Recent advances in the intramolecular Mannich reaction in natural products total synthesis

Asymmetric Total Synthesis of (-)-Gracilamine Using a Bioinspired Approach

(2017) Atish Chandra et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of (±)-Lycojaponicumin D and Lycodoline-Type Lycopodium Alkaloids

(2017) Xian-He Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enabling syntheses of diterpenoid alkaloids and related diterpenes by an oxidative dearomatization/Diels–Alder cycloaddition strategy

(2017) Xiao-Yu Liu et al.   NATURAL PRODUCT REPORTS

Asymmetric Total Synthesis of Gracilamine and Determination of Its Absolute Configuration

(2017) Xiao-Dong Zuo et al.   ORGANIC LETTERS

A Cascade Strategy Enables a Total Synthesis of (±)-Morphine

(2016) Shuyu Chu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expedient Synthesis of (+)-Lycopalhine A

(2016) Benjamin M. Williams et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pyrone Diels-Alder Routes to Indolines and Hydroindolines: Syntheses of Gracilamine, Mesembrine, and Δ7 -Mesembrenone

(2016) Pei Gan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of (−)-Nakadomarin A

(2016) J. Stephen Clark et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of Camptothecin and Related Natural Products by a Flexible Strategy

(2016) Ke Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Formal Synthesis of Gracilamine Using Rh(I)-Catalyzed [3 + 2 + 1] Cycloaddition of 1-Yne–Vinylcyclopropanes and CO

(2016) Sritama Bose et al.   JOURNAL OF ORGANIC CHEMISTRY

A Scalable Total Synthesis of (−)-Nakadomarin A

(2016) Robert K. Boeckman et al.   ORGANIC LETTERS

Biomimetic Total Synthesis of the Pentacyclic Amaryllidaceae Alkaloid Derivative Gracilamine

(2016) Nadia (Yuqian) Gao et al.   ORGANIC LETTERS

The Quest for a Practical Synthesis of Morphine Alkaloids and Their Derivatives by Chemoenzymatic Methods

(2015) Josephine W. Reed et al.   ACCOUNTS OF CHEMICAL RESEARCH

Total Synthesis of Vinblastine, Related Natural Products, and Key Analogues and Development of Inspired Methodology Suitable for the Systematic Study of Their Structure–Function Properties

(2015) Justin E. Sears et al.   ACCOUNTS OF CHEMICAL RESEARCH

Enantioselective Total Synthesis of (+)-Gephyrotoxin 287C

(2015) Tetsuhiro Nemoto et al.   ADVANCED SYNTHESIS & CATALYSIS

Total Syntheses of (±)-Gephyrotoxin and (±)-Perhydrogephyrotoxin

(2015) Kenji Shirokane et al.   BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN

Total Synthesis of Codeine

(2015) Qilin Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ecteinascidins. A review of the chemistry, biology and clinical utility of potent tetrahydroisoquinoline antitumor antibiotics

(2015) V. H. Le et al.   NATURAL PRODUCT REPORTS

Biomimetic Total Syntheses of (+)-Dihydrolyfoline and (−)-5-epi-Dihydrolyfoline

(2015) Ruoming Mei et al.   ORGANIC LETTERS

Total synthesis of (+)-gelsemine via an organocatalytic Diels–Alder approach

(2015) Xiaoming Chen et al.   Nature Communications

Ongoing Pursuit of Diterpenoid Alkaloids: A Synthetic View

(2015) Xiao-Yu Liu et al.   Asian Journal of Organic Chemistry

Progress in Asymmetric Synthesis of Galanthamine-Type Alkaloids

(2015) Haiming Wang et al.   CHINESE JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of (−)-Lundurine A and Determination of its Absolute Configuration

(2014) Shuaijiang Jin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Divergent Total Syntheses of Lyconadins A and C

(2014) Yang Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Asymmetric Mannich Cyclization of Hydroxylactams with Acetals: Total Syntheses of (−)-Epilupinine, (−)-Tashiromine, and (−)-Trachelanthamidine

