Article
Biophysics
S. Oliviero, M. Roberts, R. Owen, G. C. Reilly, I. Bellantuono, E. Dall'Ara
Summary: Different microCT-based microFE models were evaluated for predicting mechanical properties of mouse tibia under compressive load. The study found that hexahedral models with homogeneous material properties based on in vivo microCT images showed the best prediction accuracy.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2021)
Article
Engineering, Biomedical
S. Oliviero, R. Owen, G. C. Reilly, I Bellantuono, E. Dall'Ara
Summary: This study evaluates the ability of different microCT-based bone parameters and microFE models to predict tibial structural mechanical properties in compression. Results show that microFE models can improve the estimation of mouse tibia structural properties and define an optimal failure criterion. The non-invasive method can be longitudinally applied for evaluating temporal changes in bone strength.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Engineering, Biomedical
Mohammad Saber Hashemi, Aaron McCrary, Karl H. Kraus, Azadeh Sheidaei
Summary: A tunable stiffness bone rod was designed to address the shortcomings of existing bone fixation devices, offering patient-specific design and preventing further deformation under higher-than-normal loads.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Endocrinology & Metabolism
Sara Oliviero, Vee San Cheong, Bryant C. Roberts, Carlos Amnael Orozco Diaz, William Griffiths, Ilaria Bellantuono, Enrico Dall'Ara
Summary: The aim of this study was to evaluate the intra- and inter-operator reproducibility of several bone parameters measured from microCT images. The results showed that both intra- and inter-operator reproducibility were acceptable, although there were slight differences in some parameters. MicroCT and microFE models provide reproducible measurements for non-invasive assessment of the mouse tibia properties.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Qian Chen, Ziyan Wang, Chengyu Yang, Baochen Li, Xingxing Ren, Chao Liu, Lei Xi
Summary: Osteogenesis and angiogenesis are crucial for bone homeostasis and repair, but the understanding of neovascular dynamics has been limited. In this study, optical-resolution photoacoustic microscopy (ORPAM) was used for label-free, intravital, long-term observation of bone vascular dynamics, including angiogenesis and remodeling. The efficacy of locally-applied vascular endothelial growth factor (VEGF) in promoting angiogenesis was confirmed using ex vivo confocal microscopy and micro-computed tomography imaging. The findings demonstrated the usefulness of ORPAM in detecting functional capillaries and evaluating therapeutic agents' effectiveness during bone regeneration.
Article
Engineering, Biomedical
Helene Ozanne, Loic Moubri, Lea Abou-Nassif, Olivier Thoumire, Aline Echalard, Sandrine Morin-Grognet, Hassan Atmani, Guy Ladam, Beatrice Labat
Summary: A cell-instructive 2.5D platform is developed to mimic bone microenvironments and control the fate of preosteoblast cells, leading to the coexistence of mature osteoblasts and bone lining cells. This culture system offers potential for advanced tissue-engineered modeling and can be applied to precellularized bone biomaterials.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Juhi Chakraborty, Subhadeep Roy, Sourabh Ghosh
Summary: This study demonstrates the potential of 3D printed hydroxyapatite (HAP) scaffolds for in vivo bone regeneration in a rat tibial defect model. The 3D printed scaffolds provide precise control over the scaffold's geometry and chemistry. The results show that the implanted scaffolds promote substantial bone ingrowth without evident immunoinflammatory response, suggesting the suitability of 3D printed HAP scaffolds for patient-specific and defect-specific bone formation.
BIOMEDICAL MATERIALS
(2022)
Review
Sport Sciences
Sarah Whitehead, Jonathon Weakley, Stuart Cormack, Helen Alfano, Jim Kerss, Mitch Mooney, Ben Jones
Summary: This scoping review summarizes the current evidence base and key findings in the applied sports science and medicine of netball, which can be used to enhance support for netball athletes across different playing standards and to support the growth of the sport. It is highlighted that there are still gaps in the literature, particularly in the areas of nutrition, training load, and fatigue and recovery.
Article
Engineering, Biomedical
Zhehao Liu, Jiazi Gao, He Gong
Summary: High-level strain can significantly stimulate the osteogenic response of bone in a short period of time, while prolonging the experiment time under mid-level strain can improve the microstructure and macromechanical properties of bone. This study provides a theoretical basis for further research on improving human bone quality and preventing aging-related bone diseases through mechanical stimulation.
