Review
Endocrinology & Metabolism
Taysa Bervian Bassani, Cynthia Silva Bartolomeo, Rafaela Brito Oliveira, Rodrigo Portes Ureshino
Summary: Neuroactive steroids can have various effects on the nervous system and play a role in the treatment of neurodegenerative disorders. This review aims to summarize the findings related to the actions of neuroactive steroids, particularly progesterone and its derivatives, in experimental models and clinical trials of Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis.
NEUROENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Eva Davila-Bouziguet, Arnau Casoliba-Melich, Georgina Targa-Fabra, Lorena Galera-Lopez, Andres Ozaita, Rafael Maldonado, Jesus Avila, Jose M. Delgado-Garcia, Agnes Gruart, Eduardo Soriano, Marta Pascual
Summary: Alzheimer's disease is a neurodegenerative disease characterized by the accumulation of amyloid-beta and hyperphosphorylated Tau, imbalanced neuronal activity, and cognitive deficits. A new clinical entity has been identified, which shows amyloid-beta and Tau pathologies but preserved cognition. A study using mice models found that J20/VLW mice, which accumulate amyloid-beta and hyperphosphorylated Tau, exhibit preserved hippocampal rhythmic activity and cognition, while single mutant mice show significant alterations. Furthermore, the overexpression of mutant human Tau in the hippocampal interneurons leads to a specific hyperphosphorylated Tau signature. These findings contribute to understanding the mechanisms underlying cognitive preservation in non-demented individuals with Alzheimer's disease neuropathology.
Article
Endocrinology & Metabolism
Josephine F. Trott, Anke Schennink, Katherine C. Horigan, Danielle G. Lemay, Julia R. Cohen, Thomas R. Famula, Julie A. Dragon, Russell C. Hovey
Summary: This study found that ovarian steroids and pituitary-derived prolactin play important regulatory roles in the growth and differentiation of the mammary gland in pigs. Estrogen affects mitosis and gene expression, while prolactin is associated with fatty acid metabolism and inflammatory response. The findings provide insights into the connection between the hormone-regulated genome and phenome of the mammary gland, and shed light on the synergistic actions of estrogen and prolactin during mammary gland development.
Article
Biochemistry & Molecular Biology
Britta Bartelt-Kirbach, Christoph Wiegreffe, Samuel Birk, Tina Baur, Margarethe Moron, Stefan Britsch, Nikola Golenhofen
Summary: The study investigated the ability of heat shock protein B5 (HspB5) to increase dendritic complexity in vitro and in vivo, as well as its potential to counteract dendritic rarefaction under pathophysiological conditions. The results showed that HspB5 and the mutant HspB5-AEE significantly increased dendritic complexity and counteracted dendritic rarefaction, suggesting that up-regulation and selective phosphorylation of HspB5 may help preserve dendritic morphology and counteract neuronal dysfunction in neurodegenerative diseases.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Environmental Sciences
Zhifang Sun, Rufei Gao, Xuemei Chen, Xueqing Liu, Yubin Ding, Yanqing Geng, Xinyi Mu, Taihang Liu, Fangfang Li, Yingxiong Wang, Junlin He
Summary: This study found that gestational exposure to BHT inhibits decidualization of mouse endometrium during early pregnancy, resulting in a decrease in the number of implantation sites and uterine weight. Additionally, BHT suppressed the decidual morphology of endometrial stromal cells and significantly decreased the expression of decidual markers. Furthermore, BHT exposure led to upregulation of reproductive hormones and hormone receptor signals in early pregnancy.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Cell Biology
Sumaiya Khan, Md. Imtaiyaz Hassan, Mohammad Shahid, Asimul Islam
Summary: Tau aggregation is a key feature in neurodegenerative disorders, and inhibiting this aggregation is a potential treatment approach. Natural compounds, such as flavonoids, alkaloids, resveratrol, and curcumin, have shown promise in inhibiting tau aggregation. Further research is needed to understand their mechanisms and evaluate their safety and efficacy in clinical studies. Nature-derived tau aggregation inhibitors offer a promising new direction for research in the field of neurodegenerative diseases.
