CD4+ /CD8+ double-positive T cells: more than just a developmental stage?

Peripheral CD4CD8 Double Positive T Cells with a Distinct Helper Cytokine Profile Are Increased in Rheumatoid Arthritis

(2014) Dagmar Quandt et al.   PLoS One

CD4CD8αα Lymphocytes, A Novel Human Regulatory T Cell Subset Induced by Colonic Bacteria and Deficient in Patients with Inflammatory Bowel Disease

(2014) Guillaume Sarrabayrouse et al.   PLOS BIOLOGY

Transcriptional reprogramming of mature CD4+ helper T cells generates distinct MHC class II–restricted cytotoxic T lymphocytes

(2013) Daniel Mucida et al.   NATURE IMMUNOLOGY

Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4+ T cell immunity

(2013) Bernardo Sgarbi Reis et al.   NATURE IMMUNOLOGY

In Vitro Induction of Regulatory CD4+CD8α+ T Cells by TGF-β, IL-7 and IFN-γ

(2013) Luc Van Kaer et al.   PLoS One

Extrathymic CD4+CD8+ lymphocytes in Chagas disease: possible relationship with an immunoendocrine imbalance

(2012) Ana R. Pérez et al.   Annals of the New York Academy of Sciences

CD4+CD8+ T Cells Represent a Significant Portion of the Anti-HIV T Cell Response to Acute HIV Infection

(2012) M. A. Frahm et al.   JOURNAL OF IMMUNOLOGY

Isolation of Human CD4/CD8 Double-Positive, Graft-Versus-Host Disease-Protective, Minor Histocompatibility Antigen-Specific Regulatory T Cells and of a Novel HLA-DR7-Restricted HY-Specific CD4 Clone

(2012) A. Eljaafari et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of T Cell Development and Transformation

(2011) Ute Koch et al.   Annual Review of Cell and Developmental Biology

Distinct CD4+CD8+ Double-Positive T Cells in the Blood and Liver of Patients during Chronic Hepatitis B and C

(2011) Michelina Nascimbeni et al.   PLoS One

Increased CD4+/CD8+ Double-Positive T Cells in Chronic Chagasic Patients

(2011) Nicolas A. Giraldo et al.   PLoS Neglected Tropical Diseases

The Role of ThPOK in Control of CD4/CD8 Lineage Commitment

(2010) Xi He et al.   Annual Review of Immunology

The presence of CD8+ invariant NKT cells in mice

(2010) Hyunji Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Tumor-reactive CD4+CD8αβ+ CD103+ αβT cells: A prevalent tumor-reactive T-cell subset in metastatic colorectal cancers

(2010) Guillaume Sarrabayrouse et al.   INTERNATIONAL JOURNAL OF CANCER

The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes

(2010) Shinya Sakaguchi et al.   NATURE IMMUNOLOGY

Double Positive CD4CD8 αβ T Cells: A New Tumor-Reactive Population in Human Melanomas

(2010) Juliette Desfrançois et al.   PLoS One

Increased frequency of nonconventional double positive CD4CD8 αβ T cells in human breast pleural effusions

(2009) Juliette Desfrançois et al.   INTERNATIONAL JOURNAL OF CANCER

The Zinc Finger Transcription Factor Zbtb7b Represses CD8-Lineage Gene Expression in Peripheral CD4+ T Cells

(2008) Lie Wang et al.   IMMUNITY

Peripheral NKT Cells in Simian Immunodeficiency Virus-Infected Macaques

(2008) C. S. Fernandez et al.   JOURNAL OF VIROLOGY

ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage

(2008) Takeshi Egawa et al.   NATURE IMMUNOLOGY

Repression of the Transcription Factor Th-POK by Runx Complexes in Cytotoxic T Cell Development

(2008) R. Setoguchi et al.   SCIENCE