MEDICAL ENGINEERING & PHYSICS
(2022)
Article
Engineering, Manufacturing
Mang Zhang, Wenbin Lu, Pelagia Irene Gouma, Zhiping Xu, Lifeng Wang
Summary: The study develops a theoretical model based on the microstructure and microstructure evolution of nonwoven fibrous networks in the loading process, revealing that the effective stiffness is influenced by fiber stretching, bending, and rotation deformation of crosslinks between fibers. Curvature effects on the effective stiffness are also systematically studied. Finite element simulation verifies the theoretical predictions on the elastic properties of nonwoven fibrous networks, showing that the model captures the elastic mechanical behavior of complex nonwoven network systems from micro to nano length scales.
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
(2021)
Article
Chemistry, Physical
Ikiru Atsuta, Tokihisa Mizokami, Yohei Jinno, Bin Ji, Tingyu Xie, Yasunori Ayukawa
Summary: The combination of CO(3)Ap and AB has been demonstrated as a clinically effective bone substitute. While Mix did not increase the number of osteoclasts or osteoblasts in vitro, it significantly increased the rate of bone replacement in dome-shaped areas in vivo.
Article
Chemistry, Multidisciplinary
Xiao Li, Lasse H. Klausen, Wei Zhang, Zeinab Jahed, Ching-Ting Tsai, Thomas L. Li, Bianxiao Cui
Summary: The presence of nanotopography drastically alters cell behavior, making neurons and stem cells behave as if they were on soft hydrogels when cultured on rigid glass substrates. Rigid nanotopography resembles the effects of soft hydrogels in reducing cell stiffness and membrane tension. Nanotopography reduces focal adhesions and cell stiffness by enhancing endocytosis and subsequent removal of integrin receptors.
Article
Physiology
Joonbum Lee, Yuguo Tompkins, Dong-Hwan Kim, Woo Kyun Kim, Kichoon Lee
Summary: The production of large amounts of meat within a short growth period provides economic benefits to the poultry industry. However, rapid growth in modern broilers leads to poor bone qualities. Mutation of the myostatin gene has been found to not only increase muscle mass, but also improve bone qualities. In this study, tibia bones from MSTN mutant quail were compared to wild-type quail, and it was found that the mutant group exhibited increased bone sizes, strength, and mineralization. These findings suggest that targeting the MSTN gene has the potential to improve not only meat yield, but also bone qualities in the broiler industry.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Materials Science, Composites
Shoab Ahmed Chowdhury, Suyi Li, Oliver J. Myers
Summary: This study investigates the stiffness and damage progression of bistable composite laminates under fatigue loading, and evaluates their bistable performance. The results show that the laminates can maintain their bistable performance under high-intensity fatigue cycles within a certain range.
JOURNAL OF COMPOSITE MATERIALS
(2023)
Article
Construction & Building Technology
Vasco Zeferina, F. Ruth Wood, Rodger Edwards, Wei Tian
Summary: This study examined the sensitivity of cooling demand related results in a large office building using two global sensitivity analysis methods. The findings showed that changes in peak demand were more significant than in annual demand, with ventilation rate being the parameter that contributed the largest for the uncertainty in electricity demand of the HVAC end-use.
ENERGY AND BUILDINGS
(2021)
Review
Orthopedics
Russell P. Main, Sandra J. Shefelbine, Lee B. Meakin, Matthew J. Silva, Marjolein C. H. van der Meulen, Bettina M. Willie
JOURNAL OF ORTHOPAEDIC RESEARCH
(2020)
Editorial Material
Orthopedics
Tamara Alliston, Kharma C. Foucher, Brenda Frederick, Christopher J. Hernandez, James C. Iatridis, Kenneth M. Kozloff, Karl J. Lewis, X. Sherry Liu, Deana M. Mercer, Ruth Ochia, Robin M. Queen, Clare M. Rimnac, Marjolein C. H. van der Meulen, Jennifer J. Westendorf
JOURNAL OF ORTHOPAEDIC RESEARCH
(2020)
Article
Orthopedics
Marysol Luna, Jason D. Guss, Laura S. Vasquez-Bolanos, Adrian J. Alepuz, Sophie Dornevil, Jasmin Strong, Denise Alabi, Qiaojuan Shi, Tania Pannellini, Miguel Otero, Ilana L. Brito, Marjolein C. H. van der Meulen, Steven R. Goldring, Christopher J. Hernandez
Summary: Obesity may not influence cartilage loss after a single mechanical insult without surgery/fracture, suggesting that damage to surrounding tissues or repeated mechanical insult is necessary for obesity to affect cartilage degeneration.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Orthopedics
Mengying Wang, Samantha G. Lessard, Purva Singh, Tania Pannellini, Tony Chen, Brennan J. Rourke, Luvana Chowdhury, Vinicius Craveiro, Peter K. Sculco, Marjolein C. H. van der Meulen, Miguel Otero
Summary: The study showed that fibrosis primarily occurred in the synovium, capsule, and IFP in a load-induced OA mouse model, accompanied by increased macrophage presence and a significant increase in T cells.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Orthopedics
Joseph H. Choi, Zhiwei Wang, Frederick P. Ross, Marjolein C. H. van der Meulen, Mathias P. G. Bostrom
Summary: The study found that OPG does not enhance osseointegration and may have detrimental effects, particularly at high doses.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Engineering, Biomedical
Maximilian Rummler, Fani Ziouti, Alice L. Bouchard, Andreas Brandl, Georg N. Duda, Bjarne Bogen, Andreas Beilhack, Maureen E. Lynch, Franziska Jundt, Bettina M. Willie
Summary: This study found that mechanical loading can enhance bone mass, prevent osteolytic destruction, and inhibit the growth and dissemination of multiple myeloma cells in mice. These findings suggest that physical stimuli may serve as an anabolic treatment for osteolytic bone destruction in patients with multiple myeloma.
