Article
Engineering, Environmental
Saba Nazari, Mitra Naeimi, Mohammad Rafienia, Majid Monajjemi
Summary: This study fabricated PCL-GEL scaffolds with varying concentrations of NHA and NC particles using 3D printing technology and evaluated their physiochemical and biological properties. The inclusion of NHA and NC particles improved the properties of the scaffolds, such as hydrophilicity, strength, adhesiveness, biocompatibility, biodegradability, and osteoconductivity.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Chemistry, Physical
Hee-Yeon Kim, Byung-Hoon Kim, Myung-Sun Kim
Summary: This study investigates the surface characterization and pre-osteoblast biological behaviors of a 3D poly(ε-caprolactone)/beta-tricalcium phosphate scaffold modified by amine plasma-polymerization. The results demonstrate that the scaffold treated with DACH plasma-polymerization exhibits the highest bioactivity, making it a promising candidate for pre-osteoblast osteoblast differentiation.
Review
Biochemistry & Molecular Biology
Zia Ullah Arif, Muhammad Yasir Khalid, Reza Noroozi, Ali Sadeghianmaryan, Meisam Jalalvand, Mokarram Hossain
Summary: This article systematically summarizes the recent advancements in PLA and PCL biodegradable polymer-based composites manufactured through 3DP, as well as their applications in bone, cardiac, neural, vascularized and skin tissue regeneration. The interaction between implanted polymers and evaluation methods are also illustrated. The final section discusses the current challenges and future opportunities in 3DP of PCL and PLA-based composites for biomedical engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Chemistry, Multidisciplinary
Shenqiang Wang, Sheng Zhao, Jicheng Yu, Zhen Gu, Yuqi Zhang
Summary: 3D printing technology has great potential in the field of tissue engineering, allowing the fabrication of biomimetic tissue structures for personalized therapy of various diseases. This review introduces the recently developed 3D printing techniques and summarizes their applications in cartilage, bone, and osteochondral tissue regeneration.
Article
Polymer Science
Franca Scocozza, Mirena Sakaj, Ferdinando Auricchio, Stefania Marconi, Pietro Riello, Cinzia Ferrari, Laura Cansolino, Laura Catenacci, Milena Sorrenti, Marco Scatto, Michele Conti
Summary: The study proposed a method to sterilize PCL-HA composite pellets using a 3D bioprinter, successfully achieving the goal of printing sterile scaffolds suitable for tissue engineering applications.
JOURNAL OF POLYMER RESEARCH
(2021)
Article
Materials Science, Ceramics
Baboucarr Lowe, Eero Huotilainen, Markku Laitinen, Anna-Maria Henell, Qingsong Ye, Maria J. Troulis, Laurence J. Walsh
Summary: In bone regenerative engineering, the biomechanical performance of the scaffold at the bone-tissue interface is crucial. Evaluation of parameters such as compressive modulus and finite element analysis can inform the design and optimization of bone substitute materials for clinical applications.
CERAMICS INTERNATIONAL
(2021)
Review
Pharmacology & Pharmacy
Amber F. MacDonald, Meaghan E. Harley-Troxell, Steven D. Newby, Madhu S. Dhar
Summary: This article summarizes the application of graphene-based materials in tissue engineering, with a focus on bone tissue engineering. It discusses the need for developing 3D graphene scaffolds and introduces the current manufacturing techniques and limitations.
Article
Polymer Science
Yuanhang Xu, Feiyang Zhang, Weijie Zhai, Shujie Cheng, Jinghua Li, Yi Wang
Summary: The repair of large-area irregular bone defects is a complex issue in orthopedic clinical treatment. Among various bone repair scaffolds, 3D printed polymer-based scaffolds show the most promise for clinical applications. This review introduces different 3D printing technologies, bone healing processes, and discusses the characteristics and potential prospects of ideal bone tissue scaffolds. Challenges in this field are also discussed.
