CD137+CD154− Expression As a Regulatory T Cell (Treg)-Specific Activation Signature for Identification and Sorting of Stable Human Tregs from In Vitro Expansion Cultures
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Title
CD137+CD154− Expression As a Regulatory T Cell (Treg)-Specific Activation Signature for Identification and Sorting of Stable Human Tregs from In Vitro Expansion Cultures
Authors
Keywords
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Journal
Frontiers in Immunology
Volume 9, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2018-02-07
DOI
10.3389/fimmu.2018.00199
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Note: Only part of the references are listed.- Generation of human islet-specific regulatory T cells by TCR gene transfer
- (2017) Caroline M. Hull et al. JOURNAL OF AUTOIMMUNITY
- Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths
- (2017) Victoria S. Pelly et al. JOURNAL OF EXPERIMENTAL MEDICINE
- CD45RA Distinguishes CD4+CD25+CD127−/low TSDR Demethylated Regulatory T Cell Subpopulations With Differential Stability and Susceptibility to Tacrolimus-Mediated Inhibition of Suppression
- (2017) Rebeca Arroyo Hornero et al. TRANSPLANTATION
- Chimeric Antigen Receptor-Redirected Regulatory T Cells Suppress Experimental Allergic Airway Inflammation, a Model of Asthma
- (2017) Jelena Skuljec et al. Frontiers in Immunology
- Expansion of Human Tregs from Cryopreserved Umbilical Cord Blood for GMP-Compliant Autologous Adoptive Cell Transfer Therapy
- (2017) Howard R. Seay et al. Molecular Therapy-Methods & Clinical Development
- FVIII-specific human chimeric antigen receptor T-regulatory cells suppress T- and B-cell responses to FVIII
- (2016) Jeongheon Yoon et al. BLOOD
- Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans
- (2016) Petra Bacher et al. CELL
- Making Better Chimeric Antigen Receptors for Adoptive T-cell Therapy
- (2016) M. V. Maus et al. CLINICAL CANCER RESEARCH
- Thymus-Derived Regulatory T Cells Are Positively Selected on Natural Self-Antigen through Cognate Interactions of High Functional Avidity
- (2016) Elisa Kieback et al. IMMUNITY
- Epigenomic Profiling of Human CD4 + T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development
- (2016) Pawel Durek et al. IMMUNITY
- Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor
- (2016) Katherine G. MacDonald et al. JOURNAL OF CLINICAL INVESTIGATION
- Factors affecting long-term efficacy of T regulatory cell-based therapy in type 1 diabetes
- (2016) Natalia Marek-Trzonkowska et al. Journal of Translational Medicine
- Combining FoxP3 and Helios with GARP/LAP markers can identify expanded Treg subsets in cancer patients
- (2016) May Abd Al Samid et al. Oncotarget
- Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect
- (2015) C. G. Brunstein et al. BLOOD
- Adoptive transfer of allogeneic regulatory T cells into patients with chronic graft-versus-host disease
- (2015) Anke Theil et al. CYTOTHERAPY
- Regulatory T Cell Reprogramming toward a Th2-Cell-like Lineage Impairs Oral Tolerance and Promotes Food Allergy
- (2015) Magali Noval Rivas et al. IMMUNITY
- 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors
- (2015) Adrienne H Long et al. NATURE MEDICINE
- Type 1 diabetes immunotherapy using polyclonal regulatory T cells
- (2015) Jeffrey A. Bluestone et al. Science Translational Medicine
- Helios, and not FoxP3, is the marker of activated Tregs expressing GARP/LAP
- (2015) Eyad Elkord et al. Oncotarget
- Genetic and epigenetic variation in the lineage specification of regulatory T cells
- (2015) Aaron Arvey et al. eLife
- Is CD137 Ligand (CD137L) Signaling a Fine Tuner of Immune Responses?