ACTA BIOMATERIALIA
(2021)
Article
Endocrinology & Metabolism
Sophia N. Ziemian, Ana M. Witkowski, Timothy M. Wright, Miguel Otero, Marjolein C. H. van Der Meulen
Summary: Research suggests that inhibiting subchondral bone remodeling immediately after the initiation of posttraumatic osteoarthritis (PTOA) can effectively slow the progression of joint damage. Delaying the inhibition of bone remodeling also works in attenuating cartilage degeneration, but is less effective in preventing changes in the subchondral bone.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Sophia N. Ziemian, Olufunmilayo O. Ayobami, Amanda M. Rooney, Natalie H. Kelly, Derek T. Holyoak, F. Patrick Ross, Marjolein C. H. van der Meulen
Summary: The study found that the loss of estrogen receptor-alpha in bone cells resulted in reduced subchondral bone mass, exacerbating load-induced OA pathology. Changes in bone specific to estrogen loss may contribute to the increased incidence of OA in post-menopausal women.
Article
Endocrinology & Metabolism
Amanda M. Rooney, Olufunmilayo O. Ayobami, Natalie H. Kelly, John C. Schimenti, F. Patrick Ross, Marjolein C. H. van der Meulen
Summary: Estrogen receptor-alpha (ER alpha) plays a crucial role in skeletal maintenance and adaptation to mechanical loading, with its effects depending on sex and age. Deletion of ER alpha in mature osteoblasts leads to reduced bone mass and increased mechanoadaptation in adult female mice, while the effects in male mice are minimal.
Review
Genetics & Heredity
Francis H. Glorieux, Lynda F. Bonewald, Nicholas C. Harvey, Marjolein C. H. van der Meulen
Summary: Recent progress has been made in understanding the mechanisms of bone growth and development, particularly in the crosstalk between muscle and bone. However, limited knowledge exists on how these mechanisms apply or are compromised in pathological states. This review summarizes the research opinions and potential outcomes for XLH patients.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Biology
Jung-Min Kim, Yeon-Suk Yang, Jaehyoung Hong, Sachin Chaugule, Hyonho Chun, Marjolein C. H. van Der Meulen, Ren Xu, Matthew B. Greenblatt, Jae-Hyuck Shim
Summary: Emerging evidence suggests that the ERK pathway in osteoblasts controls bone formation by suppressing the mTOR pathway, promoting mitochondrial function and SGK1 phosphorylation. While ERK inhibition blocks early differentiation of osteogenic precursors, it surprisingly promotes later stages of osteoblast differentiation, leading to enhanced bone formation. This study reveals a surprising dichotomy of ERK pathway functions in osteoblasts, where ERK activation promotes early differentiation but inhibits the subsequent differentiation via mTOR-mediated regulation of mitochondrial function and SGK1.