AGEING RESEARCH REVIEWS
(2023)
Article
Neurosciences
Zuha Waheed, Jawaria Choudhary, Faria Hasan Jatala, Aneeqa Noor, Inga Zerr, Saima Zafar
Summary: Tau is a microtubule-associated binding protein in the nervous system that stabilizes microtubules in nerve cells. It accumulates as aggregates and tangles, leading to various pathologies. Different splice variants of tau are expressed in the brain and contribute to neurodegenerative diseases. The isoforms have different roles and undergo post-translational modifications at different rates, affecting their physiological and pathological attributes. This article aims to review the roles of tau isoforms and their underlying mechanisms in neurological deficits.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
F. A. Concepcion, N. A. Ekstrom, M. N. Khan O. O. Estes, N. P. Poolos
Summary: This study investigated the expression and phosphorylation of the intracellular protein Tau in a rat model of temporal lobe epilepsy. The results showed that although Tau expression levels had a modest reduction at two months post-seizure, they had returned to normal by four months. However, there was a significant decrease in phosphorylation levels at the S202/T205 locus. These findings suggest that Tau may play a different role in epilepsy compared to Alzheimer's disease.
Article
Medicine, General & Internal
Maria Sztachelska, Donata Ponikwicka-Tyszko, Lydia Martinez-Rodrigo, Piotr Bernaczyk, Ewelina Palak, Weronika Polchlopek, Tomasz Bielawski, Slawomir Wolczynski
Summary: This study characterized the expression of nuclear and membrane estrogen and progesterone receptors in adenomyosis and investigated their functional effects. The results showed upregulation of membrane progesterone receptors and estrogen receptor beta in adenomyosis compared to normal tissue. Estradiol promoted cell proliferation in adenomyosis, while progesterone and cAMP stimulated prolactin secretion in a similar pattern as in normal tissue. These findings provide new insights into the role of sex steroid receptors in adenomyosis pathophysiology.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Jiahui Niu, Khalid Iqbal, Fei Liu, Wen Hu
Summary: The study revealed that male and female rats have comparable levels of total tau, 3R-tau, and 4R-tau, but females exhibit higher levels of tau phosphorylated at multiple sites, potentially underlying the gender disparity in brain tau burden and risk for AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Shu-Yu Liang, Zuo-Teng Wang, Lan Tan, Jin-Tai Yu
Summary: This article introduces the function and dysfunction of microtubule-associated protein tau in the central nervous system and discusses its role in neurodegenerative diseases, tau phosphorylation-related enzymes and proteins, and its relationship with cell dysfunction. The study of tau neurotoxicity provides new directions for the treatment of tauopathies.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Fernando Gonzalez-Ortiz, Michael Turton, Przemyslaw R. Kac, Denis Smirnov, Enrico Premi, Roberta Ghidoni, Luisa Benussi, Valentina Cantoni, Claudia Saraceno, Jasmine Rivolta, Nicholas J. Ashton, Barbara Borroni, Douglas Galasko, Peter Harrison, Henrik Zetterberg, Kaj Blennow, Thomas K. Karikari
Summary: Blood-based biomarkers for amyloid beta and phosphorylated tau show good diagnostic accuracies and agreements with their corresponding CSF and neuroimaging biomarkers, while the blood-based neurodegeneration marker neurofilament light is not specific to Alzheimer's disease. A newly developed blood-based assay for brain-derived tau has shown equivalent diagnostic performance as CSF total-tau, accurately distinguishing Alzheimer's disease from other neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Marta Jorge-Oliva, Jan R. T. van Weering, Wiep Scheper
Summary: Tau aggregation plays a central role in the pathogenesis of tauopathies, but the response of neurons to tau pathology and the mechanisms leading to neurodegeneration are still unclear. This study investigated the accumulation of granulovacuolar degeneration bodies (GVBs), lysosomal structures that respond to tau pathology, in different tau aggregation models in primary neurons. The results showed that the structure and subcellular localization of tau aggregates may be important factors affecting GVB accumulation. The findings provide insights into the relationship between tau pathology and neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Pramod Kumar, Aarti Singh, Anurag Kumar, Rahul Kumar, Rishi Pal, Amod Kumar Sachan, Rakesh Kumar Dixit, Rajendra Nath
Summary: The study aims to assess the effects of curcumin and coenzyme Q10 on learning and memory in Alzheimer's disease. Both herbal medicines have shown significant improvements, especially at higher doses. This suggests that curcumin and coenzyme Q10 can be used as standalone or add-on therapies for cognitive impairment in Alzheimer's disease.
