Article
Endocrinology & Metabolism
Qiaoli Zeng, Bing Tan, Fengqiong Han, Xiujuan Huang, Jinzhi Huang, Yue Wei, Runmin Guo
Summary: This study aimed to investigate the impact of SLC30A8 gene polymorphisms on gestational diabetes mellitus (GDM). The results showed that rs2466293 was associated with an increased risk of GDM, while rs13266634 was associated with a decreased risk of GDM in individuals aged >= 30 years. Additionally, the CG haplotype was associated with a higher risk of GDM.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mathias Ziegler, Magnus Monne, Andrey Nikiforov, Gennaro Agrimi, Ines Heiland, Ferdinando Palmieri
Summary: Subcellular compartmentation is a fundamental property of eukaryotic cells, where the transport of solutes across membranes plays a crucial role in cellular communication and metabolic regulation. In mammals, the SLC family comprises carriers that selectively transport molecules across biological membranes, with the SLC25 family playing a particularly important role in supplying mitochondria with metabolic intermediates. The recent discovery of SLC25A51 as the major mitochondrial NAD(+) carrier in mammals has resolved a long-standing mystery in NAD(+) biology.
Article
Biochemistry & Molecular Biology
Jiaheng Xie, Zhechen Zhu, Yuan Cao, Shujie Ruan, Ming Wang, Jingping Shi
Summary: SLC16A1 is a robust prognostic biomarker for melanoma, associated with decreased overall survival in patients. It plays important roles in metabolic regulation, protein ubiquitination, and substance localization, and may serve as a novel target in immunotherapy.
Article
Multidisciplinary Sciences
Maria F. Noterman, Kalyani Chaubey, Kristi Lin-Rahardja, Anjali M. Rajadhyaksha, Andrew A. Pieper, Eric B. Taylor
Summary: Researching the composition and function of brain mitochondria is challenging but crucial for developing improved neuroprotective therapies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Daniel J. Styrpejko, Math P. Cuajungco
Summary: The review highlights the role of TMEM163 as a zinc binding protein and transporter, potentially belonging to the CDF superfamily. It discusses its implications in human health and various diseases, suggesting a significant impact on zinc metabolism.
Article
Microbiology
Zhenyao Luo, Jacqueline R. Morey, Evelyne Deplazes, Alina Motygullina, Aimee Tan, Katherine Ganio, Stephanie L. Neville, Nikolaos Eleftheriadis, Michael Isselstein, Victoria G. Pederick, James C. Paton, Thorben Cordes, Jeffrey R. Harmer, Bostjan Kobe, Christopher A. McDevitt
Summary: This study elucidates a novel mechanism for zinc binding in Streptococcus pneumoniae's AdcA protein and highlights the importance of the N-terminal domain for zinc import, as well as a conserved loop region crucial for zinc acquisition. These findings provide insights into the structural and functional basis of selective zinc uptake in prokaryotes.
Article
Pharmacology & Pharmacy
Ole Jensen, Muhammad Rafehi, Lukas Gebauer, Jurgen Brockmoeller
Summary: Psychostimulants and hallucinogens have been found to be substrates of OCTs, with genetic polymorphisms in OCT1 playing a significant role in the cellular uptake of mescaline.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Jiamei Le, Yi Fu, Qiuqin Han, Xindong Wei, Houlin Ji, Yifan Chen, Qiuying Wang, Peixian Pi, Jilei Li, Xinjie Lin, Xiaoying Zhang, Yong Zhang, Jianping Ye
Summary: Metformin improves insulin sensitivity in type 2 diabetes by targeting liver, intestine, and other organs. This study found that more genes were altered in the liver than in the colon of diet-induced obese mice, with 20 Slc genes confirmed to be altered in the liver and 15 of them restored by MET, leading to improved insulin sensitivity and obesity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Eugene C. Chen, Par Matsson, Mina Azimi, Xujia Zhou, Niklas Handin, Sook Wah Yee, Per Artursson, Kathleen M. Giacomini
Summary: This study identified several prescription drugs as inhibitors of OCT3, with some compounds showing potent inhibition at therapeutic unbound plasma levels, which may lead to drug-drug interactions or off-target pharmacologic effects.