(2014) Dipankar Koley et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of Gracilamine

(2014) Yingbo Shi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Cascade Strategy Enables a Total Synthesis of (−)-Gephyrotoxin

(2014) Shuyu Chu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Short Protecting Group-free Syntheses of Camptothecin and 10-Hydroxycamptothecin Using Cascade Methodologies

(2014) Peng Xu et al.   Chemistry-An Asian Journal

Applications of Mannich Reaction in Total Syntheses of Natural Products

(2014) Majid Heravi et al.   CURRENT ORGANIC CHEMISTRY

Total Synthesis of (−)-Lepenine

(2014) Yoshitake Nishiyama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthetic strategies toward hetidine and hetisine-type diterpenoid alkaloids

(2014) Amy M. Hamlin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Total Synthesis of (±)-Gephyrotoxin by Amide-Selective Reductive Nucleophilic Addition

(2013) Kenji Shirokane et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of the C18-Norditerpenoid Alkaloid Neofinaconitine: A Lesson in Convergent Synthesis Planning

(2013) Xiao-Yu Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nature as a source of metabolites with cholinesterase-inhibitory activity: an approach to Alzheimer's disease treatment

(2013) Brígida R. Pinho et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Total Synthesis, Relay Synthesis, and Structural Confirmation of the C18-Norditerpenoid Alkaloid Neofinaconitine

(2013) Yuan Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (−)-Nakadomarin A

(2013) Simone Bonazzi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (−)-Hippodamine by Stereocontrolled Construction of Azaphenalene Skeleton Based on Extended One-Pot Asymmetric Azaelectrocyclization

(2013) Shintaro Fujita et al.   ORGANIC LETTERS

Highly facile approach to the formal total synthesis of camptothecin

(2013) Changqing Wei et al.   TETRAHEDRON LETTERS

A biomimetic approach for bicyclic alkaloids using acetal pro-nucleophile: total synthesis of (±)-epilupinine and formal syntheses of (±)-laburnine, (±)-isoretronecanol, (±)-tashiromine

(2013) Dipankar Koley et al.   RSC Advances

Potentially Biomimetic Total Synthesis and Relative Stereochemical Assignment of (±)-Gracilamine

(2012) Songchuan Tian et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biomimetic Total Synthesis of (+)-Gelsemine

(2012) Xuan Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of (−)-Galanthamine and (−)-Lycoramine via Catalytic Asymmetric Hydrogenation and Intramolecular Reductive Heck Cyclization

(2012) Ji-Qiang Chen et al.   ORGANIC LETTERS

Lycojaponicumins D and E: Two New Alkaloids from Lycopodium japonicum

(2012) Xiao-Jing Wang et al.   ORGANIC LETTERS

Studies toward the total synthesis of (+)-gelsemine and synthesis of spirocyclopentaneoxindole through intramolecular Michael cyclization

(2012) Shiyi Zhou et al.   TETRAHEDRON LETTERS

Total Synthesis of Indoline Alkaloids: A Cyclopropanation Strategy

(2011) Dan Zhang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Asymmetric Synthesis of Bioactive Hydrodibenzofuran Alkaloids: (−)-Lycoramine, (−)-Galanthamine, and (+)-Lunarine

(2011) Peng Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total synthesis of (−)-nakadomarin A

(2011) Andrew F. Kyle et al.   CHEMICAL COMMUNICATIONS

Efficient Total Synthesis of Marine Alkaloid (−)-Nakadomarin A

(2011) Bin Cheng et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total Synthesis of Camptothecin and SN-38

(2011) Shanbao Yu et al.   JOURNAL OF ORGANIC CHEMISTRY

Application of the Helquist Annulation inLycopodiumAlkaloid Synthesis: Unified Total Syntheses of (−)-8-Deoxyserratinine, (+)-Fawcettimine, and (+)-Lycoflexine

(2011) Yu-Rong Yang et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of macrocyclic natural products by catalyst-controlled stereoselective ring-closing metathesis