Article
Nanoscience & Nanotechnology
Pengfei Cai, Chunchun Li, Yangfan Ding, Hanting Lu, Xiao Yu, Jie Cui, Fan Yu, Hongsheng Wang, Jinglei Wu, Mohamed EL-Newehy, Meera Moydeen Abdulhameed, Liang Song, Xiumei Mo, Binbin Sun
Summary: This research introduces a novel method that combines electrospun nanofibers with 3D printing techniques to fabricate composite scaffolds for bone defect treatment. Compared to nanoparticle-reinforced scaffolds, these scaffolds infused with nanofibers exhibit superior mechanical attributes and bioactivity.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Polymer Science
Stepan Krobot, Veronika Melcova, Premysl Mencik, Sona Kontarova, Michala Rampichova, Vera Hedvicakova, Ema Mojzisova, Andrej Baco, Radek Prikryl
Summary: In this study, composite blends based on poly(3-hydroxybutyrate) (PHB) were prepared and characterized for bone medical applications and tissue engineering. PHB was blended with poly(lactic acid) (PLA) or polycaprolactone (PCL) and plasticized with oligomeric adipate ester (SN), with the addition of tricalcium phosphate (TCP) particles as a bioactive filler. The mechanical properties, surface properties, and cytotoxicity of the blends were evaluated, and it was found that PHB/PCL blends showed good performance in 3D printing and were non-cytotoxic.
Article
Chemistry, Physical
Fangli Gang, Weilong Ye, Chunyang Ma, Wenting Wang, Yi Xiao, Chang Liu, Xiaodan Sun
Summary: The study proposes a new idea for constructing a 3D scaffold with a growth-factor-free biomimetic structure, personalized customization ability, and osteo-inductive activity.
Article
Polymer Science
Evangelos Daskalakis, Boyang Huang, Cian Vyas, Anil Ahmet Acar, Ali Fallah, Glen Cooper, Andrew Weightman, Bahattin Koc, Gordon Blunn, Paulo Bartolo
Summary: This study proposes a method for preparing polycaprolactone/bioglass scaffolds with pore size gradient by investigating the coupled effect between material composition and scaffold architecture. The results show that the addition of bioglass improves the mechanical properties and biological performance of the scaffolds.
Article
Materials Science, Multidisciplinary
Fereshteh Mahmoodiyan Najafabadi, Saeed Karbasi, Soheila Zamanlui Benisi, Shahrokh Shojaei, S. Ali Poursamar, Reyhaneh Nasr Azadani
Summary: This study synthesized magnetic mesoporous bioactive glass using the sol-gel method and incorporated alumina nanowires. The synthesized glass exhibited a mesoporous structure and paramagnetic properties. The 3D printed scaffold showed homogeneous structures with interconnected pores. The addition of alumina nanowires improved the mechanical strength, contact angle, degradation, and bioactivity of the scaffold.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Materials Science, Composites
Elham Sadeghi, Seyed Mojtaba Zebarjad, Farzaneh Khademi, Elham Bagherzadeh
Summary: In this study, PCL/Ge/HA core-shell nanocomposites were produced using coaxial electrospinning method. The resulting nanofibrous scaffolds showed good mechanical properties and biological activity, making them promising candidates for bone scaffolds.
POLYMER COMPOSITES
(2022)
Review
Nanoscience & Nanotechnology
Lijia Cheng, Shoma K. Suresh, Hongyan He, Ritu Singh Rajput, Qiyang Feng, Saravanan Ramesh, Yuzhuang Wang, Sasirekha Krishnan, Serge Ostrovidov, Gulden Camci-Unal, Murugan Ramalingam
Summary: Recent advancements in 3D printing technology show great potential in fabricating scaffolds and implants for biomedical applications, particularly in bone repair and regeneration. The integration of different living cells in 3D constructs made from conventional biomaterials can create artificial bone grafts capable of regenerating damaged tissues. Various conventional and nanomaterials have been utilized in the production of 3D-printed scaffolds for bone tissue engineering applications.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Cell Biology
Wenfeng Luo, Jie Deng, Jiecheng He, Liang Yin, Rong You, Lingkun Zhang, Jian Shen, Zeping Han, Fangmei Xie, Jinhua He, Yanqing Guan
Summary: This study elucidates the active constituents and potential mechanisms of fenugreek against diabetes using molecular docking and network pharmacology methods. The findings suggest that fenugreek regulates diabetes through active compounds such as diosgenin, luteolin and quercetin, and their related genes. Cell experiments demonstrate the safety and efficacy of fenugreek in improving glucose consumption. Pathway enrichment analysis reveals the involvement of the AGE-RAGE and NF-kappa B signaling pathways, highlighting the anti-oxidative stress, anti-inflammatory response, and beta-cell protection as key factors in fenugreek's anti-diabetic effect.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