PHARMACEUTICAL RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Solene Marie, Irene Hernandez-Lozano, Oliver Langer, Nicolas Tournier
Summary: Hepatocyte transporters play a crucial role in the hepatobiliary elimination of various substances, influenced by different pathophysiological conditions and specific drugs; Tc-99m-mebrofenin has been used for hepatobiliary scintigraphy for years, but the specific transporters controlling its liver kinetics have only recently been characterized; Pharmacokinetic modeling offers a translational method to study transporter-mediated drug interactions, providing insights into liver function as a biomarker.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Genetics & Heredity
Wei Wei, Rubin Xu, Xiaomei Ying, Liang Chen, Xiaohuan Lu, Qikai Tang, Jiaheng Xie, Hongzhu Yu
Summary: This study constructed a prognostic signature consisting of nine SLC genes in hepatocellular carcinoma (HCC) through comprehensive analysis. By calculating risk scores, HCC patients could be divided into high-risk and low-risk groups, and a hub gene SLC7A11 was identified as a robust prognostic marker of HCC.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Yue Li, Weidong Wang, Hui-Ying Lim
Summary: Through genetic studies, it was found that the regulation of glucose absorption in the Drosophila midgut is mediated by the Solute Carrier 5A5 (dSLC5A5). Genetically knocking down dSLC5A5 in flies leads to decreased glucose and trehalose levels in the system and circulation, while overexpression of dSLC5A5 increases these levels and promotes glucose uptake in enterocytes. Additionally, it was shown that dSLC5A5 undergoes apical endocytosis in a dynamin-dependent manner, crucial for glucose uptake in enterocytes, and that glucose upregulates dSLC5A5 levels in the midgut, influencing systemic glucose homeostasis on a high-sugar diet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Charles R. Lefevre, Marc Le Vee, Sophie Gaubert, Elodie Jouan, Arnaud Bruyere, Caroline Moreau, Olivier Fardel
Summary: The study analyzed the characteristics of 15 OCT2 substrates and found that only 4 of them exhibited trans-stimulation effect, with differences in molecular properties compared to non-trans-stimulating substrates. Therefore, the sensitivity of the trans-stimulation assay for identifying OCT2 substrates was relatively low, caution should be exercised in the use of this method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Rachel-Ann A. Garibsingh, Elias Ndaru, Alisa A. Garaeva, Yueyue Shi, Laura Zielewicz, Paul Zakrepine, Massimiliano Bonomi, Dirk J. Slotboom, Cristina Paulino, Christof Grewer, Avner Schlessinger
Summary: ASCT2 is up-regulated in cancer and plays a crucial role in promoting cell proliferation by modulating intracellular glutamine levels; Inhibiting nutrient uptake via ASCT2 could be a potential strategy for cancer therapy; We designed a series of unique ASCT2 inhibitors using computational modeling and cryo-EM, providing a framework for the development of cancer therapeutics targeting ASCT2.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Saleh Alquethamy, Katherine Ganio, Zhenyao Luo, Sheikh I. Hossain, Andrew J. Hayes, Thomas Ve, Mark R. Davies, Evelyne Deplazes, Bostjan Kobe, Christopher A. McDevitt
Summary: In this study, A. baumannii ZnuA, a zinc-recruiting protein, was characterized using genomic, biochemical, and structural approaches. The findings revealed the high conservation of ZnuA and provided insight into the mechanism of zinc recruitment by ZnuA, expanding our understanding of the functional diversity of zinc-recruiting proteins.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Yan-yan Li, Xin-xing Yang, Hong-yu Geng, Ge Gong
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2018)
Article
Cell Biology
Yan-yan Li, Hui Wang, Jing-jing Wu, Hyun Jun Kim, Xin-xing Yang, Hong-yu Geng, Ge Gong
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2018)
Article
Oncology
Yan-Yan Li, Hui Wang, Xin-Xing Yang, Jing-Jing Wu, Hong-Yu Geng, Hyun Jun Kim, Zhi-Jian Yang, Lian-Sheng Wang
Article
Physiology
Yan-yan Li, Yan-hong Zhou, Ge Gong, Hong-yu Geng, Xin-xing Yang
FRONTIERS IN PHYSIOLOGY
(2017)
Article
Physiology
Yan-yan Li, Jing-jing Wu, Xin-xing Yang, Hong-yu Geng, Ge Gong, Hyun Jun Kim
FRONTIERS IN PHYSIOLOGY
(2017)
Article
Respiratory System
Ge Gong, Xin-Xing Yang, Yanyan Li, Hong-Yu Geng, Zhi-Jian Yang, Lian-Sheng Wang, Hyun Jun Kim, Xin-Zheng Lu
JOURNAL OF THORACIC DISEASE
(2017)
Article
Medicine, General & Internal
Yan-yan Li, Yan-hong Zhou, Ge Gong, Hong-yu Geng, Xin-xing Yang, Xiang-ming Wang, Chuan-wei Zhou, Jian Xu, Yun Qian
KOREAN JOURNAL OF INTERNAL MEDICINE
(2017)
Article
Cardiac & Cardiovascular Systems
Ge Gong, Yanyan Li, Xinxing Yang, Hongyu Geng, Xinzheng Lu, Liansheng Wang, Zhijian Yang
ANATOLIAN JOURNAL OF CARDIOLOGY
(2017)
Article
Endocrinology & Metabolism
Yan-yan Li, Hui Wang, Xin-xing Yang, Hong-yu Geng, Ge Gong, Hyun Jun Kim, Yan-hong Zhou, Jing-jing Wu
FRONTIERS IN ENDOCRINOLOGY
(2017)
Article
Respiratory System
Ge Gong, Xin-Xing Yang, Yan-Yan Li, Hong-Yu Geng, Hui Wang, Lian-Sheng Wang, Zhi-Jian Yang
JOURNAL OF THORACIC DISEASE
(2018)
Review
Genetics & Heredity
Yan-yan Li, Xin-zheng Lu, Hui Wang, Yan-hong Zhou, Xin-xing Yang, Hong-yu Geng, Ge Gong, Hyun Jun Kim
FRONTIERS IN GENETICS
(2018)
Review
Endocrinology & Metabolism
Yan-yan Li, Xin-zheng Lu, Xin-xing Yang, Hui Wang, Hong-yu Geng, Ge Gong, Yi-yang Zhan, Hyun Jun Kim, Zhi-jian Yang
FRONTIERS IN ENDOCRINOLOGY
(2019)
Article
Cell Biology
Xin-Xing Yang, Yan-Yan Li, Ge Gong, Hong-Yu Geng
Summary: This study demonstrated that lncRNA260 siRNA could promote M2 polarization of macrophages under hypoxia by regulating IL28RA, suggesting a potential therapeutic strategy for cardiac diseases.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Cardiac & Cardiovascular Systems
Yan-yan Li, Hui Wang, Xin-xing Yang, Hong-yu Geng, Ge Gong, Xin-zheng Lu
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2020)