Diverse Epitope Specificity, Immunodominance Hierarchy, and Functional Avidity of Effector CD4 T Cells Established During Priming Is Maintained in Lung After Influenza A Virus Infection

The IRF4 Gene Regulatory Module Functions as a Read-Write Integrator to Dynamically Coordinate T Helper Cell Fate

(2017) Veena Krishnamoorthy et al.   IMMUNITY

Persistence in Temporary Lung Niches: A Survival Strategy of Lung-Resident Memory CD8+ T Cells

(2017) Shiki Takamura   VIRAL IMMUNOLOGY

Pandemic 2009 H1N1 Influenza Venus reporter virus reveals broad diversity of MHC class II-positive antigen-bearing cells following infection in vivo

(2017) Anthony DiPiazza et al.   Scientific Reports

Short-Lived Antigen Recognition but Not Viral Infection at a Defined Checkpoint Programs Effector CD4 T Cells To Become Protective Memory

(2016) Bianca L. Bautista et al.   JOURNAL OF IMMUNOLOGY

Detection, phenotyping, and quantification of antigen-specific T cells using a peptide-MHC dodecamer

(2016) Jun Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low-affinity CD4+ T cells are major responders in the primary immune response

(2016) Ryan J. Martinez et al.   Nature Communications

CD4 T cell epitope specificity determines follicular versus non-follicular helper differentiation in the polyclonal response to influenza infection or vaccination

(2016) Zackery A. G. Knowlden et al.   Scientific Reports

New Insights into the Generation of CD4 Memory May Shape Future Vaccine Strategies for Influenza

(2016) Priyadharshini Devarajan et al.   Frontiers in Immunology

The Role of CD4 T Cell Memory in Generating Protective Immunity to Novel and Potentially Pandemic Strains of Influenza

(2016) Anthony DiPiazza et al.   Frontiers in Immunology

Robust Anti-viral Immunity Requires Multiple Distinct T Cell-Dendritic Cell Interactions

(2015) Sarah Eickhoff et al.   CELL

Distinct germinal center selection at local sites shapes memory B cell response to viral escape

(2015) Yu Adachi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tissue instruction for migration and retention of TRM cells

(2015) Norifumi Iijima et al.   TRENDS IN IMMUNOLOGY

Lower Affinity T Cells are Critical Components and Active Participants of the Immune Response

(2015) Ryan J. Martinez et al.   Frontiers in Immunology

Distinct Dendritic Cell Subsets Dictate the Fate Decision between Effector and Memory CD8+ T Cell Differentiation by a CD24-Dependent Mechanism

(2014) Taeg S. Kim et al.   IMMUNITY

Tissue-Resident Memory T Cells

(2014) Jason M. Schenkel et al.   IMMUNITY

CD4+ T Cell Help Guides Formation of CD103+ Lung-Resident Memory CD8+ T Cells during Influenza Viral Infection

(2014) Brian J. Laidlaw et al.   IMMUNITY

Peripheral regulation of T cells by dendritic cells during infection

(2014) Emily A. Hemann et al.   IMMUNOLOGIC RESEARCH

Cutting Edge: Control of Mycobacterium tuberculosis Infection by a Subset of Lung Parenchyma-Homing CD4 T Cells

(2014) S. Sakai et al.   JOURNAL OF IMMUNOLOGY

The Pulmonary Localization of Virus-Specific T Lymphocytes Is Governed by the Tissue Tropism of Infection

(2014) C. J. Knudson et al.   JOURNAL OF VIROLOGY

Intravascular staining for discrimination of vascular and tissue leukocytes

(2014) Kristin G Anderson et al.   Nature Protocols

TCR signal quantity and quality in CD4+ T cell differentiation

(2014) Noah J. Tubo et al.   TRENDS IN IMMUNOLOGY

Playing Hide and Seek: How Glycosylation of the Influenza Virus Hemagglutinin Can Modulate the Immune Response to Infection