Review
Endocrinology & Metabolism
G. Molina-Salinas, N. A. Rivero-Segura, E. A. Cabrera-Reyes, V Rodriguez-Chavez, E. Langley, M. Cerbon
Summary: Prolactin plays a crucial role in neuroprotection against excitotoxicity, although the underlying signaling pathways, such as PI3K/AKT, NF-kappa B, and JAK2/STAT5, remain unclear and require further investigation. Its remarkable neuroprotective effects may hold promise for the treatment of certain neurological diseases.
FRONTIERS IN NEUROENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Rebeca Corona, Preethi Jayakumar, Maria Antonieta Carbajo Mata, Maria Fernanda Del Valle-Diaz, Luis Antonio Luna-Garcia, Teresa Morales
Summary: PRL affects puberty development and maturity of MOB-AOB in a sex-dependent manner during the murine juvenile period.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ilektra Anagnostou, Daniel Munoz-Mayorga, Teresa Morales
Summary: The study demonstrated a neuroprotective role of PRL in the male mouse hippocampus against excitotoxic damage, with a preferential effect in the CA3 region and activation of the Akt cell survival pathway. PRL treatment also led to downregulation of active MAPK, independent of excitotoxic damage.
Article
Medicine, Research & Experimental
Bertha Fenton-Navarro, Diana Garduno Rios, Luz Torner, Graciela Letechipia-Vallejo, Miguel Cervantes
Summary: This study investigated the changes in circulating Galectin-3 (Gal-3) and cytokines (TNF-alpha, IL-6, IL-10) following global cerebral ischemia (GCI) in a rat model, as well as the effects of melatonin treatment. The results showed that melatonin treatment reduced pro-inflammatory factors, Gal-3 levels, locomotion, and anxiety, suggesting its potential as a supplementary treatment for ischemic stroke.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Review
Neurosciences
D. C. Lacerda, M. V. Urquiza-Martinez, R. Manhaes-de-Castro, D. B. Visco, C. Derosier, R. Mercado-Camargo, L. Torner, A. E. Toscano, O. Guzman-Quevedo
Summary: This review evaluates the metabolic and neurological effects of polyphenols-based treatment in rodent models of NCDs, showing that polyphenols can attenuate changes in energy balance and body weight, and are associated with neuroprotective responses.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Cell Biology
Preethi Jayakumar, Carlos G. Martinez-Moreno, Mary Y. Lorenson, Ameae M. Walker, Teresa Morales
Summary: The study found that prolactin has anti-inflammatory effects in microglial cells by reducing pro-inflammatory mediators and suppressing the corresponding signaling pathways.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Dermatology
Claudia Cervantes-Duran, Miguel Avalos-Viveros, Luz Torner, Sandra-Guadalupe Sanchez-Ceja, Alain-Raimundo Rodriguez-Orozco, Hector-Eduardo Martinez-Flores, Martha-Estrella Garcia-Perez
Summary: The study found that in the IMQ-induced psoriasis mice model, the development of secondary chronic allodynia and hyperalgesia could be modulated by anti-inflammatory agents and compound 48/80, and the activation of 5-HT1A receptor might regulate these nociceptive behaviours. Additionally, it was observed that the long-lasting pain resulting from psoriasis inflammation is associated with the serotonergic system, indicating that the 5-HT1A receptor could be a potential therapeutic target for psoriasis pain modulation.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Neurosciences
Pedro A. Romero-Juarez, Diego Bulcao Visco, Raul Manhaes-de-Castro, Mercedes Urquiza-Martinez, Luis Miguel Saavedra, Mari C. Gonzalez-Vargas, Rosalio Mercado-Camargo, Jailane de Souza Aquino, Ana E. Toscano, Luz Torner, Omar Guzman-Quevedo
Summary: In this study, the effects of kaempferol (KF) on hypothalamic inflammation and energy balance (EB) regulation in obese mice were investigated. The results showed that chronic treatment with KF reduced microglia activation in the hypothalamic arcuate nucleus, leading to weight loss and improved metabolic parameters. The findings suggest that KF may have potential therapeutic effects against obesity by modulating central processes associated with EB regulation and hypothalamic inflammation.
