Dopaminergic Stimulation of Myeloid Antigen-Presenting Cells Attenuates Signal Transducer and Activator of Transcription 3-Activation Favouring the Development of Experimental Autoimmune Encephalomyelitis

Dopamine, T cells and multiple sclerosis (MS)

(2017) Mia Levite et al.   JOURNAL OF NEURAL TRANSMISSION

The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype on DCs

(2016) Cristian Doñas et al.   JOURNAL OF AUTOIMMUNITY

Repurposing dopaminergic drugs for MS — the evidence mounts

(2016) Franca Marino et al.   Nature Reviews Neurology

Modulation of monocytes by bioactive lipid anandamide in multiple sclerosis involves distinct Toll-like receptors

(2016) Valerio Chiurchiù et al.   PHARMACOLOGICAL RESEARCH

JAK1/STAT3 activation directly inhibits IL-12 production in dendritic cells by preventing CDK9/P-TEFb recruitment to the p35 promoter

(2015) Andreas H. Wagner et al.   BIOCHEMICAL PHARMACOLOGY

Analysis of TGF-β1 and TGF-β3 as regulators of encephalitogenic Th17 cells: Implications for multiple sclerosis

(2015) Priscilla W. Lee et al.   BRAIN BEHAVIOR AND IMMUNITY

GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c+MHCII+ Macrophages and Dendritic Cells

(2015) Julie Helft et al.   IMMUNITY

Canonical Wnt Signaling in Dendritic Cells Regulates Th1/Th17 Responses and Suppresses Autoimmune Neuroinflammation

(2015) Amol Suryawanshi et al.   JOURNAL OF IMMUNOLOGY

Dopamine receptors D3 and D5 regulate CD4+T-cell activation and differentiation by modulating ERK activation and cAMP production

(2015) Dafne Franz et al.   JOURNAL OF NEUROIMMUNOLOGY

CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells

(2015) Ervin E. Kara et al.   Nature Communications

Non-Classical monocytes display inflammatory features: Validation in Sepsis and Systemic Lupus Erythematous

(2015) Ratnadeep Mukherjee et al.   Scientific Reports

The Transcription Factor IRF8 Activates Integrin-Mediated TGF-β Signaling and Promotes Neuroinflammation

(2014) Yuko Yoshida et al.   IMMUNITY

Essential Role of CD8+CD122+ Regulatory T Cells in the Recovery from Experimental Autoimmune Encephalomyelitis

(2014) Y.-H. Lee et al.   JOURNAL OF IMMUNOLOGY

Expression of Dopaminergic Receptors on Human CD4+ T Lymphocytes: Flow Cytometric Analysis of Naive and Memory Subsets and Relevance for the Neuroimmunology of Neurodegenerative Disease

(2014) Natasa Kustrimovic et al.   Journal of Neuroimmune Pharmacology

The vital role of constitutive GPCR activity in the mesolimbic dopamine system

(2014) F J Meye et al.   Translational Psychiatry

The Dopaminergic System in Autoimmune Diseases

(2014) Rodrigo Pacheco et al.   Frontiers in Immunology

T-bet is essential for Th1-mediated, but not Th17-mediated, CNS autoimmune disease

(2013) Richard A. O'Connor et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cell-extrinsic CTLA4-mediated regulation of dendritic cell maturation depends on STAT3

(2013) Aleksandra Kowalczyk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Blockade of dopamine D1-like receptor signalling protects mice against OVA-induced acute asthma by inhibiting B-cell activating transcription factor signalling and Th17 function

(2013) Subo Gong et al.   FEBS Journal

Autoimmune Memory T Helper 17 Cell Function and Expansion Are Dependent on Interleukin-23

(2013) Christopher J. Haines et al.   Cell Reports

Modulation of T-cell Mediated Immunity by Dopamine Receptor D5

(2013) Carolina Prado et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Stimulation of Dopamine Receptor D5 Expressed on Dendritic Cells Potentiates Th17-Mediated Immunity

(2012) C. Prado et al.   JOURNAL OF IMMUNOLOGY

Adrenergic and Dopaminergic Modulation of Immunity in Multiple Sclerosis: Teaching Old Drugs New Tricks?

