Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 357, Issue 11, Pages 2547-2555Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201500378
Keywords
alkaloids; allylic substitution; asymmetric catalysis; synthetic methods; total synthesis
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Funding
- JSPS KAKENHI Grant [15K07850]
- Chiba University
- Grants-in-Aid for Scientific Research [15K07850] Funding Source: KAKEN
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Gephyrotoxin 287C, a bioactive alkaloid bearing a perhydropyrrolo[1,2-a]quinoline skeleton with five stereocenters, is an attractive target for synthetic organic chemistry. We achieved an enantioselective total synthesis of (+)-gephyrotoxin 287C, for which the key steps were palladium-catalyzed asymmetric allylic amination using a chiral diaminophosphine oxide (DIAPHOX) preligand, diastereoselective intramolecular Mannich reaction, and tin tetrachloride-catalyzed diastereoselective conjugate addition/protonation.
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