NUTRITIONAL NEUROSCIENCE
(2023)
Review
Behavioral Sciences
Rebeca Corona, Benito Ordaz, Ludivina Robles-Osorio, Ernesto Sabath, Teresa Morales
Summary: Chronic kidney disease is a multifactorial pathology that affects metabolic functions and is associated with inflammation, nutritional status, and olfactory deficits.
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2022)
Article
Neurosciences
Cesar Huerta, Raul G. Paredes, Teresa Morales, Mario Daniel Caba-Flores, Enrique Meza, Mario Caba
Summary: This study aims to establish whether rabbits can be conditioned using CPP protocol by conducting experiments with caloric restriction. It demonstrates for the first time that rabbits can be conditioned using CPP paradigm through food-induced place preference, opening up new opportunities to study positive affective states in a species with important behavioral and physiological differences from rodents.
Review
Biochemistry & Molecular Biology
Henrique J. C. B. Gouveia, Mercedes V. Urquiza-Martinez, Raul Manhaes-de-Castro, Barbara J. R. Costa-de-Santana, Jose Perez Villarreal, Rosalio Mercado-Camargo, Luz Torner, Jailane de Souza Aquino, Ana E. Toscano, Omar Guzman-Quevedo
Summary: Flavonoids as supplements can significantly improve multiple metabolic parameters and reduce the risk of diseases associated with metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ecology
Nancy M. Unda-Diaz, Bryan V. Phillips-Farfan, Hector Nava, Leonel Lopez-Toledo, Chiharu Murata, Naima Lajud, Ma. Antonia Herrera-Vargas, Claudia A. Arreola Camacho, Luz Torner, Alma L. Fuentes-Farias, Esperanza Melendez-Herrera
Summary: Ex situ incubation of sea turtle eggs has a negative impact on neurogenesis, ovariogenesis, body size, and self-righting ability in hatchlings. Future studies should evaluate the long-term effects on cognitive and reproductive performance and understand the differential contributions of egg movement, reburial, nesting environment, and parental origin to development.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2022)
Article
Cell Biology
Daniel Munoz-Mayorga, Adriana Tovar, Mauricio Diaz-Munoz, Teresa Morales
Summary: Reactive oxygen species (ROS) are important for cellular functioning and signaling, but can also be toxic during oxidative stress. The balance between pro-oxidant reactions and antioxidant defenses maintains an oxidative status and mediates potential pathological events.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Neurosciences
Barbara Juacy Rodrigues Costa-de-Santana, Raul Manhaes-de-Castro, Henrique Jose Cavalcanti Bezerra Gouveia, Eliesly Roberto Silva, Marcos Antonio da Silva Araujo, Diego Cabral Lacerda, Omar Guzman-Quevedo, Luz Torner, Ana Elisa Toscano
Summary: The present study successfully replicated motor, behavioral, and neural deficits of cerebral palsy (CP) using a rat model of perinatal anoxia and sensorimotor restriction. The CP animals exhibited delayed satiety, impaired locomotion, reduced muscle strength, and compromised motor coordination. Additionally, CP resulted in reduced brain and muscle weight, as well as increased activation of astrocytes and microglia in the cerebellum and hypothalamus.
Review
Biochemistry & Molecular Biology
Raziel Alejandro Arias-Sanchez, Luz Torner, Bertha Fenton Navarro
Summary: The increase in people's longevity has led to more brain involvement and neurodegenerative diseases, presenting greater public health problems. Medicinal plants containing polyphenols have been proven to provide curative effects against various diseases and brain disorders through neuroprotective effects. Polyphenols can cross the blood-brain barrier, eliminate reactive oxygen species, and bind to neurotrophic factor receptors, promoting neuronal cell plasticity and improving learning, memory, and cognition without serious adverse side effects.