(2012) Marco Cosentino et al.   Journal of Neuroimmune Pharmacology

TLR-4 ligation of dendritic cells is sufficient to drive pathogenic T cell function in experimental autoimmune encephalomyelitis

(2012) Richard J Mellanby et al.   Journal of Neuroinflammation

Prostaglandin E2 inhibits IL-23 and IL-12 production by human monocytes through down-regulation of their common p40 subunit

(2012) Khalid W. Kalim et al.   MOLECULAR IMMUNOLOGY

Dopaminergic Modulation of CD4+CD25high Regulatory T Lymphocytes in Multiple Sclerosis Patients during Interferon-ß Therapy

(2012) Marco Cosentino et al.   NEUROIMMUNOMODULATION

NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis

(2012) M. Inoue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dopamine Induces IL-6-Dependent IL-17 Production via D1-Like Receptor on CD4 Naive T Cells and D1-Like Receptor Antagonist SCH-23390 Inhibits Cartilage Destruction in a Human Rheumatoid Arthritis/SCID Mouse Chimera Model

(2011) K. Nakano et al.   JOURNAL OF IMMUNOLOGY

Caspase-1-Processed Cytokines IL-1  and IL-18 Promote IL-17 Production by    and CD4 T Cells That Mediate Autoimmunity

(2011) S. J. Lalor et al.   JOURNAL OF IMMUNOLOGY

Dopamine D1-Like Receptor Antagonist Attenuates Th17-Mediated Immune Response and Ovalbumin Antigen-Induced Neutrophilic Airway Inflammation

(2011) K. Nakagome et al.   JOURNAL OF IMMUNOLOGY

Lymph node-derived donor encephalitogenic CD4+ T cells in C57BL/6 mice adoptive transfer experimental autoimmune encephalomyelitis highly express GM-CSF and T-bet

(2011) Petra D Cravens et al.   Journal of Neuroinflammation

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

Physiological Induction of Regulatory Qa-1-Restricted CD8+ T Cells Triggered by Endogenous CD4+ T Cell Responses

(2011) Aditi Varthaman et al.   PLoS One

γδ T Cells Enhance Autoimmunity by Restraining Regulatory T Cell Responses via an Interleukin-23-Dependent Mechanism

(2010) Franziska Petermann et al.   IMMUNITY

Leptin potentiates antiproliferative action of cAMP elevation via protein kinase A down-regulation in breast cancer cells

(2010) Silvio Naviglio et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Regulatory B Cells (B10 Cells) and Regulatory T Cells Have Independent Roles in Controlling Experimental Autoimmune Encephalomyelitis Initiation and Late-Phase Immunopathogenesis

(2010) T. Matsushita et al.   JOURNAL OF IMMUNOLOGY

Therapeutic effect of D1-like dopamine receptor antagonist on collagen-induced arthritis of mice

(2010) Hiroki Nakashioya et al.   Modern Rheumatology

Activation of  -Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine

(2010) S. Manicassamy et al.   SCIENCE

D1-Like Receptor Antagonist Inhibits IL-17 Expression and Attenuates Crescent Formation in Nephrotoxic Serum Nephritis

(2009) Hirokazu Okada et al.   AMERICAN JOURNAL OF NEPHROLOGY

Dopamine D1-like receptor antagonist, SCH23390, exhibits a preventive effect on diabetes mellitus that occurs naturally in NOD mice

(2009) Kumiko Hashimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel CD8+Treg suppress EAE by TGF-β- and IFN-γ-dependent mechanisms

(2009) Mei-Ling Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dopamine released by dendritic cells polarizes Th2 differentiation

(2009) K. Nakano et al.   INTERNATIONAL IMMUNOLOGY

Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

(2009) Caspar Ohnmacht et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of dopamine in the physiology of T-cells and dendritic cells

(2009) Rodrigo Pacheco et al.   JOURNAL OF NEUROIMMUNOLOGY

Th17 cells in immunity and autoimmunity

(2008) M Oukka   ANNALS OF THE RHEUMATIC DISEASES

Antagonizing dopamine D1-like receptor inhibits Th17 cell differentiation: Preventive and therapeutic effects on experimental autoimmune encephalomyelitis

(2008) Kazuhisa Nakano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A six-color flow cytometric assay for the analysis of peripheral blood dendritic cells

(2008) Stefania Giannelli et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Interleukin-6 Inhibits Receptor Activator of Nuclear Factor κB Ligand-Induced Osteoclastogenesis by Diverting Cells into the Macrophage Lineage: Key Role of Serine727Phosphorylation of Signal Transducer and Activator of Transcription 3

(2008) Laurence Duplomb et al.   ENDOCRINOLOGY

A novel CD11c.DTR transgenic mouse for depletion of dendritic cells reveals their requirement for homeostatic proliferation of natural killer cells

(2008) Kristin Hochweller et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Therapy with interferon-β modulates endogenous catecholamines in lymphocytes of patients with multiple sclerosis

(2008) Mauro Zaffaroni et al.   EXPERIMENTAL NEUROLOGY

Role of Th1 and Th17 cells in organ-specific autoimmunity

(2008) Valérie Dardalhon et al.   JOURNAL OF AUTOIMMUNITY

Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression

(2008) Takashi Matsushita et al.   JOURNAL OF CLINICAL INVESTIGATION