- (2015) Byungsuk Kwon Immune Network
- HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse
- (2014) M. F. Martelli et al. BLOOD
- Therapy of type 1 diabetes with CD4+CD25highCD127-regulatory T cells prolongs survival of pancreatic islets — Results of one year follow-up
- (2014) Natalia Marek-Trzonkowska et al. CLINICAL IMMUNOLOGY
- Isolation of human antigen-specific regulatory T cells with high suppressive function
- (2014) Fatih Noyan et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Human antigen-specific CD4+CD25+CD134+CD39+T cells are enriched for regulatory T cells and comprise a substantial proportion of recall responses
- (2014) Nabila Seddiki et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Retargeting of Human T Cells to Tumor-Associated MUC1: The Evolution of a Chimeric Antigen Receptor
- (2014) S. Wilkie et al. JOURNAL OF IMMUNOLOGY
- Antigen Sensitivity of CD22-Specific Chimeric TCR Is Modulated by Target Epitope Distance from the Cell Membrane
- (2014) S. E. James et al. JOURNAL OF IMMUNOLOGY
- Identification of Immunogenic Antigens fromAspergillus fumigatusby Direct Multiparameter Characterization of Specific Conventional and Regulatory CD4+T Cells
- (2014) Petra Bacher et al. JOURNAL OF IMMUNOLOGY
- Suppression of Murine Colitis and its Associated Cancer by Carcinoembryonic Antigen-Specific Regulatory T Cells
- (2014) Dan Blat et al. MOLECULAR THERAPY
- The Nonsignaling Extracellular Spacer Domain of Chimeric Antigen Receptors Is Decisive for In Vivo Antitumor Activity
- (2014) M. Hudecek et al. Cancer Immunology Research
- Clinical Grade Manufacturing of Human Alloantigen-Reactive Regulatory T Cells for Use in Transplantation
- (2013) A. L. Putnam et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Adoptive Transfer of Umbilical Cord Blood-Derived Regulatory T Cells and Early Viral Reactivation
- (2013) Claudio G. Brunstein et al. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
- CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines
- (2013) A. M. Pesenacker et al. BLOOD
- Receptor Affinity and Extracellular Domain Modifications Affect Tumor Recognition by ROR1-Specific Chimeric Antigen Receptor T Cells
- (2013) M. Hudecek et al. CLINICAL CANCER RESEARCH
- CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT3-dependent manner
- (2013) Behdad Afzali et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Self-antigen-Driven Activation Induces Instability of Regulatory T Cells during an Inflammatory Autoimmune Response
- (2013) Samantha L. Bailey-Bucktrout et al. IMMUNITY
- Increased Prevalence of Circulating Novel IL-17 Secreting Foxp3 Expressing CD4+ T Cells and Defective Suppressive Function of Circulating Foxp3+ Regulatory Cells Support Plasticity Between Th17 and Regulatory T Cells in Inflammatory Bowel Disease Patients
- (2013) Aito Ueno et al. INFLAMMATORY BOWEL DISEASES
- Antigen-specific expansion of human regulatory T cells as a major tolerance mechanism against mucosal fungi
- (2013) P Bacher et al. Mucosal Immunology
- Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis
- (2013) Noriko Komatsu et al. NATURE MEDICINE
- Clinical application of regulatory T cells in type 1 diabetes
- (2013) Natalia Marek-Trzonkowska et al. PEDIATRIC DIABETES
- TCR affinity and specificity requirements for human regulatory T-cell function
- (2012) G. Plesa et al. BLOOD
- Administration of CD4+CD25highCD127- Regulatory T Cells Preserves -Cell Function in Type 1 Diabetes in Children
- (2012) N. Marek-Trzonkowska et al. DIABETES CARE
- A Converse 4-1BB and CD40 Ligand Expression Pattern Delineates Activated Regulatory T Cells (Treg) and Conventional T Cells Enabling Direct Isolation of Alloantigen-Reactive Natural Foxp3+ Treg
- (2012) A. Schoenbrunn et al. JOURNAL OF IMMUNOLOGY
- The Potency of Allospecific Tregs Cells Appears to Correlate With T Cell Receptor Functional Avidity
- (2011) J. Y. S. Tsang et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Host CD25+CD4+Foxp3+ Regulatory T Cells Primed by anti-CD137 mAbs Inhibit Graft-versus-Host Disease
- (2011) Juyang Kim et al. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
- Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
- (2011) M. Di Ianni et al. BLOOD
- Regulatory T cells in stem cell transplantation: strategies and first clinical experiences
- (2011) Matthias Edinger et al. CURRENT OPINION IN IMMUNOLOGY
- Isolation strategies of regulatory T cells for clinical trials: Phenotype, function, stability, and expansion capacity
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- CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients
- (2011) Barbara Savoldo et al. JOURNAL OF CLINICAL INVESTIGATION
- IL-17 + Regulatory T Cells in the Microenvironments of Chronic Inflammation and Cancer
- (2011) Ilona Kryczek et al. JOURNAL OF IMMUNOLOGY
- Plasticity of Human Regulatory T Cells in Healthy Subjects and Patients with Type 1 Diabetes
- (2011) Stephanie A. McClymont et al. JOURNAL OF IMMUNOLOGY
- Single-Cell Analysis of the Human T Regulatory Population Uncovers Functional Heterogeneity and Instability within FOXP3+ Cells
- (2011) E. d'Hennezel et al. JOURNAL OF IMMUNOLOGY
- Foxp3+ Regulatory T Cells of Psoriasis Patients Easily Differentiate into IL-17A-Producing Cells and Are Found in Lesional Skin
- (2011) H. Jorn Bovenschen et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease
- (2011) Margarita Dominguez-Villar et al. NATURE MEDICINE
- BiQ Analyzer HT: locus-specific analysis of DNA methylation by high-throughput bisulfite sequencing
- (2011) Pavlo Lutsik et al. NUCLEIC ACIDS RESEARCH
- Human Regulatory T Cells with Alloantigen Specificity Are More Potent Inhibitors of Alloimmune Skin Graft Damage than Polyclonal Regulatory T Cells
- (2011) P. Sagoo et al. Science Translational Medicine
- Clinical perspectives for regulatory T cells in transplantation tolerance
- (2011) Keli L. Hippen et al. SEMINARS IN IMMUNOLOGY
- Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics
- (2010) C. G. Brunstein et al. BLOOD
- Characterization of Interleukin-17–Producing Regulatory T Cells in Inflamed Intestinal Mucosa From Patients With Inflammatory Bowel Diseases
- (2010) Zaruhi Hovhannisyan et al. GASTROENTEROLOGY
- Cutting Edge: Human Latency-Associated Peptide+ T Cells: A Novel Regulatory T Cell Subset
- (2010) R. Gandhi et al. JOURNAL OF IMMUNOLOGY
- Human Antigen-Specific Regulatory T Cells Generated by T Cell Receptor Gene Transfer
- (2010) Todd M. Brusko et al. PLoS One
- Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures
- (2009) D. Q. Tran et al. BLOOD
- First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127− T regulatory cells
- (2009) Piotr Trzonkowski et al. CLINICAL IMMUNOLOGY
- Loss of FOXP3 expression in natural human CD4+CD25+regulatory T cells upon repetitivein vitrostimulation
- (2009) Petra Hoffmann et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Curing CNS autoimmune disease with myelin-reactive Foxp3+Treg
- (2009) Leigh A. Stephens et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Membrane protein GARP is a receptor for latent TGF-β on the surface of activated human Treg
- (2009) Julie Stockis et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Comparison of stable human Treg and Th clones by transcriptional profiling
- (2009) Julie Stockis et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Amelioration of Colitis by Genetically Engineered Murine Regulatory T Cells Redirected by Antigen-Specific Chimeric Receptor
- (2009) Eran Elinav et al. GASTROENTEROLOGY
- Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity
- (2009) C. Schmidl et al. GENOME RESEARCH
- Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor
- (2009) Makoto Miyara et al. IMMUNITY
- A Herceptin-Based Chimeric Antigen Receptor with Modified Signaling Domains Leads to Enhanced Survival of Transduced T Lymphocytes and Antitumor Activity
- (2009) Y. Zhao et al. JOURNAL OF IMMUNOLOGY
- Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo
- (2009) Michael C. Milone et al. MOLECULAR THERAPY
- Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo
- (2009) Xuyu Zhou et al. NATURE IMMUNOLOGY
- GARP (LRRC32) is essential for the surface expression of latent TGF- on platelets and activated FOXP3+ regulatory T cells
- (2009) D. Q. Tran et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells
- (2009) R. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis
- (2009) Graham P. Wright et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells
- (2008) H. J. P. M. Koenen et al. BLOOD
- Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes
- (2008) A. L. Putnam et al. DIABETES
- DNA methylation controls Foxp3 gene expression
- (2008) Julia K. Polansky et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Redirection of Regulatory T Cells With Predetermined Specificity for the Treatment of Experimental Colitis in Mice
- (2008) Eran Elinav et al. GASTROENTEROLOGY
- Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice
- (2008) Julia Yuen-Shan Tsang et al. JOURNAL OF CLINICAL INVESTIGATION
- Rapid identification and sorting of viable virus-reactive CD4+ and CD8+ T cells based on antigen-triggered CD137 expression
- (2008) Thomas C. Wehler et al. JOURNAL OF IMMUNOLOGICAL METHODS
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