Article
Endocrinology & Metabolism
Amanda M. Rooney, Tyler J. McNeill, F. Patrick Ross, Mathias P. G. Bostrom, Marjolein C. H. van der Meulen
Summary: Parathyroid hormone (PTH) is an effective treatment for increasing bone mass and reducing fracture risk in osteoporosis. Its effects vary depending on the site, with greater bone mass increase at the spine than the hip and no increase at the radius. The differences in local loading mode may contribute to these variations. This study found that compression loading is more anabolic than tension loading, and PTH enhances the effect of loading, particularly under compression.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Carolyn Chlebek, Jacob A. Moore, F. Patrick Ross, Marjolein C. H. van der Meulen
Summary: Osteoporosis affects over 200 million women worldwide, with one-third of them predicted to experience osteoporotic fractures in their lifetime. A study using a mouse model found that mechanical loading can stimulate bone formation, potentially identifying new pathways for oral treatment.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Cell Biology
Sheela R. Damle, Agata K. Krzyzanowska, Maximilian K. Korsun, Kyle W. Morse, Susannah Gilbert, Han Jo Kim, Oheneba Boachie-Adjei, Bernard A. Rawlins, Marjolein C. H. van der Meulen, Matthew B. Greenblatt, Chisa Hidaka, Matthew E. Cunningham
Summary: This study investigated the possibility of inducing bone formation and angiogenesis in the intervertebral discs (IVDs) by manipulating the IVD environment. The results showed that gene delivery and proteoglycanase treatment can promote bone and vascular growth in the IVD. However, proteoglycanase treatment impaired bone formation and reduced histological staining in the IVD.
Article
Infectious Diseases
Aleksey Dvorzhinskiy, Giorgio Perino, Robert Chojnowski, Marjolein C. H. van der Meulen, Mathias P. G. Bostrom, Xu Yang
Summary: The study found that ceramic void filler with gentamicin (CERAMENT G) reduced the rate of persistent infection and promoted new bone growth as compared to the void filler without antibiotics (CERAMENT) and an empty defect in a rat model of debrided osteomyelitis.
JOURNAL OF BONE AND JOINT INFECTION
(2021)
Article
Biophysics
Nathan D. Camarillo, Rafael Jimenez-Silva, Frances T. Sheehan
Summary: This article discusses the statistical dependence between multiple measurements from the same participant and provides recommendations for using these measurements when they are not independent.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
J. Huet, A. -S. Boureau, A. Sarcher, C. Cornu, A. Nordez
Summary: Standard compression in freehand 3D ultrasound induces a bias in volume calculations, but minimal compression and gel pad methods have similar results. With a trained examiner and precautions, the bias can be minimized and become acceptable in clinical applications.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
C. Lariviere, A. H. Eskandari, H. Mecheri, F. Ghezelbash, D. Gagnon, A. Shirazi-Adl
Summary: Recent developments in musculoskeletal modeling have focused on model customization. Personalization of the spine profile may affect estimates of spinal loading and stability. This study investigates the biomechanical consequences of changes in the spinal profile and finds that personalizing the spine profile has medium to large effects on trunk muscle forces and negligible to small effects on spinal loading and stability.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Luke T. Mattar, Arash B. Mahboobin, Adam J. Popchak, William J. Anderst, Volker Musahl, James J. Irrgang, Richard E. Debski
Summary: Exercise therapy fails in about 25.0% of cases for individuals with rotator cuff tears, and one reason for this failure may be the inability to strengthen and balance the muscle forces that keep the humeral head in the correct position. This study developed computational musculoskeletal models to compare the net muscle force before and after exercise therapy between successfully and unsuccessfully treated patients. The study found that unsuccessfully treated patients had less inferiorly oriented net muscle forces, which may increase the risk of impingement.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Natsuki Sado, Takeshi Edagawa, Toshihide Fujimori, Shogo Hashimoto, Yoshikazu Okamoto, Takahito Nakajima
Summary: The existing methods for predicting hip and lumbosacral joint centres in Japanese adults are biased and differ between sexes. We propose new regression equations that consider soft-tissue thickness, sex differences, and a height-directional measure, and validate them using leave-one-out cross-validation.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Peimin Yu, Xuanzhen Cen, Qichang Mei, Alan Wang, Yaodong Gu, Justin Fernandez
Summary: This study aimed to explore the intra-foot biomechanical differences among individuals with chronic ankle instability (CAI), copers, and healthy individuals during dynamic tasks. The study found that copers and CAI individuals had smaller dorsiflexion angles and copers presented a more eversion position compared to healthy participants. Copers also had greater dorsiflexion angles in the metatarsophalangeal joint and more inversion moments in the subtalar joint during certain tasks. These findings can help in designing interventions to restore ankle joint functions in CAI individuals.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Jon Skovgaard Jensen, Anders Holsgaard-Larsen, Anders Stengaard Sorensen, Per Aagaard, Jens Bojsen-Moller
Summary: This study investigates the biomechanical effects of robot-assisted body weight unloading (BWU) on gait patterns in healthy young adults. The results show that dynamic robot-assisted BWU enables reduced kinetic requirements without distorting biomechanically normal gait patterns during overground walking.
JOURNAL OF BIOMECHANICS
(2024)