contribute to health benefits.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Agriculture, Multidisciplinary
Shivraj Hariram Nile, Baskar Venkidasamy, Ramkumar Samynathan, Arti Nile, Keding Shao, Tingting Chen, Meihong Sun, Muhammad Usman Khan, Nalok Dutta, Muthu Thiruvengadam, Mohammad Ali Shariati, Maksim Rebezov, Guoyin Kai
Summary: Soybean processing waste has the potential to be a sustainable source of phytochemicals and functional foods. Various analytical methods have been used to characterize phytochemicals, nutrients, and minerals from soybean processing waste. Utilization of this waste can increase production of bioactive compounds, nutritional supplements, and cosmetic ingredients, while also reducing environmental pollution through proper use.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Plant Sciences
Shivraj Hariram Nile, Yi Liang, Zengyuan Wang, Jiayi Zheng, Chengtao Sun, Arti Nile, Gopal Patel, Guoyin Kai
Summary: The ethanol extract of ashwagandha roots contains bioactive compounds that demonstrate antioxidant, anti-inflammatory, and cytotoxic effects on lung cancer cells. These findings suggest that ashwagandha could be a potential candidate for the treatment of inflammation, oxidative stress, and lung cancer.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Plant Sciences
Eun Young Ko, Shivraj Hariram Nile
Summary: Different cooking methods have an impact on the composition and biological properties of organosulfur compounds in onions. Stir-frying is an effective method to retain the highest amount of health-beneficial organosulfur compounds in onions.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Review
Biotechnology & Applied Microbiology
Shivraj Hariram Nile, Muthu Thiruvengadam, Yao Wang, Ramkumar Samynathan, Mohammad Ali Shariati, Maksim Rebezov, Arti Nile, Meihong Sun, Baskar Venkidasamy, Jianbo Xiao, Guoyin Kai
Summary: Nano-priming is an innovative seed priming technology that improves seed germination, growth, and yield by providing resistance to various stresses in plants. It induces multiple mechanisms such as breaking seed dormancy and promoting seed germination, leading to the production of primary and secondary metabolites in plants.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Cell Biology
Rohini Pungle, Shivraj Hariram Nile, Nilesh Makwana, Ragini Singh, Rana P. Singh, Arun S. Kharat
Summary: Green synthesis of silver nanoparticles using Tridax procumbens leaf extract showed antimicrobial and anticancer activities.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Editorial Material
Plant Sciences
Muthu Thiruvengadam, Shivraj Nile, Baskar Venkidasamy
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Pharmacology & Pharmacy
Yuqin Zhang, Liping Hua, Chunfeng Lin, Mingzhou Yuan, Wei Xu, Anand D. Raj, Baskar Venkidasamy, Carlos L. Cespedes-Acuna, Shivraj Hariram Nile, Guohong Yan, Haiyin Zheng
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Asha S. Salunke, Shivraj Hariram Nile, Arun S. Kharat
Summary: This study identified potential fibrinolytic enzymes from six Bacillus spp. isolated from fruit and vegetable waste. The purified enzymes showed excellent fibrinolytic activity and could significantly degrade blood clot.
Article
Biochemistry & Molecular Biology
Shivraj Hariram Nile, Dipalee Thombre, Amruta Shelar, Krithika Gosavi, Jaiprakash Sangshetti, Weiping Zhang, Elwira Sieniawska, Rajendra Patil, Guoyin Kai
Summary: In this study, biogenic selenium nanoparticles were prepared and functionalized with nystatin to inhibit the growth, morphogenesis, and biofilm of Candida albicans. The nanoparticles were spherical in shape with a size range of 220-240 nm. The functionalization of nystatin on the nanoparticles was confirmed, and the nanoparticles showed antifungal activity on C. albicans. The nanoparticles act through the RAS/cAMP/PKA signaling pathway, and they are not cytotoxic.
Review
Nanoscience & Nanotechnology
Amruta Shelar, Shivraj Hariram Nile, Ajay Vikram Singh, Dirk Rothenstein, Joachim Bill, Jianbo Xiao, Manohar Chaskar, Guoyin Kai, Rajendra Patil
Summary: Agro seeds are susceptible to environmental stress, harming seed vigor, crop growth, and productivity. Chemical seed treatments can enhance germination but they also have negative environmental impacts. Sustainable nano-based agrochemicals can improve seed viability and control release of active ingredients, but their application raises concerns about nanomaterial safety, exposure, and toxicity to the environment and human health.
NANO-MICRO LETTERS
(2023)