(2011) Miao Yu et al.   NATURE

Asymmetric Total Synthesis of Clavolonine

(2011) Kenji Nakahara et al.   ORGANIC LETTERS

Intramolecular isomünchnone cycloaddition approach to the antitumor agent camptothecin

(2011) François Grillet et al.   TETRAHEDRON

Total synthesis of (−)-nakadomarin A: alkyne ring-closing metathesis

(2011) Pavol Jakubec et al.   TETRAHEDRON LETTERS

Concise Synthesis of (−)-Nakadomarin A

(2010) David B. C. Martin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lyconadins D and E, and complanadine E, new Lycopodium alkaloids from Lycopodium complanatum

(2010) Kan’ichiro Ishiuchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Total synthesis of (+)-vinblastine: Control of the stereochemistry at C18′

(2010) Satoshi Yokoshima et al.   CHEMICAL RECORD

Development of an Enantioselective Route toward theLycopodiumAlkaloids: Total Synthesis of Lycopodine

(2010) Hua Yang et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of (±)- and (−)-Actinophyllic Acid

(2010) Connor L. Martin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (+)-Fastigiatine

(2010) Brian B. Liau et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diterpenoid alkaloids

(2010) Feng-Peng Wang et al.   NATURAL PRODUCT REPORTS

Total Synthesis of (−)-Nakadomarin A

(2010) Mark G. Nilson et al.   ORGANIC LETTERS

Studies directed toward the synthesis of nakadomarin A

(2010) Thomas Haimowitz et al.   TETRAHEDRON LETTERS

Lyconadins C and F, new Lycopodium alkaloids from Lycopodium complanatum

(2010) Kan’ichiro Ishiuchi et al.   TETRAHEDRON LETTERS

Galantamine improves apomorphine-induced deficits in prepulse inhibition via muscarinic ACh receptors in mice

(2009) K Yano et al.   BRITISH JOURNAL OF PHARMACOLOGY

Alkaloids fromAconitum barbatumvar.puberulum

(2009) Li-Mei Sun et al.   HELVETICA CHIMICA ACTA

Synthesis, Determination of the Absolute Stereochemistry, and Evaluations at the Nicotinic Acetylcholine Receptors of a Hydroxyindolizidine Alkaloid from the Ant Myrmicaria melanogaster

(2009) Naoki Toyooka et al.   HETEROCYCLES

Biphenylquinolizidine Alkaloids fromLagerstroemia indica

(2009) Hong Jin Kim et al.   JOURNAL OF NATURAL PRODUCTS

Total Synthesis of theAkuammilineAlkaloid (±)-Vincorine

(2009) Min Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient Assembly of an Indole Alkaloid Skeleton by Cyclopropanation: Concise Total Synthesis of (±)-Minfiensine

(2008) Liqun Shen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A two-directional approach to the anatoxin alkaloids: second synthesis of homoanatoxin and efficient synthesis of anatoxin-a

(2008) Stephen J. Roe et al.   CHEMICAL COMMUNICATIONS

Clinical impact of trabectedin (ecteinascidin-743) in advanced/metastatic soft tissue sarcoma

(2008) Patrick Schöffski et al.   EXPERT OPINION ON PHARMACOTHERAPY

Synthetic Studies on Camptothecins. Part 1

(2008) Li-Peng Zhang et al.   HELVETICA CHIMICA ACTA

Total Synthesis of (±)-Actinophyllic Acid

(2008) Connor L. Martin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Total Synthesis of (−)-Quinocarcin

(2008) Yan-Chao Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Total Synthesis of Lycopodine

(2008) Hua Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expeditious Total Syntheses of Camptothecin and 10-Hydroxycamptothecin

(2008) Guan-Sai Liu et al.   ORGANIC LETTERS

Galantamine in Alzheimer’s disease

(2007) George Razay et al.   Expert Review of Neurotherapeutics

Indolizidine and quinolizidine alkaloids

(2007) Joseph P. Michael   NATURAL PRODUCT REPORTS