(2014) Michelle Tate et al.   Viruses-Basel

FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability

(2014) Beatriz León et al.   Nature Communications

Mucosal Resident Memory CD4 T Cells in Protection and Immunopathology

(2014) Damian Lanz Turner et al.   Frontiers in Immunology

HLA-DM and HLA-DO, key regulators of MHC-II processing and presentation

(2013) Elizabeth D Mellins et al.   CURRENT OPINION IN IMMUNOLOGY

Multipronged CD4+T-cell effector and memory responses cooperate to provide potent immunity against respiratory virus

(2013) Tara M. Strutt et al.   IMMUNOLOGICAL REVIEWS

Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4

(2013) Zamaneh Mikhak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lung niches for the generation and maintenance of tissue-resident memory T cells

(2013) D L Turner et al.   Mucosal Immunology

CXCR3 Chemokine Receptor-Ligand Interactions in the Lymph Node Optimize CD4+ T Helper 1 Cell Differentiation

(2012) Joanna R. Groom et al.   IMMUNITY

Cross-presenting CD103+ dendritic cells are protected from influenza virus infection

(2012) Julie Helft et al.   JOURNAL OF CLINICAL INVESTIGATION

Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung

(2012) Emily E. Thornton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Intravascular Staining Redefines Lung CD8 T Cell Responses

(2012) K. G. Anderson et al.   JOURNAL OF IMMUNOLOGY

Multifunctional CD4 Cells Expressing Gamma Interferon and Perforin Mediate Protection against Lethal Influenza Virus Infection

(2012) D. M. Brown et al.   JOURNAL OF VIROLOGY

Trivalent inactivated influenza vaccines induce broad immunological reactivity to both internal virion components and influenza surface proteins

(2012) Katherine A. Richards et al.   VACCINE

CXCR3 in T cell function

(2011) Joanna R. Groom et al.   EXPERIMENTAL CELL RESEARCH

The memory phase of the CD4 T-cell response to influenza virus infection maintains its diverse antigen specificity

(2011) Katherine A. Richards et al.   IMMUNOLOGY

Mouse neutrophils are professional antigen-presenting cells programmed to instruct Th1 and Th17 T-cell differentiation

(2011) D. S. Abi Abdallah et al.   INTERNATIONAL IMMUNOLOGY

Cytotoxic CD4 T Cells in Antiviral Immunity

(2011) Nikki B. Marshall et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

High prevalence of low affinity peptide–MHC II tetramer–negative effectors during polyclonal CD4+T cell responses

(2011) Joseph J. Sabatino et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Tissue-Retentive Lung Memory CD4 T Cells Mediate Optimal Protection to Respiratory Virus Infection

(2011) J. R. Teijaro et al.   JOURNAL OF IMMUNOLOGY

Cell-surface receptors on macrophages and dendritic cells for attachment and entry of influenza virus

(2011) Sarah L. Londrigan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Immune responses to influenza virus infection

(2011) J.H.C.M. Kreijtz et al.   VIRUS RESEARCH

Antigen persistence and the control of local T cell memory by migrant respiratory dendritic cells after acute virus infection

(2010) Taeg S. Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection

(2010) Jodi McGill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Analyses of the Specificity of CD4 T Cells During the Primary Immune Response to Influenza Virus Reveals Dramatic MHC-Linked Asymmetries in Reactivity to Individual Viral Proteins

(2010) Jennifer L. Nayak et al.   VIRAL IMMUNOLOGY

CXCR3 Directs Antigen-Specific Effector CD4+ T Cell Migration to the Lung During Parainfluenza Virus Infection

(2009) J. E. Kohlmeier et al.   JOURNAL OF IMMUNOLOGY

Infection of HLA-DR1 Transgenic Mice with a Human Isolate of Influenza A Virus (H1N1) Primes a Diverse CD4 T-Cell Repertoire That Includes CD4 T Cells with Heterosubtypic Cross-Reactivity to Avian (H5N1) Influenza Virus

(2009) K. A. Richards et al.   JOURNAL OF VIROLOGY

The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

(2009) Nicolas Fazilleau et al.   NATURE IMMUNOLOGY

Respiratory Dendritic Cell Subsets Differ in Their Capacity to Support the Induction of Virus-Specific Cytotoxic CD8+ T Cell Responses

(2009) Taeg S. Kim et al.   PLoS One

Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs

(2008) Jodi McGill et al.   JOURNAL OF EXPERIMENTAL MEDICINE