Genetically Induced Tumors in the Oncopig Model Invoke an Antitumor Immune Response Dominated by Cytotoxic CD8β+ T Cells and Differentiated γδ T Cells Alongside a Regulatory Response Mediated by FOXP3+ T Cells and Immunoregulatory Molecules

An in-depth comparison of the porcine, murine and human inflammasomes; lessons from the porcine genome and transcriptome

(2017) Harry D. Dawson et al.   VETERINARY MICROBIOLOGY

A validated, transitional and translational porcine model of hepatocellular carcinoma

(2017) Kyle M. Schachtschneider et al.   Oncotarget

Oncopig Soft-Tissue Sarcomas Recapitulate Key Transcriptional Features of Human Sarcomas

(2017) Kyle M. Schachtschneider et al.   Scientific Reports

Immunoscore and Immunoprofiling in cancer: an update from the melanoma and immunotherapy bridge 2015

(2016) J. Galon et al.   Journal of Translational Medicine

Pigs as models of human cancers

(2016) Tatiana Flisikowska et al.   THERIOGENOLOGY

NK cells are intrinsically functional in pigs with Severe Combined Immunodeficiency (SCID) caused by spontaneous mutations in the Artemis gene

(2016) Ellis J. Powell et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Animal models of head and neck squamous cell carcinoma

(2016) Wachiraphan Supsavhad et al.   VETERINARY JOURNAL

Engineered Swine Models of Cancer

(2016) Adrienne L. Watson et al.   Frontiers in Genetics

Cross-species models of human melanoma

(2015) Louise van der Weyden et al.   JOURNAL OF PATHOLOGY

Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial

(2015) Jeffrey S Weber et al.   LANCET ONCOLOGY

A Genetic Porcine Model of Cancer

(2015) Lawrence B. Schook et al.   PLoS One

Human and Mouse CD8+CD25+FOXP3+ Regulatory T Cells at Steady State and during Interleukin-2 Therapy

(2015) Guillaume Churlaud et al.   Frontiers in Immunology

Establishing the pig as a large animal model for vaccine development against human cancer

(2015) Nana H. Overgaard et al.   Frontiers in Genetics

CD2 and CD8α define porcine γδ T cells with distinct cytokine production profiles

(2014) Corinna Sedlak et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Development and translational imaging of a TP53 porcine tumorigenesis model

(2014) Jessica C. Sieren et al.   JOURNAL OF CLINICAL INVESTIGATION

CD4+ /CD8+ double-positive T cells: more than just a developmental stage?

(2014) Nana H. Overgaard et al.   JOURNAL OF LEUKOCYTE BIOLOGY

iRegulon: From a Gene List to a Gene Regulatory Network Using Large Motif and Track Collections

(2014) Rekin's Janky et al.   PLoS Computational Biology

Structural and functional annotation of the porcine immunome

(2013) Harry D Dawson et al.   BMC GENOMICS

Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours

(2013) Jérôme Galon et al.   JOURNAL OF PATHOLOGY

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

Levels of peripheral CD4+FoxP3+ regulatory T cells are negatively associated with clinical response to adoptive immunotherapy of human cancer

(2012) X. Yao et al.   BLOOD

Characterization of immune modulating functions of γδ T cell subsets in a gnotobiotic pig model of human rotavirus infection

(2012) Ke Wen et al.   COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

Cancer classification using the Immunoscore: a worldwide task force

(2012) Jérôme Galon et al.   Journal of Translational Medicine

The immune score as a new possible approach for the classification of cancer

(2012) Jérôme Galon et al.   Journal of Translational Medicine

Analyses of pig genomes provide insight into porcine demography and evolution

(2012) Martien A. M. Groenen et al.   NATURE

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inactivation and Inducible Oncogenic Mutation of p53 in Gene Targeted Pigs

(2012) Simon Leuchs et al.   PLoS One

The Present and Future of Peptide Vaccines for Cancer

(2011) Craig L. Slingluff   CANCER JOURNAL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The expression of CD25, CD11b, SWC1, SWC7, MHC-II, and family of CD45 molecules can be used to characterize different stages of γδ T lymphocytes in pigs

(2011) Kateřina Štěpánová et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Canine tumors: a spontaneous animal model of human carcinogenesis

(2011) Salomé S. Pinho et al.   Translational Research

The pig: a model for human infectious diseases

(2011) François Meurens et al.   TRENDS IN MICROBIOLOGY

Granzymes in cancer and immunity

(2010) S P Cullen et al.   CELL DEATH AND DIFFERENTIATION

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

High efficiency of BRCA1 knockout using rAAV-mediated gene targeting: developing a pig model for breast cancer

(2010) Yonglun Luo et al.   TRANSGENIC RESEARCH

Coordination of Intratumoral Immune Reaction and Human Colorectal Cancer Recurrence

(2009) M. Camus et al.   CANCER RESEARCH

Arginase I–Producing Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma Are a Subpopulation of Activated Granulocytes

(2009) Paulo C. Rodriguez et al.   CANCER RESEARCH

Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine

(2009) M. K. Srivastava et al.   CANCER RESEARCH

Biomolecular Network Reconstruction Identifies T-Cell Homing Factors Associated With Survival in Colorectal Cancer

(2009) Bernhard Mlecnik et al.   GASTROENTEROLOGY

In Situ Cytotoxic and Memory T Cells Predict Outcome in Patients With Early-Stage Colorectal Cancer

(2009) Franck Pagès et al.   JOURNAL OF CLINICAL ONCOLOGY

Immune infiltration in human tumors: a prognostic factor that should not be ignored

(2009) F Pagès et al.   ONCOGENE

Tumor Escape Mechanism Governed by Myeloid-Derived Suppressor Cells

(2008) S. Nagaraj et al.   CANCER RESEARCH

Evolutionarily conserved cytogenetic changes in hematological malignancies of dogs and humans – man and his best friend share more than companionship

(2008) Matthew Breen et al.   CHROMOSOME RESEARCH

Anatomical particularities of the porcine immune system—A physician's view

(2008) Hermann-Josef Rothkötter   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Porcine T lymphocytes and NK cells – An update

(2008) Wilhelm Gerner et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells

(2008) Ilaria Marigo et al.   IMMUNOLOGICAL REVIEWS

Transcription analysis in the MeLiM swine model identifies RACK1 as a potential marker of malignancy for human melanocytic proliferation

(2008) Giorgia Egidy et al.   Molecular Cancer

Membrane markers of the immune cells in swine: an update

(2008) Laurence Piriou-Guzylack et al.   VETERINARY RESEARCH